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Cited by 161

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Risk factors that may modify the innate and adaptive immune responses in periodontal diseases

Knight, Ellie T., Liu, Jenny, Seymour, Gregory J., Faggion, Clovis M., Cullinan, Mary P.·2016·Periodontology 2000
DOI 10.1111/prd.12110
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Abstract

Plaque‐induced periodontal diseases occur in response to the accumulation of dental plaque. Disease manifestation and progression is determined by the nature of the immune response to the bacterial complexes in plaque. In general, predisposing factors for these periodontal diseases can be defined as those factors which retain or hinder the removal of plaque and, depending upon the nature of the immune response to this plaque, the disease will either remain stable and not progress or it may progress and result in chronic periodontitis. In contrast, modifying factors can be defined as those factors that alter the nature or course of the inflammatory lesion. These factors do not cause the disease but rather modify the chronic inflammatory response, which, in turn, is determined by the nature of the innate and adaptive immune responses and the local cytokine and inflammatory mediator networks. Chronic inflammation is characterized by vascular, cellular and repair responses within the tissues. This paper will focus on how common modifying factors, such as smoking, stress, hormonal changes, diabetes, metabolic syndrome and HIV/AIDS, influence each of these responses, together with treatment implications. As treatment planning in periodontics requires an understanding of the etiology and pathogenesis of the disease, it is important for all modifying factors to be taken into account. For some of these, such as smoking, stress and diabetic control, supportive health behavior advice within the dental setting should be an integral component for overall patient management.

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Metadata

Authors
Knight, E. T., Liu, J., Seymour, G. J., Faggion, C. M., & Cullinan, M. P.
Venue
Periodontology 2000
Publisher
Wiley
Published
2016-04-04
Volume
71
Issue
1
Pages
22-51
ISSN
  • 0906-6713 (ISSN-L)
  • 1600-0757
DOI
10.1111/prd.12110
OpenAlex
W2327914772
Cited by
161
References
23
FWCI
27.39
Type
journal article
Language
en
Open access
closed

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