The Programming Power of the Placenta

Sferruzzi-Perri, Amanda N.; Camm, Emily J.

doi:10.3389/fphys.2016.00033

Cited by 223Birth, Development, and HealthPregnancy and preeclampsia studiesPrenatal Substance Exposure Effects

The Programming Power of the Placenta

Open access

Sferruzzi-Perri, Amanda N., Camm, Emily J.·2016·Frontiers in Physiology

DOI 10.3389/fphys.2016.00033PMC PMC4789467

Open this paper in CoChat — free account Open PDF

Abstract

Size at birth is a critical determinant of life expectancy, and is dependent primarily on the placental supply of nutrients. However, the placenta is not just a passive organ for the materno-fetal transfer of nutrients and oxygen. Studies show that the placenta can adapt morphologically and functionally to optimize substrate supply, and thus fetal growth, under adverse intrauterine conditions. These adaptations help meet the fetal drive for growth, and their effectiveness will determine the amount and relative proportions of specific metabolic substrates supplied to the fetus at different stages of development. This flow of nutrients will ultimately program physiological systems at the gene, cell, tissue, organ, and system levels, and inadequacies can cause permanent structural and functional changes that lead to overt disease, particularly with increasing age. This review examines the environmental regulation of the placental phenotype with particular emphasis on the impact of maternal nutritional challenges and oxygen scarcity in mice, rats and guinea pigs. It also focuses on the effects of such conditions on fetal growth and the developmental programming of disease postnatally. A challenge for future research is to link placental structure and function with clinical phenotypes in the offspring.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fphys.2016.00033

Cites

261 of 261 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Exposure to a diverse array of suboptimal maternal environments, including nutritionally unbalanced diets, low oxygen availability, and high body mass index (BMI) during gestation, modifies the risk of the offspring developing obesity.
“Extensions of this work using human population and experimental animal data have shown that exposure to a diverse array of suboptimal maternal environments, including nutritionally unbalanced diets, low oxygen availability, and high body mass index (BMI) during gestation, modifies the risk of the offspring developing obesity [9, 10].”
From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [9]
The section on offspring metabolic systems reports increased adult-offspring adiposity after maternal calorie restriction, low-protein diets, and high-calorie diets; the section on cerebral structure and function also links calorie restriction to increased obesity risk. However, the passages on hypoxia describe birth weight, later growth, and cardiovascular effects—not offspring obesity—and the retrieved passages do not establish an effect of high maternal BMI or provide human population evidence for the stated obesity risk. (LLM, conf=0.87)
Experimental — accuracy not yet measured
The placenta is the functional interface between mother and fetus and the main determinant of maternal nutrient, oxygen, and hormonal supply to the fetus during gestation.
“The placenta is the functional interface between mother and fetus and the main determinant of maternal nutrient, oxygen, and hormonal supply to the fetus during gestation [9, 147].”
From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [9]
The sections on placental structure and transport describe the placenta as the materno-fetal interface through which oxygen and nutrients reach the fetus. The section on other essential placental functions says the placenta regulates exposure to circulating maternal hormones, but emphasizes its role as a barrier and its hormonal output into the mother. It does not establish that the placenta is the main determinant of maternal hormonal supply to the fetus. (LLM, conf=0.84)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

