The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Placental phenotype and the insulin‐like growth factors: resource allocation to fetal growth
Open accessAbstract
The placenta is the main determinant of fetal growth and development in utero. It supplies all the nutrients and oxygen required for fetal growth and secretes hormones that facilitate maternal allocation of nutrients to the fetus. Furthermore, the placenta responds to nutritional and metabolic signals in the mother by altering its structural and functional phenotype, which can lead to changes in maternal resource allocation to the fetus. The molecular mechanisms by which the placenta senses and responds to environmental cues are poorly understood. This review discusses the role of the insulin‐like growth factors (IGFs) in controlling placental resource allocation to fetal growth, particularly in response to adverse gestational environments. In particular, it assesses the impact of the IGFs and their signalling machinery on placental morphogenesis, substrate transport and hormone secretion, primarily in the laboratory species, although it draws on data from human and other species where relevant. It also considers the role of the IGFs as environmental signals in linking resource availability to fetal growth through changes in the morphological and functional phenotype of the placenta. As altered fetal growth is associated with increased perinatal morbidity and mortality and a greater risk of developing adult‐onset diseases in later life, understanding the role of IGFs during pregnancy in regulating placental resource allocation to fetal growth is important for identifying the mechanisms underlying the developmental programming of offspring phenotype by suboptimal intrauterine growth. image
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Cites
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
Mcmillen, I. C., & Robinson, J. S. (2005) · Physiological Reviews · doi:10.1152/physrev.00053.2003 · Cited by 1,910
Placental-specific IGF-II is a major modulator of placental and fetal growth
Constância, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., et al. (2002) · Nature · doi:10.1038/nature00819 · Cited by 1,054
Self-citationThe many faces of insulin-like peptide signalling in the brain
Fernandez, A. M., & Torres-Alemán, I. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3209 · Cited by 872
Yung, H.-W., Calabrese, S., Hynx, D., Hemmings, B. A., Cetin, I., Charnock-Jones, D. S., & Burton, G. J. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.071193 · Cited by 388
Protein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth
Yang, Z.-Z., Tschopp, O., Hemmings-Mieszczak, M., Feng, J., Brodbeck, D., Perentes, E., & Hemmings, B. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302847200 · Cited by 384
Constância, M., Angiolini, E., Sandovici, I., Smith, P., Smith, R., Kelsey, G., Dean, W., Ferguson-Smith, A., Sibley, C. P., Reik, W., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504468103 · Cited by 323 · cited 3×
“In the complete Igf2 null, placental and fetal growth restriction occurs concurrently and becomes evident in mid-gestation (Table 2; Baker et al. 1993; Constancia et al. 2005).”
BackgroundSelf-citationJansson, N., Rosario, F. J., Gaccioli, F., Lager, S., Jones, H. N., Roos, S., Jansson, T., & Powell, T. L. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2667 · Cited by 305
Gallou-Kabani, C., Gabory, A., Tost, J., Karimi, M., Mayeur, S., Lesage, J., Boudadi, E., Gross, M.-S., Taurelle, J., Vigé, A., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014398 · Cited by 229
Comparative Placentation: Structures, Functions and Evolution
Wooding, P., & Burton, G. (2008) · doi:10.1007/978-3-540-78797-6 · Cited by 228
The Programming Power of the Placenta
Sferruzzi-Perri, A. N., & Camm, E. J. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00033 · Cited by 223
Self-citationGabory, A., Ferry, L., Fajardy, I., Jouneau, L., Gothié, J.-D., Vigé, A., Fleur, C., Mayeur, S., Gallou-Kabani, C., Gross, M.-S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047986 · Cited by 204
Coan, P. M., Vaughan, O. R., Sekita, Y., Finn, S. L., Burton, G. J., Constancia, M., & Fowden, A. L. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.181214 · Cited by 199
Self-citationCoan, P. M., Angiolini, E., Sandovici, I., Burton, G. J., Constância, M., & Fowden, A. L. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.156133 · Cited by 194 · cited 3×
“Moreover, the naturally small placenta that supports more fetal mass per gram shows increased expression of Igf2P0 coupled with a preservation of Lz growth and with increased placental System A transport capacity and SNAT2/Snat2/Slc38a2 abundance compared to the large placenta in the litter (Coan et al. 2008).”
BackgroundSelf-citationSferruzzi‐Perri, A. N., Vaughan, O. R., Haro, M., Cooper, W. N., Musial, B., Charalambous, M., Pestana, D., Ayyar, S., Ferguson‐Smith, A. C., Burton, G. J., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-234823 · Cited by 134
Self-citationDevelopment and Mechanisms of Fetal Hypoxia in Severe Fetal Growth Restriction
Regnault, T. R. H., de Vrijer, B., Galan, H. L., Wilkening, R. B., Battaglia, F. C., & Meschia, G. (2007) · Placenta · doi:10.1016/j.placenta.2006.06.007 · Cited by 131
Rosario, F. J., Kanai, Y., Powell, T. L., & Jansson, T. (2015) · Obesity · doi:10.1002/oby.21165 · Cited by 128
Cuffe, J. S. M., Walton, S. L., Singh, R. R., Spiers, J. G., Bielefeldt‐Ohmann, H., Wilkinson, L., Little, M. H., & Moritz, K. M. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.272856 · Cited by 128
Eckert, J. J., Porter, R., Watkins, A. J., Burt, E., Brooks, S., Leese, H. J., Humpherson, P. G., Cameron, I. T., & Fleming, T. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052791 · Cited by 119
Placental-Specific Igf2 Deficiency Alters Developmental Adaptations to Undernutrition in Mice
Sferruzzi-Perri, A. N., Vaughan, O. R., Coan, P. M., Suciu, M. C., Darbyshire, R., Constancia, M., Burton, G. J., & Fowden, A. L. (2011) · Endocrinology · doi:10.1210/en.2011-0240 · Cited by 115
Self-citationEffects of chronic hypoxia in vivo on the expression of human placental glucose transporters
Zamudio, S., Baumann, M. U., & Illsley, N. P. (2006) · Placenta · doi:10.1016/j.placenta.2004.12.010 · Cited by 114 · cited 1×
“Placental expression of the PI3K–AKT and mTORC1 signalling pathways and GLUT1/Glut1/Slc2a1 expression are decreased in women at 3100 m above sea level who deliver growth-restricted babies (Zamudio et al. 2006; Yung et al. 2012a).”
