The DOI matches its Crossref record; 256 of the 256 references it cites were found in a registry or an index.
MC 1R, the c AMP pathway, and the response to solar UV: extending the horizon beyond pigmentation
Open accessAbstract
Summary: The melanocortin 1 receptor (MC 1R) is a G protein‐coupled receptor crucial for the regulation of melanocyte proliferation and function. Upon binding melanocortins, MC 1R activates several signaling cascades, notably the c AMP pathway leading to synthesis of photoprotective eumelanin. Polymorphisms in the MC 1R gene are a major source of normal variation of human hair color and skin pigmentation, response to ultraviolet radiation (UVR), and skin cancer susceptibility. The identification of a surprisingly high number of MC 1R natural variants strongly associated with pigmentary phenotypes and increased skin cancer risk has prompted research on the functional properties of the wild‐type receptor and frequent mutant alleles. We summarize current knowledge on MC 1R structural and functional properties, as well as on its intracellular trafficking and signaling. We also review the current knowledge about the function of MC 1R as a skin cancer, particularly melanoma, susceptibility gene and how it modulates the response of melanocytes to UVR.
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“In wild-type eumelanic subjects, α-MSH-mediated stimulation of MC1R results in activation of the associated Gs protein, which activates adenyl cyclase and increases the levels of cellular cyclic adenosine 3’,5’-monophosphate (cAMP), which is responsible for many of the effects of α-MSH, such as activation of tyrosinase (the rate-limiting enzyme in melanogenesis), tyrosinase-related protein 1 (Tyrp”
From “Fifty Shades” of Black and Red or How Carboxyl Groups Fine Tune Eumelanin and Pheomelanin Properties (2016) · cites this paper as [11]
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A landscape of driver mutations in melanoma
Hodis, E., Watson, I. R., Kryukov, G. V., Arold, S. T., Imielinski, M., Theurillat, J.-P., Nickerson, E., Auclair, D., Li, L., Place, C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.024 · Cited by 2,610
Melanin pigmentation in mammalian skin and its hormonal regulation
Slominski, A., Tobin, D. J., Shibahara, S., & Wortsman, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00044.2003 · Cited by 2,015
Krude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G. E., & Grüters, A. (1998) · Nature Genetics · doi:10.1038/509 · Cited by 1,769
The Protective Role of Melanin Against UV Damage in Human Skin †
Brenner, M., & Hearing, V. J. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00226.x · Cited by 1,741
High frequency of BRAF mutations in nevi
Pollock, P. M., Harper, U. L., Hansen, K. S., Yudt, L. M., Stark, M., Robbins, C. M., Moses, T. Y., Hostetter, G., Wagner, U., Kakareka, J., et al. (2003) · Nature Genetics · doi:10.1038/ng1054 · Cited by 1,730
The cloning of a family of genes that encode the melanocortin receptors
Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., & Cone, R. D. (1992) · Science · doi:10.1126/science.1325670 · Cited by 1,635
Molecular signatures of G-protein-coupled receptors
Venkatakrishnan, A., Deupí, X., Lebon, G., Tate, C. G., Schertler, G. F. X., & Babu, M. M. (2013) · Nature · doi:10.1038/nature11896 · Cited by 1,534
β-Arrestins and Cell Signaling
DeWire, S. M., Ahn, S., Lefkowitz, R. J., & Shenoy, S. K. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.022405.154749 · Cited by 1,397
Melanocyte biology and skin pigmentation
Lin, J. Y., & Fisher, D. E. (2007) · Nature · doi:10.1038/nature05660 · Cited by 1,379 · cited 2×
“In human skin, melanin synthesized in epidermal melanocytes is transferred to the surrounding keratinocytes to allow for homogenous pigmentation (Lin and Fisher, 2007).”
BackgroundThe RAF proteins take centre stage
Wellbrock, C., Karasarides, M., & Marais, R. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1498 · Cited by 1,223
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Melanins and melanogenesis: from pigment cells to human health and technological applications
d’Ischia, M., Wakamatsu, K., Cicoira, F., Mauro, E. D., García-Borrón, J. C., Commo, S., Galván, I., Ghanem, G., Kenzo, K., Meredith, P., et al. (2015) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12393 · Cited by 499
Self-citationMITF and UV responses in skin: From pigmentation to addiction
Nguyen, N. T., & Fisher, D. E. (2018) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12726 · Cited by 168
The Genetics of Human Skin and Hair Pigmentation
Pavan, W. J., & Sturm, R. A. (2019) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-083118-015230 · Cited by 165
Roles of UVA radiation and DNA damage responses in melanoma pathogenesis
Khan, A. Q., Travers, J. B., & Kemp, M. G. (2018) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22176 · Cited by 152
Melanoma Epidemiology and Prevention
Berwick, M., Buller, D. B., Cust, A. E., Gallagher, R. P., Lee, T. K., Meyskens, F. L., Pandey, S., Thomas, N. E., Veierød, M. B., & Ward, S. V. (2015) · Cancer treatment and research · doi:10.1007/978-3-319-22539-5_2 · Cited by 155
Metadata
- Authors
- García‐Borrón, J. C., Abdel‐Malek, Z., & Jiménez‐Cervantes, C.
- Affiliations
- Department of Biochemistry and Molecular Biology School of Medicine University of Murcia Murcia Spain
- University of Cincinnati (US)
- Instituto Murciano de Investigación Biosanitaria (ES)
- Venue
- Pigment Cell & Melanoma Research
- Publisher
- Wiley
- Published
- 2014-05-30
- Volume
- 27
- Issue
- 5
- Pages
- 699-720
- ISSN
- 1755-1471 (ISSN-L)
- 1755-148X
- PMC
- PMC4150834
- OpenAlex
- W2036734230
- Cited by
- 187
- References
- 256
- Citations by year
- 2026: 12 · 2025: 11 · 2024: 16 · 2023: 14 · 2022: 13 · 2021: 16 · 2020: 24 · 2019: 14 · 2018: 18 · 2017: 16 · 2016: 19 · 2015: 11 · 2014: 2
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pigment Cell & Melanoma Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- MINECO, Spain (SAF2012-32134)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- MC1R, cAMP signaling, melanocyte proliferation, skin pigmentation, hair color, melanoma susceptibility, skin cancer predisposition, receptor trafficking, G protein-coupled receptor signaling
- MeSH terms
- Cyclic AMP, Alleles, Animals, DNA Damage, Humans, Ligands, Melanocytes, Melanoma, Mutation, Neoplasms, Radiation-Induced, Phenotype, Pigmentation, Polymorphism, Genetic, Protein Processing, Post-Translational, Skin Neoplasms, Skin Pigmentation, Ultraviolet Rays, Genetic Variation, Signal Transduction, Protein Structure, Tertiary, Genetic Predisposition to Disease, Gene Expression Profiling, Protein Transport, Receptor, Melanocortin, Type 1, Mice
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