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Cited by 342Diabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and CancerDiabetes Management and Research

Enhanced Peripheral and Splanchnic Insulin Sensitivity in NIDDM Men After Single Bout of Exercise

Devlin, John T, Hirshman, Michael, Horton, Elizabeth D, Horton, Edward S·1987·Diabetes
DOI 10.2337/diab.36.4.434
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Abstract

We studied glucose metabolism in non-insulin-dependent diabetic (NIDDM) men with and without glycogen-depleting cycle exercise 12 h beforehand and have compared the results to our previous data in lean and obese subjects. Rates of total glucose utilization, glucose oxidation, nonoxidative glucose disposal (NOGD), glucose metabolic clearance rate (MCR), and endogenous glucose production (EGP) were determined with a "two-level" insulin-clamp technique (100-min infusions at 40 and 400 mU X m-2 X min-1) combined with indirect calorimetry and D-3-[3H]glucose infusion. Muscle biopsy specimens from vastus lateralis were analyzed for glycogen content and glycogen synthase activity before and after insulin infusions. After exercise, NIDDM subjects had muscle glycogen concentrations comparable with those of lean and obese subjects. The activation of glycogen synthase both by prior exercise and insulin infusion was similar to lean controls. After exercise, total glucose disposal was significantly increased during the 40-mU X m-2 X min-1 infusion (P less than .05), but the increase observed during the 400-mU X m-2 X min-1 infusion was not significant. These increases after exercise were the result of significantly higher NOGD during both levels of insulin infusion. The MCR of glucose during both insulin infusions was reduced in NIDDM compared with lean subjects but was very similar to that in obese nondiabetics. Basal EGP was significantly reduced on the morning after exercise (4.03 +/-…

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  • In the postabsorptive state, moderate-intensity exercise decreases plasma glucose concentrations and is followed by an increase in insulin sensitivity in NIDDM patients.

    “In the postabsorptive state exercise of moderate intensity has been shown to decrease plasma glucose concentrations and is followed by an increase in insulin sensitivity [1-5].”

    From The effect of moderate exercise on postprandial glucose homeostasis in NIDDM patients (1997) · cites this paper as [4]

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Authors
Devlin, J. T., Hirshman, M., Horton, E. D., & Horton, E. S.
Affiliations
University of Vermont (US)
ORCID
Venue
Diabetes
Publisher
American Diabetes Association
Published
1987-04-01
Volume
36
Issue
4
Pages
434-439
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diab.36.4.434
OpenAlex
W2041265416
Cited by
342
References
0
Citations by year
2026: 1 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 9 · 2021: 15 · 2020: 6 · 2019: 13 · 2018: 13 · 2017: 9 · 2016: 14 · 2015: 11 · 2014: 9 · 2013: 13 · 2012: 6
FWCI
3.00
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (2r01am026317-05)
  • U.S. Public Health Service (5-F32-07034-02, R23-29866-03)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
type 2 diabetes, insulin sensitivity, glucose metabolism, nonoxidative glucose disposal, endogenous glucose production, glucose oxidation, muscle glycogen, glycogen synthase, peripheral insulin sensitivity, fasting blood glucose, glucose storage, vastus lateralis, obesity, insulin resistance, glucose metabolic clearance rate
MeSH terms
Adult, Blood Glucose, C-Peptide, Diabetes Mellitus, Type 2, Physical Exertion, Glucose, Glycogen, Glycogen Synthase, Humans, Insulin, Insulin Resistance, Male, Muscles

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