Cited by 189melanin and skin pigmentationMelanoma and MAPK PathwaysReceptor Mechanisms and Signaling

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MC 1R, the c AMP pathway, and the response to solar UV: extending the horizon beyond pigmentation

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García‐Borrón, Jose C., Abdel‐Malek, Zalfa, Jiménez‐Cervantes, Celia·2014·Pigment Cell & Melanoma Research

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Abstract

Summary: The melanocortin 1 receptor (MC 1R) is a G protein‐coupled receptor crucial for the regulation of melanocyte proliferation and function. Upon binding melanocortins, MC 1R activates several signaling cascades, notably the c AMP pathway leading to synthesis of photoprotective eumelanin. Polymorphisms in the MC 1R gene are a major source of normal variation of human hair color and skin pigmentation, response to ultraviolet radiation (UVR), and skin cancer susceptibility. The identification of a surprisingly high number of MC 1R natural variants strongly associated with pigmentary phenotypes and increased skin cancer risk has prompted research on the functional properties of the wild‐type receptor and frequent mutant alleles. We summarize current knowledge on MC 1R structural and functional properties, as well as on its intracellular trafficking and signaling. We also review the current knowledge about the function of MC 1R as a skin cancer, particularly melanoma, susceptibility gene and how it modulates the response of melanocytes to UVR.

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Authors: García‐Borrón, J. C., Abdel‐Malek, Z., & Jiménez‐Cervantes, C.
Affiliations: Department of Biochemistry and Molecular Biology School of Medicine University of Murcia Murcia Spain
University of Cincinnati (US)
Instituto Murciano de Investigación Biosanitaria (ES)
ORCID: Abdel‐Malek, Zalfa
Jiménez‐Cervantes, Celia
Venue: Pigment Cell & Melanoma Research
Publisher: Wiley
Published: 2014-05-30
Volume: 27
Issue: 5
Pages: 699-720
ISSN: 1755-1471 (ISSN-L)
1755-148X
DOI: 10.1111/pcmr.12257
PMC: PMC4150834
OpenAlex: W2036734230
Cited by: 187
References: 256
Citations by year: 2026: 12 · 2025: 11 · 2024: 16 · 2023: 14 · 2022: 13 · 2021: 16 · 2020: 24 · 2019: 14 · 2018: 18 · 2017: 16 · 2016: 19 · 2015: 11 · 2014: 2
FWCI: 1.60
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Pigment Cell & Melanoma Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: MINECO, Spain (SAF2012-32134)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: MC1R, cAMP signaling, melanocyte proliferation, skin pigmentation, hair color, melanoma susceptibility, skin cancer predisposition, receptor trafficking, G protein-coupled receptor signaling
MeSH terms: Cyclic AMP, Alleles, Animals, DNA Damage, Humans, Ligands, Melanocytes, Melanoma, Mutation, Neoplasms, Radiation-Induced, Phenotype, Pigmentation, Polymorphism, Genetic, Protein Processing, Post-Translational, Skin Neoplasms, Skin Pigmentation, Ultraviolet Rays, Genetic Variation, Signal Transduction, Protein Structure, Tertiary, Genetic Predisposition to Disease, Gene Expression Profiling, Protein Transport, Receptor, Melanocortin, Type 1, Mice

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MC 1R, the c AMP pathway, and the response to solar UV: extending the horizon beyond pigmentation

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