The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
The effects of pH on wound healing, biofilms, and antimicrobial efficacy
Open accessAbstract
It is known that pH has a role to play in wound healing. In particular, pH has been shown to affect matrix metalloproteinase activity, tissue inhibitors of matrix metalloproteinases activity, fibroblast activity, keratinocyte proliferation, microbial proliferation, and also immunological responses in a wound; the patient's defense mechanisms change the local pH of a wound to effect microorganism invasion and proliferation; this pH change has been found to affect the performance of antimicrobials, and therefore the efficacy in biological environments directly relevant to wound healing. Based on the available body of scientific evidence to date, it is clear that pH has a role to play in both the healing of and treatment of chronic and acute wounds. It is the purpose of this review to evaluate the published knowledge base that concerns the effect of pH changes, the role it plays in wound healing and biofilm formation, and how it can affect treatment efficacy and wound management strategies.
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Citations
Cites
1 retracted
The impact of Manuka honey dressings on the surface pH of chronic wounds
Gethin, G. T., Cowman, S., & Conroy, R. M. (2008) · International Wound Journal · doi:10.1111/j.1742-481x.2007.00424.x · Cited by 162
RetractedBacterial biofilms: from the Natural environment to infectious diseases
Hall-Stoodley, L., Costerton, J. W., & Stoodley, P. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro821 · Cited by 7,143
Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms
Donlan, R. M., & Costerton, J. W. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.2.167-193.2002 · Cited by 6,644
Singer, A. J., & Clark, R. A. F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411006 · Cited by 6,106
Wound Healing--Aiming for Perfect Skin Regeneration
Martin, P. (1997) · Science · doi:10.1126/science.276.5309.75 · Cited by 4,804
Antiseptics and Disinfectants: Activity, Action, and Resistance
McDonnell, G., & Russell, A. D. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.1.147 · Cited by 4,780
A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms
Allesen‐Holm, M., Barken, K. B., Yang, L., Klausen, M., Webb, J. S., Kjelleberg, S., Molin, S., Givskov, M., & Tolker‐Nielsen, T. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.05008.x · Cited by 1,086
Influence of pH on wound-healing: a new perspective for wound-therapy?
Schneider, L. A., Korber, A., Grabbe, S., & Dissemond, J. (2007) · Archives of Dermatological Research · doi:10.1007/s00403-006-0713-x · Cited by 1,066
Pearson, J. P., Pesci, E. C., & Iglewski, B. H. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.18.5756-5767.1997 · Cited by 1,028
Wagner, V. E., Bushnell, D., Passador, L., Brooks, A. I., & Iglewski, B. H. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.7.2080-2095.2003 · Cited by 920
Cited by
Smart wound dressings for wound healing
Dong, R., & Guo, B. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101290 · Cited by 959
Advanced Hydrogels as Wound Dressings
Tavakoli, S., & Klar, A. S. (2020) · Biomolecules · doi:10.3390/biom10081169 · Cited by 544
A flexible multiplexed immunosensor for point-of-care in situ wound monitoring
Gao, Y., Nguyen, D. T., Yeo, T., Lim, S. B., Tan, W. X., Madden, L. E., Jin, L., Long, J. Y. K., Aloweni, F. A. B., Liew, Y. J. A., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg9614 · Cited by 283
Challenges of antibiotic resistance biofilms and potential combating strategies: a review
Khan, J., Tarar, S. M., Gul, I., Nawaz, U., & Arshad, M. (2021) · 3 Biotech · doi:10.1007/s13205-021-02707-w · Cited by 172
Biofilm therapy for chronic wounds
Liu, Y., Long, S., Wang, H., & Wang, Y. (2024) · International Wound Journal · doi:10.1111/iwj.14667 · Cited by 70
Metadata
- Authors
- Percival, S. L., McCarty, S., Hunt, J. A., & Woods, E. J.
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 2014-02-24
- Volume
- 22
- Issue
- 2
- Pages
- 174-186
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- OpenAlex
- W1809035786
- Cited by
- 471
- References
- 110
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- This page
- CoChat. (2026). Citation check: The effects of pH on wound healing, biofilms, and antimicrobial efficacy. https://app.cochat.ai/papers/10.1111/wrr.12125
- The paper
- Percival, S. L., McCarty, S., Hunt, J. A., & Woods, E. J. (2014). The effects of pH on wound healing, biofilms, and antimicrobial efficacy. Wound Repair and Regeneration. https://doi.org/10.1111/wrr.12125
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
