Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition
Open accessAbstract
Despite increasing research on the gut-skin axis, there is a lack of comprehensive studies on the improvement of skin health through the regulation of the intestinal condition in humans. In this study, we investigated the benefits of Lactobacillus plantarum HY7714 (HY7714) consumption on skin health through its modulatory effects on the intestine and ensuing immune responses. HY7714 consumption led to differences in bacterial abundances from phylum to genus level, including increases in Actinobacteria followed by Bifidobacterium and a decrease in Proteobacteria. Additionally, HY7714 significantly ameliorated inflammation by reducing matrix metallopeptidases (MMP-2 and MMP-9), zonulin, and calprotectin in plasma, all of which are related to skin and intestinal permeability. Furthermore, RNA-seq analysis revealed its efficacy at restoring the integrity of the gut barrier by regulating gene expression associated with the extracellular matrix and immunity. This was evident by the upregulation of IGFBP5, SERPINE1, EFEMP1, COL6A3, and SEMA3B and downregulation of MT2A, MT1E, MT1X, MT1G, and MT1F between TNF- α and TNF- α plus HY7714 treated Caco-2 cells. These results propose the potential mechanistic role of HY7714 on skin health by the regulation of the gut condition.
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L. plantarum HY7714 improved skin health by reducing MMPs and other inflammatory markers.
“For instance, L. plantarum HY7714 improved skin health by reducing matrix metalloproteinases (MMPs) and other inflammatory markers [9].”
From Anti-Photoaging and Anti-Melanogenic Effects of a Novel <i>Lactiplantibacillus plantarum</i> RKBP Isolated from Giant <i>Centella asiatica</i> (2026) · cites this paper as [9]
The Results section reports significant reductions in plasma MMP-2, MMP-9, and calprotectin after HY7714 consumption. The Discussion says the MMP reductions may attenuate inflammation and collagen destruction in skin, but treats the link to improved skin health as an extrapolation rather than a demonstrated effect of those reductions. (LLM, conf=0.87)
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Cites
A Mathematical Theory of Communication
Shannon, C. E. (1948) · Bell System Technical Journal · doi:10.1002/j.1538-7305.1948.tb01338.x · Cited by 88,486 · see citing works
Proteobacteria: Microbial signature of dysbiosis in gut microbiota
Shin, N.-R., Whon, T. W., & Bae, J.-W. (2015) · Trends in Biotechnology · doi:10.1016/j.tibtech.2015.06.011 · Cited by 3,954 · see citing works
Intestinal permeability – a new target for disease prevention and therapy
Bischoff, S. C., Barbara, G., Buurman, W., Ockhuizen, T., Schulzke, J.-D., Serino, M., Tilg, H., Watson, A., & Wells, J. M. (2014) · BMC Gastroenterology · doi:10.1186/s12876-014-0189-7 · Cited by 1,755 · see citing works
Pinto, M. (1983) · HAL · Cited by 1,752 · see citing works
Metallothionein: the multipurpose protein
Coyle, P. V., Philcox, J. C., Carey, L. C., & Rofe, A. M. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8454-2 · Cited by 1,305 · see citing works
Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls
Chen, J., Chia, N., Kalari, K. R., Yao, J. Z., Novotna, M., Paz Soldan, M. M., Luckey, D. H., Marietta, E. V., Jeraldo, P. R., Chen, X., et al. (2016) · Scientific Reports · doi:10.1038/srep28484 · Cited by 933 · see citing works
Probiotic species in the modulation of gut microbiota: An overview
Azad, M. A. K., Sarker, M., Li, T., & Yin, J. (2018) · BioMed Research International · doi:10.1155/2018/9478630 · Cited by 803 · see citing works
van Rheenen, P. F., de Vijver, E. V., & Fidler, V. (2010) · BMJ · doi:10.1136/bmj.c3369 · Cited by 715 · see citing works
The “Perfect Storm” for Type 1 Diabetes
Vaarala, O., Atkinson, M. A., & Neu, J. (2008) · Diabetes · doi:10.2337/db08-0331 · Cited by 497 · see citing works
Human zonulin, a potential modulator of intestinal tight junctions
Wang, W., Uzzau, S., Goldblum, S. E., & Fasano, A. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.24.4435 · Cited by 470 · see citing works
Calprotectin – a pleiotropic molecule in acute and chronic inflammation.
