A randomized trial of L actobacillus plantarum CJLP 133 for the treatment of atopic dermatitis
Abstract
Background: There have been considerable disagreements regarding the therapeutic effects of probiotics in atopic dermatitis ( AD ). We performed this study to examine whether the oral administration of L actobacillus plantarum CJLP 133 improves pediatric AD . Methods: In a randomized, double‐blind, placebo‐controlled study, either L . plantarum CJLP 133 at a dosage of 0.5 × 10 10 colony‐forming units or placebo in children aged 12 months to 13 yr was given twice a day for 12 wk. SCOring of Atopic Dermatitis ( SCORAD ) scores, eosinophil counts, serum total IgE, and cytokines were evaluated. Results: Forty‐four of 58 patients in the probiotic group and 39 of 60 patients in the placebo group completed the study. The SCORAD score at week 14 was lower in the probiotic group than in the placebo group (p = 0.044). The mean change in the SCORAD score from weeks 2 to 14 was 9.1 in the probiotic group, which was greater than the mean change of 1.8 in the placebo group (p = 0.004). No statistical differences in the total use of topical corticosteroids were found between two groups (p = 0.815). In the probiotic group, the total eosinophil count was significantly lower at the end of the intervention compared to the baseline measurements (p = 0.023). Logarithmic IFN ‐γ and IL ‐4 were significantly decreased by the end of the intervention compared to baseline measurements in the probiotic group (p < 0.001 and 0.049). Conclusions: Our results suggest that supplementation with probiotic L . plantarum CJLP 133 is beneficial in the treatment of pediatric AD .
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L. plantarum CJLP133 alleviated atopic dermatitis in clinical studies.
“Additionally, L. plantarum CJLP133 alleviated atopic dermatitis in clinical studies [10].”
From Anti-Photoaging and Anti-Melanogenic Effects of a Novel <i>Lactiplantibacillus plantarum</i> RKBP Isolated from Giant <i>Centella asiatica</i> (2026) · cites this paper as [10]
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- Authors
- Han, Y., Kim, B., Ban, J., Lee, J., Kim, B. J., Choi, B. S., Hwang, S., Ahn, K., & Kim, J.
- Affiliations
- Samsung Medical Center (KR)
- CJ CheilJedang (South Korea) (KR)
- Chung-Ang University (KR)
- Corresponding author
- Kim, Jihyun
- Venue
- Pediatric Allergy and Immunology
- Publisher
- Wiley
- Published
- 2012-10-11
- Volume
- 23
- Issue
- 7
- Pages
- 667-673
- ISSN
- 0905-6157 (ISSN-L)
- 1399-3038
- OpenAlex
- W2060956173
- Cited by
- 127
- References
- 30
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 8 · 2023: 8 · 2022: 15 · 2021: 19 · 2020: 10 · 2019: 6 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 7 · 2014: 9 · 2013: 5
- FWCI
- 10.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Allergy and Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- probiotics, atopic dermatitis, pediatric atopic dermatitis, SCORAD, eosinophil count, total IgE, interferon-gamma, IL-4, topical corticosteroid use
- MeSH terms
- Adolescent, Child, Child, Preschool, Dermatitis, Atopic, Eosinophils, Female, Humans, Immunoglobulin E, Infant, Interferon-gamma, Male, Interleukin-4, Treatment Outcome, Disease Progression, Dietary Supplements, Probiotics, Lactiplantibacillus plantarum, Lactobacillus plantarum
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