WEIGHT IN INFANCY AND DEATH FROM ISCHAEMIC HEART DISEASE
Barker, D. J. P., Osmond, C., Winter, P. D., Margetts, B., & Simmonds, S. J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90710-1 · Cited by 3,574 · see citing works
INFANT MORTALITY, CHILDHOOD NUTRITION, AND ISCHAEMIC HEART DISEASE IN ENGLAND AND WALES
BARKER, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91340-1 · Cited by 2,892 · see citing works
Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth
Barker, D. J. P., Hales, C. N., Fall, C. H. D., Osmond, C., Phipps, K., & Clark, P. M. S. (1993) · Diabetologia · doi:10.1007/bf00399095 · Cited by 2,468 · see citing works
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
Mcmillen, I. C., & Robinson, J. S. (2005) · Physiological Reviews · doi:10.1152/physrev.00053.2003 · Cited by 1,910 · see citing works
The Developmental Origins of Adult Disease
Barker, D. J. P. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719428 · Cited by 1,854 · see citing works
CARBOPLATIN OR CISPLATIN?
Calvert, H., Horwich, A., Newlands, E. S., Beǵent, R. H. J., Rustin, G. J. S., Kaye, S. B., Harris, A. L., Williams, C. J., & Slevin, M. L. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92709-2 · Cited by 1,183 · see citing works
Dietary Protein Restriction of Pregnant Rats Induces and Folic Acid Supplementation Prevents Epigenetic Modification of Hepatic Gene Expression in the Offspring
Lillycrop, K. A., Phillips, E. S., Jackson, A. A., Hanson, M. A., & Burdge, G. C. (2005) · Journal of Nutrition · doi:10.1093/jn/135.6.1382 · Cited by 1,139 · see citing works
Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition
Vickers, M. H., Breier, B. H., Cutfield, W. S., Hofman, P. L., & Gluckman, P. D. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.1.e83 · Cited by 999 · see citing works
The Prevention of Accidents
Culpin, M. (1934) · The Lancet · Cited by 971 · see citing works
Review: Sex and the human placenta: Mediating differential strategies of fetal growth and survival
Clifton, V. L. (2010) · Placenta · doi:10.1016/j.placenta.2009.11.010 · Cited by 868 · see citing works
Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension
Kwong, W. Y., Wild, A. E., Roberts, P., Willis, A. C., & Fleming, T. P. (2000) · Development · doi:10.1242/dev.127.19.4195 · Cited by 798 · see citing works
Defective STAT signaling by the leptin receptor in diabetic mice.
Ghilardi, N., Ziegler, S., Wiestner, A. C., Stoffel, R., Heim, M. H., & Skoda, R. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6231 · Cited by 793 · see citing works
Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications
Lillycrop, K. A., Slater-Jefferies, J. L., Hanson, M. A., Godfrey, K. M., Jackson, A. A., & Burdge, G. C. (2007) · British Journal Of Nutrition · doi:10.1017/s000711450769196x · Cited by 563 · see citing works
Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals?
Armitage, J. A., Khan, I. Y., Taylor, P. D., Nathanielsz, P. W., & Poston, L. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.072009 · Cited by 531 · see citing works
Maternal Diet-Induced Obesity Alters Mitochondrial Activity and Redox Status in Mouse Oocytes and Zygotes
Igosheva, N., Abramov, A. Y., Poston, L., Eckert, J. J., Fleming, T. P., Duchen, M. R., & McConnell, J. M. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010074 · Cited by 466 · see citing works
Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet
Howie, G., Sloboda, D. M., Kamal, T., & Vickers, M. H. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.163477 · Cited by 463 · see citing works
Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPARα promoter of the offspring
Lillycrop, K. A., Phillips, E. S., Torrens, C., Hanson, M. A., Jackson, A. A., & Burdge, G. C. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114507894438 · Cited by 461 · see citing works
Regulation of Nutrient Transport across the Placenta
Lager, S., & Powell, T. L. (2012) · Journal of Pregnancy · doi:10.1155/2012/179827 · Cited by 456 · see citing works
Developmental origins of adult health and disease
Barker, D. J. P. (2004) · Journal of Epidemiology & Community Health · doi:10.1136/jech.58.2.114 · Cited by 454 · see citing works
Dietary protein restriction of pregnant rats in the F 0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F 1 and F 2 generations
Burdge, G. C., Slater-Jefferies, J. L., Torrens, C., Phillips, E. S., Hanson, M. A., & Lillycrop, K. A. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507352392 · Cited by 418 · see citing works
Maternal Undernutrition during Late Gestation Induces Fetal Overexposure to Glucocorticoids and Intrauterine Growth Retardation, and Disturbs the Hypothalamo-Pituitary Adrenal Axis in the Newborn Rat1
Lésage, J., Blondeau, B., Grino, M., Bréant, B., & Dupouy, J. (2001) · Endocrinology · doi:10.1210/endo.142.5.8139 · Cited by 380 · see citing works
The developmental origins of well–being
Barker, D. J. P. (2004) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2004.1518 · Cited by 378 · see citing works
Diet-Induced Obesity Model: Abnormal Oocytes and Persistent Growth Abnormalities in the Offspring
Jungheim, E. S., Schoeller, E. L., Marquard, K. L., Louden, E. D., Schaffer, J. E., & Moley, K. H. (2010) · Endocrinology · doi:10.1210/en.2010-0098 · Cited by 365 · see citing works
Prenatal undernutrition and cognitive function in late adulthood
de Rooij, S. R., Wouters, H., Yonker, J. E., Painter, R. C., & Roseboom, T. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009459107 · Cited by 364 · see citing works
Placental efficiency and adaptation: endocrine regulation
Fowden, A. L., Sferruzzi-Perri, A. N., Coan, P. M., Constância, M., & Burton, G. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173013 · Cited by 359 · see citing works
Self-citation
Developmental Origins of Health and Disease: New Insights
Hanson, M. A., & Gluckman, P. D. (2008) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2007.00186.x · Cited by 359 · see citing works
High Fat Diet Induced Developmental Defects in the Mouse: Oocyte Meiotic Aneuploidy and Fetal Growth Retardation/Brain Defects
Luzzo, K. M., Wang, Q., Purcell, S. H., Chi, M. M.-Y., Jimenez, P. T., Grindler, N. M., Schedl, T., & Moley, K. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049217 · Cited by 356 · see citing works
Transport of fatty acids across the human placenta: A review
Duttaroy, A. K. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.11.001 · Cited by 349 · see citing works
Programmed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition
Desai, M., Gayle, D. A., Babu, J., & Ross, M. G. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00340.2004 · Cited by 338 · see citing works
Programming placental nutrient transport capacity
Fowden, A. L., Ward, J. W., Wooding, F. P. B., Forhead, A. J., & Constancia, M. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.104141 · Cited by 334 · see citing works
Causes and Mechanisms of Intrauterine Hypoxia and Its Impact on the Fetal Cardiovascular System: A Review
Hutter, D., Kingdom, J. C., & JAEGGI, E. T. (2010) · International Journal of Pediatrics · doi:10.1155/2010/401323 · Cited by 311 · see citing works
High‐fat diet before and during pregnancy causes marked up‐regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice
Jones, H. N., Woollett, L. A., Barbour, N., Prasad, P. D., Powell, T. L., & Jansson, T. (2008) · The FASEB Journal · doi:10.1096/fj.08-116889 · Cited by 310 · see citing works
Reduced Uterine Perfusion Pressure During Pregnancy in the Rat Is Associated With Increases in Arterial Pressure and Changes in Renal Nitric Oxide
Alexander, B. T., Kassab, S. E., Miller, M. T., Abram, S. R., Reckelhoff, J. F., Bennett, W. A., & Granger, J. P. (2001) · Hypertension · doi:10.1161/01.hyp.37.4.1191 · Cited by 285 · see citing works
Developmental Programming of Cardiovascular Dysfunction by Prenatal Hypoxia and Oxidative Stress
Giussani, D. A., Camm, E. J., Niu, Y., Richter, H. G., Blanco, C. E., Gottschalk, R., Blake, E. Z., Horder, K. A., Thakor, A. S., Hansell, J. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031017 · Cited by 278 · see citing works
Self-citation
Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors
Wu, L., Russell, D. L., Wong, S. L., Chen, M., Tsai, T., John, J. C. S., Norman, R. J., Febbraio, M. A., Carroll, J., & Robker, R. L. (2015) · Development · doi:10.1242/dev.114850 · Cited by 276 · see citing works
The Placenta and Intrauterine Programming
Fowden, A. L., Forhead, A. J., Coan, P. M., & Burton, G. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01663.x · Cited by 267 · see citing works
Maternal Perinatal Undernutrition Drastically Reduces Postnatal Leptin Surge and Affects the Development of Arcuate Nucleus Proopiomelanocortin Neurons in Neonatal Male Rat Pups
Delahaye, F., Breton, C., Risold, P., Enache, M., Dutriez-Casteloot, I., Laborie, C., Lésage, J., & Vieau, D. (2007) · Endocrinology · doi:10.1210/en.2007-1263 · Cited by 266 · see citing works
Down‐regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet
Jansson, N., Pettersson, J., Haafiz, A., Ericsson, A., Palmberg, I., Tranberg, M., Ganapathy, V., Powell, T. L., & Jansson, T. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.550004 · Cited by 265 · see citing works
Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet
Jansson, N., Pettersson, J., Haafiz, A., Ericsson, A., Palmberg, I., Tranberg, M., Ganapathy, V., Powell, T. L., & Jansson, T. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.116509 · Cited by 261 · see citing works
Human Placental Transport in Altered Fetal Growth: Does the Placenta Function as a Nutrient Sensor? – A Review
Jansson, T., & Powell, T. L. (2006) · Placenta · doi:10.1016/j.placenta.2005.11.010 · Cited by 257 · see citing works
Dietary Protein Restriction in Pregnancy Induces Hypertension and Vascular Defects in Rat Male Offspring
Brawley, L., Itoh, S., Torrens, C., Barker, A. C., Bertram, C. E., Poston, L., & Hanson, M. A. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000065731.00639.02 · Cited by 244 · see citing works
Sex- and Diet-Specific Changes of Imprinted Gene Expression and DNA Methylation in Mouse Placenta under a High-Fat Diet
Gallou-Kabani, C., Gabory, A., Tost, J., Karimi, M., Mayeur, S., Lesage, J., Boudadi, E., Gross, M.-S., Taurelle, J., Vigé, A., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014398 · Cited by 229 · see citing works
Adaptive Responses by Mouse Early Embryos to Maternal Diet Protect Fetal Growth but Predispose to Adult Onset Disease1
Watkins, A. J., Ursell, E., Panton, R. W., Papenbrock, T., Hollis, L. J., Cunningham, C. M., Wilkins, A., Perry, V. H., Sheth, B., Kwong, W. Y., et al. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.107.064220 · Cited by 227 · see citing works
Epigenetic Changes in Early Life and Future Risk of Obesity
Lillycrop, K. A., & Burdge, G. C. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.122 · Cited by 222 · see citing works
Folate Supplementation During Pregnancy Improves Offspring Cardiovascular Dysfunction Induced by Protein Restriction
Torrens, C., Brawley, L., Anthony, F. W., Dance, C. S., Dunn, R. L., Jackson, A. A., Poston, L., & Hanson, M. A. (2006) · Hypertension · doi:10.1161/01.hyp.0000215580.43711.d1 · Cited by 217 · see citing works
Normal Lactational Environment Restores Nephron Endowment and Prevents Hypertension after Placental Restriction in the Rat
Wlodek, M. E., Mibus, A., Tan, A. L. Y., Siebel, A. L., Owens, J. A., & Moritz, K. M. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007010015 · Cited by 213 · see citing works
The surface area of the placenta and hypertension in the offspring in later life
Barker, D. J. P., Thornburg, K. L., Osmond, C., Kajantie, E., & Eriksson, J. G. (2010) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082760db · Cited by 212 · see citing works
Peroxisome Proliferator-Activated Receptor-γ Agonist Rosiglitazone Reverses the Adverse Effects of Diet-Induced Obesity on Oocyte Quality
Minge, C. E., Bennett, B. D., Norman, R. J., & Robker, R. L. (2008) · Endocrinology · doi:10.1210/en.2007-1570 · Cited by 210 · see citing works
Body Weight Set-Points: Determination and Adjustment
Keesey, R. E., & Hirvonen, M. D. (1997) · Journal of Nutrition · doi:10.1093/jn/127.9.1875s · Cited by 206 · see citing works
Maternal Diets Trigger Sex-Specific Divergent Trajectories of Gene Expression and Epigenetic Systems in Mouse Placenta
Gabory, A., Ferry, L., Fajardy, I., Jouneau, L., Gothié, J.-D., Vigé, A., Fleur, C., Mayeur, S., Gallou-Kabani, C., Gross, M.-S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047986 · Cited by 204 · see citing works
Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice: Undernutrition and placental phenotype
Coan, P. M., Vaughan, O. R., Sekita, Y., Finn, S. L., Burton, G. J., Constancia, M., & Fowden, A. L. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.181214 · Cited by 199 · see citing works
Poor maternal nutrition followed by accelerated postnatal growth leads to telomere shortening and increased markers of cell senescence in rat islets
Tarry‐Adkins, J. L., Chen, J. H., Smith, N. S., Jones, R. H., Cherif, H., & Ozanne, S. E. (2009) · The FASEB Journal · doi:10.1096/fj.08-122796 · Cited by 198 · see citing works
Growth restriction before or after birth reduces nephron number and increases blood pressure in male rats
Wlodek, M. E., Westcott, K. T., Siebel, A. L., Owens, J. A., & Moritz, K. M. (2008) · Kidney International · doi:10.1038/ki.2008.153 · Cited by 193 · see citing works
Melatonin improves placental efficiency and birth weight and increases the placental expression of antioxidant enzymes in undernourished pregnancy
Richter, H. G., Hansell, J. A., Raut, S., & Giussani, D. A. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00671.x · Cited by 188 · see citing works
Estrogen Protects Against Increased Blood Pressure in Postpubertal Female Growth Restricted Offspring
Ojeda, N. B., Grigore, D., Robertson, E. B., & Alexander, B. T. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.091785 · Cited by 178 · see citing works