Střı́ž, I., & Trebichavský, I. (2004) · Physiological Research · doi:10.33549/physiolres.930448 · Cited by 466 · see citing works
The gut-skin axis in health and disease: A paradigm with therapeutic implications
O'Neill, C. A., Monteleone, G., McLaughlin, J. T., & Paus, R. (2016) · BioEssays · doi:10.1002/bies.201600008 · Cited by 449 · see citing works
Intestinal permeability and its regulation by zonulin: Diagnostic and therapeutic implications
Fasano, A. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.08.012 · Cited by 402 · see citing works
Specific gut microbiota features and metabolic markers in postmenopausal women with obesity
Brahe, L. K., Chatelier, E. L., Prifti, E., Pons, N., Kennedy, S., Hansen, T. F., Pedersen, O. B., Astrup, A. V., Ehrlich, S. D., & Larsen, L. H. (2015) · Nutrition and Diabetes · doi:10.1038/nutd.2015.9 · Cited by 305 · see citing works
Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?
Bowe, W. P., & Logan, A. C. (2011) · Gut Pathogens · doi:10.1186/1757-4749-3-1 · Cited by 292 · see citing works
Chichlowski, M., De Lartigue, G., German, J. B., Raybould, H. E., & Mills, D. A. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31824fb899 · Cited by 276 · see citing works
Bergmann, K. R., Liu, S. X. L., Tian, R., Kushnir, A., Turner, J. R., Li, H.-L., Chou, P. M., Weber, C. R., & Plaen, I. G. D. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.01.013 · Cited by 268 · see citing works
Lactobacillus‐ and bifidobacterium‐mediated antigenotoxicity in the colon of rats
Pool-Zobel, B. L., Neudecker, C., Domizlaff, I., Ji, S., Schillinger, U., Rumney, C. J., Moretti, M., Vilarini, I., Scassellati‐Sforzolini, R., & Rowland, I. R. (1996) · Nutrition and Cancer · doi:10.1080/01635589609514492 · Cited by 256 · see citing works
Wei, Z., Cao, S., Liu, S., Yao, Z., Sun, T., Li, Y., Li, J., Zhang, D., & Zhou, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.10064 · Cited by 224 · see citing works
Recommendations for Probiotic Use—2011 Update
Floch, M. H., Walker, W. A., Madsen, K. L., Sanders, M. E., Macfarlane, G. T., Flint, H. J., Dieleman, L. A., Ringel, Y., Guandalini, S., Kelly, C. P., et al. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318230928b · Cited by 207 · see citing works
Probiotic Bacteria Induce a ‘Glow of Health’
Levkovich, T., Poutahidis, T., Smillie, C. S., Varian, B. J., Ibrahim, Y. M., Lakritz, J. R., Alm, E. J., & Erdman, S. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053867 · Cited by 196 · see citing works
Lactobacilluscasei reduces CD8+ T cell‐mediated skin inflammation
Chapat, L., Chemin, K., Dubois, B., Bourdet‐Sicard, R., & Kaiserlian, D. (2004) · European Journal of Immunology · doi:10.1002/eji.200425139 · Cited by 175 · see citing works
Bifidobacterium longum lysate, a new ingredient for reactive skin
Guéniche, A., Bastien, P., Ovigne, J.-M., Kermici, M., Courchay, G., Chevalier, V., Breton, L., & Castiel‐Higounenc, I. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00932.x · Cited by 169 · see citing works
Lee, D.-E., Huh, C., Ra, J., Choi, I.-D., Jeong, J.-W., Kim, S. H., Ryu, J. H., Seo, Y. K., Koh, J. S., Lee, J., et al. (2015) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1509.09021 · Cited by 163 · see citing works
Self-citationAltered gut microbiota and microbial biomarkers associated with chronic kidney disease
Lun, H., Yang, W., Zhao, S., Jiang, M., Xu, M., Liu, F., & Wang, Y. (2018) · MicrobiologyOpen · doi:10.1002/mbo3.678 · Cited by 158 · see citing works
The ubiquitous role of zinc in health and disease
Cummings, J. E., & Kovacic, J. P. (2009) · Journal of Veterinary Emergency and Critical Care · doi:10.1111/j.1476-4431.2009.00418.x · Cited by 142 · see citing works
ARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer
Mazzoccoli, G., Pazienza, V., Panza, A., Valvano, M. R., Benegiamo, G., Vinciguerra, M., Andriulli, A., & Piepoli, A. (2011) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-011-1126-6 · Cited by 140 · see citing works
IGFBP-3 and IGFBP-5 association with endothelial cells: role of C-terminal heparin binding domain.
