Functional magnetic resonance imaging study of external source memory and its relation to cognitive insight in non-clinical subjects
Abstract
AIM: Previous research has linked cognitive insight (a measure of self-reflectiveness and self-certainty) in psychosis with neurocognitive and neuroanatomical disturbances in the fronto-hippocampal neural network. The authors' goal was to use functional magnetic resonance imaging (fMRI) to investigate the neural correlates of cognitive insight during an external source memory paradigm in non-clinical subjects. METHODS: At encoding, 24 non-clinical subjects travelled through a virtual city where they came across 20 separate people, each paired with a unique object in a distinct location. fMRI data were then acquired while participants viewed images of the city, and completed source recognition memory judgments of where and with whom objects were seen, which is known to involve prefrontal cortex. Cognitive insight was assessed with the Beck Cognitive Insight Scale. RESULTS: External source memory was associated with neural activity in a widespread network consisting of frontal cortex, including ventrolateral prefrontal cortex (VLPFC), temporal and occipital cortices. Activation in VLPFC correlated with higher self-reflectiveness and activation in midbrain correlated with lower self-certainty during source memory attributions. Neither self-reflectiveness nor self-certainty significantly correlated with source memory accuracy. CONCLUSION: By means of virtual reality and in the context of an external source memory paradigm, the study identified a preliminary functional neural basis for cognitive insight in the VLPFC in healthy people that accords with our fronto-hippocampal theoretical model as well as recent neuroimaging data in people with psychosis. The results may facilitate the understanding of the role of neural mechanisms in psychotic disorders associated with cognitive insight distortions.
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Most prior laboratory-based EM studies used cue words or images to trigger memory retrieval and mental time travel to the past in a controlled fashion.
“Most prior laboratory-based EM studies used cue words or images to trigger memory retrieval and mental time travel to the past in a controlled fashion [5,6,12,31,60,80,87,103–105].”
From First-person view of one’s body in immersive virtual reality: Influence on episodic memory (2019) · cites this paper as [105]
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- Authors
- Buchy, L., Hawco, C., Bodnar, M., Izadi, S., Dell'Elce, J., Messina, K., & Lepage, M.
- Affiliations
- Montreal Neurological Institute and Hospital (CA)
- Prevention and Early Intervention Program for Psychoses Douglas Mental Health University Institute Verdun Canada
- Douglas Mental Health University Institute (CA)
- Department of Neurology & Neurosurgery Montreal Neurological Institute McGill University Montreal Canada
- ORCID
- Hawco, Colin
- Venue
- Psychiatry and Clinical Neurosciences
- Publisher
- Wiley
- Published
- 2014-04-13
- Volume
- 68
- Issue
- 9
- Pages
- 683-691
- ISSN
- 1323-1316 (ISSN-L)
- 1440-1819
- OpenAlex
- W1932502812
- Cited by
- 17
- References
- 39
- Citations by year
- 2023: 1 · 2022: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 1
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry and Clinical Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Fonds de Recherche du Québec - Santé
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- cognitive insight, ventrolateral prefrontal cortex, self-reflection, self-certainty, source memory, virtual reality, psychosis, neural correlates
- MeSH terms
- Adolescent, Adult, Cerebral Cortex, Cognition, Humans, Magnetic Resonance Imaging, Male, Memory, Mesencephalon, User-Computer Interface, Recognition, Psychology, Young Adult, Functional Neuroimaging, Healthy Volunteers
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