Maternal Protein Restriction in the Rat Inhibits Placental Insulin, mTOR, and STAT3 Signaling and Down-Regulates Placental Amino Acid Transporters
Rosario, F. J., Jansson, N., Kanai, Y., Prasad, P. D., Powell, T. L., & Jansson, T. (2011) · Endocrinology · doi:10.1210/en.2010-1153 · Cited by 176 · see citing works
The Early Origins of Chronic Heart Failure: Impaired Placental Growth and Initiation of Insulin Resistance in Childhood
Barker, D. J. P., Gelow, J., Thornburg, K., Osmond, C., Kajantie, E., & Eriksson, J. G. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq069 · Cited by 176 · see citing works
Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions
Chakraborty, D., Rumi, M. A. K., Konno, T., & Soares, M. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109478108 · Cited by 169 · see citing works
Pre- and Postnatal Nutritional Histories Influence Reproductive Maturation and Ovarian Function in the Rat
Sloboda, D. M., Howie, G., Pleasants, A. B., Gluckman, P. D., & Vickers, M. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006744 · Cited by 167 · see citing works
Nature, nurture or nutrition? Impact of maternal nutrition on maternal care, offspring development and reproductive function
Connor, K. L., Vickers, M. H., Beltrand, J., Meaney, M. J., & Sloboda, D. M. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.223305 · Cited by 165 · see citing works
Offspring of Mothers Fed a High Fat Diet Display Hepatic Cell Cycle Inhibition and Associated Changes in Gene Expression and DNA Methylation
Dudley, K., Sloboda, D., Connor, K., Beltrand, J., & Vickers, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021662 · Cited by 161 · see citing works
The Placenta at High Altitude
Zamudio, S. (2003) · High Altitude Medicine & Biology · doi:10.1089/152702903322022785 · Cited by 161 · see citing works
An adverse intrauterine environment: implications for injury and altered development of the brain
Rees, S., Harding, R., & Walker, D. (2008) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.08.020 · Cited by 160 · see citing works
Vulnerability of Developing Brain: Relative Effects of Growth Restriction during the Fetal and Suckling Periods on Behavior and Brain Composition of Adult Rats
Smart, J. L., Dobbing, J., ADLARD, B. P. F., Lynch, A., & Sands, J. (1973) · Journal of Nutrition · doi:10.1093/jn/103.9.1327 · Cited by 160 · see citing works
The Mechanisms and Regulation of Placental Amino Acid Transport to the Human Foetus
Cleal, J. K., & Lewis, R. M. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01662.x · Cited by 157 · see citing works
Maternal Fructose Intake during Pregnancy and Lactation Alters Placental Growth and Leads to Sex-Specific Changes in Fetal and Neonatal Endocrine Function
Vickers, M. H., Clayton, Z. E., Yap, C., & Sloboda, D. M. (2011) · Endocrinology · doi:10.1210/en.2010-1093 · Cited by 157 · see citing works
Maternal hypoxia activates endovascular trophoblast cell invasion
Rosario, G. X., Konno, T., & Soares, M. J. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2007.12.007 · Cited by 153 · see citing works
Diet-induced obesity in the rat: A model for gestational diabetes mellitus
Holemans, K., Caluwaerts, S., Poston, L., & Assche, F. A. V. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2003.09.025 · Cited by 152 · see citing works
Effects of Perinatal Maternal Food Restriction on Pituitary-Gonadal Axis and Plasma Leptin Level in Rat Pup at Birth and Weaning and on Timing of Puberty
Léonhardt, M., Lésage, J., Croix, D., Dutriez-Casteloot, I., Beauvillain, J. C., & Dupouy, J. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.003269 · Cited by 151 · see citing works
Effect of low-protein diet-induced intrauterine growth retardation on rat placental amino acid transport
Malandro, M. S., Beveridge, M. J., Kilberg, M. S., & Novak, D. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.1.c295 · Cited by 150 · see citing works
Uteroplacental insufficiency causes a nephron deficit, modest renal insufficiency but no hypertension with ageing in female rats
Moritz, K. M., Mazzuca, M. Q., Siebel, A. L., Mibus, A., Arena, D., Tare, M., Owens, J. A., & Wlodek, M. E. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.170407 · Cited by 144 · see citing works
Obesity During Pregnancy Disrupts Placental Morphology, Cell Proliferation, and Inflammation in a Sex-Specific Manner Across Gestation in the Mouse1
Kim, D. W., Young, S. L., Grattan, D. R., & Jasoni, C. L. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.113.117259 · Cited by 138 · see citing works
High–saturated-fat diet induces gestational diabetes and placental vasculopathy in C57BL/6 mice
Liang, C., Decourcy, K. R., & Prater, M. R. (2009) · Metabolism · doi:10.1016/j.metabol.2009.10.015 · Cited by 136 · see citing works
An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory
Sferruzzi‐Perri, A. N., Vaughan, O. R., Haro, M., Cooper, W. N., Musial, B., Charalambous, M., Pestana, D., Ayyar, S., Ferguson‐Smith, A. C., Burton, G. J., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-234823 · Cited by 134 · see citing works
Self-citation
Mid‐ to late term hypoxia in the mouse alters placental morphology, glucocorticoid regulatory pathways and nutrient transporters in a sex‐specific manner
Cuffe, J. S. M., Walton, S. L., Singh, R. R., Spiers, J. G., Bielefeldt‐Ohmann, H., Wilkinson, L., Little, M. H., & Moritz, K. M. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.272856 · Cited by 128 · see citing works
Adverse Fetal and Neonatal Outcomes Associated with a Life-Long High Fat Diet: Role of Altered Development of the Placental Vasculature
Hayes, E. K., Lechowicz, A., Petrik, J., Storozhuk, Y., Paez-Parent, S., Dai, Q., Samjoo, I. A., Mansell, M., Gruslin, A., Holloway, A. C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033370 · Cited by 127 · see citing works
Effect of maternal feed restriction during pregnancy on glucose tolerance in the adult guinea pig
Kind, K. L., Clifton, P. M., Grant, P. A., Owens, P. C., Sohlström, A., Roberts, C. T., Robinson, J. S., & Owens, J. A. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00587.2001 · Cited by 124 · see citing works
Maternal Food Restriction Reduces the Exchange Surface Area and Increases the Barrier Thickness of the Placenta in the Guinea-pig
Roberts, C. T., Sohlström, A., Kind, K. L., Earl, R., Khong, T. Y., Robinson, J. S., Owens, P. C., & Owens, J. A. (2001) · Placenta · doi:10.1053/plac.2000.0602 · Cited by 124 · see citing works
Intrauterine exposure to high saturated fat diet elevates risk of adult‐onset chronic diseases in C57BL/6 mice
Liang, C., Oest, M. E., & Prater, M. R. (2009) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20206 · Cited by 123 · see citing works
Imprinted gene expression in the rat embryo–fetal axis is altered in response to periconceptional maternal low protein diet
Kwong, W. Y., Miller, D. J., Ursell, E., Wild, A. E., Wilkins, A., Osmond, C., Anthony, F. W., & Fleming, T. P. (2006) · Reproduction · doi:10.1530/rep.1.01038 · Cited by 123 · see citing works
Prenatal protein malnutrition affects exploratory behavior of female rats in the elevated plus-maze test
Almeida, S. S., Tonkiss, J., & Galler, J. R. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)80047-3 · Cited by 121 · see citing works
Programmed Hyperphagia Due to Reduced Anorexigenic Mechanisms in Intrauterine Growth-Restricted Offspring
Desai, M., Gayle, D. A., Han, G., & Ross, M. G. (2007) · Reproductive Sciences · doi:10.1177/1933719107303983 · Cited by 120 · see citing works
Effects of maternal iron restriction in the rat on blood pressure, glucose tolerance, and serum lipids in the 3-month-old offspring
Lewis, R. M., Petry, C. J., Ozanne, S. E., & Hales, C. N. (2001) · Metabolism · doi:10.1053/meta.2001.22516 · Cited by 120 · see citing works
The timing of nutrient restriction during rat pregnancy/lactation alters metabolic syndrome phenotype
Desai, M., Gayle, D. A., Babu, J., & Ross, M. G. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.11.036 · Cited by 119 · see citing works
Pre-gestational vs gestational exposure to maternal obesity differentially programs the offspring in mice
Sasson, I. E., Vitins, A. P., Mainigi, M. A., Moley, K. H., & Simmons, R. A. (2014) · Diabetologia · doi:10.1007/s00125-014-3466-7 · Cited by 119 · see citing works
HPA axis programming by maternal undernutrition in the male rat offspring
Vieau, D., Sebaai, N., Léonhardt, M., Dutriez-Casteloot, I., Molendi‐Coste, O., Laborie, C., Breton, C., DELOOF, S., & Lésage, J. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.03.014 · Cited by 117 · see citing works
Placental-Specific Igf2 Deficiency Alters Developmental Adaptations to Undernutrition in Mice
Sferruzzi-Perri, A. N., Vaughan, O. R., Coan, P. M., Suciu, M. C., Darbyshire, R., Constancia, M., Burton, G. J., & Fowden, A. L. (2011) · Endocrinology · doi:10.1210/en.2011-0240 · Cited by 115 · see citing works
Self-citation
Impaired Mitochondrial Function in the Preimplantation Embryo Perturbs Fetal and Placental Development in the Mouse1
Wakefield, S. L., Lane, M., & Mitchell, M. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.087262 · Cited by 115 · see citing works
The sex-specific effects of famine on the association between placental size and later hypertension
van Abeelen, A. F. M., de Rooij, S. R., Osmond, C., Painter, R. C., Veenendaal, M. V. E., Bossuyt, P. M. M., Elias, S. G., Grobbee, D. E., van der Schouw, Y. T., Barker, D. J. P., et al. (2011) · Placenta · doi:10.1016/j.placenta.2011.06.012 · Cited by 114 · see citing works
Maternal-fetal resource allocation: Co-operation and conflict
Fowden, A. L., & Moore, T. (2012) · Placenta · doi:10.1016/j.placenta.2012.05.002 · Cited by 114 · see citing works
Angiotensin-Converting Enzyme 2 (ACE2) and ACE Activities Display Tissue-Specific Sensitivity to Undernutrition-Programmed Hypertension in the Adult Rat
Rivière, G., Michaud, A., Breton, C., Camp, G. V., Laborie, C., Enache, M., Lésage, J., DELOOF, S., Corvol, P. L., & Vieau, D. (2005) · Hypertension · doi:10.1161/01.hyp.0000185148.27901.fe · Cited by 111 · see citing works
Maternal undernutrition during late gestation-induced intrauterine growth restriction in the rat is associated with impaired placental GLUT3 expression, but does not correlate with endogenous corticosterone levels
Lésage, J., Hahn, D., Léonhardt, M., Blondeau, B., Bréant, B., & Dupouy, J. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1740037 · Cited by 107 · see citing works
Human placental metabolic adaptation to chronic hypoxia, high altitude: hypoxic preconditioning
Tissot van Patot, M. C., Murray, A. J., Beckey, V., Cindrova-Davies, T., Johns, J., Zwerdlinger, L., Jauniaux, E., Burton, G. J., & Serkova, N. J. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00383.2009 · Cited by 107 · see citing works
Gestational diabetes induces chronic hypoxia stress and excessive inflammatory response in murine placenta.
Li, H., Chen, X., & Li, M. (2013) · PubMed · Cited by 106 · see citing works
Ascorbate prevents placental oxidative stress and enhances birth weight in hypoxic pregnancy in rats
Richter, H. G., Camm, E. J., Modi, B., Naeem, F., Cross, C. M., Cindrová‐Davies, T., Spasic‐Boskovic, O., Dunster, C., Mudway, I., Kelly, F. J., et al. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.226340 · Cited by 106 · see citing works
Self-citation
The effects of anaemia on heart, placenta and body weight, and blood pressure in fetal and neonatal rats.
Crowe, C., Dandekar, P., Fox, M., Dhingra, K., Bennet, L., & Hanson, M. A. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020986 · Cited by 104 · see citing works
Effects of uteroplacental insufficiency and reducing litter size on maternal mammary function and postnatal offspring growth
OʼDowd, R., Kent, J. C., Moseley, J. M., & Wlodek, M. E. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00628.2007 · Cited by 103 · see citing works
Restricted fetal growth and the response to dietary cholesterol in the guinea pig
Kind, K. L., Clifton, P. M., Katsman, A. I., Tsiounis, M., Robinson, J. S., & Owens, J. A. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.6.r1675 · Cited by 103 · see citing works
Maternal prenatal undernutrition alters the response of POMC neurons to energy status variation in adult male rat offspring
Breton, C., Lukaszewski, M., Risold, P., Enache, M., Guillemot, J., Rivière, G., Delahaye, F., Lésage, J., Dutriez-Casteloot, I., Laborie, C., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90740.2008 · Cited by 102 · see citing works
Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy
Higgins, J., Vaughan, O. R., de Liger, E. F., Fowden, A. L., & Sferruzzi-Perri, A. N. (2015) · The Journal of Physiology · doi:10.1113/jp271057 · Cited by 102 · see citing works
Self-citation
A prolactin family paralog regulates reproductive adaptations to a physiological stressor
Ain, R., Dai, G., Dunmore, J. H., Godwin, A. R. F., & Soares, M. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406185101 · Cited by 101 · see citing works
Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring
Dahlhoff, M., Pfister, S., Blutke, A., Rozman, J., Klingenspor, M., Deutsch, M. J., Rathkolb, B., Fink, B., Gimpfl, M., de Angelis, M. H., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.11.021 · Cited by 100 · see citing works
Transmission of raised blood pressure and endothelial dysfunction to the F2generation induced by maternal protein restriction in the F0, in the absence of dietary challenge in the F1generation
Torrens, C., Poston, L., & Hanson, M. A. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508921747 · Cited by 99 · see citing works
Physiological importance of system A-mediated amino acid transport to rat fetal development
Cramer, S., Beveridge, M. J., Kilberg, M. S., & Novak, D. A. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2002.282.1.c153 · Cited by 97 · see citing works