Booth, B. A., Boes, M. K., Dl, A., et al. (1995) · PubMed · Cited by 130 · see citing works
Han, Y., Kim, B., Ban, J., Lee, J., Kim, B. J., Choi, B. S., Hwang, S., Ahn, K., & Kim, J. (2012) · Pediatric Allergy and Immunology · doi:10.1111/pai.12010 · Cited by 127 · see citing works
Self-citationGueniche, A., Philippe, D., Bastien, P., Reuteler, G., Blum, S., Castiel-Higounenc, I., Breton, L., & Benyacoub, J. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0001 · Cited by 114 · see citing works
FUNCTIONAL MECHANISMS OF PROBIOTICS
Bajaj, B. K., Claes, I. J. J., & Lebeer, S. (2015) · Journal of Microbiology Biotechnology and Food Sciences · doi:10.15414/jmbfs.2015.4.4.321-327 · Cited by 112 · see citing works
Januchowski, R., Zawierucha, P., Ruciński, M., Nowicki, M. O., & Zabel, M. (2014) · BioMed Research International · doi:10.1155/2014/365867 · Cited by 101 · see citing works
Wang, J., Ding, N., Li, Y., Cheng, H., Wang, D., Yang, Q., Deng, Y., Yang, Y., 李艳鸣, 阮修艳, et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4114 · Cited by 92 · see citing works
Guéniche, A., Benyacoub, J., Buetler, T. M., Smola, H., & Blum, S. (2006) · PubMed · Cited by 87 · see citing works
Kim, H. M., Lee, D. E., Park, S. D., Kim, Y.-T., Kim, Y. J., Jeong, J. W., Jang, S. S., Ahn, Y.-T., Sim, J.-H., Huh, C.-S., et al. (2014) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1406.06038 · Cited by 85 · see citing works
Self-citationMetallothioneins and zinc in cancer diagnosis and therapy
Křížková, S., Ryvolová, M., Hraběta, J., Adam, V., Stiborová, M., Eckschlager, T., & Kizek, R. (2012) · Drug Metabolism Reviews · doi:10.3109/03602532.2012.725414 · Cited by 83 · see citing works
Chen, Q., Chen, O., Martins, I. M., Hou, H., Zhao, X., Blumberg, J. B., & Li, B. (2017) · Food & Function · doi:10.1039/c6fo01347c · Cited by 77 · see citing works
IGFBP-5 Promotes Fibrosis via Increasing Its Own Expression and That of Other Pro-fibrotic Mediators
Nguyen, X.-X., Muhammad, L. N., Nietert, P. J., & Feghali‐Bostwick, C. A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00601 · Cited by 72 · see citing works
Modes of Action of Probiotics: Recent Developments
Brown, M. H. (2011) · Journal of Animal and Veterinary Advances · doi:10.3923/javaa.2011.1895.1900 · Cited by 71 · see citing works
The fibril structure of type V collagen triple-helical domain
Mizuno, K., Adachi, E., Imamura, Y., et al. (2001) · Micron · doi:10.1016/s0968-4328(00)00036-6 · Cited by 48 · see citing works
Huang, L. S., Kong, C., Gao, R. Y., Yan, X., Yu, H. J., Wen, B., Zhu, Q., Shen, T. Y., Sun, Z. L., & Qin, H. L. (2018) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-017-3149-7 · Cited by 42 · see citing works
Ra, J., Lee, D. E., Kim, S. H., Jeong, J.-W., Ku, H. K., Kim, T.-Y., Choi, I.-D., Jeung, W., Sim, J.-H., & Ahn, Y. (2014) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1408.08023 · Cited by 39 · see citing works
