Serotonergic Agonists and Antagonists Affect Endurance Performance in the Rat
Abstract
The purpose of this experiment was to examine the effects of administration of serotonergic (5-HT) agonist and antagonist drugs on run-time to exhaustion (RUN-EXH) in male and female rats. RUN-EXH was reduced (p < 0.05) in a dose related manner by increasing dosages of quipazine dimaleate (QD: general 5-HT agonist) (0-5 mg.kg-1 i.p.) administered immediately prior to exercise (treadmill running at 20 m.min-1 and 5% grade). Conversely, RUN-EXH was increased (p < 0.05) by the greatest dosage of LY 53,857 (LY: 5-HT1C and 5-HT2 antagonist) (1.5 mg.kg-1 i.p.). Drug effects were similar in male and female rats. The negative effects of QD administration on RUN-EXH were not attenuated by administration of the peripherally restricted antagonist, xylamidine tosylate (up to 200 ug.kg-1 i.p.). The results of this investigation indicated that fatigue during prolonged exercise can be influenced by direct pharmacological administration of a serotonergic agonist and antagonist and that the mechanisms underlying these effects are likely to be central (brain) in nature.
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Fatigue can set in during exercise when dopamine levels start to drop while serotonin levels are still elevated.
“Fatigue can set in during exercise when dopamine levels start to drop while serotonin levels are still elevated [98].”
From Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes (2016) · cites this paper as [98]
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- Authors
- Bailey, S., Davis, J., & Ahlborn, E.
- Affiliations
- University of South Carolina (US)
- ORCID
- Davis, J.
- Venue
- International Journal of Sports Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 1993-08
- Volume
- 14
- Issue
- 06
- Pages
- 330-333
- ISSN
- 0172-4622 (ISSN-L)
- 1439-3964
- OpenAlex
- W2002111073
- Cited by
- 114
- References
- 0
- Citations by year
- 2026: 2 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 11 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 4
- FWCI
- 7.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- serotonergic agonists, serotonergic antagonists, endurance performance, xylazine, prolonged exercise, sex differences, central nervous system mechanisms
- MeSH terms
- Amidines, Animals, Dose-Response Relationship, Drug, Ergolines, Female, Injections, Intraperitoneal, Male, Physical Endurance, Placebos, Quipazine, Running, Serotonin Antagonists, Time Factors, Rats, Wistar, Rats
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