Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 271

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Effects of stretch‐activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse

Yeung, Ella W., Whitehead, Nicholas P., Suchyna, Thomas M., Gottlieb, Philip A., Sachs, Frederick, Allen, David G.·2005·The Journal of Physiology
DOI 10.1113/jphysiol.2004.075275
Open this paper in CoChat — free account

Abstract

The mdx mouse lacks dystrophin and is a model of human Duchenne muscular dystrophy. Single mdx muscle fibres were isolated and subjected to a series of stretched (eccentric) contractions while measuring intracellular calcium concentration ([Ca 2+]i) with fluo‐3 and confocal microscopy. Following the stretched contractions there was a slow rise in resting [Ca 2+]i and after 30 min both the [Ca 2+]i during a tetanus (tetanic [Ca 2+]i) and the tetanic force were reduced. Two blockers of stretch‐activated channels, streptomycin and the spider venom toxin GsMTx4, prevented the rise of resting [Ca 2+]i and partially prevented the decline of tetanic [Ca 2+]i and force. Reducing extracellular calcium to zero also prevented the rise in resting [Ca 2+]i and prevented some of the decline in tetanic [Ca 2+]i and force. Patch‐clamping experiments identified a stretch‐activated channel in both wild‐type and mdx myotubes which was blocked by GsMTx4. These data suggest that blockers of stretch‐activated channels can ameliorate the force reduction following stretched contractions by reducing the influx of Ca 2+ into the muscle. We therefore tested whether in intact mdx mice streptomycin, added to the drinking water, was capable of reducing muscle damage. mdx mice show a period of muscle damage from 20 to 40 days of life and fibres which regenerate from this damage display central nuclei. We measured the frequency of central nuclei in control mdx mice compared to streptomycin‐treated mdx mice and showed that the incidence of central nuclei was significantly reduced by streptomycin treatment. This result suggests that blockers of stretch‐activated channels may protect against muscle damage in the intact mdx mouse.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1113/jphysiol.2004.075275

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Cited by

See all 271

Metadata

Authors
Yeung, E. W., Whitehead, N. P., Suchyna, T. M., Gottlieb, P. A., Sachs, F., & Allen, D. G.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2005-01-07
Volume
562
Issue
2
Pages
367-380
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.2004.075275
OpenAlex
W1594958231
Cited by
271
References
55
FWCI
3.50
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.