Time-dependent physiological regulation of rodent and ovine placental glucose transporter (GLUT-1) protein
Das, U. G., Sadiq, H. F., Soares, M. J., Hay, W. W., & Devaskar, S. U. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.2.r339 · Cited by 96 · see citing works
Placental anatomy and diffusing capacity in guinea pigs following long-term maternal hypoxia
Bacon, B. J., Gilbert, R. D., Kaufmann, P., Smith, A. D., Trevino, F. T., & Longo, L. D. (1984) · Placenta · doi:10.1016/s0143-4004(84)80002-8 · Cited by 96 · see citing works
Uteroplacental restriction in the rat impairs fetal growth in association with alterations in placental growth factors including PTHrP
Wlodek, M. E., Westcott, K. T., OʼDowd, R., Serruto, A., Wassef, L., Moritz, K. M., & Moseley, J. M. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00789.2004 · Cited by 95 · see citing works
Long-term programming of blood pressure by maternal dietary iron restriction in the rat
Lewis, R. M., Forhead, A. J., Petry, C. J., Ozanne, S. E., & Hales, C. N. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002656 · Cited by 94 · see citing works
The placental origins of sudden cardiac death
Barker, D. J., Larsen, G., Osmond, C., Thornburg, K. L., Kajantie, E., & Eriksson, J. G. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dys116 · Cited by 93 · see citing works
Uteroplacental insufficiency programs regional vascular dysfunction and alters arterial stiffness in female offspring
Mazzuca, M. Q., Wlodek, M. E., Dragomir, N. M., Parkington, H. C., & Tare, M. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.187849 · Cited by 92 · see citing works
Intrauterine calorie restriction affects placental DNA methylation and gene expression
Chen, P., Ganguly, A., Rubbi, L., Orozco, L. D., Morselli, M., Ashraf, D. C., Jaroszewicz, A., Feng, S., Jacobsen, S. E., Nakano, A., et al. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00034.2013 · Cited by 90 · see citing works
Uterine Artery Function in Pregnant Rats Fed a Diet Supplemented with Animal Lard
Taylor, P. D., Khan, I. Y., Lakasing, L., DEKOU, V., O'Brien-Coker, I., Mallet, A. I., Hanson, M. A., & Poston, L. (2003) · Experimental Physiology · doi:10.1113/eph8802495 · Cited by 90 · see citing works
Prenatal famine and adult mental illness: Interpreting concordant and discordant results from the Dutch and Chinese Famines
Susser, E., & Clair, D. S. (2013) · Social Science & Medicine · doi:10.1016/j.socscimed.2013.02.049 · Cited by 89 · see citing works
Maternal high-fat diet acts as a stressor increasing maternal glucocorticoids’ signaling to the fetus and disrupting maternal behavior and brain activation in C57BL/6J mice
Bellisario, V., Panetta, P., Balsevich, G., Baumann, V., Noble, J., Raggi, C., Nathan, O., Berry, A., Seckl, J., Schmidt, M., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.06.012 · Cited by 88 · see citing works
Maternal undernutrition reduces P-glycoprotein in guinea pig placenta and developing brain in late gestation
Soo, P. S., Hiscock, J. J., Botting, K. J., Roberts, C. T., Davey, A. K., & Morrison, J. L. (2012) · Reproductive Toxicology · doi:10.1016/j.reprotox.2012.01.013 · Cited by 88 · see citing works
Programmed Upregulation of Adipogenic Transcription Factors in Intrauterine Growth-Restricted Offspring
Desai, M., Han, G., Ferelli, M., Kallichanda, N., & Lane, R. H. (2008) · Reproductive Sciences · doi:10.1177/1933719108318597 · Cited by 87 · see citing works
Partial contributions of developmental hypoxia and undernutrition to prenatal alterations in somatic growth and cardiovascular structure and function
Camm, E. J., Hansell, J. A., Kane, A. D., Herrera, E. A., Lewis, C., Wong, S. Y. S., Morrell, N. W., & Giussani, D. A. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.06.046 · Cited by 87 · see citing works
Self-citation
Effect of maternal feed restriction on blood pressure in the adult guinea pig
Kind, K. L., Simonetta, G., Clifton, P. M., Robinson, J. S., & Owens, J. A. (2002) · Experimental Physiology · doi:10.1111/j.1469-445x.2002.tb00060.x · Cited by 87 · see citing works
Placental transporter activity and expression in relation to fetal growth
Sibley, C. P., Glazier, J. D., & D’Souza, S. W. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004034 · Cited by 86 · see citing works
Maternal Undernutrition during Late Gestation Induces Fetal Overexposure to Glucocorticoids and Intrauterine Growth Retardation, and Disturbs the Hypothalamo-Pituitary Adrenal Axis in the Newborn Rat
Lésage, J. (2001) · Endocrinology · doi:10.1210/en.142.5.1692 · Cited by 86 · see citing works
Sex differences in the developmental programming of hypertension
Ojeda, N. B., Intapad, S., & Alexander, B. T. (2013) · Acta Physiologica · doi:10.1111/apha.12206 · Cited by 85 · see citing works
Fetal exposure to a maternal low-protein diet is associated with altered left ventricular pressure response to ischaemia–reperfusion injury
Elmes, M. J., Gardner, D. S., & Langley‐Evans, S. C. (2007) · British Journal Of Nutrition · doi:10.1017/s000711450769182x · Cited by 84 · see citing works
Metabolic and Mitochondrial Dysfunction in Early Mouse Embryos Following Maternal Dietary Protein Intervention1
Mitchell, M., Schulz, S. L., Armstrong, D. T., & Lane, M. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.072595 · Cited by 83 · see citing works
Altered placental development in undernourished rats: role of maternal glucocorticoids
Belkacemi, L., Jelks, A. T., Chen, C., Ross, M. G., & Desai, M. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-105 · Cited by 83 · see citing works
Heart Disease Link to Fetal Hypoxia and Oxidative Stress
Giussani, D. A., Niu, Y., Herrera, E. A., Richter, H. G., Camm, E. J., Thakor, A. S., Kane, A. D., Hansell, J. A., Brain, K. L., Skeffington, K. L., et al. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-1031-1_7 · Cited by 81 · see citing works
Self-citation
Down-regulation of transcription factor peroxisome proliferator-activated receptor in programmed hepatic lipid dysregulation and inflammation in intrauterine growth–restricted offspring
Magee, T. R., Han, G., Cherian, B., Khorram, O., Ross, M. G., & Desai, M. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.05.022 · Cited by 79 · see citing works
Regulation of placental metabolism by glucose supply
Hay, W. (1995) · Reproduction Fertility and Development · doi:10.1071/rd9950365 · Cited by 76 · see citing works
Improved Lactational Nutrition and Postnatal Growth Ameliorates Impairment of Glucose Tolerance by Uteroplacental Insufficiency in Male Rat Offspring
Siebel, A. L., Mibus, A., Blasio, M. J. D., Westcott, K. T., Morris, M. J., Prior, L. J., Owens, J. A., & Wlodek, M. E. (2008) · Endocrinology · doi:10.1210/en.2008-0128 · Cited by 76 · see citing works
Maternal Overweight Induced by a Diet with High Content of Saturated Fat Activates Placental mTOR and eIF2alpha Signaling and Increases Fetal Growth in Rats1
Gaccioli, F., White, V., Capobianco, E., Powell, T. L., Jawerbaum, A., & Jansson, T. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.109702 · Cited by 76 · see citing works
Prenatal hypoxia independent of undernutrition promotes molecular markers of insulin resistance in adult offspring
Camm, E. J., Martin‐Gronert, M. S., Wright, N., Hansell, J. A., Ozanne, S. E., & Giussani, D. A. (2010) · The FASEB Journal · doi:10.1096/fj.10-158188 · Cited by 75 · see citing works
Self-citation
Maternal corticosterone regulates nutrient allocation to fetal growth in mice
Vaughan, O. R., Sferruzzi‐Perri, A. N., & Fowden, A. L. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.239426 · Cited by 75 · see citing works
Self-citation
Maternal High-Fat Feeding Increases Placental Lipoprotein Lipase Activity by Reducing SIRT1 Expression in Mice
Qiao, L., Guo, Z., Bosco, C., Guidotti, S., Wang, Y., Wang, M., Parast, M., Schaack, J., Hay, W. W., Moore, T. R., et al. (2015) · Diabetes · doi:10.2337/db14-1627 · Cited by 75 · see citing works
Perinatal Malnutrition Programs Sympathoadrenal and Hypothalamic‐Pituitary‐Adrenal Axis Responsiveness to Restraint Stress in Adult Male Rats
Lésage, J., Dufourny, L., Laborie, C., Bernet, F., Blondeau, B., Avril, I., Bréant, B., & Dupouy, J. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.0007-1331.2001.00753.x · Cited by 73 · see citing works
Perinatal Maternal Food Restriction Induces Alterations in Hypothalamo-Pituitary-Adrenal Axis Activity and in Plasma Corticosterone-Binding Globulin Capacity of Weaning Rat Pups
Léonhardt, M., Lésage, J., Dufourny, L., Dickès-Coopman, A., Montel, V., & Dupouy, J. (2002) · Neuroendocrinology · doi:10.1159/000048220 · Cited by 73 · see citing works
Maternal high fat and/or salt consumption induces sex-specific inflammatory and nutrient transport in the rat placenta
Reynolds, C. M., Vickers, M. H., Harrison, C. J., Segovia, S. A., & Gray, C. L. (2015) · Physiological Reports · doi:10.14814/phy2.12399 · Cited by 73 · see citing works
Protein Restriction during Pregnancy Induces Hypertension and Impairs Endothelium-Dependent Vascular Function in Adult Female Offspring
Sathishkumar, K., Elkins, R., Yallampalli, U., & Yallampalli, C. (2008) · Journal of Vascular Research · doi:10.1159/000166390 · Cited by 72 · see citing works
Dietary Protein Restriction during F0 Pregnancy in Rats Induces Transgenerational Changes in the Hepatic Transcriptome in Female Offspring
Hoile, S. P., Lillycrop, K. A., Thomas, N. A., Hanson, M. A., & Burdge, G. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021668 · Cited by 71 · see citing works
Morphological and molecular changes in the murine placenta exposed to normobaric hypoxia throughout pregnancy
Matheson, H., Veerbeek, J. H. W., Charnock‐Jones, D. S., Burton, G. J., & Yung, H. W. (2016) · The Journal of Physiology · doi:10.1113/jp271073 · Cited by 71 · see citing works
Reduced uterine perfusion pressure induces hypertension in the pregnant mouse
Intapad, S., Warrington, J. P., Spradley, F. T., Palei, A. C., Drummond, H. A., Ryan, M. J., Granger, J. P., & Alexander, B. T. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00268.2014 · Cited by 71 · see citing works
Food restriction alters pregnancy-associated changes in IGF and IGFBP in the guinea pig
Sohlström, A., Katsman, A. I., Kind, K. L., Roberts, C. T., Owens, P. C., Robinson, J. S., & Owens, J. A. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.3.e410 · Cited by 70 · see citing works
Hypoxia, AMPK activation and uterine artery vasoreactivity
Skeffington, K. L., Higgins, J. S., Mahmoud, A. D., Evans, A. M., Sferruzzi‐Perri, A. N., Fowden, A. L., Yung, H. W., Burton, G. J., Giussani, D. A., & Moore, L. G. (2016) · The Journal of Physiology · doi:10.1113/jp270995 · Cited by 69 · cited 1× · see citing works
“…for blood flow and the delivery of substrates to the placenta (Ahokas et al., 1981, 1983; Itoh et al., 2002; Taylor et al., 2003; Alam et al., 2007; Rosario et al., 2008; Chakraborty et al., 2011; Hayes et al., 2012, 2014; Rueda-Clausen et al., 2014; Lineker et al., 2015; Skeffington et al., 2015).”
BackgroundSelf-citation
Vitamin C Prevents Intrauterine Programming of in vivo Cardiovascular Dysfunction in the Rat
Kane, A. D., Herrera, E. A., Camm, E. J., & Giussani, D. A. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-0311 · Cited by 69 · see citing works
Self-citation
Maternal prenatal undernutrition programs adipose tissue gene expression in adult male rat offspring under high-fat diet
Lukaszewski, M., Mayeur, S., Fajardy, I., Delahaye, F., Dutriez-Casteloot, I., Montel, V., Dickès-Coopman, A., Laborie, C., Lésage, J., Vieau, D., et al. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00011.2011 · Cited by 69 · see citing works
Chronic maternal feed restriction impairs growth but increases adiposity of the fetal guinea pig
Kind, K. L., Roberts, C. T., Sohlström, A., Katsman, A. I., Clifton, P. M., Robinson, J. S., & Owens, J. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00360.2004 · Cited by 69 · see citing works
Feeding a protein-restricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor-α in the heart of the offspring
Slater-Jefferies, J. L., Lillycrop, K. A., Townsend, P. A., Torrens, C., Hoile, S. P., Hanson, M. A., & Burdge, G. C. (2010) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174410000425 · Cited by 67 · see citing works
Dietary composition programmes placental phenotype in mice
Coan, P. M., Vaughan, O. R., McCarthy, J., Mactier, C., Burton, G. J., Constância, M., & Fowden, A. L. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.208629 · Cited by 67 · see citing works
Maternal calorie restriction modulates placental mitochondrial biogenesis and bioenergetic efficiency: putative involvement in fetoplacental growth defects in rats
Mayeur, S., Lancel, S., Theys, N., Lukaszewski, M., Duban‐Deweer, S., Bastide, B., Hachani, J., Cecchelli, R., Breton, C., Gabory, A., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00332.2012 · Cited by 65 · see citing works
Perinatal Undernutrition Modifies Cell Proliferation and Brain‐Derived Neurotrophic Factor Levels During Critical Time‐Windows for Hypothalamic and Hippocampal Development in the Male Rat
Coupé, B., Dutriez-Casteloot, I., Breton, C., Lefèvre, F., Mairesse, J., Dickès-Coopman, A., Silhol, M., Tapia‐Arancibia, L., Lésage, J., & Vieau, D. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01806.x · Cited by 65 · see citing works
Maternal-Fetal Exchange During Protein Malnutrition in the Rat. Placental Transfer of α-amino Isobutyric Acid
Rosso, P. (1977) · Journal of Nutrition · doi:10.1093/jn/107.11.2002 · Cited by 65 · see citing works
Permanent reduction in heart and kidney organ growth in offspring of undernourished rat dams
Desai, M., Gayle, D. A., Babu, J., & Ross, M. G. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.05.041 · Cited by 64 · see citing works
A maternal high-fat diet in rat pregnancy reduces growth of the fetus and the placental junctional zone, but not placental labyrinth zone growth
