Cited by 355NF-κB Signaling PathwaysCancer, Hypoxia, and MetabolismSignaling Pathways in Disease

Interdependent roles for hypoxia inducible factor and nuclear factor‐κB in hypoxic inflammation

Open access
Taylor, Cormac T.·2008·The Journal of Physiology

Abstract

Decreased oxygen availability (hypoxia) is a hallmark feature of the microenvironment in a number of chronic inflammatory conditions including arthritis and inflammatory bowel disease (IBD). Recent advances in our understanding of oxygen‐dependent cell signalling have uncovered several mechanisms by which hypoxia impacts upon the development of inflammation through the coordinated expression of adaptive, inflammatory and apoptotic genes. Two central transcription factors involved in the regulation of this response are hypoxia inducible factor (HIF) and nuclear factor‐κB (NF‐κB) which display different degrees of sensitivity to activation during hypoxia. Furthermore, HIF and NF‐κB demonstrate an intimate interdependence at several mechanistic levels. Recent studies indicate that these pathways may represent important new therapeutic targets in diseases characterized by hypoxic inflammation.

Integrity signals

Registry

Crossref · 10.1113/jphysiol.2008.157669

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • NF-κB has recently been reported to be regulated by HIF hydroxylases in a number of studies.

    “For example, NF-κB has recently been reported to be regulated by HIF hydroxylases in a number of studies37,44.”

    From Hypoxia: an alarm signal during intestinal inflammation (2010) · cites this paper as [44]

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Taylor, C. T.
Affiliations
University College Dublin (IE)
Corresponding author
Taylor, Cormac T.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2008-09
Volume
586
Issue
17
Pages
4055-4059
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
OpenAlex
W1515667338
Cited by
354
References
39
Citations by year
2026: 9 · 2025: 14 · 2024: 12 · 2023: 15 · 2022: 15 · 2021: 14 · 2020: 20 · 2019: 19 · 2018: 23 · 2017: 16 · 2016: 25 · 2015: 24 · 2014: 21 · 2013: 31 · 2012: 23
FWCI
1.75
Type
journal article
Language
en
Open access
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords
hypoxia, hypoxia-inducible factor, NF-κB, transcription factors, chronic inflammation, arthritis, inflammatory bowel disease, oxygen sensing, therapeutic target
MeSH terms
Animals, Hypoxia, Humans, Inflammation, NF-kappa B, Mice, Hypoxia-Inducible Factor 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review