Cited by 515Iron Metabolism and DisordersFerroptosis and cancer prognosisTrace Elements in Health

The DOI matches its Crossref record; 120 of the 121 references it cites were found in a registry or an index.

Iron and cancer: recent insights

Open access

Manz, David H., Blanchette, Nicole L., Paul, Bibbin T., Torti, Frank M., Torti, Suzy V.·2016·Annals of the New York Academy of Sciences

DOI 10.1111/nyas.13008PMC PMC4870095

Open this paper in CoChat — free account

Abstract

Iron is an essential dietary element. However, the ability of iron to cycle between oxidized and reduced forms also renders it capable of contributing to free radical formation, which can have deleterious effects, including promutagenic effects that can potentiate tumor formation. Dysregulation of iron metabolism can increase cancer risk and promote tumor growth. Cancer cells exhibit an enhanced dependence on iron relative to their normal counterparts, a phenomenon we have termed iron addiction. Work conducted in the past few years has revealed new cellular processes and mechanisms that deepen our understanding of the link between iron and cancer. Control of iron efflux through the combined action of ferroportin, an iron efflux pump, and its regulator hepcidin appears to play an important role in tumorigenesis. Ferroptosis is a form of iron‐dependent cell death involving the production of reactive oxygen species. Specific mechanisms involved in ferroptosis, including depletion of glutathione and inhibition of glutathione peroxidase 4, have been uncovered. Ferritinophagy is a newly identified mechanism for degradation of the iron storage protein ferritin. Perturbations of mechanisms that control transcripts encoding proteins that regulate iron have been observed in cancer cells, including differences in miRNA, methylation, and acetylation. These new insights may ultimately provide new therapeutic opportunities for treating cancer.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/nyas.13008

Cites

120 of 120 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
MicroRNAs: small RNAs with a big role in gene regulation
He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 7,118
Functions of DNA methylation: islands, start sites, gene bodies and beyond
Jones, P. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3230 · Cited by 6,061
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Ferroptosis as a p53-mediated activity during tumour suppression
Jiang, L., Kon, N., Li, T., Wang, S.-J., Su, T., Hibshoosh, H., Baer, R., & Gu, W. (2015) · Nature · doi:10.1038/nature14344 · Cited by 3,398
Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163
[44] Glutathione peroxidase
Wendel, A. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)77046-0 · Cited by 3,032
The role of iron and reactive oxygen species in cell death
Dixon, S. J., & Stockwell, B. R. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1416 · Cited by 2,381
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
Yu, H., Lee, H., Herrmann, A., Buettner, R., & Jove, R. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3818 · Cited by 2,137