Self-citationHu, J., Duan, B., Jiang, W., et al. (2019) · Cancer Medicine · doi:10.1002/cam4.2144 · Cited by 37 · see citing works
The distinct roles of MMP-2 and MMP-9 in acute DSS colitis
Heimesaat, M. M., Dunay, I. R., Fuchs, D., Trautmann, D., Fischer, A., Kühl, A. A., Loddenkemper, C., Siegmund, B., Batra, A., Bereswill, S., et al. (2011) · European Journal of Microbiology and Immunology · doi:10.1556/eujmi.1.2011.4.6 · Cited by 36 · see citing works
Li, Q., Higgins, S. P., Lu, Q., Samarakoon, R., Wilkins-Port, C. E., Ye, Q., Higgins, C. E., Staiano‐Coico, L., & Higgins, P. J. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701068 · Cited by 28 · see citing works
Saarialho‐Kere, U. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200406003-00009 · Cited by 22 · see citing works
Marakhonov, A. V., Tabakov, V. Y., Zernov, N. V., et al. (2018) · Gene · doi:10.1016/j.gene.2018.06.026 · Cited by 20 · see citing works
Lactobacillus plantarum HY7714 Restores TNF-α Induced Defects on Tight Junctions.
Nam, B., Kim, S. A., Nam, W., Jeung, W. H., Park, S.-D., Lee, J.-L., Sim, J.-H., & Jang, S. S. (2019) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2019.24.1.64 · Cited by 12 · see citing works
Self-citationMechanism of SEMA3B gene silencing and clinical significance in glioma
Pang, C., Du, W., Long, J., et al. (2016) · Genetics and Molecular Research · doi:10.4238/gmr.15017664 · Cited by 9 · see citing works
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Seo, J., Sung, E. J., Son, D. Y., Yoo, D. S., Seo, D. B., Kim, M., & Yoo, C. (2026) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2603.03011
- Authors
- Nam, B., Kim, S. A., Park, S. D., Kim, H. J., Kim, J. S., Bae, C. H., Kim, J. Y., Nam, W., Lee, J. L., & Sim, J. H.
- Affiliations
- Korea Yakult (South Korea) (KR)
- Corresponding author
- Sim, Jae Hun
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2020-04-10
- Volume
- 15
- Issue
- 4
- Pages
- e0231268
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC7147770
- OpenAlex
- W3015211639
- Cited by
- 35
- References
- 49
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 3 · 2022: 12 · 2021: 3 · 2020: 3
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- skin health, gut-skin axis, gut microbiota, intestinal barrier integrity, intestinal permeability, matrix metalloproteinases, zonulin, calprotectin, extracellular matrix, matrix metalloproteinase inhibitors, Caco-2 cells, Bifidobacterium, skin inflammation, probiotics
- MeSH terms
- Gastrointestinal Microbiome, Adult, Aged, Female, Humans, Inflammation, Intestines, Middle Aged, Skin, Tumor Necrosis Factor-alpha, Biomarkers, Caco-2 Cells, Biodiversity, Lactiplantibacillus plantarum, Young Adult, Gene Ontology
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