Rapid and reversible formation of spine head filopodia in response to muscarinic receptor activation in CA1 pyramidal cells
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Non‐technical summary Changes in the shape and number of spines on neuronal dendrites modify synaptic transmission and circuit properties, processes considered important for learning and memory. We show, in hippocampal pyramidal neurons, that brief activation of acetylcholine receptors of the muscarinic subtype induces the emergence of fine filopodia from spine heads in all CA1 pyramidal neurons examined. Experiments to test whether changes in the cytoskeleton play a role in the emergence of filopodia revealed that the extension of microtubules, but not actin polymerization, was necessary. These findings reveal a new form of structural plasticity at the subspine level where the heads of mature dendritic spines can modulate the degree of interaction with their presynaptic partners. Knowledge of how the cholinergic system in the brain affects spine morphology and physiology is important for understanding memory formation.
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These observations confirm that spine head filopodia induction might trigger spine switching and potentially the replacement of inefficient with more efficient synapses.
“These observations confirm that spine head filopodia induction might trigger spine switching and potentially the replacement of inefficient with more efficient synapses41,42,53.”
From Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction (2018) · cites this paper as [53]
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Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
Weinhard, L., di Bartolomei, G., Bolasco, G., Machado, P., Schieber, N. L., Neniskyte, U., Exiga, M., Vadisiute, A., Raggioli, A., Schertel, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03566-5 · Cited by 790 · see citing works
- Authors
- Schätzle, P., Ster, J., Verbich, D., McKinney, R. A., Gerber, U., Sonderegger, P., & María Mateos, J.
- Affiliations
- University of Zurich (CH)
- Brain Research Institute, Niigata University (JP)
- McGill University (CA)
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2011-08-30
- Volume
- 589
- Issue
- 17
- Pages
- 4353-4364
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC3180587
- OpenAlex
- W2147452663
- Cited by
- 20
- References
- 33
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2013: 1 · 2012: 5
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- muscarinic receptors, CA1 pyramidal neurons, presynaptic terminals, miniature EPSCs, microtubule assembly, nocodazole, methacholine, atropine, synaptic plasticity
- MeSH terms
- Animals, Hippocampus, Synaptic Transmission, Pseudopodia, Receptors, Muscarinic, Synapses, Pyramidal Cells, Dendritic Spines
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