In vitro efficacy of disinfectants utilised for skin decolonisation and environmental decontamination during a hospital outbreak with Candida auris
Abstract
Summary Candida auris has caused nosocomial infections and transmissions within hospital settings. As little is known about the efficacy of skin and environmental decontamination products to kill C. auris, this study investigated the in vitro activity of chlorine, chlorhexidine, iodine povidone and vaporised hydrogen peroxide products against C. auris. H2O2 vapour showed 96.6%‐100% effective killing of C. auris. All isolates were inhibited by chlorhexidine gluconate concentrations at 0.125%‐1.5% and for iodinated povidone at 0.07%‐1.25%. Other species of Candida were also killed at 1000 ppm chlorine except C. parapsilosis which failed to be killed at 3 minutes contact time. We conclude that chlorhexidine gluconate, iodinated povidone, chlorine and H2O2 vapour demonstrate effective killing activity against C. auris at concentrations used in clinical practice.
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The age of the individual has been reported as a predisposing factor for C. auris skin colonization in some studies, with C. auris-colonized patients aged 65-80 years at greater risk.
“The age of the individual has been reported as a predisposing factor for C. auris skin colonization in some studies, with C. auris-colonized patients aged 65–80 years at greater risk [62–64].”
From Host–Candida auris interactions in the skin (2026) · cites this paper as [64]
C. auris demonstrates a remarkable ability to persist on both host skin and inanimate objects for extended periods of time, posing great challenges to eradicate from hospital settings.
“C. auris demonstrates a remarkable ability to persist on both host skin and inanimate objects for extended periods of time, posing great challenges to eradicate from hospital settings.”
From Host–Candida auris interactions in the skin (2026) · cites this paper as [64]
Many hospital-grade disinfectants have limited efficacy against C. auris.
“Notably, many hospital-grade disinfectants have limited efficacy against C. auris [12,64,65].”
From Host–Candida auris interactions in the skin (2026) · cites this paper as [64]
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- Authors
- Abdolrasouli, A., Armstrong‐James, D., Ryan, L., & Schelenz, S.
- Affiliations
- Imperial College London (GB)
- Fungal Pathogens Laboratory National Heart and Lung Institute Imperial College London London UK
- Royal Brompton Hospital (GB)
- Corresponding author
- Schelenz, Silke
- Venue
- Mycoses
- Publisher
- Wiley
- Published
- 2017-09-15
- Volume
- 60
- Issue
- 11
- Pages
- 758-763
- ISSN
- 0027-5557 (ISSN-L)
- 0933-7407
- 1439-0507
- OpenAlex
- W2753228732
- Cited by
- 150
- References
- 15
- Citations by year
- 2026: 15 · 2025: 12 · 2024: 15 · 2023: 21 · 2022: 9 · 2021: 13 · 2020: 17 · 2019: 22 · 2018: 21 · 2017: 5
- FWCI
- 13.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mycoses (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- Candida auris, environmental decontamination, hospital outbreak, chlorhexidine gluconate, povidone-iodine, chlorine, hydrogen peroxide vapor, Candida parapsilosis, nosocomial fungal infections
- MeSH terms
- Candida, Candidiasis, Chlorhexidine, Chlorine, Cross Infection, Decontamination, Disease Outbreaks, Disinfectants, Hospitals, Humans, Hydrogen Peroxide, Povidone-Iodine, Volatilization
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