BackgroundYung, H. W., Cox, M., van Patot, M. T., & Burton, G. J. (2012) · The FASEB Journal · doi:10.1096/fj.11-190082 · Cited by 112
Das, U. G., Sadiq, H. F., Soares, M. J., Hay, W. W., & Devaskar, S. U. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.2.r339 · Cited by 96
Cuffe, J. S. M., Dickinson, H., Simmons, D. G., & Moritz, K. M. (2011) · Placenta · doi:10.1016/j.placenta.2011.09.009 · Cited by 86
Mina, T. H., Räikkönen, K., Riley, S. C., Norman, J. E., & Reynolds, R. M. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.05.004 · Cited by 76
Maternal corticosterone regulates nutrient allocation to fetal growth in mice
Vaughan, O. R., Sferruzzi‐Perri, A. N., & Fowden, A. L. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.239426 · Cited by 75
Self-citationMatheson, H., Veerbeek, J. H. W., Charnock‐Jones, D. S., Burton, G. J., & Yung, H. W. (2016) · The Journal of Physiology · doi:10.1113/jp271073 · Cited by 71
Ma, Y., Zhu, M. J., Zhang, L., Hein, S. M., Nathanielsz, P. W., & Ford, S. P. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00498.2009 · Cited by 70
Hypoxia, AMPK activation and uterine artery vasoreactivity
Skeffington, K. L., Higgins, J. S., Mahmoud, A. D., Evans, A. M., Sferruzzi‐Perri, A. N., Fowden, A. L., Yung, H. W., Burton, G. J., Giussani, D. A., & Moore, L. G. (2016) · The Journal of Physiology · doi:10.1113/jp270995 · Cited by 69
Self-citationJones, H. N., Crombleholme, T., & Habli, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074632 · Cited by 64 · cited 2×
“However, these changes in nutrient uptake do not always track with the expression of the transporter genes or proteins, suggesting that the IGFs may also affect post-transcriptional/translational mechanisms (Fang et al. 2006; Jones et al. 2013, 2014).”
BackgroundAngiolini, E., Coan, P. M., Sandovici, I., Iwajomo, O. H., Peck, G., Burton, G. J., Sibley, C. P., Reik, W., Fowden, A. L., & Constância, M. (2011) · The FASEB Journal · doi:10.1096/fj.10-175273 · Cited by 64
Self-citationMa, Y., Zhu, M. J., Uthlaut, A. B., Nijland, M. J., Nathanielsz, P. W., Hess, B. W., & Ford, S. P. (2011) · Placenta · doi:10.1016/j.placenta.2011.01.007 · Cited by 58 · cited 2×
“In the undernourished sheep placenta with increased PI3K–AKT and MAPK signalling, the expression of glucose and fatty acid transporters is also increased (Ma et al. 2011).”
BackgroundZhu, M. J., Du, M., Nijland, M. J., Nathanielsz, P. W., Hess, B. W., Moss, G. E., & Ford, S. P. (2009) · Placenta · doi:10.1016/j.placenta.2009.02.001 · Cited by 54
Brett, K. E., Ferraro, Z. M., Holcik, M., & Adamo, K. B. (2015) · Placenta · doi:10.1016/j.placenta.2014.11.015 · Cited by 50
Diet-induced obesity in mice reduces placental efficiency and inhibits placental mTOR signaling
Lager, S., Samulesson, A.-M., Taylor, P. D., Poston, L., Powell, T. L., & Jansson, T. (2014) · Physiological Reports · doi:10.1002/phy2.242 · Cited by 44
Petry, C. J., Evans, M. L., Wingate, D. L., Ong, K. K., Reik, W., Constância, M., & Dunger, D. B. (2010) · Diabetes · doi:10.2337/db09-0757 · Cited by 44
Self-citationZhu, M. J., Du, M., Hess, B. W., Nathanielsz, P. W., & Ford, S. P. (2007) · Placenta · doi:10.1016/j.placenta.2007.05.004 · Cited by 41
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The socioeconomic landscape of the exposome during pregnancy
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Metadata
- Authors
- Sferruzzi‐Perri, A. N., Sandovici, I., Constancia, M., & Fowden, A. L.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2017-05-23
- Volume
- 595
- Issue
- 15
- Pages
- 5057-5093
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2602685374
- Cited by
- 186
- References
- 36
- FWCI
- 12.84
- Type
- journal article
- Language
- en
- Open access
- green
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