Mark, P. J., Sisala, C., Connor, K. L., Patel, R., Lewis, J. L., Vickers, M. H., Waddell, B. J., & Sloboda, D. M. (2011) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174410000681 · Cited by 62 · see citing works
The prenatal origins of lung cancer. II. The placenta
Barker, D. J. P., Thornburg, K. L., Osmond, C., Kajantie, E., & Eriksson, J. G. (2010) · American Journal of Human Biology · doi:10.1002/ajhb.21041 · Cited by 61 · see citing works
A uterine decidual cell cytokine ensures pregnancy-dependent adaptations to a physiological stressor
Alam, S. M. K., Konno, T., Dai, G., Lu, L., Wang, D., Dunmore, J. H., Godwin, A. R. F., & Soares, M. J. (2006) · Development · doi:10.1242/dev.02743 · Cited by 61 · see citing works
Mouse early extra-embryonic lineages activate compensatory endocytosis in response to poor maternal nutrition
Sun, C., Velazquez, M. A., Marfy-Smith, S., Sheth, B., Cox, A. L., Johnston, D. A., Smyth, N. R., & Fleming, T. P. (2014) · Development · doi:10.1242/dev.103952 · Cited by 60 · see citing works
Trophoblast Invasion and Blood Vessel Remodeling Are Altered in a Rat Model of Lifelong Maternal Obesity
Hayes, E. K., Tessier, D. R., Percival, M. E., Holloway, A. C., Petrik, J., Gruslin, A., & Raha, S. (2013) · Reproductive Sciences · doi:10.1177/1933719113508815 · Cited by 60 · see citing works
Placental Gene Expression Responses to Maternal Protein Restriction in the Mouse
Gheorghe, C. P., Goyal, R., Holweger, J. D., & Longo, L. D. (2009) · Placenta · doi:10.1016/j.placenta.2009.03.002 · Cited by 59 · see citing works
Effects of maternal iron restriction in the rat on hypoxia-induced gene expression and fetal metabolite levels
Lewis, R. M., James, L. A., Zhang, J., Byrne, C. D., & Hales, C. N. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2000247 · Cited by 59 · see citing works
Endothelial dysfunction and reduced antioxidant protection in an animal model of the developmental origins of cardiovascular disease
Rodford, J. L., Torrens, C., Siow, R., Mann, G., Hanson, M., & Clough, G. (2008) · Journal of Physiology · doi:10.1113/jphysiol.2008.156976 · Cited by 58 · see citing works
A Modification of the Uterine Artery Restriction Technique in the Guinea Pig Fetus Produces Asymmetrical Ultrasound Growth
Turner, A. J., & Trudinger, B. (2009) · Placenta · doi:10.1016/j.placenta.2008.11.023 · Cited by 58 · see citing works
Placental diffusing capacity and fetal development in exercising or hypoxic guinea pigs
Gilbert, R. D., Cummings, L. A., Juchau, M. R., & Longo, L. D. (1979) · Journal of Applied Physiology · doi:10.1152/jappl.1979.46.4.828 · Cited by 58 · see citing works
Perinatal Food Deprivation Induces Marked Alterations of the Hypothalamo-Pituitary-Adrenal Axis in 8-Month-Old Male Rats both under Basal Conditions and after a Dehydration Period
Sebaai, N., Lésage, J., Breton, C., Vieau, D., & DELOOF, S. (2004) · Neuroendocrinology · doi:10.1159/000078098 · Cited by 57 · see citing works
Uteroplacental insufficiency and reducing litter size alters skeletal muscle mitochondrial biogenesis in a sex-specific manner in the adult rat
Wadley, G. D., Siebel, A. L., Gj, C., McConell, G. K., Wlodek, M. E., & Owens, J. A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00037.2008 · Cited by 57 · see citing works
Maternal undernutrition induces premature reproductive senescence in adult female rat offspring
Khorram, O., Keen‐Rhinehart, E., Chuang, T., Ross, M. G., & Desai, M. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.09.026 · Cited by 57 · see citing works
Placental Glucose and Amino Acid Transport in Calorie-Restricted Wild-Type and Glut3 Null Heterozygous Mice
Ganguly, A., Collis, L., & Devaskar, S. U. (2012) · Endocrinology · doi:10.1210/en.2011-1973 · Cited by 56 · see citing works
Vasodilation to Vascular Endothelial Growth Factor in the Uterine Artery of the Pregnant Rat Is Blunted by Low Dietary Protein Intake
Itoh, S., Brawley, L., Wheeler, T., Anthony, F. W., Poston, L., & Hanson, M. A. (2002) · Pediatric Research · doi:10.1203/00006450-200204000-00014 · Cited by 56 · see citing works
Effect of Gestational Nutrition on Vascular Integrity in the Murine Placenta
Rutland, C. S., Latunde‐Dada, A. O., Thorpe, A., Plant, R., Langley‐Evans, S. C., & Leach, L. (2006) · Placenta · doi:10.1016/j.placenta.2006.07.001 · Cited by 56 · see citing works
Cardio‐renal and metabolic adaptations during pregnancy in female rats born small: implications for maternal health and second generation fetal growth
Gallo, L. A., Tran, M., Moritz, K. M., Mazzuca, M. Q., Parry, L. J., Westcott, K. T., Jefferies, A. J., Cullen‐McEwen, L. A., & Wlodek, M. E. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.219147 · Cited by 55 · see citing works
Environmental regulation of placental phenotype: implications for fetal growth
Vaughan, O. R., Sferruzzi-Perri, A. N., Coan, P. M., & Fowden, A. L. (2011) · Reproduction Fertility and Development · doi:10.1071/rd11909 · Cited by 55 · see citing works
Self-citation
Effects of Maternal Iron Restriction on Placental Vascularization in the Rat
Lewis, R. M., Doherty, C., James, L. A., Burton, G. J., & Hales, C. N. (2001) · Placenta · doi:10.1053/plac.2001.0679 · Cited by 55 · see citing works
Maternal-Fetal Exchange During Protein Malnutrition in the Rat. Placental Transfer of Glucose and a Nonmetabolizable Glucose Analog
Rosso, P. (1977) · Journal of Nutrition · doi:10.1093/jn/107.11.2006 · Cited by 54 · see citing works
Early Life Exposure to Fructose Alters Maternal, Fetal and Neonatal Hepatic Gene Expression and Leads to Sex-Dependent Changes in Lipid Metabolism in Rat Offspring
Clayton, Z. E., Vickers, M. H., Bernal, A. B., Yap, C., & Sloboda, D. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141962 · Cited by 54 · see citing works
Gestational high saturated fat diet alters C57BL/6 mouse perinatal skeletal formation
Liang, C., Oest, M. E., Jones, J. C., & Prater, M. R. (2009) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20204 · Cited by 54 · see citing works
Adiponectin Enhances Mouse Fetal Fat Deposition
Qiao, L., Yoo, H. S., Madon, A., Kinney, B., Hay, W. W., & Shao, J. (2012) · Diabetes · doi:10.2337/db12-0055 · Cited by 53 · see citing works
Timing of Maternal Exposure to a High Fat Diet and Development of Obesity and Hyperinsulinemia in Male Rat Offspring: Same Metabolic Phenotype, Different Developmental Pathways?
Howie, G., Sloboda, D. M., Reynolds, C. M., & Vickers, M. H. (2013) · Journal of Nutrition and Metabolism · doi:10.1155/2013/517384 · Cited by 52 · see citing works
Gene Expression Patterns in the Hypoxic Murine Placenta: A Role in Epigenesis?
Gheorghe, C. P., Mohan, S., Oberg, K. C., & Longo, L. D. (2007) · Reproductive Sciences · doi:10.1177/1933719107302860 · Cited by 51 · see citing works
Altered expression of IGFs and IGF-binding proteins during intrauterine growth restriction in guinea pigs
Carter, A. M., Kingston, M. J., Han, K. K., Mazzuca, D. M., Nygard, K. L., & Han, V. K. M. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05781 · Cited by 51 · see citing works
Effect of Prenatal Hypoxia in Transgenic Mouse Models of Preeclampsia and Fetal Growth Restriction
Rueda‐Clausen, C. F., Stanley, J. L., Thambiraj, D. F., Poudel, R., Davidge, S. T., & Baker, P. N. (2013) · Reproductive Sciences · doi:10.1177/1933719113503401 · Cited by 50 · see citing works
Maternal Fructose and/or Salt Intake and Reproductive Outcome in the Rat: Effects on Growth, Fertility, Sex Ratio, and Birth Order1
Gray, C. L., Long, S., Green, C., Gardiner, S. M., Craigon, J., & Gardner, D. S. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.109595 · Cited by 50 · see citing works
Placental Composition and Surface Area but not Vascularization are Altered by Maternal Protein Restriction in the Rat
Doherty, C., Lewis, R. M., Sharkey, A., & Burton, G. J. (2002) · Placenta · doi:10.1053/plac.2002.0858 · Cited by 50 · see citing works
Normal lactational environment restores cardiomyocyte number after uteroplacental insufficiency: implications for the preterm neonate
Black, M. J., Siebel, A. L., Gezmish, O., Moritz, K. M., & Wlodek, M. E. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00030.2012 · Cited by 50 · see citing works
Chronic maternal hypoxia retards fetal growth and increases glucose utilization of select fetal tissues in the rat
Lueder, F. L., Kim, S.-B., Buroker, C. A., Bangalore, S., & Ogata, E. S. (1995) · Metabolism · doi:10.1016/0026-0495(95)90063-2 · Cited by 49 · see citing works
Foetal and childhood growth and asthma in adult life
Barker, D. J. P., Osmond, C., Forsén, T., Thornburg, K. L. R., Kajantie, E., & Eriksson, J. G. (2013) · Acta Paediatrica · doi:10.1111/apa.12257 · Cited by 48 · see citing works
Uteroplacental Insufficiency and Lactational Environment Separately Influence Arterial Stiffness and Vascular Function in Adult Male Rats
Tare, M., Parkington, H. C., Bubb, K. J., & Wlodek, M. E. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.190876 · Cited by 48 · see citing works
The lifespan of men and the shape of their placental surface at birth
Barker, D. J. P., Osmond, C., Thornburg, K. L. R., Kajantie, E., & Eriksson, J. G. (2011) · Placenta · doi:10.1016/j.placenta.2011.07.031 · Cited by 48 · see citing works
The shape of the placental surface at birth and colorectal cancer in later life
Barker, D. J. P., Osmond, C., Thornburg, K. L., Kajantie, E., & Eriksson, J. G. (2013) · American Journal of Human Biology · doi:10.1002/ajhb.22409 · Cited by 48 · see citing works
Leptin and the Placental Response to Maternal Food Restriction During Early Pregnancy in Mice1
Schulz, L. C., Schlitt, J. M., Caesar, G., & Pennington, K. A. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.112.103218 · Cited by 47 · see citing works
Nutrient Restriction In Utero Induces Remodeling of the Vascular Extracellular Matrix in Rat Offspring
Khorram, O., Momeni, M., Desai, M., & Ross, M. G. (2007) · Reproductive Sciences · doi:10.1177/1933719106298215 · Cited by 47 · see citing works
Maternal nutrition modifies trophoblast giant cell phenotype and fetal growth in mice
Watkins, A. J., Lucas, E. S., Marfy-Smith, S., Bates, N., Kimber, S. J., & Fleming, T. P. (2015) · Reproduction · doi:10.1530/rep-14-0667 · Cited by 46 · see citing works
Fetal weight and its relationship to placental blood flow and placental weight in experimental intrauterine growth retardation in the rat.
Gilbert, M., & Leturque, A. (1982) · PubMed · Cited by 45 · see citing works
Increased palatable food intake and response to food cues in intrauterine growth-restricted rats are related to tyrosine hydroxylase content in the orbitofrontal cortex and nucleus accumbens
Alves, M. B., Dalle Molle, R., Desai, M., Ross, M. G., & Silveira, P. P. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.03.019 · Cited by 45 · see citing works
Maternal undernutrition inhibits angiogenesis in the offspring: a potential mechanism of programmed hypertension
Khorram, O., Khorram, N. M., Momeni, M., Han, G., Halem, J., Desai, M., & Ross, M. G. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00131.2007 · Cited by 45 · see citing works
Diet-induced obesity in mice reduces placental efficiency and inhibits placental mTOR signaling
Lager, S., Samulesson, A.-M., Taylor, P. D., Poston, L., Powell, T. L., & Jansson, T. (2014) · Physiological Reports · doi:10.1002/phy2.242 · Cited by 44 · cited 1× · see citing works
“…with both unchanged and reduced fetal and placental weights depending on the length of exposure (before, during or part of pregnancy) and whether gross maternal food intake was reduced (Holemans et al., 2004; Vickers et al., 2011; Gray et al., 2013; Mukai et al., 2013; Lager et al., 2014).”
Background
Effect of maternal undernutrition on vascular expression of micro and messenger RNA in newborn and aging offspring
Khorram, O., Han, G., Bagherpour, R., Magee, T. R., Desai, M., Ross, M. G., Chaudhri, A. A., Toloubeydokhti, T., & Pearce, W. J. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00704.2009 · Cited by 44 · see citing works
Dietary fat impacts fetal growth and metabolism: uptake of chylomicron remnant core lipids by the placenta
Rebholz, S. L., Burke, K. T., Yang, Q., Tso, P., & Woollett, L. A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00619.2010 · Cited by 43 · see citing works
Corticosterone alters materno‐fetal glucose partitioning and insulin signalling in pregnant mice
Vaughan, O. R., Fisher, H. M., Dionelis, K. N., Jefferies, E. C., Higgins, J., Musiał, B., Sferruzzi-Perri, A. N., & Fowden, A. L. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.287177 · Cited by 42 · see citing works
Self-citation
Effects of acute and chronic food restriction on the insulin-like growth factor axis in the guinea pig
Sohlström, A., Katsman, A. I., Kind, K. L., Grant, P. A., Owens, P. C., Robinson, J. S., & Owens, J. A. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1570107 · Cited by 41 · see citing works
The effects of an obesogenic diet during pregnancy on fetal growth and placental gene expression are gestation dependent
King, V. M., Hibbert, N., Seckl, J. R., Norman, J. E., & Drake, A. J. (2013) · Placenta · doi:10.1016/j.placenta.2013.09.006 · Cited by 40 · see citing works
A Low-Protein Diet during Gestation in Rats Activates the Placental Mammalian Amino Acid Response Pathway and Programs the Growth Capacity of Offspring
Strakovsky, R. S., Zhou, D., & Pan, Y. (2010) · Journal of Nutrition · doi:10.3945/jn.110.127803 · Cited by 39 · see citing works
Protein restriction during pregnancy induces hypertension in adult female rat offspring – influence of oestradiol
Sathishkumar, K., Elkins, R., Yallampalli, U., & Yallampalli, C. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511003448 · Cited by 39 · see citing works
Maternal perinatal undernutrition programs a “brown-like” phenotype of gonadal white fat in male rat at weaning
Delahaye, F., Lukaszewski, M., Wattez, J.-S., Cissé, O., Dutriez-Casteloot, I., Fajardy, I., Montel, V., Dickès-Coopman, A., Laborie, C., Lésage, J., et al. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00604.2009 · Cited by 38 · see citing works

