The physiology of salivary secretion
Open accessAbstract
Saliva in the mouth is a biofluid produced mainly by three pairs of major salivary glands – the submandibular, parotid and sublingual glands – along with secretions from many minor submucosal salivary glands. Salivary gland secretion is a nerve‐mediated reflex and the volume of saliva secreted is dependent on the intensity and type of taste and on chemosensory, masticatory or tactile stimulation. Long periods of low (resting or unstimulated) flow are broken by short periods of high flow, which is stimulated by taste and mastication. The nerve‐mediated salivary reflex is modulated by nerve signals from other centers in the central nervous system, which is most obvious as hyposalivation at times of anxiety. An example of other neurohormonal influences on the salivary reflex is the circadian rhythm, which affects salivary flow and ionic composition. Cholinergic parasympathetic and adrenergic sympathetic autonomic nerves evoke salivary secretion, signaling through muscarinic M3 and adrenoceptors on salivary acinar cells and leading to secretion of fluid and salivary proteins. Saliva gland acinar cells are chloride and sodium secreting, and the isotonic fluid produced is rendered hypotonic by salivary gland duct cells as it flows to the mouth. The major proteins present in saliva are secreted by salivary glands, creating viscoelasticity and enabling the coating of oral surfaces with saliva. Salivary films are essential for maintaining oral health and regulating the oral microbiome. Saliva in the mouth contains a range of validated and potential disease biomarkers derived from epithelial cells, neutrophils, the microbiome, gingival crevicular fluid and serum. For example, cortisol levels are used in the assessment of stress, matrix metalloproteinases‐8 and ‐9 appear to be promising markers of caries and periodontal disease, and a panel of mRNA and proteins has been proposed as a marker of oral squamous cell carcinoma. Understanding the mechanisms by which components enter saliva is an important aspect of validating their use as biomarkers of health and disease.
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- Authors
- Proctor, G. B.
- Affiliations
- King's College London (GB)
- Corresponding author
- Proctor, Gordon B.
- ORCID
- Proctor, Gordon B.
- Venue
- Periodontology 2000
- Publisher
- Wiley
- Published
- 2015-12-10
- Volume
- 70
- Issue
- 1
- Pages
- 11-25
- ISSN
- 0906-6713 (ISSN-L)
- 1600-0757
- OpenAlex
- W2190127445
- Cited by
- 583
- References
- 98
- Citations by year
- 2026: 87 · 2025: 68 · 2024: 57 · 2023: 63 · 2022: 62 · 2021: 60 · 2020: 61 · 2019: 48 · 2018: 33 · 2017: 29 · 2016: 13 · 2015: 1
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Licence
- Locations
- Periodontology 2000 (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › HIV/AIDS oral health manifestations
- Health Sciences › Medicine › Surgery › Salivary Gland Tumors Diagnosis and Treatment
- Keywords
- salivary secretion, salivary glands, submandibular gland, parotid gland, sublingual gland, taste stimulation, mastication, anxiety, hyposalivation, circadian rhythm, adrenergic innervation, M3 muscarinic receptor, salivary proteins, oral microbiota, oral health, salivary biomarkers, cortisol, matrix metalloproteinases, dental caries, periodontal disease, oral squamous cell carcinoma
- MeSH terms
- Animals, Humans, Saliva, Salivary Glands
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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