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Cited by 65Nerve injury and regenerationNeuroscience and Neural EngineeringSpinal Cord Injury Research

Long‐term effects of axotomy on neural activity during cat locomotion.

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Gordon, T, Hoffer, J A, Jhamandas, J, Stein, R B·1980·The Journal of Physiology
DOI 10.1113/jphysiol.1980.sp013283PMC PMC1282889
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Abstract

1. Neural activity was recorded from cats during locomotion on a treadmill using electrodes in Silastic cuffs placed around the sciatic nerve and the lateral gastrocnemius‐soleus, medial gastrocnemius, common peroneal and tibial nerve branches. Each branch gave characteristic patterns of activity which were studied before and after it was cut distal to the recording cuffs. Sensory and motor components were separated and measured using cross‐correlation techniques. The amplitude of the cross‐correlation peaks was compared with the amplitude of compound action potentials evoked by electrical stimulation and recorded from the same sites in the anaesthetized animal. 2. Sensory activity declined rapidly following axotomy and did not recover unless reinnervation occurred. Sensory activity even 5 months after nerve section and resuture had recovered to only a fraction of the control values. This reduction is attributed to a decline in the evoked compound potentials and to many fibres being unsuccessful in regenerating to appropriate sensory organs. 3. Motor activity declined more than could be accounted for by a decline in evoked potentials over the first month after axotomy. The extra reduction represents a decline in the number of impulses generated by alpha‐motoneurones after axotomy. If regeneration was permitted, motor activity recovered to higher levels than did the evoked potentials for the whole nerve. Even if regeneration was prevented by nerve ligation, motoneurones continued to generate activity at a stable level over a period of months during which whole nerve compound potentials continued to decline. 4. The modulation of motor activity in ligated nerves during the step cycle was still appropriate to the required movement. Thus, activity recorded from severed nerves in human amputees may be useful in controlling powered artificial limbs. The persistence of motor activity may be responsible for the lesser degree of atrophy found in motor fibres than in sensory fibres following ligation (Hoffer, Stein & Gordon, 1979b).

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Crossref · 10.1113/jphysiol.1980.sp013283

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  1. Severin F. V., Orlovskii G. N., Shik M. L. Rabota myshechnykh retseptorov pri upravliaemoi lokomotsii. Biofizika. 1967 May-Jun;12(3):502–511. [PubMed] [Google Scholar]

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Authors
Gordon, T., Hoffer, J. A., Jhamandas, J., & Stein, R. B.
ORCID
Venue
The Journal of Physiology
Publisher
Wiley
Published
1980-06
Volume
303
Issue
1
Pages
243-263
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.1980.sp013283
PMC
PMC1282889
OpenAlex
W2065584726
Cited by
65
References
43
Citations by year
2024: 5 · 2022: 3 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 2 · 2013: 1 · 2012: 2
FWCI
0.95
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
Keywords
axotomy, nerve regeneration, sciatic nerve, locomotion, sensory nerve activity, alpha motoneurons, compound action potential, nerve ligation, reinnervation, treadmill locomotion, cats
MeSH terms
Action Potentials, Animals, Axons, Cats, Hindlimb, Locomotion, Motor Activity, Motor Neurons, Muscles, Time Factors

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