Flagged first, then by citations

Show all 121 references

1 of the 121 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

10.1371/journal.pgen.1003408 · DOI

Sorted by citations

Items 201–300 of 515

Ferroptosis-related long non-coding RNA signature predicts the prognosis of bladder cancer
Hou, J. Y., Lu, Z., Cheng, X.-B., Dong, R., Jiang, Y., Wu, G., Qu, G., & Xu, Y. (2022) · BMC Cancer · doi:10.1186/s12885-022-09805-9 · Cited by 22
“Discussion Ferroptosis or iron-dependent cell death can regulate tumor proliferation, invasion, and progression [29].”
Background
NIR-promoted ferrous ion regeneration enhances ferroptosis for glioblastoma treatment
Xue, K., Yang, R., An, Y., Ding, Y., Li, S., Miao, F., Liu, D., Chen, D., & Tang, Q. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.01.004 · Cited by 22
The Impact of Iron on Cancer-Related Immune Functions in Oncology: Molecular Mechanisms and Clinical Evidence
Badran, O., Cohen, I., & Bar‐Sela, G. (2024) · Cancers · doi:10.3390/cancers16244156 · Cited by 26
Homéostasie du fer et autophagie
Hamaï, A., & Mehrpour, M. (2017) · médecine/sciences · doi:10.1051/medsci/20173303012 · Cited by 24
“L’homéostasie du fer est donc très finement régulée à la fois au niveau systémique et au niveau de la cellule [1-5].”
In vitro assessment of the cytotoxicity of Gallium(III) complexes with Isoniazid-Derived Hydrazones: Effects on clonogenic survival of HCT-116 cells
Firmino, G. S. S., André, S. C., Hastenreiter, Z., Campos, V. K., Abdel-Salam, M. A. L., de Souza-Fagundes, E. M., & Lessa, J. A. (2019) · Inorganica Chimica Acta · doi:10.1016/j.ica.2019.119079 · Cited by 22
A novel four-gene of iron metabolism-related and methylated for prognosis prediction of hepatocellular carcinoma
Shen, H., Wu, H., Sun, F., Qi, J., & Zhu, Q. (2020) · Bioengineered · doi:10.1080/21655979.2020.1866303 · Cited by 22
Oxidative Stress and Inflammation in the Liver
Lemasters, J. J., & Jaeschke, H. (2020) · Wiley eBooks · doi:10.1002/9781119436812.ch55 · Cited by 23
Modulating Nrf2 to control lipid peroxidation and ferroptosis: implications for cancer management
Tunc, R., Ateş, İ., Yılmaz, B., Medoro, A., Davinelli, S., Süzen, S., & Saso, L. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1701249 · Cited by 21
“While iron accumulation and redox imbalance can promote genomic instability and tumor growth, they also create conditions that sensitize cancer cells to ferroptosis (56).”
Role of bioactive peptides derived from food proteins in programmed cell death to treat inflammatory diseases and cancer
Deng, Z., Yang, Z., & Peng, J. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1992606 · Cited by 21
Identification of Five Ferroptosis-Related LncRNAs as Novel Prognosis and Diagnosis Signatures for Renal Cancer
Shu, X., Zhang, Z., Yao, Z.-Y., & Xing, X. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.763697 · Cited by 21
“Iron is an essential element for the human body, and itsmetabolic disorder is involved in the occurrence and development of many diseases (Huang, 2003; Manz et al., 2016).”
Background
Identification of the Ferroptosis-Related Long Non-Coding RNAs Signature to Improve the Prognosis Prediction in Papillary Renal Cell Carcinoma
Tang, X., Jiang, F., Wang, X., Xia, Y., Mao, Y., & Chen, Y. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.741726 · Cited by 21
“Cancer cells, in comparison to normal cells, have iron addiction, or an excessive reliance on iron for proliferation (9).”
Background
Ferroptosis contributes to the progression of female-specific neoplasms, from breast cancer to gynecological malignancies in a manner regulated by non-coding RNAs: Mechanistic implications
Hushmandi, K., Klionsky, D. J., Aref, A. R., Bonyadi, M., Reiter, R. J., Nabavi, N., Salimimoghadam, S., & Saadat, S. H. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.05.008 · Cited by 21
“Moreover, iron is strongly correlated with the onset and expansion of tumors, and thus iron metabolism defects might result in tumor growth [37,38].”
Background
Insight into the influence of the polymerization time of polydopamine nanoparticles on their size, surface properties and nanomedical applications
Djermane, R., Nieto, C., Vargas, J., Vega, M. A., & del Valle, E. M. M. (2021) · Polymer Chemistry · doi:10.1039/d1py01473k · Cited by 21
Ferroptosis-related long non-coding RNA signature predicts the prognosis of hepatocellular carcinoma
Yang, X. Y., Mei, M., Yang, J., Guo, J., Du, F., & Liu, S. (2022) · Aging · doi:10.18632/aging.204073 · Cited by 20
Trace element levels in serum and gastric mucosa in patients with Helicobacter pylori positive and negative gastritis
Aslan, A., Karapınar, H. S., Kilicel, F., Boyacıoğlu, T., Pekin, C., Toprak, Ş. S., Cihan, M., & Yılmaz, B. S. (2022) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2022.127108 · Cited by 20
Deferiprone and Iron–Maltol: Forty Years since Their Discovery and Insights into Their Drug Design, Development, Clinical Use and Future Prospects
Kontoghiorghes, G. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054970 · Cited by 20
Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model
Acker, Z. P. V., Raemdonck, G. A. V., Logie, E., Acker, S. I. V., Baggerman, G., Berghe, W. V., Ponsaerts, P., & Dewilde, S. (2019) · Cells · doi:10.3390/cells8080873 · Cited by 20
“, Sorafenib and artemisinin derivatives) [14].”
