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Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease

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β-Secretase Activity Increases with Aging in Human, Monkey, and Mouse Brain

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Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β

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Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons.

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Translation of the Alzheimer Amyloid Precursor Protein mRNA Is Up-regulated by Interleukin-1 through 5′-Untranslated Region Sequences

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Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in <i>BACE1</i> -null mice

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Intracellular Aβ42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease

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Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis

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Molecular genetics of Alzheimer’s disease

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Advanced glycation endproducts in ageing and Alzheimer's disease

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A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

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Long-Term Accumulation of Amyloid-β, β-Secretase, Presenilin-1, and Caspase-3 in Damaged Axons Following Brain Trauma

Chen, X.-H., Siman, R., Iwata, A., Meaney, D. F., Trojanowski, J. Q., & Smith, D. H. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63303-2 · Cited by 271 · see citing works

Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors

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The Production of Amyloid β Peptide Is a Critical Requirement for the Viability of Central Neurons

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Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury

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Ryanodine Receptor Blockade Reduces Amyloid-β Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

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The up‐regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

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Calcium Ionophore Increases Amyloid .beta. Peptide Production by Cultured Cells

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The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease

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β-Amyloid-Induced Neuronal Apoptosis Involves c-Jun N-Terminal Kinase-Dependent Downregulation of Bcl-w

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GGA Proteins Mediate the Recycling Pathway of Memapsin 2 (BACE)

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Global Ischemia Activates Nuclear Factor-κB in Forebrain Neurons of Rats

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Oxidative stress potentiates BACE1 gene expression and A? generation

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Transcriptional Regulation of BACE1, the β-Amyloid Precursor Protein β-Secretase, by Sp1

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Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing

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Transcriptional and translational regulation of BACE1 expression—Implications for Alzheimer's disease

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High molecular weight hyaluronic acid inhibits advanced glycation endproduct‐induced NF‐κB activation and cytokine expression

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Differential regulation of BACE1 promoter activity by nuclear factor‐κB in neurons and glia upon exposure to β‐amyloid peptides

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The β-Secretase, BACE: A Prime Drug Target for Alzheimer's Disease

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JNK: A Stress-Activated Protein Kinase Therapeutic Strategies and Involvement in Alzheimer’s and Various Neurodegenerative Abnormalities

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β ‐Amyloid Degradation and Alzheimer′s Disease

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Changes of p53 in the Brains of Patients with Alzheimer's Disease

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Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner.

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Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer?s disease �-secretase (BACE-1)

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Challenging the Amyloid Cascade Hypothesis: Senile Plaques and Amyloid‐β as Protective Adaptations to Alzheimer Disease

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REVIEW: Pin1 in Alzheimer's disease

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Gene structure and organization of the human β‐secretase ( BACE ) promoter

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The Role of NF‐κB in Hypoxia‐Induced Gene Expression

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Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of β-amyloid peptide

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Age-related neuroinflammatory changes negatively impact on neuronal function

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Truncation and Activation of Calcineurin A by Calpain I in Alzheimer Disease Brain

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Expression and functional profiling of neprilysin, insulin‐degrading enzyme, and endothelin‐converting enzyme in prospectively studied elderly and Alzheimer’s brain

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Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease

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Neuroinflammation, microglia and implications for anti-inflammatory treatment in Alzheimer’s disease

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Presenilin-Dependent  -Secretase-Mediated Control of p53-Associated Cell Death in Alzheimer's Disease

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AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation

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BACE1 Deficiency Causes Altered Neuronal Activity and Neurodegeneration

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Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats

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Alzheimer's disease β‐secretase BACE1 is not a neuron‐specific enzyme

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The physiology of the β‐amyloid precursor protein intracellular domain AICD

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Astrocytic expression of the Alzheimer's disease β‐secretase (BACE1) is stimulus‐dependent

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Advanced glycation endproducts: from precursors to RAGE: round and round we go

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Synaptotoxicity of Alzheimer Beta Amyloid Can Be Explained by Its Membrane Perforating Property

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Modulation of Nuclear Factor-κB Activity by Indomethacin Influences Aβ Levels but Not Aβ Precursor Protein Metabolism in a Model of Alzheimer's Disease

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NF‐κB pathway: a target for preventing β‐amyloid (Aβ)‐induced neuronal damage and Aβ42 production

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Interactions between Alzheimer's disease and cerebral ischemia—focus on inflammation

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Why Pleiotropic Interventions are Needed for Alzheimer's Disease

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Oxidative Stress Induces Increase in Intracellular Amyloid β-Protein Production and Selective Activation of βI and βII PKCs in NT2 Cells

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Pathophysiology of Neuronal Energy Crisis in Alzheimer’s Disease

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Oxidative stress mediates the pathogenic effect of different Alzheimer’s disease risk factors

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Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

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Genetics of Alzheimer's disease: new evidences for an old hypothesis?

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Alzheimer's β-Secretase (BACE1) Regulates the cAMP/PKA/CREB Pathway Independently of β-Amyloid

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GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network

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Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease

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NFκB-dependent Control of BACE1 Promoter Transactivation by Aβ42

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RAGE regulates BACE1 and Aβ generation via NFAT1 activation in Alzheimer's disease animal model

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Calpain as a novel target for treating acute neurodegenerative disorders

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Nuclear Factor-κB Regulates βAPP and β- and γ-Secretases Differently at Physiological and Supraphysiological Aβ Concentrations

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Calcium-mediated Transient Phosphorylation of Tau and Amyloid Precursor Protein Followed by Intraneuronal Amyloid-β Accumulation

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The various aggregation states of β-amyloid 1–42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression

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IFN‐γ‐induced BACE1 expression is mediated by activation of JAK2 and ERK1/2 signaling pathways and direct binding of STAT1 to BACE1 promoter in astrocytes

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The Pathogenesis of Alzheimer′s Disease: A Reevaluation of the “Amyloid Cascade Hypothesis”

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Calpain Activation Promotes BACE1 Expression, Amyloid Precursor Protein Processing, and Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease

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Aminopeptidase A contributes to the N‐terminal truncation of amyloid β‐peptide

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Demonstration of BACE (β-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy

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The unsolved relationship of brain aging and late-onset Alzheimer disease

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The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: Characterizing a new regulatory motif

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