Etomidate and propofol inhibit the neurotransmitter release machinery at different sites
Open accessAbstract
Non‐technical summary Alterations in synaptic efficacy are thought to underlie changes in learning and behaviour and are vital to normal neuronal function. Using a variety of different cells and techniques we investigate whether anaesthetics can modify neurotransmitter release as part of their mechanism of action. Our data suggest that inhibition of neurotransmitter release may be a critical mechanism for the actions of anaesthetics like etomidate and propofol. In the future this information may be used to design new generations of clinically useful anaesthetics.
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Syntaxin mutations curtail isoflurane effects on neurotransmission in cultured cell lines.
“The extraordinary power of syntaxin mutations to curtail the effects of isoflurane on neurotransmission has also been replicated in cultured cell lines [74, 75].”
From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [74]
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(2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.217539
- Authors
- Herring, B. E., McMillan, K., Pike, C. M., Marks, J., Fox, A. P., & Xie, Z.
- Affiliations
- University of Chicago (US)
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2011-02-25
- Volume
- 589
- Issue
- 5
- Pages
- 1103-1115
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC3060590
- OpenAlex
- W1594046881
- Cited by
- 50
- References
- 22
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 7
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM116119)
- National Institute of Neurological Disorders and Stroke (R01NS056313)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- etomidate, propofol, intravenous anesthetics, neurotransmitter release, presynaptic inhibition, SNARE proteins, syntaxin, calcium-dependent release, hippocampal neurons, PC12 cells
- MeSH terms
- Animals, Cells, Cultured, Dose-Response Relationship, Drug, Etomidate, Hippocampus, Synaptic Transmission, Neurons, Synaptic Vesicles, Blotting, Western, Propofol, PC12 Cells, Rats, Sprague-Dawley, Patch-Clamp Techniques, Anesthetics, Intravenous, Rats
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