Background
A Systematic Review of Nanoparticle-Mediated Ferroptosis in Glioma Therapy
Jing, L., Xiao, W., Hu, Z.-X., Liu, X., & Yuan, M.-Q. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s523008 · Cited by 19
“14,15 As such, ferroptosis represents a promising novel strategy to improve the treatment and prognosis of glioma and related malignancies.”
Iron overload and mitochondrial dysfunction orchestrate pulmonary fibrosis
Li, S., Zhang, H., Chang, J., Li, D., & Cao, P. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174613 · Cited by 20
A Ferroptosis-Related lncRNA Model to Enhance the Predicted Value of Cervical Cancer
Jiang, Z., Li, J., Feng, W., Sun, Y., & Bu, J. (2022) · Journal of Oncology · doi:10.1155/2022/6080049 · Cited by 19
“Different from normal cells, cancer cells rely too much on iron for cell proliferation [11].”
Background
RETRACTED: Borax regulates iron chaperone‐ and autophagy‐mediated ferroptosis pathway in glioblastoma cells
Hacıoğlu, C., Kar, F., Davran, F., & Tuncer, C. (2023) · Environmental Toxicology · doi:10.1002/tox.23797 · Cited by 19
“However, the energy deficit and the increased reactive oxygen species (ROS) caused by Fenton reactions might cause cell death with enhanced autophagy through as yet fully undiscovered pathways.(5) Recently, studies have revealed that increased autophagy and lysosomal degradation followed by redox imbalance can trigger…”
Background
Retracted
Modulation of Ferroptosis by microRNAs in Human Cancer
Velkova, I., Pasino, M., Khalid, Z., Menichini, P., Martorana, E., Izzotti, A., & Pulliero, A. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13050719 · Cited by 19
“Indeed, LOXs are enzymes that contain the iron element and use it as a cofactor for catalyzing the deoxygenation of both esterified and not esterified PUFAs to produce lipid hydroperoxide in a pro-ferroptosis full picture [11,35,43].”
Background
Ferroptosis in Cancer: Epigenetic Control and Therapeutic Opportunities
Tranchese, R. V., Battista, S., Cerchia, L., & Fedele, M. (2024) · Biomolecules · doi:10.3390/biom14111443 · Cited by 20
“They activate long-chain fatty acids (FAs) into fatty acyl-CoA esters, serving as substrates for synthesizing membrane phospholipids and triacylglycerols, or undergoing beta-fatty acid oxidation in mitochondria for energy.”
Iron chelates in the anticancer therapy
Szlasa, W., Gachowska, M., Kiszka, K., Rakoczy, K., Kiełbik, A., Wala, K., Puchała, J., Chorążykiewicz, K., Saczko, J., & Kulbacka, J. (2021) · Chemical Papers · doi:10.1007/s11696-021-02001-2 · Cited by 19
“Iron cellular hemostasis is partially mediated by tumor suppressor genes and oncogenes (Manz et al. 2016).”
Background
Role of ferroptosis in gastrointestinal tumors: From mechanisms to therapies
Si, C., Zhou, X., Deng, J., Ye, S., Kong, L., Zhang, B., & Wang, W. (2022) · Cell Biology International · doi:10.1002/cbin.11804 · Cited by 18
“A N ec ro su lf o na m i‐ d e | 999 esterification to membrane phospholipids and oxidation catalyzed by ACSL4 (fatty acid metabolism intermediary) and phospholipid choline acyltransferase 3 (lpcat3, lipid remodeling), eventually lead to ferroptosis (Koppula et al., 2020; Manz et al., 2016).”
Background
Cuproptosis-Related Ferroptosis genes for Predicting Prognosis in kidney renal clear cell carcinoma
Luo, G., Wang, L., Zheng, Z., Gao, B., & Lei, C. (2023) · European journal of medical research · doi:10.1186/s40001-023-01137-z · Cited by 18
“Meanwhile, Ferroptosis is another type of iron-reliant cell death by reactive oxygen species (ROS) accumulation, but differs from autophagy pyroptosis, necrosis and apoptosis [15, 16].”
Background
RETRACTED: Expression of transferrin receptor/TFRC protein in bladder cancer cell T24 and its role in inducing iron death in bladder cancer
Qin, J., Li, Z., Su, L., Wen, X., Tang, X., Huang, M., & Wu, J. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133323 · Cited by 18
Retracted
A tandem activity-based sensing and labeling strategy reveals antioxidant response element regulation of labile iron pools
Pezacki, A. T., Gonciarz, R. L., Okamura, T., Matier, C. D., Torrente, L., Cheng, K., Miller, S. G., Ralle, M., Ward, N. P., DeNicola, G. M., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2401579121 · Cited by 18
Current advances on the role of ferroptosis in tumor immune evasion
Gao, C., Zhang, H., & Wang, X. (2024) · Discover Oncology · doi:10.1007/s12672-024-01573-1 · Cited by 18
Antimony enhances c-Myc stability in prostate cancer via activating CtBP2-ROCK1 signaling pathway
Zhang, C., Lü, C., Wang, Z., Feng, G., Du, E., Liu, Y., Wang, L., Qiao, B., Xu, Y. H., & Zhang, Z. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.07.070 · Cited by 18
Bio-inspired melanin nanoparticles induce cancer cell death by iron adsorption
Perring, J. C., Crawshay‐Williams, F., Huang, C. T.-L., & Townley, H. E. (2018) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-018-6190-x · Cited by 17
Ferroptosis‐Related lncRNA Signature Correlates with the Prognosis, Tumor Microenvironment, and Therapeutic Sensitivity of Esophageal Squamous Cell Carcinoma
Zhu, J., Zhao, Y., Wu, G., Zhang, X., Chen, Q., Yang, B., Guo, X., Ji, S., & Gu, K. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7465880 · Cited by 17
“Tumor cells frequently exhibit abnormal expression of FRLs, which is associated with tumor development [20, 21].”