Flagged first, then by citations

1 of the 262 references couldn’t be matched to a known paper.

Sorted by citations

Developmental origins of metabolic diseases
Hoffman, D. J., Powell, T. L., Barrett, E. S., & Hardy, D. B. (2020) · Physiological Reviews · doi:10.1152/physrev.00002.2020 · Cited by 483 · see citing works
Human placental development and function
Cindrová‐Davies, T., & Sferruzzi-Perri, A. N. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.03.039 · Cited by 280 · see citing works
Self-citation
Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia
Marı́n, R., Chiarello, D. I., Abad, C., Rojas, D., Toledo, F., & Sobrevía, L. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165961 · Cited by 190 · see citing works
Placental phenotype and the insulin‐like growth factors: resource allocation to fetal growth
Sferruzzi-Perri, A. N., Sandovici, I., Constância, M., & Fowden, A. L. (2017) · The Journal of Physiology · doi:10.1113/jp273330 · Cited by 178 · see citing works
Self-citation
The health outcomes of human offspring conceived by assisted reproductive technologies (ART)
Chen, M., & Heilbronn, L. K. (2017) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174417000228 · Cited by 173 · see citing works
Epigenetics and the Developmental Origins of Health and Disease: Parental environment signalling to the epigenome, critical time windows and sculpting the adult phenotype.
Safi-Stibler, S., & Gabory, A. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.09.008 · Cited by 127 · see citing works
Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction
Colson, A., Sonveaux, P., Debiève, F., & Sferruzzi-Perri, A. N. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa053 · Cited by 145 · see citing works
Self-citation
Placental mitochondria and reactive oxygen species in the physiology and pathophysiology of pregnancy
Fisher, J. J., Bartho, L. A., Perkins, A. V., & Holland, O. J. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13172 · Cited by 126 · see citing works
Effects of maternal and paternal exercise on offspring metabolism
Kusuyama, J., Alves-Wagner, A. B., Makarewicz, N., & Goodyear, L. J. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00274-7 · Cited by 122 · see citing works
Placental mitochondria adapt developmentally and in response to hypoxia to support fetal growth
Sferruzzi-Perri, A. N., Higgins, J., Vaughan, O. R., Murray, A. J., & Fowden, A. L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816056116 · Cited by 116 · see citing works
Self-citation
Regulation of maternal–fetal metabolic communication
Bowman, C. E., Arany, Z. P., & Wolfgang, M. J. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03674-w · Cited by 116 · see citing works
Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health
Kusuyama, J., Alves-Wagner, A. B., Conlin, R. H., Makarewicz, N., Albertson, B. G., Prince, N. B., Kobayashi, S., Kozuka, C., Leth‐Møller, M., Bjerre, M., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.03.004 · Cited by 114 · see citing works
Nanoparticles and female reproductive system: how do nanoparticles affect oogenesis and embryonic development
Hou, C.-C., & Zhu, J. (2017) · Oncotarget · doi:10.18632/oncotarget.19087 · Cited by 111 · see citing works
Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects
Hsu, C., Hou, C., Hsu, W.-H., & Tain, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111872 · Cited by 111 · see citing works
Long term effects of ART: What do animals tell us?
Duranthon, V., & Chavatte‐Palmer, P. (2018) · Molecular Reproduction and Development · doi:10.1002/mrd.22970 · Cited by 103 · see citing works
Placental Adaptation to Early-Onset Hypoxic Pregnancy and Mitochondria-Targeted Antioxidant Therapy in a Rodent Model
Nuzzo, A. M., Camm, E. J., Sferruzzi-Perri, A. N., Ashmore, T. J., Yung, H. W., Cindrová‐Davies, T., Spiroski, A., Sutherland, M. R., Logan, A., Austin‐Williams, S., et al. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.07.027 · Cited by 94 · see citing works
Self-citation
Placental adaptations supporting fetal growth during normal and adverse gestational environments
Sferruzzi-Perri, A. N., López‐Tello, J., & Salazar‐Petres, E. (2022) · Experimental Physiology · doi:10.1113/ep090442 · Cited by 104 · see citing works
Self-citation
Hyperandrogenism and insulin resistance‐induced fetal loss: evidence for placental mitochondrial abnormalities and elevated reactive oxygen species production in pregnant rats that mimic the clinical features of polycystic ovary syndrome
Zhang, Y., Zhao, W., Xu, H., Hu, M., Guo, X., Jia, W., Liu, G., Li, J., Cui, P., Lager, S., et al. (2019) · The Journal of Physiology · doi:10.1113/jp277879 · Cited by 96 · see citing works
Self-citation
Maternal obesity increases the risk of metabolic disease and impacts renal health in offspring
Glastras, S. J., Chen, H., Pollock, C. A., & Saad, S. (2018) · Bioscience Reports · doi:10.1042/bsr20180050 · Cited by 83 · see citing works
Near to One's Heart: The Intimate Relationship Between the Placenta and Fetal Heart
Camm, E. J., Botting, K. J., & Sferruzzi-Perri, A. N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00629 · Cited by 82 · see citing works
Self-citation
Maternal immune activation and role of placenta in the prenatal programming of neurodevelopmental disorders
Woods, R. M., Lorusso, J. M., Fletcher, J., ElTaher, H., McEwan, F., Harris, I., Kowash, H. M., D'Souza, S. W., Harte, M., Hager, R., et al. (2023) · Neuronal Signaling · doi:10.1042/ns20220064 · Cited by 84 · see citing works
Fetal brain and placental programming in maternal obesity: A review of human and animal model studies
Shook, L. L., Kışlal, S., & Edlow, A. G. (2020) · Prenatal Diagnosis · doi:10.1002/pd.5724 · Cited by 81 · see citing works
Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene
López‐Tello, J., Yong, H. E. J., Sandovici, I., Dowsett, G. K. C., Christoforou, E. R., Salazar‐Petres, E., Boyland, R., Napso, T., Yeo, G. S. H., Lam, B., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.06.007 · Cited by 83 · see citing works
Self-citation
Creatine Metabolism in Female Reproduction, Pregnancy and Newborn Health
Muccini, A. M., Tran, N. T., de Guingand, D. L., Philip, M., Gatta, P. A. D., Galinsky, R., Sherman, L. S., Kelleher, M. A., Palmer, K. R., Berry, M. J., et al. (2021) · Nutrients · doi:10.3390/nu13020490 · Cited by 86 · see citing works
Diet‐induced maternal obesity impacts feto‐placental growth and induces sex‐specific alterations in placental morphology, mitochondrial bioenergetics, dynamics, lipid metabolism and oxidative stress in mice
Napso, T., Lean, S. C., Lu, M., Mort, E. J., Desforges, M., Moghimi, A., Bartels, B., El‐Bacha, T., Fowden, A. L., Camm, E. J., et al. (2022) · Acta Physiologica · doi:10.1111/apha.13795 · Cited by 74 · see citing works
Self-citation
Placental metabolism: substrate requirements and the response to stress
Vaughan, O. R., & Fowden, A. (2016) · Reproduction in Domestic Animals · doi:10.1111/rda.12797 · Cited by 74 · see citing works
Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation
Sferruzzi-Perri, A. N., López‐Tello, J., Fowden, A. L., & Constância, M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602012113 · Cited by 73 · see citing works
Self-citation
Developmental programming of the female reproductive system—a review
Yao, S., López‐Tello, J., & Sferruzzi-Perri, A. N. (2020) · Biology of Reproduction · doi:10.1093/biolre/ioaa232 · Cited by 72 · see citing works
Self-citation
The Maternal Nutritional Buffering Model: an evolutionary framework for pregnancy nutritional intervention
Thayer, Z. M., Rutherford, J. N., & Kuzawa, C. W. (2020) · Evolution Medicine and Public Health · doi:10.1093/emph/eoz037 · Cited by 72 · see citing works
Revealing the molecular landscape of human placenta: a systematic review and meta-analysis of single-cell RNA sequencing studies
Derisoud, E., Jiang, H., Zhao, A. Z., Chavatte‐Palmer, P., & Deng, Q. (2024) · Human Reproduction Update · doi:10.1093/humupd/dmae006 · Cited by 73 · see citing works
Genetic and inflammatory factors underlying gestational diabetes mellitus: a review
Ray, G. W., Zeng, Q., Kusi, P., Zhang, H., Shao, T., Yang, T., Wei, Y., Li, M., Che, X., & Guo, R. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1399694 · Cited by 76 · see citing works
Microplastics caused embryonic growth retardation and placental dysfunction in pregnant mice by activating GRP78/IRE1α/JNK axis induced apoptosis and endoplasmic reticulum stress
Bai, J. Y., Wang, Y., Deng, S., Yang, Y., Chen, S., & Wu, Z. (2024) · Particle and Fibre Toxicology · doi:10.1186/s12989-024-00595-5 · Cited by 70 · see citing works
Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats
Napso, T., Hung, Y.-P., Davidge, S. T., Care, A. S., & Sferruzzi-Perri, A. N. (2019) · Scientific Reports · doi:10.1038/s41598-019-53199-x · Cited by 62 · see citing works
Self-citation
Cross-fostering: Elucidating the effects of gene×environment interactions on phenotypic development
McCarty, R. C. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.025 · Cited by 61 · see citing works
Placental mitochondrial function in response to gestational exposures
Lu, M., & Sferruzzi-Perri, A. N. (2020) · Placenta · doi:10.1016/j.placenta.2020.11.012 · Cited by 58 · see citing works
Self-citation
Maternal obesity and placental function: impaired maternal–fetal axis
Louwen, F., Kreis, N., Ritter, A., & Yuan, J. (2024) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-024-07462-w · Cited by 58 · see citing works
Involvement of leptin in the molecular physiology of the placenta
Schanton, M., Maymó, J. L., Pérez‐Pérez, A., Sánchez‐Margalet, V., & Varone, C. L. (2017) · Reproduction · doi:10.1530/rep-17-0512 · Cited by 58 · see citing works
Exploring the causes and consequences of maternal metabolic maladaptations during pregnancy: Lessons from animal models
Sferruzzi-Perri, A. N., Lopez-Tello, J., Napso, T., & Yong, H. E. J. (2020) · Placenta · doi:10.1016/j.placenta.2020.01.015 · Cited by 58 · see citing works
Self-citation
Developmental programming of offspring adipose tissue biology and obesity risk
Rodgers, A., & Sferruzzi-Perri, A. N. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00790-w · Cited by 57 · see citing works
Self-citation
Maternal obesity: new placental paradigms unfolded
Brombach, C., Tong, W., & Giussani, D. A. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.05.013 · Cited by 56 · see citing works
Amino Acids in Reproductive Nutrition and Health
Gao, H. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-45328-2_7 · Cited by 55 · see citing works
Models of Intrauterine growth restriction and fetal programming in rabbits
López‐Tello, J., Arias‐Álvarez, M., Gonzalez‐Bulnes, A., & Sferruzzi-Perri, A. N. (2019) · Molecular Reproduction and Development · doi:10.1002/mrd.23271 · Cited by 54 · see citing works
Self-citation
Review shows that maternal obesity induces serious adverse neonatal effects and is associated with childhood obesity in their offspring
Mitanchez, D., & Chavatte‐Palmer, P. (2018) · Acta Paediatrica · doi:10.1111/apa.14269 · Cited by 53 · see citing works
Maternal PUFAs, Placental Epigenetics, and Their Relevance to Fetal Growth and Brain Development
Basak, S., & Duttaroy, A. K. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00989-w · Cited by 52 · see citing works
Fetal undernutrition, placental insufficiency, and pancreatic β-cell development programming in utero
Mohan, R., Baumann, D. C., & Alejandro, E. U. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00072.2018 · Cited by 48 · see citing works
Rodent models in placental research. Implications for fetal origins of adult disease
Aguilera-Martínez, N., Salas‐Pérez, F., Ortíz, M., Álvarez, D., Echiburú, B., & Maliqueo, M. A. (2022) · Animal Reproduction · doi:10.1590/1984-3143-ar2021-0134 · Cited by 46 · see citing works
Placental miR-340 mediates vulnerability to activity based anorexia in mice
Schroeder, M., Jakovcevski, M., Polacheck, T., Drori, Y., Luoni, A., Röh, S., Zaugg, J., Ben‐Dor, S., Albrecht, C., & Chen, A. (2018) · Nature Communications · doi:10.1038/s41467-018-03836-2 · Cited by 44 · see citing works
Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice
López‐Tello, J., Pérez-García, V., Khaira, J., Kusinski, L. C., Cooper, W. N., Andreani, A., Grant, I. D., de Liger, E. F., Lam, B., Hemberger, M., et al. (2019) · eLife · doi:10.7554/elife.45282 · Cited by 45 · see citing works
Self-citation
Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction
Eaton, M., Davies, A., Devine, J., Zhao, X., Simmons, D. G., Maríusdóttir, E., Natale, D. R. C., Matyas, J. R., Bering, E. A., Workentine, M. L., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0226735 · Cited by 44 · see citing works
Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress
Christoforou, E. R., & Sferruzzi-Perri, A. N. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03566-z · Cited by 44 · see citing works
Self-citation
DNA Methylation Divergence and Tissue Specialization in the Developing Mouse Placenta
Decato, B. E., López‐Tello, J., Sferruzzi-Perri, A. N., Smith, A. D., & Dean, M. D. (2017) · Molecular Biology and Evolution · doi:10.1093/molbev/msx112 · Cited by 43 · see citing works
Self-citation
Vitamin D deficiency and impaired placental function: potential regulation by glucocorticoids?
Yates, N. J., Crew, R. C., & Wyrwoll, C. S. (2017) · Reproduction · doi:10.1530/rep-16-0647 · Cited by 42 · see citing works
Placenta plays a critical role in maternal–fetal resource allocation
Jansson, T. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613437113 · Cited by 40 · see citing works
