UV‐induced DNA Damage: The Role of Electronic Excited States
Open accessAbstract
The knowledge of the fundamental processes induced by the direct absorption of UV radiation by DNA allows extrapolating conclusions drawn from in vitro studies to the in‐vivoDNA photoreactivity. In this respect, the characterization of the DNA electronic excited states plays a key role. For a long time, the mechanisms of DNA lesion formation were discussed in terms of generic “singlet” and “triplet” excited state reactivity. However, since the beginning of the 21 st century, both experimental and theoretical studies revealed the existence of “collective” excited states,i.e. excited states delocalized over at least two bases. Two limiting cases are distinguished: Frenkel excitons (delocalized ππ* states) and charge‐transfer states in which positive and negative charges are located on different bases. The importance of collective excited states in photon absorption (in particular in the UVA spectral domain), the redistribution of the excitation energy within DNA, and the formation of dimeric pyrimidine photoproducts is discussed. The dependence of the behavior of the collective excited states on conformational motions of the nucleic acids is highlighted.
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6-4PPs are formed by one covalent bond between the 5-prime-end C6 and the 3-prime-end C4 carbon atoms of adjacent pyrimidines via charge-transfer states, with oxetane and azetidine rearrangements when the 3-prime-end is T or C.
“6-4PPs are formed by one covalent bond between the 5'-end C6 and the 3'-end C4 carbon atoms of adjacent pyrimidines via charge-transfer states, and oxetane and azetidine rearrangements (unstable intermediates) occur when the 3'-end is T or C, respectively [31,32].”
From Sunlight damage to cellular DNA: focus on oxidatively generated lesions (2017) · cites this paper as [31]
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- Authors
- Markovitsi, D.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Markovitsi, Dimitra
- ORCID
- Markovitsi, Dimitra
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 2015-12-18
- Volume
- 92
- Issue
- 1
- Pages
- 45-51
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- OpenAlex
- W1709525116
- Cited by
- 100
- References
- 63
- Citations by year
- 2026: 9 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 11 · 2020: 16 · 2019: 11 · 2018: 10 · 2017: 13 · 2016: 5
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Photochemistry and Photobiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- French Agency for Research (ANR-10-BLAN-0809-01, ANR -12-BS08-0001-01)
- Topics
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Spectroscopy and Quantum Chemical Studies
- Keywords
- UV-induced DNA damage, collective excited states, Frenkel excitons, charge-transfer states, UVA absorption, singlet and triplet excited states
- MeSH terms
- DNA Damage, Ultraviolet Rays
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