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Cited by 32Skin Protection and AgingProteoglycans and glycosaminoglycans researchFacial Rejuvenation and Surgery Techniques

Oral administration of hyaluronic acid to improve skin conditions via a randomized double-blind clinical test

Open access
Gao, Yan‐Rui, Wang, Rui‐Ping, Zhang, Lu, Fan, Yuan, Luan, Jin, Liu, Zhe, Yuan, Chao·2023·Skin Research and Technology
DOI 10.1111/srt.13531PMC PMC10661223
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Abstract

OBJECTIVE: To evaluate the impact of oral intake of Hyaluronic Acid (HA) on skin health. BACKGROUND: HA, an endogenous substance in the human body, plays a key role in skin health. However, its concentration in the skin decreases significantly with age. Previous studies suggested that oral intake of HA can supplement the body's HA level, but did not reveal the effects on different age groups and skin types. METHODS: A double-blind, randomized clinical trial with 129 female participants, covering young and elderly groups and differnet skin types, was conducted to assess the efficacy of orally administered HA on skin health. RESULTS: Oral administration of HA significantly promoted skin hydration after 2-8 weeks among both young and elderly groups. Skin tone improvement was observed after 4-8 weeks, while an increase in epidermal thickness was noted after 12 weeks. CONCLUSION: This study provides direct evidence supporting the clinical efficacy of oral intake of HA in promoting skin health.

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Crossref · 10.1111/srt.13531

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  • Recent randomized controlled trials evaluating oral or topical bioactive compounds-including collagen peptides and other nutraceutical ingredients-have demonstrated improvements in wrinkle-related parameters assessed using validated quantitative techniques.

    “Consistent with this, recent randomized controlled trials evaluating oral or topical bioactive compounds—including collagen peptides and other nutraceutical ingredients—have demonstrated improvements in wrinkle-related parameters assessed using validated quantitative techniques [43,44,45,46,47,48].”

    From A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women. (2026) · cites this paper as [48]

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  • Previous randomized controlled trials and meta-analyses have reported improvements in skin elasticity following oral or topical interventions, including collagen peptides and other bioactive compounds.

    “Although previous randomized controlled trials and meta-analyses have reported improvements in skin elasticity following oral or topical interventions, including collagen peptides and other bioactive compounds [43,44,45,46,47,48]”

    From A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women. (2026) · cites this paper as [48]

    The Methods and Conclusion describe a randomized double-blind trial in which oral hyaluronic acid improved skin hydration, brightness, and epidermal thickness. They do not report improved skin elasticity, and this paper is not a meta-analysis or a trial of collagen peptides or topical treatment. (LLM, conf=0.81)

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  • The direction of change observed in the present study (increased skin hydration following supplementation) is generally consistent with previous reports.

    “Although the direction of change observed in the present study (i.e., increased skin hydration following supplementation) is generally consistent with previous reports [43,44,45,46,47,48]”

    From A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women. (2026) · cites this paper as [48]

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Cites

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1 of the 23 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. [16]Sato T, Sakamoto W, Odanaka W, Yoshida K, Urushibata O. Clinical effects of hyaluronic acid diet for dry and rough skin. Aesthe Derma. 2002; 12: 109‐ 120.
  2. [18]Yoshida T, Kanemitsu T, Narabe O, Tobita M. Improvement of dry skin by a food containing hyaluronic acids derived from microbial fermentation. J New Rem & Clin. 2009; 58: 143‐ 155.

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Authors
Gao, Y., Wang, R., Zhang, L., Fan, Y., Luan, J., Liu, Z., & Yuan, C.
Affiliations
  • Department of Skin & Cosmetic Research Shanghai Skin Disease Hospital Skin Disease Hospital of Tongji University Shanghai China
  • Clinical Research Center Shanghai Skin Disease Hospital Skin Disease Hospital of Tongji University Shanghai China
  • Bloomage Biotech Co., Ltd Jinan Shandong China
  • Tongji University (CN)
Corresponding author
  • Liu, Zhe
  • Yuan, Chao
ORCID
Venue
Skin Research and Technology
Publisher
Wiley
Published
2023-11
Volume
29
Issue
11
Pages
e13531-e13531
ISSN
  • 0909-752X (ISSN-L)
  • 1600-0846
DOI
10.1111/srt.13531
PMC
PMC10661223
OpenAlex
W4388850629
Cited by
32
References
23
Citations by year
2026: 17 · 2025: 8 · 2024: 7
FWCI
8.77
Type
journal article
Language
en
Open access
Licence
Locations
  • Skin Research and Technology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
Keywords
hyaluronic acid, oral supplementation, skin hydration, skin tone, epidermal thickness, skin aging, skin health, age groups, skin type
MeSH terms
Administration, Oral, Aged, Double-Blind Method, Epidermis, Female, Humans, Hyaluronic Acid, Skin, Skin Diseases

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