The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Reversal of diet‐induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS‐1 serine phosphorylation
Open accessAbstract
Lifestyle interventions including exercise programmes are cornerstones in the prevention of obesity‐related diabetes. In this study, we demonstrate that a single bout of exercise inhibits high‐fat diet‐induced insulin resistance. Diet‐induced obesity (DIO) increased the expression and activity of the protein tyrosine phosphatase 1B (PTP1B) and attenuated insulin signalling in gastrocnemius muscle of rats, a phenomenon which was reversed by a single session of exercise. In addition, DIO was observed to lead to serine phosphorylation of insulin receptor substrate 1 (IRS‐1), which was also reversed by exercise in muscle in parallel with a reduction in c‐Jun N‐terminal kinase (JNK) activity. Thus, acute exercise increased the insulin sensitivity during high‐fat feeding in obese rats. Overall, these results provide new insights into the mechanism by which exercise restores insulin sensitivity.
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Citations
Cites
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
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Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
Virkamäki, A., Ueki, K., & Kahn, C. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6609 · Cited by 854 · cited 1×
“Once phosphorylated, Akt contributes to various biological processes including regulation of glucose uptake (Virkamaki et al. 1999).”
BackgroundUeki, K., Kondo, T., & Kahn, C. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5434-5446.2004 · Cited by 686
Muscle Glucose Metabolism following Exercise in the Rat
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“1987; Zierath, 1995) and rodents (Richter et al. 1982; Wallberg-Henriksson, 1987; Wallberg-Henriksson et al. 1988).”
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Enhanced Peripheral and Splanchnic Insulin Sensitivity in NIDDM Men After Single Bout of Exercise
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Cited by
Insulin resistance: review of the underlying molecular mechanisms
Yaribeygi, H., Farrokhi, F. R., Butler, A. E., & Sahebkar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.27603 · Cited by 929
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c110062 · Cited by 831
Schenk, S., & Horowitz, J. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30566 · Cited by 407
Ropelle, E. R., Flores, M. B., Cintra, D. E., Rocha, G. Z., Pauli, J. R., Morari, J., de Souza, C. T., Moraes, J. C., Prada, P. O., Guadagnini, D., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000465 · Cited by 326
Self-citationRetractedA 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity
Krogh-Madsen, R., Thyfault, J. P., Broholm, C., Mortensen, O. H., Olsen, R. H., Mounier, R., Plomgaard, P., van Hall, G., Booth, F. W., & Pedersen, B. K. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00977.2009 · Cited by 311
Metadata
- Authors
- Ropelle, E. R., Pauli, J. R., Prada, P. O., De Souza, C. T., Picardi, P. K., Faria, M. C., Cintra, D. E., Fernandes, M. F. D. A., Flores, M. B., Velloso, L. A., Saad, M. J. A., & Carvalheira, J. B. C.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2006-12-07
- Volume
- 577
- Issue
- 3
- Pages
- 997-1007
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2158020636
- Cited by
- 191
- References
- 11
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Ropelle, E. R., Pauli, J. R., Prada, P. O., De Souza, C. T., Picardi, P. K., Faria, M. C., Cintra, D. E., Fernandes, M. F. D. A., Flores, M. B., Velloso, L. A., Saad, M. J. A., & Carvalheira, J. B. C. (2006). Reversal of diet‐induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS‐1 serine phosphorylation. The Journal of Physiology. https://doi.org/10.1113/jphysiol.2006.120006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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