The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Effect of transdermal nicotine administration on exercise endurance in men
Abstract
Nicotine is widely reported to increase alertness, improve co‐ordination and enhance cognitive performance; however, to our knowledge there have been no attempts to replicate these findings in relation to exercise endurance. The purpose of this study was to determine the effects nicotine might have on cycling endurance, perception of exertion and a range of physiological variables. With local ethics committee approval and having obtained informed consent, 12 healthy, non‐smoking men (22 ± 3 years; maximal O 2 uptake, 56 ± 6 ml kg−1 min−1, mean ±s.d.) cycled to exhaustion at 18°C and 65% of their peak aerobic power, wearing either a 7 mg transdermal nicotine patch (NIC) or a colour‐matched placebo (PLA) in a randomized cross‐over design; water was available ad libitum. Subjects were exercising at approximately 75% of their maximal O 2 uptake with no differences in cadence between trials. Ten out of 12 subjects cycled for longer with NIC administration, and this resulted in a significant 17 ± 7% improvement in performance (P < 0.05). No differences were observed for perceived exertion, heart rate or ventilation. There were no differences in concentrations of plasma glucose, lactate or circulating fatty acids. In the absence of any effect on peripheral markers, we conclude that nicotine prolongs endurance by a central mechanism. Possible modes of action are suggested.
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In the citing paper
“Of the five studies that assessed sub- or maximal endurance, only one demonstrated an ergogenic effect with nicotine [46], whilst the other four demonstrated no change [22, 62] or did not explicitly report time or work completed [18, 58].”
From Nicotine: Sporting Friend or Foe? A Review of Athlete Use, Performance Consequences and Other Considerations (2017) · cites this paper as [46]
In the citing paper
“reported a significant improvement in endurance with nicotine.”
From Nicotine: Sporting Friend or Foe? A Review of Athlete Use, Performance Consequences and Other Considerations (2017) · cites this paper as [46]
In the citing paper
“all previous NRT studies [18, 22, 46, 47, 53] have administered fixed doses.”
From Nicotine: Sporting Friend or Foe? A Review of Athlete Use, Performance Consequences and Other Considerations (2017) · cites this paper as [46]
In the citing paper
“Only five of the performance studies report data on side effects [22, 45–47, 62]; all used nicotine-naïve participants who reported either minor (occasional coughing/sneezing, scratchy/tickly throat) or major (tachycardia, nausea, dizziness, etc.) adverse events that even led to participants suspending trials.”
From Nicotine: Sporting Friend or Foe? A Review of Athlete Use, Performance Consequences and Other Considerations (2017) · cites this paper as [46]
Citations
Cites
Psychophysical bases of perceived exertion
BORG, G. A. V. (1982) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198205000-00012 · Cited by 16,580
Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration.
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Cryer, P. E., Haymond, M. W., Santiago, J. V., & Shah, S. D. (1976) · New England Journal of Medicine · doi:10.1056/nejm197609092951101 · Cited by 1,101 · cited 3×
“Circulating levels of noradrenaline and adrenaline increase after nicotine consumption, as do concentrations of free fatty acids, glycerol and lactate (Cryer et al. 1976).”
BackgroundEffects of nicotine on the nucleus accumbens and similarity to those of addictive drugs.
Pontieri, F. E., Tanda, G., Orzi, F., & Chiara, G. D. (1996) · Nature · doi:10.1038/382255a0 · Cited by 1,073
Variability of Aerobic Performance in the Laboratory and Its Physiologic Correlates
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Possible mechanisms of central nervous system fatigue during exercise
Davis, J. M., & Bailey, S. P. (1997) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199701000-00008 · Cited by 707
A category-ratio perceived exertion scale
Noble, B. J., Borg, G. A. V., Jacobs, I. A., Ceci, R. L., & KAISER, P. (1983) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198315060-00015 · Cited by 627
Metabolic, Catecholamine, and Exercise Performance Responses to Various Doses of Caffeine
Graham, T. E., & Spriet, L. L. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.78.3.867 · Cited by 488
Respiratory weight losses during exercise.
Mitchell, J. W., Nadel, E. R., & Stolwijk, J. A. (1972) · Journal of Applied Physiology · doi:10.1152/jappl.1972.32.4.474 · Cited by 361
Research works printed but not linked: 1
- Bridge MW, 2000, The action of caffeine and perception of exertion during prolonged exercise, J Physiol, 523, 224P
Cited by
Smoking-induced Skeletal Muscle Dysfunction. From Evidence to Mechanisms
Degens, H., Gayan‐Ramirez, G., & van Hees, H. W. H. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201410-1830pp · Cited by 227
The effects of caffeine, nicotine, ethanol, and tetrahydrocannabinol on exercise performance
Pesta, D. H., Angadi, S. S., Burtscher, M., & Roberts, C. K. (2013) · Nutrition & Metabolism · doi:10.1186/1743-7075-10-71 · Cited by 145
Skeletal muscle properties and fatigue resistance in relation to smoking history
Wüst, R. C. I., Morse, C. I., de Haan, A., Rittweger, J., Jones, D. A., & Degens, H. (2008) · European Journal of Applied Physiology · doi:10.1007/s00421-008-0792-9 · Cited by 100
Self-citationThe effects of swilling an l(−)-menthol solution during exercise in the heat
Mündel, T., & Jones, D. A. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1180-9 · Cited by 119
Self-citationMündel, T. (2017) · Sports Medicine · doi:10.1007/s40279-017-0764-5 · Cited by 71
Self-citation
Metadata
- Authors
- Mündel, T., & Jones, D. A.
- Affiliations
- University of Birmingham (GB)
- Manchester Metropolitan University (GB)
- Venue
- Experimental Physiology
- Publisher
- Wiley
- Published
- 2006-06-20
- Volume
- 91
- Issue
- 4
- Pages
- 705-713
- ISSN
- 0958-0670 (ISSN-L)
- 1469-445X
- OpenAlex
- W2099923301
- Semantic Scholar
- 3405d7e94bccd92743b621682d34dbeb24e5c0f9
- Cited by
- 41
- References
- 36
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Physiology (publishedVersion)
- PubMed (publishedVersion)
- e-space (Manchester Metropolitan University) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
- Keywords
- nicotine, nicotine patch, exercise endurance, cycling to exhaustion, perceived exertion, heart rate, ventilation, plasma glucose, blood lactate, circulating fatty acids
- MeSH terms
- Adaptation, Physiological, Administration, Cutaneous, Adult, Exercise Test, Physical Exertion, Humans, Male, Nicotine, Physical Endurance, Cross-Over Studies
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