UBE2C promotes the proliferation of acute myeloid leukemia cells through PI3K/AKT activation
Wang, L., Zhao, S., Wang, Y., Liu, J., & Wang, X. (2024) · BMC Cancer · doi:10.1186/s12885-024-12212-x · Cited by 17
“Ample evidence has shown that ferroptosis can be employed in cancer treatment, since tumor cells tend to accumulate a higher level of intracellular iron for supporting the hyper-proliferation [10].”
Background
Molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology: Progress and updates
Yang, F., Sun, S., Wang, S., Guo, J., Liu, X., Ge, N., & Wang, G. (2022) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v14.i1.1 · Cited by 18
Sodium butyrate induces ferroptosis in colorectal cancer cells by promoting NCOA4-FTH1-mediated ferritinophagy
Liu, L., Liu, Y., Zhou, X., He, H., Chen, N., Qin, Y., Sun, X., Bian, Z., Zhang, Q., Mao, L., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115188 · Cited by 16
Harnessing ferroptosis for enhanced sarcoma treatment: mechanisms, progress and prospects
Zeng, J., Zhang, X., Lin, Z., Zhang, Y., Yang, J., Dou, P., & Liu, T. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00498-3 · Cited by 16
“Decreasing the LIP and elevating ferritin levels can be instrumental in preventing ferroptosis [28].”
Background
Tetramethylpyrazine inhibits ferroptosis in spinal cord injury by regulating iron metabolism through the NRF2/ARE pathway
Tao, J., Zhou, J., Zhu, H., Xu, L., Yang, J., Mu, X., & Fan, X. L. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1503064 · Cited by 16
Overexpression of CISD1 Predicts Worse Survival in Hepatocarcinoma Patients
Lu, T., Li, C., Xiang, C., Gong, Y., Peng, W., & Chen, C. (2022) · BioMed Research International · doi:10.1155/2022/7823191 · Cited by 16
“Over the past decade, researchers have identi ﬁ ed “ iron dependence ” as a key phenotype in cancer cells with unknown mechanisms [39, 40].”
High preoperative serum ferritin predicted poor prognosis in non-metastatic colorectal cancer
Tingting, H., Di, S., Xiaoping, C., Wu, X., & Hua, D. (2017) · Saudi Medical Journal · doi:10.15537/smj.2017.3.16110 · Cited by 16
3-Chloro-N′-(2-hydroxybenzylidene) benzohydrazide: An LSD1-Selective Inhibitor and Iron-Chelating Agent for Anticancer Therapy
Sarno, F., Papulino, C., Franci, G., Andersen, J. H., Cautain, B., Melardo, C., Altucci, L., & Nebbioso, A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01006 · Cited by 16
“Iron levels increase in cancer cells, thereby sustaining their growth and survival (Manz et al., 2016).”
Background
The Complex Roles of Redox and Antioxidant Biology in CancerPreprint
Hayashi, M., Okazaki, K., Papgiannakopoulos, T., & Motohashi, H. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041546 · Cited by 16
Lactoferrin—A Regulator of Iron Homeostasis and Its Implications in Cancer
Bolesławska, I., Bolesławska-Król, N., Jakubowski, K., Przysławski, J., & Drzymała-Czyż, S. (2025) · Molecules · doi:10.3390/molecules30071507 · Cited by 15
“In addition, tumor cells can affect iron-dependent enzymes, including mitochondrial dehydrogenases In addition, tumor cells can a ﬀ ect iron-de-pendent enzymes, including mitochondrial dehydrogenases and Krebs cycle enzymes [103]. and Krebs cycle enzymes [103].”
Nrf2--a hidden bridge linking cancer stem cells to ferroptosis
Li, Y., Tuerxun, H., Liu, X., Zhao, Y., Wen, S., Li, Y., Cao, J., & Zhao, Y. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104105 · Cited by 16
Ferroptosis: An Emerging Target for Bladder Cancer Therapy
Shan, Z., Tang, W., Shi, Z., & Shan, T. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45100517 · Cited by 18
“Given the high uptake of iron by cancer cells, ferroptosis might play a key role in tumor progress [11].”
Background
CISD3/MiNT is required for complex I function, mitochondrial integrity, and skeletal muscle maintenance
Nechushtai, R., Rowland, L. M., Karmi, O., Marjault, H., Nguyen, T. T., Mittal, S., Ahmed, R. S., Grant, D. G., Manrique‐Acevedo, C., Morcos, F., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2405123121 · Cited by 15
The role of zinc transporter proteins as predictive and prognostic biomarkers of hepatocellular cancer
Bitirim, C. V. (2021) · PeerJ · doi:10.7717/peerj.12314 · Cited by 15
Novel Insights in the Regulatory Mechanisms of Ferroptosis in Hepatocellular Carcinoma
Ma, S., Adzavon, Y. M., Wen, X., Zhao, P., Xie, F., Liu, M., & Ma, X. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.873029 · Cited by 15
“, 2021), and endogenous compounds such as glutathione, ubiquinone, vitamin E and selenium (Dixon et al., 2012; Homma and Fujii, 2015; Manz et al., 2016; Stockwell et al., 2017) can be used as inhibitors of ferroptosis.”
Background
Expression of transferrin receptor‐1 (TFR‐1) in canine osteosarcomas
Vico, G. D., Martano, M., Maiolino, P., Carella, F., & Leonardi, L. (2020) · Veterinary Medicine and Science · doi:10.1002/vms3.258 · Cited by 15
Mechanisms of Ferroptosis and Application to Head and Neck Squamous Cell Carcinoma Treatments
Li, S., Liu, Y., Li, J., Zhao, X. B., & Yu, D. (2021) · DNA and Cell Biology · doi:10.1089/dna.2021.0023 · Cited by 16
“Remaining Fe 2 + is oxidized to Fe 3 + and is discharged from the cell where it is included in further iron cycles (Manz et al. , 2016).”
Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment
Wang, L., Zhu, Y., Huang, C., Pan, Q., Wang, J., Li, H., Huang, Y., Yi, G., Li, Z., Qi, S., et al. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101678 · Cited by 14
“118,129 While both chemotherapy and iron deprivation halted cell proliferation in mouse induced pluripotent stem cells, only iron deprivation suppressed stemness marker expression.”
Ferroptosis: a novel pharmacological mechanism against multiple myeloma
Shi, J., Lu, Y., Wei, W., Ma, G., Li, C., Li, L., Wang, Y., Wang, Y., Xu, R., & Cui, S. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1606804 · Cited by 14
NCOA4-mediated ferritinophagy: emerging role and novel therapeutic target in precision oncology
Chen, D., Jiang, X., Duan, T., Tian, Y., Zhang, J., Wang, X., & Tan, J. (2026) · Autophagy · doi:10.1080/15548627.2026.2656779 · Cited by 14
“This uncontrolled lipid peroxidation leads to loss of membrane integrity, organelle dysfunction, and ultimately, cell death through ferroptosis [9,47].”
Prognostic factors and predictors of postoperative adjuvant transcatheter arterial chemoembolization benefit in patients with resected hepatocellular carcinoma
Chen, M., Juengpanich, S., Hu, J., Topatana, W., Cao, J., Tong, C., Lin, J., & Cai, X. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i10.1042 · Cited by 14
Implication of Ferroptosis in Cholangiocarcinoma: A Potential Future Target?
Yang, M., Li, M., Lyu, Z., & Yang, Z. (2023) · Cancer Management and Research · doi:10.2147/cmar.s406150 · Cited by 15
Mechanism of Cell Death by Combined Treatment with an xCT Inhibitor and Paclitaxel: An Alternative Therapeutic Strategy for Patients with Ovarian Clear Cell Carcinoma
Idei, U., Ohta, T., Yamatani, H., Seino, M., & Nagase, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411781 · Cited by 15
Identification of hepatocellular carcinoma-related subtypes and development of a prognostic model: a study based on ferritinophagy-related genes
Wang, G., Li, J., Zhu, L., Zhou, Z., Ma, Z., Zhang, H., Yang, Y., Niu, Q., & Wang, X. (2023) · Discover Oncology · doi:10.1007/s12672-023-00756-6 · Cited by 16
Roles of selenium-containing glutathione peroxidases and thioredoxin reductases in the regulation of processes associated with glioblastoma progression
Varlamova, E. G. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110344 · Cited by 16
Deep learning based on intratumoral heterogeneity predicts histopathologic grade of hepatocellular carcinoma
Song, S., Zhang, G., Yao, Z., Chen, R., Liu, K., Zhang, T., Zeng, G., Wang, Z., & Liu, R. (2025) · BMC Cancer · doi:10.1186/s12885-025-13781-1 · Cited by 14
“Moreover, the response to metal ions was also a significant factor influencing the degree of tumor differentiation [36, 37].”
Inflammation Mediated Hepcidin-Ferroportin Pathway and Its Therapeutic Window in Breast Cancer
Shibabaw, T., Teferi, B., Molla, M. D., & Ayelign, B. (2020) · Breast Cancer Targets and Therapy · doi:10.2147/bctt.s276404 · Cited by 15
“in iron trafficking and storage, may lead to the development of to breast cancer.(3,18,22) In this review article, we provided”
Background
Ferroportin depletes iron needed for cell cycle progression in head and neck squamous cell carcinoma
Belvin, B. R., & Lewis, J. P. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1025434 · Cited by 14
“Studies in other cancer types have implicated elevated 64 iron levels accounting for increased activity of iron containing enzymes involved in DNA 65 replication and nucleotide synthesis (22,23).”
Background
Identification of immune subtypes of Ph-neg B-ALL with ferroptosis related genes and the potential implementation of Sorafenib
Hong, Y., Zhang, L., Tian, X., Xiang, X., Yu, Y., Zeng, Z., Cao, Y., Chen, S., & Sun, A. (2021) · BMC Cancer · doi:10.1186/s12885-021-09076-w · Cited by 14
Ferroptosis and the cGAS–STING pathway into precision nano-immuno-theranostics: A mechanistic paradigm for reversing drug resistance in hepatocellular carcinoma
Elmetwalli, A. (2025) · Drug Resistance Updates · doi:10.1016/j.drup.2025.101326 · Cited by 16
Bioconjugates of versatile β-diketonate–lanthanide complexes as probes for time-gated luminescence and magnetic resonance imaging of cancer cells in vitro and in vivo
Song, B., Wen, X., Zhang, X., Liu, Q., Ma, H., Tan, M., & Yuan, J. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00144b · Cited by 14
Ferroptosis in hematological malignant tumors
Liu, Y., Du, Z., Huang, J., Li, T., Zhang, J., Li, Y., Yi, W., & Chen, C. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1127526 · Cited by 13
Research Progress on Ferroptosis and Nanotechnology-Based Treatment in Triple-Negative Breast Cancer
Zhang, J., Zhang, S., Liu, M., Yang, Z., & Huang, R. (2024) · Breast Cancer Targets and Therapy · doi:10.2147/bctt.s475199 · Cited by 13
“Studies have found 13 that when the amount of iron ions in the body is overloaded, excess ferrous iron ions generate hydroxyl radicals through the Fenton reaction to cause oxidative stress, producing a large amount of reactive oxygen species (ROS) to induce iron die.”
Background
Prognostic Model Construction and Immune Microenvironment Analysis of Breast Cancer Based on Ferroptosis-Related lncRNAs
Jia, C. L., Fu, Y., & Li, R. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s342783 · Cited by 13
