Focusing neurovisceral integration: Cognition, heart rate variability, and cerebral blood flow
Open accessAbstract
The neurovisceral integration hypothesis suggests in part that cerebral control of autonomic function conveys comparable control of executive function and, hence, correlation among vagally determined high frequency heart rate variability (HF‐HRV), executive function, and regional cerebral blood flow (CBF). In 440 middle‐aged men and women, resting HF‐HRV was related to regional CBF derived from a resting arterial spin‐labeled MRI scan and to seven neuropsychological tests of executive function. Despite some intercorrelations, regression modeling failed to support integrated central control of HF‐HRV and executive function. Integration between autonomic and cognitive control appears more circumscribed than the general integration suggested by the neurovisceral integration hypothesis.
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Reduced HRV has been independently associated with abnormal PFC activity and reduced regional cerebral blood flow in healthy individuals.
“and reduced HRV has been independently associated with abnormal PFC activity76 and reduced regional cerebral blood flow77 in healthy individuals.”
From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [76]
The Results section (page unavailable) reports associations between resting HF-HRV and regional cerebral blood flow. But the direction depends on how blood flow is measured and on the group studied: regional values normalized to global flow often show inverse relationships, and the Discussion reports differences between Caucasian and African American participants. The paper therefore does not support an unqualified claim that reduced HRV is associated with reduced regional cerebral blood flow in healthy individuals. The separate PFC-activity clause is attached to citation 76, not this source. (LLM, conf=0.86)
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Laborde, S., Mosley, E., & Thayer, J. F. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00213 · Cited by 2,336 · see citing works
“As a dependent variable, it is used to see how it relates in correlations and regression analyses (e.g., Laborde et al., 2011; Jennings et al., 2015) or how it differentiates groups split according to other criteria like individual differences (e.g., Schwerdtfeger and Derakshan, 2010; Laborde et…”
MethodSelf-citationHeart rate variability as a transdiagnostic biomarker of psychopathology
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Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health
Stogios, N., Gdanski, A., Gerretsen, P., Chintoh, A. F., Graff-Guerrero, A., Rajji, T. K., Remington, G., Hahn, M. K., & Agarwal, S. M. (2021) · npj Schizophrenia · doi:10.1038/s41537-021-00151-6 · Cited by 98 · see citing works
Jung, W., Jang, K.-I., & Lee, S.-H. (2019) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2019.17.4.459 · Cited by 81 · see citing works
- Authors
- Jennings, J. R., Allen, B., Gianaros, P. J., Thayer, J. F., & Manuck, S. B.
- Affiliations
- University of Pittsburgh (US)
- The Ohio State University (US)
- Corresponding author
- Jennings, J. Richard
- Venue
- Psychophysiology
- Publisher
- Wiley
- Published
- 2014-08-27
- Volume
- 52
- Issue
- 2
- Pages
- 214-224
- ISSN
- 0048-5772 (ISSN-L)
- 1469-8986
- PMC
- PMC4387874
- OpenAlex
- W1539845497
- Cited by
- 134
- References
- 58
- Citations by year
- 2026: 18 · 2025: 10 · 2024: 4 · 2023: 12 · 2022: 10 · 2021: 11 · 2020: 20 · 2019: 11 · 2018: 11 · 2017: 12 · 2016: 6 · 2015: 7
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychophysiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (HL101959)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- heart rate variability, executive function, regional cerebral blood flow, vagal tone, arterial spin-labeled MRI, middle-aged adults
- MeSH terms
- Adult, Autonomic Nervous System, Cerebrovascular Circulation, Cognition, Female, Heart Rate, Humans, Male, Middle Aged, Neuropsychological Tests, Executive Function
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