The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Enhancement of oxidative and drought tolerance in Arabidopsis by overaccumulation of antioxidant flavonoids
Open accessAbstract
Summary: The notion that plants use specialized metabolism to protect against environmental stresses needs to be experimentally proven by addressing the question of whether stress tolerance by specialized metabolism is directly due to metabolites such as flavonoids. We report that flavonoids with radical scavenging activity mitigate against oxidative and drought stress in Arabidopsis thaliana. Metabolome and transcriptome profiling and experiments with oxidative and drought stress in wild‐type, single overexpressors of MYB 12/PFG 1 (PRODUCTION OF FLAVONOL GLYCOSIDES 1) or MYB 75/PAP 1 (PRODUCTION OF ANTHOCYANIN PIGMENT 1), double overexpressors of MYB 12 and PAP 1, transparent testa4 (tt4) as a flavonoid‐deficient mutant, and flavonoid‐deficient MYB 12 or PAP 1 overexpressing lines (obtained by crossing tt4 and the individual MYB overexpressor) demonstrated that flavonoid overaccumulation was key to enhanced tolerance to such stresses. Antioxidative activity assays using 2,2‐diphenyl‐1‐picrylhydrazyl, methyl viologen, and 3,3′‐diaminobenzidine clearly showed that anthocyanin overaccumulation with strong in vitro antioxidative activity mitigated the accumulation of reactive oxygen species in vivo under oxidative and drought stress. These data confirm the usefulness of flavonoids for enhancing both biotic and abiotic stress tolerance in crops.
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Cited by
Response of Phenylpropanoid Pathway and the Role of Polyphenols in Plants under Abiotic Stress
Sharma, A., Shahzad, B., Rehman, A., Bhardwaj, R., Landi, M., & Zheng, B. (2019) · Molecules · doi:10.3390/molecules24132452 · Cited by 2,038
Contribution of phenylpropanoid metabolism to plant development and plant–environment interactions
Dong, N., & Lin, H. (2021) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13054 · Cited by 1,748
Plant Responses to Simultaneous Biotic and Abiotic Stress: Molecular Mechanisms
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The Role of Polyphenols in Abiotic Stress Response: The Influence of Molecular Structure
Šamec, D., Karalija, E., Šola, I., Vujčić Bok, V., & Salopek-Sondi, B. (2021) · Plants · doi:10.3390/plants10010118 · Cited by 686
Li, P., Li, Y., Zhang, F., Zhang, G., Jiang, X., Yu, H., & Hou, B. (2017) · The Plant Journal · doi:10.1111/tpj.13324 · Cited by 574
Metadata
- Authors
- Nakabayashi, R., Yonekura‐Sakakibara, K., Urano, K., Suzuki, M., Yamada, Y., Nishizawa, T., Matsuda, F., Kojima, M., Sakakibara, H., Shinozaki, K., Michael, A. J., Tohge, T., Yamazaki, M., & Saito, K.
- Venue
- The Plant Journal
- Publisher
- Wiley
- Published
- 2013-12-17
- Volume
- 77
- Issue
- 3
- Pages
- 367-379
- ISSN
- 0960-7412 (ISSN-L)
- 1365-313X
- OpenAlex
- W1972019946
- Cited by
- 1,351
- References
- 57
- FWCI
- 34.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Nakabayashi, R., Yonekura‐Sakakibara, K., Urano, K., Suzuki, M., Yamada, Y., Nishizawa, T., Matsuda, F., Kojima, M., Sakakibara, H., Shinozaki, K., Michael, A. J., Tohge, T., Yamazaki, M., & Saito, K. (2014). Enhancement of oxidative and drought tolerance in Arabidopsis by overaccumulation of antioxidant flavonoids. The Plant Journal. https://doi.org/10.1111/tpj.12388
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