“The proliferation of cancer cells showed an iron dependence compared to normal cells.(4) Some studies have found that activating the ferroptosis process in cancer cells could be a new strategy for treating tumors, especially for cancers that lack therapeutic targets.”
Background
Identification and Quantification of Iron Metabolism Landscape on Therapy and Prognosis in Bladder Cancer
Song, X., Xin, S., Zhang, Y., Mao, J., Duan, C., Cui, K., Chen, L., Li, F., Liu, Z., Wang, T., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.810272 · Cited by 14
Investigation of the effects of overexpression of jumping translocation breakpoint (JTB) protein in MCF7 cells for potential use as a biomarker in breast cancer.
Jayathirtha, M., Neagu, A.-N., Whitham, D., Alwine, S., & Darie, C. C. (2022) · PubMed Central · Cited by 13
Advances in the study of regulators of ferroptosis in head and neck squamous cell carcinoma (Review)
Yang, M., Guo, R., Chen, X., Song, G., & Zhang, F. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5248 · Cited by 12
“…catalyzes the production of ROS through the Fenton reaction, and ROS further promotes lipid peroxidation and causes lipid peroxide aggregation, which induces ferroptosis (17). cancer cells are more iron‑dependent compared to normal cells (18), and some cancer cells exhibit iron ion aggrega‑ tion.”
Engineering Iron-Based Nanomaterials for Breast Cancer Therapy Associated with Ferroptosis
Wei, R., Fu, G., Li, Z., Liu, Y., & Xue, M. (2024) · Nanomedicine · doi:10.2217/nnm-2023-0270 · Cited by 12
Europium Metal–Organic Framework Polymer Composites with Enhanced Luminescence and Selective Ferric Ion Sensing
Rozenberga, L., Bloch, W. M., Gillam, T. A., Lancaster, D. G., Skinner, W. M., Krasowska, M., Blencowe, A., & Beattie, D. A. (2024) · ACS Applied Polymer Materials · doi:10.1021/acsapm.4c00111 · Cited by 12
Design, Synthesis, and Anticancer Activity of Drug-like Iron Chelators/G-Quadruplex Binders as Synergic Dual Targeting Agents
Piccolo, M., Russo, C., Arciuolo, V., Ferraro, M. G., Abbate, V., Porzio, A. D., Cinquegrana, E., Leva, F. S. D., Pagano, B., Randazzo, A., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01665 · Cited by 12
Ferroptosis and noncoding RNAs: exploring mechanisms in lung cancer treatment
Ravari, N. R., Sadri, F., Mahdiabadi, M. A., Mohammadi, Y., Ourang, Z., & Rezaei, Z. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1522873 · Cited by 14
Potential Key Markers for Predicting the Prognosis of Gastric Adenocarcinoma Based on the Expression of Ferroptosis-Related lncRNA
Cai, Y., Wu, S., Jia, Y., Pan, X., & Li, C. (2022) · Journal of Immunology Research · doi:10.1155/2022/1249290 · Cited by 12
“Cancer cells become addicted to iron, which is a process known as iron addiction [15, 16].”
Development and Validation of a Novel Mitochondrion and Ferroptosis-Related Long Non-Coding RNA Prognostic Signature in Hepatocellular Carcinoma
Xia, W., Zeng, C., Zheng, Z., Huang, C., Yu, Z., & Bai, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.844759 · Cited by 12
“Dysfunction of iron metabolism is associated with tumorigenesis and tumor cell proliferation (Manz et al., 2016).”
Background
Control of Intracellular Molecular Networks Using Algebraic Methods
Vieira, L. S., Laubenbacher, R., & Murrugarra, D. (2019) · Bulletin of Mathematical Biology · doi:10.1007/s11538-019-00679-w · Cited by 11
“It is well accepted that iron metabolism is deregulated in several cancers [42,26].”
Background
Therapeutic efficacy of ferroptosis in the treatment of colorectal cancer (Review)
Guo, Z., Zhuang, H., & Shi, X. (2024) · Oncology Letters · doi:10.3892/ol.2024.14697 · Cited by 13
“The results of a previous study revealed that cancer cells require higher levels of iron than healthy cells, and are more susceptible to iron depletion, also known as iron addiction (61).”
Background
Arsenic induces ferroptosis in HTR-8/SVneo cells and placental damage
Dong, J., Hu, Y., Liu, S., Liu, W., Zhu, Q., Liu, S., Zhang, N., Liao, C., & Jiang, G. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.176885 · Cited by 11
RTA-408 overcomes cisplatin-resistant lung cancer by inhibiting WWP1-mediated NCOA4 ubiquitination to induce ferritinophagy and ferroptosis
Wang, X., Liu, T., Fei, Y., Zhang, S., Yang, Y., Chen, Z., Zhu, R., Deng, S., Zhang, T., Wu, D., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.07.013 · Cited by 11
Serum ferritin and primary lung cancer
Chen, Z., Zhu, B., Ou, C., & Li, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.21518 · Cited by 11
“SF has the ability to store iron [5], participate in inflammation and infection [7–10], participate in cancer and other functions [1, 2, 15].”
Background
Long Non-Coding RNAs as Novel Biomarkers in the Clinical Management of Papillary Renal Cell Carcinoma Patients: A Promise or a Pledge?
Trevisani, F., Floris, M., Vago, R., Minnei, R., & Cinque, A. (2022) · Cells · doi:10.3390/cells11101658 · Cited by 11
“With respect to what happen in other pathological processes, cancer cells have an increased iron avidity due to the necessity of rapidly proliferating and are dramatically more sensible to iron depletion; on the other hand, increasing the intracellular iron promotes tumor cell death through induction of ferroptosis [1…”
Background
Identification of ferroptosis-related molecular subtypes and a methylation-related ferroptosis gene prognostic signature in cervical squamous cell carcinoma
