Interdependent roles for hypoxia inducible factor and nuclear factor‐κB in hypoxic inflammation
Open accessAbstract
Decreased oxygen availability (hypoxia) is a hallmark feature of the microenvironment in a number of chronic inflammatory conditions including arthritis and inflammatory bowel disease (IBD). Recent advances in our understanding of oxygen‐dependent cell signalling have uncovered several mechanisms by which hypoxia impacts upon the development of inflammation through the coordinated expression of adaptive, inflammatory and apoptotic genes. Two central transcription factors involved in the regulation of this response are hypoxia inducible factor (HIF) and nuclear factor‐κB (NF‐κB) which display different degrees of sensitivity to activation during hypoxia. Furthermore, HIF and NF‐κB demonstrate an intimate interdependence at several mechanistic levels. Recent studies indicate that these pathways may represent important new therapeutic targets in diseases characterized by hypoxic inflammation.
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NF-κB has recently been reported to be regulated by HIF hydroxylases in a number of studies.
“For example, NF-κB has recently been reported to be regulated by HIF hydroxylases in a number of studies37,44.”
From Hypoxia: an alarm signal during intestinal inflammation (2010) · cites this paper as [44]
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- Authors
- Taylor, C. T.
- Affiliations
- University College Dublin (IE)
- Corresponding author
- Taylor, Cormac T.
- ORCID
- Taylor, Cormac T.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2008-09
- Volume
- 586
- Issue
- 17
- Pages
- 4055-4059
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC2652186
- OpenAlex
- W1515667338
- Cited by
- 354
- References
- 39
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 12 · 2023: 15 · 2022: 15 · 2021: 14 · 2020: 20 · 2019: 19 · 2018: 23 · 2017: 16 · 2016: 25 · 2015: 24 · 2014: 21 · 2013: 31 · 2012: 23
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- hypoxia, hypoxia-inducible factor, NF-κB, transcription factors, chronic inflammation, arthritis, inflammatory bowel disease, oxygen sensing, therapeutic target
- MeSH terms
- Animals, Hypoxia, Humans, Inflammation, NF-kappa B, Mice, Hypoxia-Inducible Factor 1
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