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Cited by 285Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorNeural dynamics and brain function

Serotonin and noradrenaline excite GABAergic neurones of the guinea-pig and cat nucleus reticularis thalami

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McCormick, D A, Wang, Z·1991·The Journal of Physiology
DOI 10.1113/jphysiol.1991.sp018791PMC PMC1179887
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Abstract

1. The actions of serotonin (5‐HT) and noradrenaline (NA) in the cat perigeniculate nucleus (PGN) and the guinea‐pig nucleus reticularis thalami (NRT) were investigated with extracellular and intracellular recordings obtained from neurones in thalamic slices maintained in vitro. 2. Single, local application of either 5‐HT or NA resulted in pronounced (5‐50 Hz) and prolonged (2‐10 min) excitation associated with the occurrence of single‐spike activity. Serotoninergic excitation was specifically blocked by the 5‐HT2/5‐HT1C antagonists ketanserin and ritanserin, but not by the 5‐HT1A antagonist pindolol or the 5‐HT3 antagonist ICS 205‐930. Furthermore, the 5‐HT response was mimicked by alpha‐methyl‐5‐HT, but not by the 5‐HT1A agonist 8‐hydroxydipropylaminotetralin (8‐OHDPAT) or the 5‐HT3 agonist 2‐methyl‐5‐HT. Together, these results indicate that this excitatory response is mediated through 5‐HT2 receptors with the possible involvement of 5‐HT1C receptors. 3. Noradrenergic excitation was specifically blocked by the alpha 1‐antagonist prazosin, but not by the beta‐antagonist propranolol or the alpha 2‐antagonist yohimbine. Similarly, the response was mimicked by the alpha‐agonist phenylephrine, but not by the beta‐agonist isoprenaline. These results indicate that the noradrenergic excitation is mediated by alpha 1‐adrenoceptors. 4. Block of synaptic transmission either by lowering external calcium concentration ([Ca2+]o) to 0.5 mM and raising external magnesium concentration ([Mg2+]o) to 10 mM or by local application of tetrodotoxin failed to block the excitatory or depolarizing response to 5‐HT or NA indicating that these responses are direct and not mediated through the release of other neurotransmitters. 5. Intracellular recordings revealed that the 5‐HT‐ and NA‐induced excitations are mediated by a pronounced slow depolarization associated with an apparent decrease in input conductance and an increase in the membrane time constant. Current versus voltage plots obtained under voltage clamp before and during the presence of 5‐HT and NA revealed that these neurotransmitters induced an inward current which reversed to an outward current at ‐107 and ‐110 mV, respectively, in 2.5 mM external potassium concentration ([K+]o). This reversal potential was identical to that associated with an increase in potassium conductance activated by acetylcholine (‐110 mV) in the same neurones. Plots of the amplitude of the 5‐HT‐ or NA‐induced current versus membrane potential revealed a linear relationship in the voltage range from ‐140 to ‐60 mV.(ABSTRACT TRUNCATED AT 400 WORDS)

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Crossref · 10.1113/jphysiol.1991.sp018791

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  • The role of the thalamus in trauma-related and possibly dissociative processes is supported by the presence of receptors for neurotransmitters previously implicated in the induction of post-traumatic and dissociative symptoms in thalamic networks, including noradrenergic and glutamatergic receptors.

    “Krystal et al. (1998) suggest that the role of the thalamus in trauma-related and possibly dissociative processes is supported by the presence of receptors for neurotransmitters previously implicated in the induction of post-traumatic (e.g., flashbacks) and dissociative symptoms in thalamic networks, including the noradrenergic (Buzsáki et al., 1991;McCormick and Wang, 1991) and glutamatergic”

    From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as McCormick and Wang, 1991

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Authors
McCormick, D. A., & Wang, Z.
Affiliations
Yale University (US)
ORCID
McCormick, D A
Venue
The Journal of Physiology
Publisher
Wiley
Published
1991-10
Volume
442
Issue
1
Pages
235-255
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.1991.sp018791
PMC
PMC1179887
OpenAlex
W1987022586
Cited by
285
References
44
Citations by year
2026: 3 · 2025: 4 · 2024: 5 · 2023: 21 · 2022: 4 · 2021: 5 · 2020: 10 · 2019: 11 · 2018: 1 · 2017: 5 · 2016: 9 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 4
FWCI
4.19
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
serotonin, norepinephrine, GABAergic neurons, nucleus reticularis thalami, perigeniculate nucleus, thalamus, 5-HT2 receptor, 5-HT2C receptor, alpha1-adrenoceptors, neuronal excitation, slow depolarization, input conductance, membrane time constant, ketanserin, ritanserin, prazosin
MeSH terms
Action Potentials, Sodium-Potassium-Exchanging ATPase, Animals, Cats, Guinea Pigs, Neural Conduction, Neurons, Afferent, Norepinephrine, Serotonin, Stimulation, Chemical, Thalamic Nuclei

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