The Relationship between PSD-95 Clustering and Spine Stability In Vivo
Open accessAbstract
The appearance and disappearance of dendritic spines, accompanied by synapse formation and elimination may underlie the experience-dependent reorganization of cortical circuits. The exact temporal relationship between spine and synapse formation in vivo remains unclear, as does the extent to which synapse formation enhances the stability of newly formed spines and whether transient spines produce synapses. We used in utero electroporation of DsRedExpress- and eGFP-tagged postsynaptic density protein 95 (PSD-95) to investigate the relationship between spine and PSD stability in mouse neocortical L2/3 pyramidal cells in vivo. Similar to previous studies, spines and synapses appeared and disappeared, even in naive animals. Cytosolic spine volumes and PSD-95-eGFP levels in spines covaried over time, suggesting that the strength of many individual synapses continuously changes in the adult neocortex. The minority of newly formed spines acquired PSD-95-eGFP puncta. Spines that failed to acquire a PSD rarely survived for more than a day. Although PSD-95-eGFP accumulation was associated with increased spine lifetimes, most new spines with a PSD did not convert into persistent spines. This indicates that transient spines may serve to produce short-lived synaptic contacts. Persistent spines that were destined to disappear showed, on average, reduced PSD-95-eGFP levels well before the actual pruning event. Altogether, our data indicate that the PSD size relates to spine stability in vivo.
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Stable spines mostly represent synaptic contacts.
“While stable spines mostly represent synaptic contacts, only a small fraction of transient spines represent short-lived synaptic contacts, and the rest of them represent failed synaptogenesis (Trachtenberg et al., 2002; Knott et al., 2006; Cane et al., 2014).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Cane et al., 2014
The rest of transient spines represent failed synaptogenesis.
“While stable spines mostly represent synaptic contacts, only a small fraction of transient spines represent short-lived synaptic contacts, and the rest of them represent failed synaptogenesis (Trachtenberg et al., 2002; Knott et al., 2006; Cane et al., 2014).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Cane et al., 2014
Only a small fraction of transient spines represent short-lived synaptic contacts.
“While stable spines mostly represent synaptic contacts, only a small fraction of transient spines represent short-lived synaptic contacts, and the rest of them represent failed synaptogenesis (Trachtenberg et al., 2002; Knott et al., 2006; Cane et al., 2014).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Cane et al., 2014
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- Authors
- Cane, M., Maco, B., Knott, G., & Holtmaat, A.
- Affiliations
- University of Geneva (CH)
- École Polytechnique Fédérale de Lausanne (CH)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2014-02-05
- Volume
- 34
- Issue
- 6
- Pages
- 2075-2086
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6608529
- OpenAlex
- W2041963605
- Cited by
- 216
- References
- 68
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 18 · 2023: 20 · 2022: 19 · 2021: 26 · 2020: 21 · 2019: 15 · 2018: 15 · 2017: 21 · 2016: 16 · 2015: 10 · 2014: 11
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (acceptedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- International Foundation for Research in Paraplegia
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (120685, 135631)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- PSD-95, dendritic spines, spinal stability, postsynaptic density, synaptogenesis, synaptic pruning, in utero electroporation, synaptic plasticity
- MeSH terms
- Disks Large Homolog 4 Protein, Animals, Female, Male, Membrane Proteins, Mice, Inbred C57BL, Pregnancy, Cluster Analysis, Dendritic Spines, Mice, Guanylate Kinases
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