Yu, L., Gao, Z., Li, Z., Liu, P., Gao, Y., & Liang, G. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05267-z · Cited by 11
“Cancer cells require high iron concentrations for their rapid proliferation, suggesting that they are more vulnerable to ferroptosis than normal cells (Manz et al. 2016; Li and Li 2020).”
Background
Comparison of Elemental Anomalies Following Implantation of Different Cell Lines of Glioblastoma Multiforme in the Rat Brain: A Total Reflection X-ray Fluorescence Spectroscopy Study
Planeta, K., Setkowicz, Z., Janik-Olchawa, N., Matusiak, K., Ryszawy, D., Dróźdż, A., Janeczko, K. J., Ostachowicz, B., & Chwiej, J. G. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00648 · Cited by 11
Ovotransferrin—Multifunctional protein: Structure, bioactivity, and industrial potential
Fijałkowski, P., Pryshchepa, O., van Eldik, R., & Pomastowski, P. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144810 · Cited by 10
Lysosome as a Chemical Reactor
Dharmasivam, M., & Kaya, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311581 · Cited by 11
“First, cancer cells often exhibit dysregulated iron metabolism, a phenomenon described as “iron addiction” [104].”
2-Aminofluorene based triazole cocktailed with organosilane as UV-visible and fluorescence sensor for the highly selective detection of Fe( iii ) ion and its anti-leishmanial activity
Singh, G., Gupta, S., Pawan, Mohit, M., Diksha, D., Saini, I., Vikas, V., Mohan, B., & Soni, S. (2023) · New Journal of Chemistry · doi:10.1039/d3nj00105a · Cited by 10
Metal-phenolic capsules with ROS scavenging reshape the oxidative microenvironment of atherosclerosis
Zhang, A., Liu, K., Liang, X., Li, H., Fu, X., Zhu, N., Li, F., & Yang, J. (2023) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2023.102700 · Cited by 10
Mitochondrial classic metabolism and its often-underappreciated facets
Moura, J. P., Oliveira, P. J., & Urbano, A. M. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167839 · Cited by 10
ETV4/ALYREF-mediated glycolytic metabolism through PKM2 enhances resistance to ferroptosis and promotes the development of intrahepatic cholangiocarcinoma
Wang, X., Duan, W., Ma, Z., Wen, H., Mao, X., & Liu, C. (2025) · Cancer & Metabolism · doi:10.1186/s40170-025-00387-1 · Cited by 10
Molecular mechanisms of reactive oxygen species in regulated cell deaths: Impact of ferroptosis in cancer therapy
Golbashirzadeh, M., Heidari, H. R., & Khosroushahi, A. Y. (2022) · Gene Reports · doi:10.1016/j.genrep.2022.101614 · Cited by 10
The Detection of Divalent Iron and Reactive Oxygen Species During Ferroptosis with the Use of a Dual-Reaction Turn-On Fluorescent Probe
Wang, Y., Li, C., Zhuo, J., Hui, H., Zhou, B., & Tian, J. (2022) · Molecular Imaging and Biology · doi:10.1007/s11307-022-01774-6 · Cited by 10
Mechanistic Development of Cancers Associated with Processed Meat Products: A Review
Bedale, W. A., Milkowski, A. L., Czuprynski, C. J., & Richards, M. P. (2023) · Meat and Muscle Biology · doi:10.22175/mmb.15762 · Cited by 11
Fat and hepatocellular carcinoma
Balsano, C., Porcu, C., Sideri, S., & Tavolaro, S. (2018) · Hepatoma Research · doi:10.20517/2394-5079.2018.51 · Cited by 10
Dissolution factors and oxidative potential of acid soluble irons from chlorite mineral particles
Xie, T., Lü, S., Rao, L., Zhang, L., Wang, X., Wang, W., & Wang, Q. (2021) · Atmospheric Environment · doi:10.1016/j.atmosenv.2021.118436 · Cited by 10
Redox-dependent cytotoxicity of ferrocene derivatives and ROS-activated prodrugs based on ferrocenyliminoboronates
Věžník, J., Konhefr, M., Fohlerová, Z., & Lacina, K. (2021) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2021.111561 · Cited by 10
HIF1α/miR-146α/TRAF6/NF-κB axis modulates hepatic iron overload-induced inflammation
Mo, F., Tang, Y., Shen, H., Wu, L., Liu, Q., Nie, S., Li, M., & Ling, C. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109499 · Cited by 9
Homo and heteromultimetallic complexes containing a group 8 transition metal and μ-diphosphine bridging ligands involved in anticancer research: A review
Roufosse, B., Serbu, C., Marschner, C., Prince, S., & Blom, B. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116528 · Cited by 9
MicroRNA-mediated regulation of Ferroptosis: Implications for disease pathogenesis and therapeutic interventions
Razi, S., Khojini, J. Y., Norioun, H., Hayati, M. J., Naseri, N., Tajbakhsh, A., & Hayat, S. M. G. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111503 · Cited by 9
Role of ferroptosis in atrial fibrillation: a review
Fan, S., Hu, Y., & Shi, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1362060 · Cited by 9
“By engul ﬁ ng ferritin through phagocytosis, autophagy elevates intracellular free iron levels, further promoting ferroptosis (Manz et al., 2016).”
Nutrient deficiency-induced downregulation of SNX1 inhibits ferroptosis through PPARs-ACSL1/4 axis in colorectal cancer
Qian, L.-H., Wen, K.-L., Guo, Y., Liao, Y.-N., Li, M.-Y., Li, Z., Li, S., & Nie, H. (2025) · APOPTOSIS · doi:10.1007/s10495-025-02088-y · Cited by 9
“Tumor cells, being more metabolically active, are highly susceptible to oxidative stress-induced cell death, which presents an opportunity for ferroptosis-based therapies to selectively target cancer cells while sparing normal tissues [9, 10].”

