Cited by 132DNA Repair MechanismsCarcinogens and Genotoxicity AssessmentDNA and Nucleic Acid Chemistry

The variety of UV-induced pyrimidine dimeric photoproducts in DNA as shown by chromatographic quantification methods

Douki, Thierry·2013·Photochemical & Photobiological Sciences

Abstract

Induction of DNA damage is one of the major consequences of exposure to solar UV radiation in living organisms. UV-induced DNA photoproducts are mostly pyrimidine dimers, including cyclobutane pyrimidine dimers, pyrimidine (6-4) pyrimidone photoproducts and Dewar valence isomers. In the last few decades, a large number of methods have been developed for the quantification of these pyrimidine dimers. The present review emphasizes the contribution of chromatographic techniques to our better understanding of the basic DNA photochemistry and the better description of damage in cells.

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Crossref · 10.1039/c3pp25451h

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Authors
Douki, T.
Affiliations
Université Joseph Fourier (FR)
Corresponding author
Douki, Thierry
Venue
Photochemical & Photobiological Sciences
Published
2013-08
Volume
12
Issue
8
Pages
1286-1302
ISSN
  • 1474-905X (ISSN-L)
  • 1474-9092
OpenAlex
W2032445218
Cited by
132
References
157
Citations by year
2026: 5 · 2025: 6 · 2024: 12 · 2023: 8 · 2022: 11 · 2021: 14 · 2020: 10 · 2019: 11 · 2018: 14 · 2017: 7 · 2016: 11 · 2015: 5 · 2014: 13 · 2013: 5
FWCI
1.07
Type
journal article
Language
en
Open access
closed
Locations
  • Photochemical & Photobiological Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
Agence Nationale de la Recherche (ANR-10-BLAN-0809, ANR-12-BS08-0001)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords
UV-induced DNA damage, pyrimidine dimers, cyclobutane pyrimidine dimers, chromatographic quantification, DNA photochemistry, solar ultraviolet radiation, chromatography
MeSH terms
Animals, Chromatography, DNA, DNA Damage, Humans, Pyrimidine Dimers, Ultraviolet Rays

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