The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Exosomes – Structure, Biogenesis and Biological Role in Non‐Small‐Cell Lung Cancer
Abstract
Many different cells produce and release membraneous microvesicles (MV) or exosomes into their microenvironment. Exosomes represent a specific subtype of secreted derived vesicles which are defined as homogenous vesicles of 30–100 nm lined by a lipid bilayer, which contain a specific set of proteins, lipids, and nucleic acids. There are clear evidences that they serve as important biological signals messengers and carriers in physiological as well as in pathological processes. Those derived from tumours (tumour‐derived exosomes, TD‐exosomes) function as protumourigenic factors that can mediate intercellular communication in the tumour microenvironment and also contribute to cancer progression. The main functions of exosomes in the cancer microenvironment include the following: promotion of primary cancer growth, stimulation of angiogenesis, activation of stromal fibroblasts, sculpting the cancer ECM, generation of a premetastatic niche and suppression of host immune response. Exosomes have recently emerged as potentially promising diagnostic and prognostic biomarkers in cancer and other diseases. This article is a summary of information about the structure and origin of exosomes and also indicates the importance of exosomes and micro RNA s in lung cancer. The role of exosomes in NSCLC is little known, and its explanation requires thorough research.
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Cites
B lymphocytes secrete antigen-presenting vesicles.
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Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells
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Microautophagy of Cytosolic Proteins by Late Endosomes
Sahu, R., Kaushik, S., Clement, C. C., Cannizzo, E. S., Scharf, B., Follenzi, A., Potolicchio, I., Nieves, E., Cuervo, A. M., & Santambrogio, L. (2011) · Developmental Cell · doi:10.1016/j.devcel.2010.12.003 · Cited by 902
Exosomes are released by cultured cortical neurones
Fauré, J., Lachenal, G., Court, M., Hirrlinger, J., Chatellard-Causse, C., Blot, B., Grange, J., Schoehn, G., Goldberg, Y., Boyer, V., et al. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.12.003 · Cited by 896
TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex
Blanchard, N., Lankar, D., Faure, F., Regnault, A., Dumont, C., Raposo, G., & Hivroz, C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3235 · Cited by 660
MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers
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Cited by
Engineering exosomes as refined biological nanoplatforms for drug delivery
Luan, X., Sansanaphongpricha, K., Myers, I., Chen, H., Yuan, H., & Sun, D. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.12 · Cited by 1,163
Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy
Yong, T., Zhang, X., Bie, N., Zhang, H., Zhang, X., Li, F., Hakeem, A., Hu, J., Gan, L., Santos, H. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11718-4 · Cited by 806
Amnion-Epithelial-Cell-Derived Exosomes Demonstrate Physiologic State of Cell under Oxidative Stress
Sheller, S., Papaconstantinou, J., Urrabaz-Garza, R., Richardson, L., Saade, G., Salomon, C., & Menon, R. (2016) · PLOS ONE · doi:10.1371/journal.pone.0157614 · Cited by 121
Exosome-like Nanoparticles: A New Type of Nanocarrier
Fernandes, M., Lopes, I., Teixeira, J., Botelho, C., & Gomes, A. C. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867326666190129142604 · Cited by 51
Mao, W., Wang, K., Wu, Z., Xu, B., & Chen, M. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02114-2 · Cited by 48
Metadata
- Authors
- Frydrychowicz, M., Kolecka‐Bednarczyk, A., Madejczyk, M., Yasar, S., & Dworacki, G.
- Venue
- Scandinavian Journal of Immunology
- Publisher
- Wiley
- Published
- 2014-12-23
- Volume
- 81
- Issue
- 1
- Pages
- 2-10
- ISSN
- 0300-9475 (ISSN-L)
- 1365-3083
- OpenAlex
- W2034583414
- Cited by
- 209
- References
- 8
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- closed
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