The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Placental phenotype and the insulin‐like growth factors: resource allocation to fetal growth
Open accessAbstract
The placenta is the main determinant of fetal growth and development in utero. It supplies all the nutrients and oxygen required for fetal growth and secretes hormones that facilitate maternal allocation of nutrients to the fetus. Furthermore, the placenta responds to nutritional and metabolic signals in the mother by altering its structural and functional phenotype, which can lead to changes in maternal resource allocation to the fetus. The molecular mechanisms by which the placenta senses and responds to environmental cues are poorly understood. This review discusses the role of the insulin‐like growth factors (IGFs) in controlling placental resource allocation to fetal growth, particularly in response to adverse gestational environments. In particular, it assesses the impact of the IGFs and their signalling machinery on placental morphogenesis, substrate transport and hormone secretion, primarily in the laboratory species, although it draws on data from human and other species where relevant. It also considers the role of the IGFs as environmental signals in linking resource availability to fetal growth through changes in the morphological and functional phenotype of the placenta. As altered fetal growth is associated with increased perinatal morbidity and mortality and a greater risk of developing adult‐onset diseases in later life, understanding the role of IGFs during pregnancy in regulating placental resource allocation to fetal growth is important for identifying the mechanisms underlying the developmental programming of offspring phenotype by suboptimal intrauterine growth. image
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Cites
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
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Placental-specific IGF-II is a major modulator of placental and fetal growth
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Self-citationThe many faces of insulin-like peptide signalling in the brain
Fernandez, A. M., & Torres-Alemán, I. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3209 · Cited by 872
Yung, H.-W., Calabrese, S., Hynx, D., Hemmings, B. A., Cetin, I., Charnock-Jones, D. S., & Burton, G. J. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.071193 · Cited by 388
Protein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth
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“In the complete Igf2 null, placental and fetal growth restriction occurs concurrently and becomes evident in mid-gestation (Table 2; Baker et al. 1993; Constancia et al. 2005).”
BackgroundSelf-citationJansson, N., Rosario, F. J., Gaccioli, F., Lager, S., Jones, H. N., Roos, S., Jansson, T., & Powell, T. L. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2667 · Cited by 305
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Comparative Placentation: Structures, Functions and Evolution
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The Programming Power of the Placenta
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Cited by
Developmental origins of metabolic diseases
Hoffman, D. J., Powell, T. L., Barrett, E. S., & Hardy, D. B. (2021) · Physiological Reviews · doi:10.1152/physrev.00002.2020 · Cited by 466
Placental Function in Maternal Obesity
Kelly, A. C., Powell, T. L., & Jansson, T. (2020) · Clinical Science · doi:10.1042/cs20190266 · Cited by 227
The socioeconomic landscape of the exposome during pregnancy
Sum, K. K., Tint, M. T., Aguilera, R., Dickens, B. S. L., Choo, S., Ang, L. T., Phua, D., Law, E. C., Ng, S., Tan, K. M.-L., et al. (2022) · Environment International · doi:10.1016/j.envint.2022.107205 · Cited by 18
Metadata
- Authors
- Sferruzzi‐Perri, A. N., Sandovici, I., Constancia, M., & Fowden, A. L.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2017-05-23
- Volume
- 595
- Issue
- 15
- Pages
- 5057-5093
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2602685374
- Cited by
- 186
- References
- 36
- FWCI
- 12.84
- Type
- journal article
- Language
- en
- Open access
- green
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