Zinc is a critical regulator of placental morphogenesis and maternal hemodynamics during pregnancy in mice
Wilson, R. L., Leemaqz, S., Goh, Z., McAninch, D., Jankovic‐Karasoulos, T., Leghi, G. E., Phillips, J. A., Colafella, K. M. M., Tran, C. D., O’Leary, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15085-2 · Cited by 39 · see citing works
Corticotropin-Releasing Hormone As the Homeostatic Rheostat of Feto-Maternal Symbiosis and Developmental Programming In Utero and Neonatal Life
Alcántara‐Alonso, V., Panetta, P., de Gortari, P., & Grammatopoulos, D. K. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00161 · Cited by 35 · see citing works
Igf2 deletion alters mouse placenta endocrine capacity in a sexually dimorphic manner
Aykroyd, B. R. L., Tunster, S. J., & Sferruzzi-Perri, A. N. (2020) · Journal of Endocrinology · doi:10.1530/joe-20-0128 · Cited by 34 · see citing works
Self-citation
Reactive oxygen species mediated placental oxidative stress, mitochondrial content, and cell cycle progression through mitogen-activated protein kinases in intrauterine growth restricted pigs
Luo, Z., Luo, W., Li, S., Zhao, S., Sho, T., Xu, X., Zhang, J., Xu, W., & Xu, J. (2018) · Reproductive Biology · doi:10.1016/j.repbio.2018.09.002 · Cited by 33 · see citing works
Effects of Maternal Obesity On Placental Phenotype
Fowden, A. L., Camm, E. J., & Sferruzzi-Perri, A. N. (2020) · Current Vascular Pharmacology · doi:10.2174/1570161118666200513115316 · Cited by 35 · see citing works
Self-citation
Placental hypoxia: What have we learnt from small animal models?
Siragher, E. J., & Sferruzzi-Perri, A. N. (2021) · Placenta · doi:10.1016/j.placenta.2021.03.018 · Cited by 34 · see citing works
Self-citation
Epigenetic Genome Modifications during Pregnancy: The Impact of Essential Nutritional Supplements on DNA Methylation
Socha, M. W., Flis, W., & Wartęga, M. (2024) · Nutrients · doi:10.3390/nu16050678 · Cited by 32 · see citing works
Sexual dimorphism of mitochondrial function in the hypoxic guinea pig placenta†
Song, H., Telugu, B. P. V. L., & Thompson, L. P. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy167 · Cited by 32 · see citing works
The placental exposome, placental epigenetic adaptations and lifelong cardio-metabolic health
Cleal, J. K., Poore, K. R., & Lewis, R. M. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101095 · Cited by 33 · see citing works
nAChRs‐ERK1/2‐Egr‐1 signaling participates in the developmental toxicity of nicotine by epigenetically down‐regulating placental 11&bgr;‐HSD2
Zhou, J., Liu, F.-L., Yu, L., Xu, D., Li, B., Zhang, G.-H., Huang, W., Li, L., Zhang, Y.-Z., Zhang, W., et al. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.02.017 · Cited by 27 · see citing works
Double-label immunohistochemistry to assess labyrinth structure of the mouse placenta with stereology
Clercq, K. D., López‐Tello, J., Vriens, J., & Sferruzzi-Perri, A. N. (2020) · Placenta · doi:10.1016/j.placenta.2020.03.014 · Cited by 29 · see citing works
Self-citation
Maternal high-fat diet sex-specifically alters placental morphology and transcriptome in rats: Assessment by next-generation sequencing
Lin, Y., Huang, L., Tsai, C., Sheen, J., Tiao, M., Yu, H., Lin, I.-C., & Tain, Y. (2019) · Placenta · doi:10.1016/j.placenta.2019.03.004 · Cited by 28 · see citing works
An interaction between fetal sex and placental weight and efficiency predicts intrauterine growth in response to maternal protein insufficiency and gestational exposure window in a mouse model of FASD
Kwan, S. T., Presswood, B. H., Helfrich, K. K., Baulch, J. W., Mooney, S. M., & Smith, S. M. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00320-9 · Cited by 28 · see citing works
Epigenetic regulation of placental glucose transporters mediates maternal cadmium-induced fetal growth restriction
Xu, P., Wu, Z., Xi, Y., & Wang, L. (2016) · Toxicology · doi:10.1016/j.tox.2016.10.011 · Cited by 28 · see citing works
Competition for Materno-Fetal Resource Partitioning in a Rabbit Model of Undernourished Pregnancy
López‐Tello, J., Arias‐Álvarez, M., Martínez, M. D. L. Á. J., García-García, R. M., Rodríguez, M., Lorenzo, P. L., Bermejo‐Poza, R., Gonzalez‐Bulnes, A., & Rebollar, P. G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169194 · Cited by 28 · see citing works
Long-term monitoring of blood biomarkers related to intrauterine growth restriction using AgNPs SERS tags-based lateral flow assay
Song, Y., Sun, J., Li, C., Lin, L., Gao, F., Yang, M., Sun, B., & Wang, Y. (2021) · Talanta · doi:10.1016/j.talanta.2021.123128 · Cited by 27 · see citing works
Social Determinants of Placental Health and Future Disease Risks for Babies
Thornburg, K. L., Boone-Heinonen, J., & Valent, A. M. (2020) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2019.11.002 · Cited by 25 · see citing works
First trimester mechanisms of gestational sac placental and foetal teratogenicity: a framework for birth cohort studies
Adibi, J. J., Layden, A. J., Birru, R. L., Miragaia, A. S., Xun, X., Smith, M. C., Yin, Q., Millenson, M. E., O’Connor, T. G., Barrett, E. S., et al. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa063 · Cited by 26 · see citing works
Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age
López‐Tello, J., & Sferruzzi-Perri, A. N. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1116770 · Cited by 25 · see citing works
Self-citation
Regulating needs: Exploring the role of insulin-like growth factor-2 signalling in materno-fetal resource allocation
Sferruzzi-Perri, A. N. (2018) · Placenta · doi:10.1016/j.placenta.2018.01.005 · Cited by 24 · see citing works
Self-citation
Dysregulation of DNA methylation and expression of imprinted genes in mouse placentas of fetal growth restriction induced by maternal cadmium exposure
Xu, P., Wu, Z., Yang, W., & Wang, L. (2017) · Toxicology · doi:10.1016/j.tox.2017.08.003 · Cited by 24 · see citing works
Ozone-induced fetal growth restriction in rats is associated with sexually dimorphic placental and fetal metabolic adaptation
Miller, C. N., Dye, J. A., Henriquez, A. R., Stewart, E. J., Lavrich, K. S., Carswell, G. K., Ren, H., Freeborn, D. L., Snow, S. J., Schladweiler, M. C. J., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101094 · Cited by 24 · see citing works
Inflammatory Mechanism of Brucella Infection in Placental Trophoblast Cells
Xiao, Y., Li, M., Guo, X., Zeng, H., Shuai, X., Guo, J., Huang, Q., Chu, Y., Zhou, B., Wen, J. J., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113417 · Cited by 23 · see citing works
Loss of imprinting of the Igf2-H19 ICR1 enhances placental endocrine capacity via sex-specific alterations in signalling pathways in the mouse
Aykroyd, B. R. L., Tunster, S. J., & Sferruzzi-Perri, A. N. (2022) · Development · doi:10.1242/dev.199811 · Cited by 22 · see citing works
Self-citation
Mapping the expression of transient receptor potential channels across murine placental development
Clercq, K. D., Pérez-García, V., Bree, R. V., Pollastro, F., Peeraer, K., Voets, T., & Vriens, J. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03837-3 · Cited by 22 · see citing works
Placental mitochondrial DNA mutational load and perinatal outcomes: Findings from a multi-ethnic pregnancy cohort
Cowell, W., Brunst, K. J., Colicino, E., Zhang, L., Zhang, X., Bloomquist, T. R., Baccarelli, A., & Wright, R. J. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.06.006 · Cited by 21 · see citing works
Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure
Iqbal, K., Pierce, S. H., Kozai, K., Dhakal, P., Scott, R. L., Roby, K. F., Vyhlidal, C. A., & Soares, M. J. (2021) · Environmental Health Perspectives · doi:10.1289/ehp9256 · Cited by 20 · see citing works
Role of the Macrophage Migration Inhibitory Factor (MIF) in the survival of first trimester human placenta under induced stress conditions
Ietta, F., Ferro, E. A. V., Bevilacqua, E. M. A. F., Benincasa, L., Maioli, E., & Paulesu, L. R. (2018) · Scientific Reports · doi:10.1038/s41598-018-29797-6 · Cited by 20 · see citing works
Hypertension Programmed in Adult Hens by Isolated Effects of Developmental Hypoxia In Ovo
Skeffington, K. L., Beck, C., Itani, N., Niu, Y., Shaw, C. J., & Giussani, D. A. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.15045 · Cited by 18 · see citing works
Combination of vitamin B12 active forms improved fetal growth in Wistar rats through up-regulation of placental miR-16 and miR-21 levels
Shah, T., Mishra, S. K., More, A., Otiv, S., Apte, K. G., & Joshi, K. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.10.017 · Cited by 19 · see citing works
Pregnancy and Cancer: Cellular Biology and Mechanisms Affecting the Placenta
Oliveira, M. D. M. S., Salgado, C. D. M., Viana, L. R., & Gomes‐Marcondes, M. C. C. (2021) · Cancers · doi:10.3390/cancers13071667 · Cited by 18 · see citing works
Maternal Diet Quality Is Associated with Placental Proteins in the Placental Insulin/Growth Factor, Environmental Stress, Inflammation, and mTOR Signaling Pathways: The Healthy Start ECHO Cohort
Francis, E. C., Dabelea, D., Boyle, K. E., Jansson, T., & Perng, W. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab403 · Cited by 18 · see citing works
Progressive uterine artery occlusion in the Guinea pig leads to defects in placental structure that relate to fetal growth
López‐Tello, J., Martínez, M. D. L. Á. J., Herrera, E. A., Krause, B. J., & Sferruzzi-Perri, A. N. (2018) · Placenta · doi:10.1016/j.placenta.2018.10.003 · Cited by 17 · see citing works
Self-citation
Mitigating hunger in pregnant sows
D’Eath, R. B., Jarvis, S., Baxter, E., & Houdijk, J. G. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-101012-9.00007-1 · Cited by 17 · see citing works
Pomegranate Juice Supplementation Alters Utero-Placental Vascular Function and Fetal Growth in the eNOS−/− Mouse Model of Fetal Growth Restriction
Finn-Sell, S. L., Cottrell, E. C., Greenwood, S. L., Dilworth, M. R., Cowley, E. J., Sibley, C. P., & Wareing, M. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01145 · Cited by 17 · see citing works
Vitamin D levels, brain volume, and genetic architecture in patients with psychosis
Berg, A. O., Jørgensen, K. N., Nerhus, M., Athanasiu, L., Popejoy, A. B., Bettella, F., Norbom, L. B., Gurholt, T. P., Dahl, S. R., Andreassen, O. A., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200250 · Cited by 17 · see citing works
Paternal programming of fetoplacental and offspring metabolic disorders
Capobianco, E., & Pirrone, I. (2023) · Placenta · doi:10.1016/j.placenta.2023.06.009 · Cited by 23 · see citing works
Boosting background suppression in the NEXT experiment through Richardson-Lucy deconvolution
Simón, A., Ifergan, Y., Redwine, A. B., Weiss-Babai, R., Arazi, L., Adams, C., Almazán, H., Álvarez, V., Aparicio, B., Aranburu, A. I., et al. (2021) · Journal of High Energy Physics · doi:10.1007/jhep07(2021)146 · Cited by 16 · see citing works
Associations between the maternal healthy lifestyle score and its individual components during early pregnancy with placental outcomes
Teo, S. M., Murrin, C. M., Mehegan, J., Douglass, A., Hébert, J. R., Segurado, R., Kelleher, C. C., & Phillips, C. M. (2023) · Placenta · doi:10.1016/j.placenta.2023.06.001 · Cited by 15 · see citing works
Human Placenta and Evolving Insights into Pathological Changes of Preeclampsia: A Comprehensive Review of the Last Decade
Chiorean, D. M., Aytekin, E. Ç., Mitranovici, M.-I., Turdean, S. G., MOHARER, P. S., Cotoi, O. S., & Toru, H. S. (2023) · Fetal and Pediatric Pathology · doi:10.1080/15513815.2023.2274823 · Cited by 15 · see citing works
Obesogenic Diet in Mice Leads to Inflammation and Oxidative Stress in the Mother in Association with Sex-Specific Changes in Fetal Development, Inflammatory Markers and Placental Transcriptome
Candia, A. A., Lean, S. C., Zhang, C. X. W., McKeating, D. R., Cochrane, A. L. K., Gulacsi, E., Herrera, E. A., Krause, B. J., & Sferruzzi-Perri, A. N. (2024) · Antioxidants · doi:10.3390/antiox13040411 · Cited by 17 · see citing works
Self-citation
Placental Adaptation to Hypoxia: The Case of High-Altitude Pregnancies
Ahrens, S., & Singer, D. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22020214 · Cited by 18 · see citing works
Maternal hypothyroidism in rats impairs placental nutrient transporter expression, increases labyrinth zone size, and impairs fetal growth
Kent, N. L., Atluri, S. C., Moritz, K. M., & Cuffe, J. S. M. (2023) · Placenta · doi:10.1016/j.placenta.2023.06.010 · Cited by 15 · see citing works
The role of placental aging in adverse pregnancy outcomes: A mitochondrial perspective
Pan, M., Zhou, J., Wang, J., Cao, W., Li, L., & Wang, L. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121924 · Cited by 14 · see citing works
Peritonitis, dialysate infusion and lung function in continuous ambulatory peritoneal dialysis (CAPD).
da Silva, A. M. T., Davis, W. B., Winchester, J. F., Coleman, D., & Weir, C. W. (1985) · PubMed · Cited by 15 · see citing works
Evidence for hypoxia‐induced dysregulated cholesterol homeostasis in preeclampsia: Insights into the mechanisms from human placental cells and tissues
Fuenzalida, B., Yañez, M. J., Mueller, M., Mistry, H. D., Leiva, A., & Albrecht, C. (2024) · The FASEB Journal · doi:10.1096/fj.202301708rr · Cited by 13 · see citing works
Effects of gestational intermittent hypoxia on the respiratory system: A tale of the placenta, fetus, and developing offspring
Valverde‐Pérez, E., Olea, E., Rocher, A., Aaronson, P. I., & Prieto‐Lloret, J. (2024) · Journal of Sleep Research · doi:10.1111/jsr.14435 · Cited by 13 · see citing works