Authors: Manz, D. H., Blanchette, N. L., Paul, B. T., Torti, F. M., & Torti, S. V.
Affiliations: Department of Molecular Biology and Biophysics
UConn Health (US)
Corresponding author: Torti, Suzy V.
ORCID: Torti, Frank M.
Torti, Suzy V.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2016-02-18
Volume: 1368
Issue: 1
Pages: 149-161
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/nyas.13008
PMC: PMC4870095
OpenAlex: W2275201610
Cited by: 507
References: 121
Citations by year: 2026: 24 · 2025: 49 · 2024: 69 · 2023: 78 · 2022: 66 · 2021: 77 · 2020: 46 · 2019: 43 · 2018: 31 · 2017: 14 · 2016: 10
FWCI: 4.64
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: S.V.T (CA188025)
F.M.T (CA171101)
D.H.M. (DE021989)
U.S. National Institutes of Health
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: iron metabolism, cancer, ferroptosis, ferroportin, hepcidin, iron efflux, reactive oxygen species, glutathione depletion, GPX4, ferritinophagy, ferritin degradation, tumor microenvironment, epigenetic regulation, microRNA, DNA methylation, histone acetylation, cancer therapy
MeSH terms: Ferroportin, Animals, Humans, Iron, Neoplasms, Reactive Oxygen Species, Iron Overload, Cation Transport Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Iron and cancer: recent insights

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks