The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
SIRT‐1 and vascular endothelial dysfunction with ageing in mice and humans
Open accessAbstract
Non‐technical summary Advancing age is a major risk factor for the development of cardiovascular disease. A key characteristic of older arteries that may lead to cardiovascular disease is reduced endothelial function, characterized by blunted endothelium‐dependent dilatation. Sirtuins, specifically sirtuin‐1, are proteins linked to increases in lifespan and lower incidence of age‐related diseases. We hypothesized that diminished sirtuin‐1 with advancing age may alter regulation of a key endothelium dilatory enzyme, nitric oxide synthase. Our findings provide novel translational evidence that sirtuin‐1 expression and activity contribute to arterial endothelial dysfunction with ageing and that this may be due to altered nitric oxide synthase activation. Importantly, our results provide further compelling support for sirtuin‐1 as a potential therapeutic target for lifestyle and pharmacological interventions aimed at the prevention and treatment of arterial ageing and age‐associated cardiovascular diseases.
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Cites
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., & Sinclair, D. A. (2004) · Science · doi:10.1126/science.1099196 · Cited by 1,924
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Aging and vascular endothelial function in humans
Seals, D. R., Jablonski, K. L., & Donato, A. J. (2011) · Clinical Science · doi:10.1042/cs20100476 · Cited by 725
Self-citationEnhanced Peroxynitrite Formation Is Associated with Vascular Aging
van der Loo, B., Labugger, R., Skepper, J. N., Bachschmid, M., Kilo, J., Powell, J. M., Palacios-Callender, M., Erusalimsky, J. D., Quaschning, T., Malinski, T., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1731 · Cited by 675
Age-Related Reduction of NO Availability and Oxidative Stress in Humans
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Reporting ethical matters in The Journal of Physiology: standards and advice
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Metabolic adaptations through the PGC‐1α and SIRT1 pathways
Rodgers, J. T., Lerin, C., Gerhart-Hines, Z., & Puigserver, P. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.11.034 · Cited by 561
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Cited by
Ungvari, Z., Tarantini, S., Donato, A. J., Galvan, V., & Csiszar, A. (2018) · Circulation Research · doi:10.1161/circresaha.118.311378 · Cited by 919
Self-citationMartens, C. R., Denman, B. A., Mazzo, M. R., Armstrong, M. L., Reisdorph, N., McQueen, M. B., Chonchol, M., & Seals, D. R. (2018) · Nature Communications · doi:10.1038/s41467-018-03421-7 · Cited by 588
Self-citationCellular and molecular biology of aging endothelial cells
Donato, A. J., Morgan, R. G., Walker, A. E., & Lesniewski, L. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.01.021 · Cited by 538
Self-citationMitochondria and Endothelial Function
Kluge, M. A., Fetterman, J. L., & Vita, J. A. (2013) · Circulation Research · doi:10.1161/circresaha.111.300233 · Cited by 508
Picciotto, N. E., Gano, L. B., Johnson, L. C., Martens, C. R., Sindler, A. L., Mills, K. F., Imai, S., & Seals, D. R. (2016) · Aging Cell · doi:10.1111/acel.12461 · Cited by 396
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Metadata
- Authors
- Donato, A. J., Magerko, K. A., Lawson, B. R., Durrant, J. R., Lesniewski, L. A., & Seals, D. R.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2011-09
- Volume
- 589
- Issue
- 18
- Pages
- 4545-4554
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1578616085
- Cited by
- 271
- References
- 40
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Donato, A. J., Magerko, K. A., Lawson, B. R., Durrant, J. R., Lesniewski, L. A., & Seals, D. R. (2011). SIRT‐1 and vascular endothelial dysfunction with ageing in mice and humans. The Journal of Physiology. https://doi.org/10.1113/jphysiol.2011.211219
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