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Cited by 41Cardiovascular and exercise physiologySports Performance and TrainingThermoregulation and physiological responses

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Effect of transdermal nicotine administration on exercise endurance in men

Mündel, Toby, Jones, David A.·2006·Experimental Physiology
DOI 10.1113/expphysiol.2006.033373
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Abstract

Nicotine is widely reported to increase alertness, improve co‐ordination and enhance cognitive performance; however, to our knowledge there have been no attempts to replicate these findings in relation to exercise endurance. The purpose of this study was to determine the effects nicotine might have on cycling endurance, perception of exertion and a range of physiological variables. With local ethics committee approval and having obtained informed consent, 12 healthy, non‐smoking men (22 ± 3 years; maximal O 2 uptake, 56 ± 6 ml kg−1 min−1, mean ±s.d.) cycled to exhaustion at 18°C and 65% of their peak aerobic power, wearing either a 7 mg transdermal nicotine patch (NIC) or a colour‐matched placebo (PLA) in a randomized cross‐over design; water was available ad libitum. Subjects were exercising at approximately 75% of their maximal O 2 uptake with no differences in cadence between trials. Ten out of 12 subjects cycled for longer with NIC administration, and this resulted in a significant 17 ± 7% improvement in performance (P < 0.05). No differences were observed for perceived exertion, heart rate or ventilation. There were no differences in concentrations of plasma glucose, lactate or circulating fatty acids. In the absence of any effect on peripheral markers, we conclude that nicotine prolongs endurance by a central mechanism. Possible modes of action are suggested.

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Crossref · 10.1113/expphysiol.2006.033373

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36 of 36 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 1

  1. Bridge MW, 2000, The action of caffeine and perception of exertion during prolonged exercise, J Physiol, 523, 224P

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Metadata

Authors
Mündel, T., & Jones, D. A.
Affiliations
  • University of Birmingham (GB)
  • Manchester Metropolitan University (GB)
ORCID
Venue
Experimental Physiology
Publisher
Wiley
Published
2006-06-20
Volume
91
Issue
4
Pages
705-713
ISSN
  • 0958-0670 (ISSN-L)
  • 1469-445X
DOI
10.1113/expphysiol.2006.033373
OpenAlex
W2099923301
Semantic Scholar
3405d7e94bccd92743b621682d34dbeb24e5c0f9
Cited by
41
References
36
Citations by year
2026: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 1
FWCI
0.68
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Experimental Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • e-space (Manchester Metropolitan University) (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
Keywords
nicotine, nicotine patch, exercise endurance, cycling to exhaustion, perceived exertion, heart rate, ventilation, plasma glucose, blood lactate, circulating fatty acids
MeSH terms
Adaptation, Physiological, Administration, Cutaneous, Adult, Exercise Test, Physical Exertion, Humans, Male, Nicotine, Physical Endurance, Cross-Over Studies

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.