Environmental regulation of placental phenotype: implications for fetal growth
Vaughan, O. R., Sferruzzi-Perri, A. N., Coan, P. M., & Fowden, A. L. (2011) · Reproduction Fertility and Development · doi:10.1071/rd11909 · Cited by 55 · see citing works
Self-citation
The Placenta and Intrauterine Programming
Fowden, A. L., Forhead, A. J., Coan, P. M., & Burton, G. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01663.x · Cited by 267 · see citing works
Placental adaptations to the maternal–fetal environment: implications for fetal growth and developmental programming
Sandovici, I., Hoelle, K., Angiolini, E., & Constância, M. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.03.017 · Cited by 224 · see citing works
Placental efficiency and adaptation: endocrine regulation
Fowden, A. L., Sferruzzi-Perri, A. N., Coan, P. M., Constância, M., & Burton, G. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173013 · Cited by 359 · see citing works
Self-citation
Placental adaptations supporting fetal growth during normal and adverse gestational environments
Sferruzzi-Perri, A. N., López‐Tello, J., & Salazar‐Petres, E. (2022) · Experimental Physiology · doi:10.1113/ep090442 · Cited by 104 · see citing works
Self-citation

Authors: Sferruzzi-Perri, A. N., & Camm, E. J.
Affiliations: University of Cambridge (GB)
Corresponding author: Sferruzzi-Perri, Amanda N.
ORCID: Sferruzzi-Perri, Amanda N.
Camm, Emily J.
Venue: Frontiers in Physiology
Publisher: Frontiers Media SA
Published: 2016-03-14
Volume: 7
Pages: 33-33
ISSN: 1664-042X (ISSN-L)
DOI: 10.3389/fphys.2016.00033
PMC: PMC4789467
OpenAlex: W2308489670
Cited by: 223
References: 262
Citations by year: 2026: 19 · 2025: 18 · 2024: 16 · 2023: 26 · 2022: 22 · 2021: 22 · 2020: 29 · 2019: 20 · 2018: 22 · 2017: 21 · 2016: 5
FWCI: 3.51
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Physiology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Apollo (University of Cambridge) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords: placenta, fetal growth, developmental programming, fetal programming, placental adaptation, maternal nutrition, hypoxia, metabolic substrates, developmental origins of health and disease, birth weight, placental morphology

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Programming Power of the Placenta

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks