Mitochondria and Endothelial Function

Kluge, Matthew A.; Fetterman, Jessica L.; Vita, Joseph A.

doi:10.1161/circresaha.111.300233

Cited by 508Mitochondrial Function and PathologyNitric Oxide and Endothelin EffectsAutophagy in Disease and Therapy

Mitochondria and Endothelial Function

Open access

Kluge, Matthew A., Fetterman, Jessica L., Vita, Joseph A.·2013·Circulation Research

DOI 10.1161/circresaha.111.300233PMC PMC3700369

Open this paper in CoChat — free account Open PDF

Abstract

In contrast to their role in cell types with higher energy demands, mitochondria in endothelial cells primarily function in signaling cellular responses to environmental cues. This article provides an overview of key aspects of mitochondrial biology in endothelial cells, including subcellular location, biogenesis, dynamics, autophagy, reactive oxygen species production and signaling, calcium homeostasis, regulated cell death, and heme biosynthesis. In each section, we introduce key concepts and then review studies showing the importance of that mechanism to endothelial control of vasomotor tone, angiogenesis, and/or inflammatory activation. We particularly highlight the small number of clinical and translational studies that have investigated each mechanism in human subjects. Finally, we review interventions that target different aspects of mitochondrial function and their effects on endothelial function. The ultimate goal of such research is the identification of new approaches for therapy. The reviewed studies make it clear that mitochondria are important in endothelial physiology and pathophysiology. A great deal of work will be needed, however, before mitochondria-directed therapies are available for the prevention and treatment of cardiovascular disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/circresaha.111.300233

Cites

213 of 213 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Mitochondrial dysregulation is implicated in impaired arterial function in animal models of cardiovascular disease.
“Accumulating evidence implicates mitochondrial dysregulation in impaired arterial function both in animal models of cardiovascular disease (94, 161, 182)”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [94]
If metformin can offset the decline in mitochondrial function, then this effect could contribute to enhancing both healthspan and lifespan.
“If metformin can offset the decline in mitochondrial function, as some studies suggest, then this effect could contribute to enhancing both healthspan and lifespan (138, 149, 150).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [149]
AMPK has been implicated in regulation of mitochondrial biogenesis, providing a link between metformin, AMPK, and improved mitochondrial function.
“AMPK has also been implicated in the regulation of mitochondrial biogenesis, thus providing another link between metformin, AMPK, and improved mitochondrial function (149, 150).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [149]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Apoptosis: A Review of Programmed Cell Death
Elmore, S. (2007) · Toxicologic Pathology · doi:10.1080/01926230701320337 · Cited by 13,853 · see citing works
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207 · see citing works
Hydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827 · see citing works
The BCL-2 protein family: opposing activities that mediate cell death
Youle, R. J., & Strasser, A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2308 · Cited by 4,704 · see citing works
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277 · see citing works
Therapeutic potential of resveratrol: the in vivo evidence
Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958 · see citing works
Mechanisms of mitophagy
Youle, R. J., & Narendra, D. P. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3028 · Cited by 3,273 · see citing works
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works
Role of Oxidative Modifications in Atherosclerosis
Stocker, R., & Keaney, J. F. (2004) · Physiological Reviews · doi:10.1152/physrev.00047.2003 · Cited by 2,611 · see citing works
Autophagy in Human Health and Disease
Choi, A. M. K., Ryter, S. W., & Levine, B. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1205406 · Cited by 2,583 · see citing works
Molecular mechanisms of necroptosis: an ordered cellular explosion
Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382 · see citing works
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321 · see citing works
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
Baines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., Brunskill, E. W., Sayen, M. R., Gottlieb, R. A., Dorn, G. W., et al. (2005) · Nature · doi:10.1038/nature03434 · Cited by 2,280 · see citing works
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193 · see citing works
Myocardial Fatty Acid Metabolism in Health and Disease
Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,180 · see citing works
The clinical implications of endothelial dysfunction
Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · cited 1× · see citing works
“function in patients with obesity, diabetes mellitus, and other risk factors.(1) A weight loss and exercise program increased expression of PGC-1α in skeletal muscle of elderly women.”
Background
Superoxide activates mitochondrial uncoupling proteins
Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., et al. (2002) · Nature · doi:10.1038/415096a · Cited by 1,382 · see citing works
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
Gerhart‐Hines, Z., Rodgers, J. T., Bare, O., Lerin, C., Kim, S., Mostoslavsky, R., Alt, F. W., Wu, Z., & Puigserver, P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601633 · Cited by 1,294 · see citing works
Mitochondrial dynamics and apoptosis
Suen, D.-F., Norris, K. L., & Youle, R. J. (2008) · Genes & Development · doi:10.1101/gad.1658508 · Cited by 1,270 · see citing works
Mitochondria and the Autophagy–Inflammation–Cell Death Axis in Organismal Aging
Green, D. R., Galluzzi, L., & Kroemer, G. (2011) · Science · doi:10.1126/science.1201940 · Cited by 1,245 · see citing works
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide
Nisoli, E., Clementi, E., Paolucci, C., Cozzi, V., Tonello, C., Sciorati, C., Bracale, R., Valerio, A., Francolini, M., Moncada, S., et al. (2003) · Science · doi:10.1126/science.1079368 · Cited by 1,243 · see citing works
Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences
Rizzuto, R., & Pozzan, T. (2005) · Physiological Reviews · doi:10.1152/physrev.00004.2005 · Cited by 1,201 · see citing works
Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization
Cassidy-Stone, A., Chipuk, J. E., Ingerman, E., Song, C., Yoo, C., Kuwana, T., Kurth, M. J., Shaw, J. T., Hinshaw, J. E., Green, D. R., et al. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.11.019 · Cited by 1,200 · see citing works
The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes
Vega, R. B., Huss, J. M., & Kelly, D. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1868-1876.2000 · Cited by 1,195 · see citing works
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis
Giorgio, M., Migliaccio, E., Orsini, F., Paolucci, D., Moroni, M., Contursi, C., Pelliccia, G., Luzi, L., Minucci, S., Marcaccio, M., et al. (2005) · Cell · doi:10.1016/j.cell.2005.05.011 · Cited by 1,176 · see citing works
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
He, C., Bassik, M. C., Moresi, V., Sun, K., Wei, Y., Zou, Z., An, Z., Loh, J., Fisher, J., Sun, Q., et al. (2012) · Nature · doi:10.1038/nature10758 · Cited by 1,136 · see citing works
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107 · see citing works
Mitochondrial ROS-induced ROS release: An update and review
Zorov, D. B., Juhaszova, M., & Sollott, S. J. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.04.029 · Cited by 1,081 · see citing works
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Arany, Z., Foo, S.-Y., Ma, Y., Ruas, J. L., Bommi-Reddy, A., Girnun, G., Cooper, M., Laznik, D., Chinsomboon, J., Rangwala, S. M., et al. (2008) · Nature · doi:10.1038/nature06613 · Cited by 1,054 · see citing works
Reversible phosphorylation of Drp1 by cyclic AMP‐dependent protein kinase and calcineurin regulates mitochondrial fission and cell death
Cribbs, J. T., & Strack, S. (2007) · EMBO Reports · doi:10.1038/sj.embor.7401062 · Cited by 1,024 · see citing works
Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury
Ong, S.-B., Subrayan, S., Lim, S. Y., Yellon, D. M., Davidson, S. M., & Hausenloy, D. J. (2010) · Circulation · doi:10.1161/circulationaha.109.906610 · Cited by 986 · see citing works
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death
Baines, C. P., Kaiser, R. A., Sheiko, T., Craigen, W. J., & Molkentin, J. D. (2007) · Nature Cell Biology · doi:10.1038/ncb1575 · Cited by 971 · see citing works
The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways
Wang, Z., Jiang, H., Chen, S., Du, F., & Wang, X. (2012) · Cell · doi:10.1016/j.cell.2011.11.030 · Cited by 949 · see citing works
Oxidative Stress and Cardiovascular Injury
Griendling, K. K., & FitzGerald, G. A. (2003) · Circulation · doi:10.1161/01.cir.0000093660.86242.bb · Cited by 940 · see citing works
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
Tao, R., Coleman, M. C., Pennington, J. D., Ozden, O., Park, S.-H., Jiang, H., Kim, H.-S., Flynn, C. R., Hill, S., Hayes McDonald, W., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.12.013 · Cited by 899 · see citing works
SIRT1 Promotes Endothelium-Dependent Vascular Relaxation by Activating Endothelial Nitric Oxide Synthase
Mattagajasingh, I., Kim, C.-S., Naqvi, A., Yamamori, T., Hoffman, T. A., Jung, S.-B., DeRicco, J., Kasuno, K., & Irani, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704329104 · Cited by 881 · see citing works
The heme synthesis and degradation pathways: role in oxidant sensitivity
Ryter, S. W., & Tyrrell, R. M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00223-3 · Cited by 822 · see citing works
The Mitochondrial Protein hFis1 Regulates Mitochondrial Fission in Mammalian Cells through an Interaction with the Dynamin-Like Protein DLP1
Yoon, Y., Krueger, E. W., Oswald, B. J., & McNiven, M. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5409-5420.2003 · Cited by 820 · see citing works
Mitochondria and Mitophagy
Kubli, D. A., & Gustafsson, Å. B. (2012) · Circulation Research · doi:10.1161/circresaha.112.265819 · Cited by 792 · see citing works
Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System
Lassegue, B. P., Martín, A. S., & Griendling, K. K. (2012) · Circulation Research · doi:10.1161/circresaha.111.243972 · Cited by 768 · see citing works
Therapeutic Targeting of Mitochondrial Superoxide in Hypertension
Dikalova, A., Bikineyeva, A. T., Budzyn, K., Nazarewicz, R. R., McCann, L. A., Lewis, W., Harrison, D. G., & Dikalov, S. (2010) · Circulation Research · doi:10.1161/circresaha.109.214601 · Cited by 737 · see citing works
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
Nogueiras, R., Habegger, K. M., Chaudhary, N., Finan, B., Banks, A. S., Dietrich, M. O., Horváth, T. L., Sinclair, D. A., Pfluger, P. T., & Tschöp, M. H. (2012) · Physiological Reviews · doi:10.1152/physrev.00022.2011 · Cited by 712 · see citing works
Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction: Linking Mitochondrial Oxidative Damage and Vascular Endothelial Dysfunction
Doughan, A. K., Harrison, D. G., & Dikalov, S. I. (2008) · Circulation Research · doi:10.1161/circresaha.107.162800 · Cited by 710 · see citing works
MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2
Chan, S. Y., Zhang, Y.-Y., Hemann, C., Mahoney, C. E., Zweier, J. L., & Loscalzo, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.015 · Cited by 702 · see citing works
Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice
Zang, M., Xu, S., Maitland, K. A., Zuccollo, A., Hou, X., Jiang, B., Wierzbicki, M., Verbeuren, T. J., & Cohen, R. A. (2006) · Diabetes · doi:10.2337/db05-1188 · Cited by 663 · see citing works
The large apparent work capability of the blood‐brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat
Oldendorf, W. H., Cornford, M. E., & Brown, W. J. (1977) · Annals of Neurology · doi:10.1002/ana.410010502 · Cited by 651 · see citing works
Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view
Twig, G., Hyde, B. B., & Shirihai, O. S. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.05.001 · Cited by 646 · see citing works
MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles
van Rooij, E., & Olson, E. N. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3864 · Cited by 620 · see citing works
SIRT1 Controls Endothelial Angiogenic Functions During Vascular Growth
Potente, M., Ghaeni, L., Baldessari, D., Mostoslavsky, R., Rossig, L., Dequiedt, F., Haendeler, J., Mione, M., Dejana, E., Alt, F. W., et al. (2007) · Genes & Development · doi:10.1101/gad.435107 · Cited by 608 · see citing works
A double‐blind, placebo‐controlled study to assess the mitochondria‐targeted antioxidant MitoQ as a disease‐modifying therapy in Parkinson's disease
Snow, B. J., Rolfe, F. L., Lockhart, M. M., Frampton, C. M., O'Sullivan, J. D., Fung, V., Smith, R. A. J., Murphy, M. P., Taylor, K. M., & On behalf of the Protect Study Group (2010) · Movement Disorders · doi:10.1002/mds.23148 · Cited by 606 · see citing works
Autophagy Links Inflammasomes to Atherosclerotic Progression
Razani, B., Feng, C., Coleman, T., Emanuel, R., Wen, H., Hwang, S., Ting, J. P., Virgin, H. W., Kastan, M. B., & Semenkovich, C. F. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.011 · Cited by 601 · see citing works
A signalling role for 4‐hydroxy‐2‐nonenal in regulation of mitochondrial uncoupling
Echtay, K. S., Esteves, T. C., Pakay, J. L., Jekabsons, M. B., Lambert, A. J., Portero‐Otín, M., Pamplona, R., Vidal‐Puig, A. J., Wang, S., Roebuck, S. J., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg412 · Cited by 597 · see citing works
SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria
Onyango, P. O., Celic, I., McCaffery, J. M., Boeke, J. D., & Feinberg, A. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222538099 · Cited by 573 · see citing works
Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus
Shenouda, S. M., Widlansky, M. E., Chen, K., Xu, G., Holbrook, M., Tabit, C. E., Hamburg, N. M., Frame, A. A., Caiano, T. L., Kluge, M. A., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.014506 · Cited by 570 · see citing works
PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells
VALLE, I., ALVAREZBARRIENTOS, A., ARZA, E., LAMAS, S., & MONSALVE, M. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.01.026 · Cited by 556 · see citing works
Mitochondrial Control of Cellular Life, Stress, and Death
Galluzzi, L., Kepp, O., Trojel‐Hansen, C., & Kroemer, G. (2012) · Circulation Research · doi:10.1161/circresaha.112.268946 · Cited by 545 · see citing works
Uncoupling proteins and the control of mitochondrial reactive oxygen species production
Mailloux, R. J., & Harper, M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.022 · Cited by 534 · see citing works
Improved Endothelial Function With Metformin in Type 2 Diabetes Mellitus
Mather, K. J., Verma, S., & Anderson, T. J. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01129-9 · Cited by 513 · see citing works
Peroxynitrite-Mediated Inactivation of Manganese Superoxide Dismutase Involves Nitration and Oxidation of Critical Tyrosine Residues
MacMillan-Crow, L. A., Crow, J. P., & Thompson, J. A. (1998) · Biochemistry · doi:10.1021/bi971894b · Cited by 508 · see citing works
Mitochondrial Fusion is Essential for Organelle Function and Cardiac Homeostasis
Chen, Y., Liu, Y., & Dorn, G. W. (2011) · Circulation Research · doi:10.1161/circresaha.111.258723 · Cited by 506 · see citing works
Mitochondrial pharmacology
Smith, R. A. J., Hartley, R. C., Cochemé, H. M., & Murphy, M. P. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.03.010 · Cited by 501 · see citing works
Integration of cellular bioenergetics with mitochondrial quality control and autophagy
Hill, B. G., Benavides, G. A., Lancaster, J. R., Ballinger, S. W., Dell’Italia, L., Zhang, J., & Darley-Usmar, V. M. (2012) · Biological Chemistry · doi:10.1515/hsz-2012-0198 · Cited by 481 · see citing works
Mitochondrial Integrity and Function in Atherogenesis
Ballinger, S. W., Patterson, C., Knight-Lozano, C. A., Burow, D. L., Conklin, C. A., Hu, Z., Reuf, J., Horaist, C., Lebovitz, R. M., Hunter, G. C., et al. (2002) · Circulation · doi:10.1161/01.cir.0000023921.93743.89 · Cited by 478 · see citing works
Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells
Wang, W., Wang, Y., Long, J., Wang, J., Haudek, S. B., Overbeek, P., Chang, B. H. J., Schumacker, P. T., & Danesh, F. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.009 · Cited by 476 · see citing works
Resveratrol induces mitochondrial biogenesis in endothelial cells
Csiszár, A., Labinskyy, N., Pinto, J. T., Ballabh, P., Zhang, H., Losonczy, G., Pearson, K. J., de Cabo, R., Pacher, P., Zhang, C., et al. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00368.2009 · Cited by 450 · see citing works
Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)
Raturi, A., & Simmen, T. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.04.013 · Cited by 448 · see citing works
Hydrogen Peroxide– and Peroxynitrite-Induced Mitochondrial DNA Damage and Dysfunction in Vascular Endothelial and Smooth Muscle Cells
Ballinger, S. W., Patterson, C., Yan, C.-N., Doan, R., Burow, D. L., Young, C. G., Yakes, F. M., Houten, B. V., Ballinger, C. A., Freeman, B. Α., et al. (2000) · Circulation Research · doi:10.1161/01.res.86.9.960 · Cited by 442 · see citing works
Ultrastructural quantitation of mitochondria and myofilaments in cardiac muscle from 10 different animal species including man
Barth, E. (1992) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(92)93381-s · Cited by 439 · see citing works
Can autophagy promote longevity?
Madeo, F., Tavernarakis, N., & Kroemer, G. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-842 · Cited by 433 · see citing works
Mitochondria: The Hub of Cellular Ca2+Signaling
Szabadkai, G., & Duchen, M. R. (2008) · Physiology · doi:10.1152/physiol.00046.2007 · Cited by 403 · see citing works
Relation Between Endothelial Cell Apoptosis and Blood Flow Direction in Human Atherosclerotic Plaques
Tricot, O., Mallat, Z., Heymes, C., Belmin, J., Lesèche, G., & Tedgui, A. (2000) · Circulation · doi:10.1161/01.cir.101.21.2450 · Cited by 401 · see citing works
Alterations of cellular bioenergetics in pulmonary artery endothelial cells
Xu, W., Koeck, T., Lara, A., Neumann, D. R., DiFilippo, F. P., Koo, M., Janocha, A. J., Masri, F. A., Arroliga, A. C., Jennings, C. A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605080104 · Cited by 390 · see citing works
Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription
Al‐Mehdi, A., Pastukh, V. M., Swiger, B. M., Reed, D., Patel, M., Bardwell, G. C., Pastukh, V. V., ALEXEYEV, M. F., & Gillespie, M. N. (2012) · Science Signaling · doi:10.1126/scisignal.2002712 · Cited by 386 · see citing works
Endothelial Mitochondria: Contributing to Vascular Function and Disease
Davidson, S. M., & Duchen, M. R. (2007) · Circulation Research · doi:10.1161/01.res.0000261970.18328.1d · Cited by 381 · see citing works
Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α
Handschin, C., Lin, J. D., Rhee, J., Peyer, A., Chin, S., Wu, P., Meyer, U., & Spiegelman, B. M. (2005) · Cell · doi:10.1016/j.cell.2005.06.040 · Cited by 380 · see citing works
The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients: Mitoquinone and liver damage
Gane, E. J., Weilert, F., Orr, D. W., Keogh, G. F., Gibson, M., Lockhart, M. M., Frampton, C. M., Taylor, K. M., Smith, R. A. J., & Murphy, M. P. (2010) · Liver International · doi:10.1111/j.1478-3231.2010.02250.x · Cited by 379 · see citing works
Angiotensin II Induces Apoptosis of Human Endothelial Cells
Dimmeler, S., Rippmann, V., Weiland, U., Haendeler, J., & Zeiher, A. M. (1997) · Circulation Research · doi:10.1161/01.res.81.6.970 · Cited by 373 · see citing works
Oxidized Low-Density Lipoprotein Induces Apoptosis of Human Endothelial Cells by Activation of CPP32-Like Proteases
Dimmeler, S., Haendeler, J., Galle, J., & Zeiher, A. M. (1997) · Circulation · doi:10.1161/01.cir.95.7.1760 · Cited by 371 · see citing works
Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy
Graham, D., Huynh, N. N., Hamilton, C. A., Beattie, E., Smith, R. A. J., Cochemé, H. M., Murphy, M. P., & Dominiczak, A. F. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.130351 · Cited by 367 · see citing works
Aging Enhances the Sensitivity of Endothelial Cells Toward Apoptotic Stimuli
Hoffmann, J., Haendeler, J., Aicher, A., Rössig, L., Vasa‐Nicotera, M., Zeiher, A. M., & Dimmeler, S. (2001) · Circulation Research · doi:10.1161/hh2001.097796 · Cited by 355 · see citing works
Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins
Brooks, C., Wei, Q., Feng, L., Dong, G., Tao, Y., Mei, L., Xie, Z.-J., & Dong, Z. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703976104 · Cited by 351 · see citing works
Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species
Daiber, A. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.01.032 · Cited by 347 · see citing works
Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells
Ungvari, Z. I., Labinskyy, N., Mukhopadhyay, P., Pinto, J. T., Bagi, Z. A., Ballabh, P., Zhang, C., Pacher, P., & Csiszár, A. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00375.2009 · Cited by 343 · see citing works
Nitric Oxide and Mitochondrial Signaling: From Physiology to Pathophysiology
Erusalimsky, J. D., & Moncada, S. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.151167 · Cited by 336 · see citing works
Mitochondrial reactive oxygen species and Ca 2+ signaling
Camello-Almaraz, C., Gomez-Pinilla, P. J., Pozo, M. J., & Camello, P. J. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00217.2006 · Cited by 336 · see citing works
Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species
Dranka, B. P., Hill, B. G., & Darley-Usmar, V. M. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.01.015 · Cited by 329 · see citing works
α‐Lipoic acid inhibits TNF‐a‐induced NF‐κB activation and adhesion molecule expression in human aortic endothelial cells
Zhang, W., & Frei, B. B. (2001) · The FASEB Journal · doi:10.1096/fj.01-0260com · Cited by 300 · see citing works
Programmed Necrosis, Not Apoptosis, in the Heart
Kung, G., Konstantinidis, K., & Kitsis, R. N. (2011) · Circulation Research · doi:10.1161/circresaha.110.225730 · Cited by 290 · see citing works
Transient Limb Ischemia Induces Remote Preconditioning and Remote Postconditioning in Humans by a K ATP Channel–Dependent Mechanism
Loukogeorgakis, S., Williams, R., Panagiotidou, A. T., Kolvekar, S. K., Donald, A. E., Cole, T. J., Yellon, D. M., Deanfield, J. E., & MacAllister, R. J. (2007) · Circulation · doi:10.1161/circulationaha.106.653782 · Cited by 288 · see citing works
Irbesartan and Lipoic Acid Improve Endothelial Function and Reduce Markers of Inflammation in the Metabolic Syndrome
Sola, S., Mir, M. Q. S., Cheema, F. A., Merchant, N., Menon, R. G., Parthasarathy, S., & Khan, B. V. (2005) · Circulation · doi:10.1161/01.cir.0000153272.48711.b9 · Cited by 281 · see citing works
Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure
Wong, R. H. X., Howe, P. R. C., Buckley, J. D., Coates, A. M., Kunz, I., & Berry, N. M. (2011) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.03.003 · Cited by 277 · see citing works
SIRT‐1 and vascular endothelial dysfunction with ageing in mice and humans
Donato, A. J., Magerko, K. A., Lawson, B. R., Durrant, J., Lesniewski, L. A., & Seals, D. R. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.211219 · Cited by 270 · see citing works
Mitochondria as a Drug Target in Ischemic Heart Disease and Cardiomyopathy
Walters, A. M., Porter, G. A., Jr., & Brookes, P. S. (2012) · Circulation Research · doi:10.1161/circresaha.112.265660 · Cited by 268 · see citing works
Metformin Prevents High-Glucose–Induced Endothelial Cell Death Through a Mitochondrial Permeability Transition-Dependent Process
Detaille, D., Guigas, B., Chauvin, C., Batandier, C., Fontaine, E., Wiernsperger, N., & Leverve, X. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2179 · Cited by 263 · cited 2× · see citing works
“Apoptosis is observed in cells exposed to high glucose and in animal models of diabetes mellitus, and under these conditions, apoptosis is inhibited by interventions that decrease ROS or inhibit MPT pore opening.(146,147) Hyperglycemia-induced apoptosis has been shown to involve activation of nuclear factor-κB and pro…”
Background
Mitochondria in the diabetic heart
Bugger, H., & Abel, E. D. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq239 · Cited by 261 · see citing works
Carbon Monoxide Specifically Inhibits Cytochrome C Oxidase of Human Mitochondrial Respiratory Chain
Alonso, J., Cardellach, F., López, S., Casademont, J., & Miró, Ò. (2003) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2003.930306.x · Cited by 260 · see citing works
Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1
Mai, S., Klinkenberg, M., Auburger, G., Bereiter-Hahn, J., & Jendrach, M. (2010) · Journal of Cell Science · doi:10.1242/jcs.059246 · Cited by 256 · see citing works
Gene Silencing of the Mitochondrial Adaptor p66 Shc Suppresses Vascular Hyperglycemic Memory in Diabetes
Paneni, F., Mocharla, P. S., Akhmedov, A. T., Costantino, S., Osto, E., Volpe, M., Lüscher, T. F., & Cosentino, F. (2012) · Circulation Research · doi:10.1161/circresaha.112.266593 · Cited by 256 · see citing works
Translational evidence that impaired autophagy contributes to arterial ageing
LaRocca, T. J., Henson, G. D., Thorburn, A. M., Sindler, A. L., Pierce, G. L., & Seals, D. R. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.229690 · Cited by 255 · see citing works
Acetyl- l -carnitine fed to old rats partially restores mitochondrial function and ambulatory activity
Hagen, T. M., Ingersoll, R. T., Wehr, C. M., Lykkesfeldt, J., Vinarsky, V., Bartholomew, J. C., Song, M. H., & Ames, B. N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9562 · Cited by 252 · see citing works
Genetic deletion of p66 Shc adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress
Camici, G. G., Schiavoni, M., Francia, P., Bachschmid, M., Martin-Padura, I., Hersberger, M., Tanner, F. C., Pelicci, P., Volpe, M., Anversa, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609656104 · Cited by 249 · see citing works
Supplementation of Endothelial Cells with Mitochondria-targeted Antioxidants Inhibit Peroxide-induced Mitochondrial Iron Uptake, Oxidative Damage, and Apoptosis
Dhanasekaran, A., Kotamraju, S., Kalivendi, S. V., Matsunaga, T., Shang, T., Keszler, A., Joseph, J., & Kalyanaraman, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404003200 · Cited by 241 · see citing works
Translocation of Connexin 43 to the Inner Mitochondrial Membrane of Cardiomyocytes Through the Heat Shock Protein 90–Dependent TOM Pathway and Its Importance for Cardioprotection
Rodríguez‐Sinovas, A., Boengler, K., Cabestrero, A., Gres, P., Morente, M., Ruiz‐Meana, M., Konietzka, I., Miró‐Casas, E., Totzeck, A., Heusch, G., et al. (2006) · Circulation Research · doi:10.1161/01.res.0000230315.56904.de · Cited by 240 · see citing works
The Role of Nogo and the Mitochondria–Endoplasmic Reticulum Unit in Pulmonary Hypertension
Sutendra, G., Dromparis, P., Wright, P. L., Bonnet, S., Haromy, A., Hao, Z., McMurtry, M. S., Michalak, M., Vance, J. E., Sessa, W. C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002194 · Cited by 239 · see citing works
Mitochondrial Network Determines Intracellular ROS Dynamics and Sensitivity to Oxidative Stress through Switching Inter-Mitochondrial Messengers
Park, J., Lee, J., & Choi, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023211 · Cited by 230 · see citing works
Short- and long-term alterations of mitochondrial morphology, dynamics and mtDNA after transient oxidative stress
Jendrach, M., Mai, S., Pohl, S., Vöth, M., & Bereiter‐Hahn, J. (2008) · Mitochondrion · doi:10.1016/j.mito.2008.06.001 · Cited by 225 · see citing works
Monoamine Oxidase A–Mediated Enhanced Catabolism of Norepinephrine Contributes to Adverse Remodeling and Pump Failure in Hearts With Pressure Overload
Kaludercic, N., Takimoto, E., Nagayama, T., Feng, N., Lai, E. W., Bedja, D., Chen, K., Gabrielson, K. L., Blakely, R., Shih, J. C., et al. (2009) · Circulation Research · doi:10.1161/circresaha.109.198366 · Cited by 222 · see citing works
Energy turnover of vascular endothelial cells
Culic, O., Gruwel, M. L. H., & Schrader, J. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.1.c205 · Cited by 220 · see citing works
Cigarette Smoke Exposure and Hypercholesterolemia Increase Mitochondrial Damage in Cardiovascular Tissues
Knight-Lozano, C. A., Young, C. G., Burow, D. L., Hu, Z., Uyeminami, D. L., Pinkerton, K. E., Ischiropoulos, H., & Ballinger, S. W. (2002) · Circulation · doi:10.1161/hc0702.103977 · Cited by 217 · see citing works
Regulation of Endothelial Function by Mitochondrial Reactive Oxygen Species
Widlansky, M. E., & Gutterman, D. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3642 · Cited by 211 · see citing works
Generation of reactive oxygen intermediates, activation of NF-κB, and induction of apoptosis in human endothelial cells by glucose: role of nitric oxide synthase?
Du, X., Stockklauser, K., & Rosen, P. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00079-9 · Cited by 210 · see citing works
Bovine Brain Endothelial Cells Express Tight Junctions and Monoamine Oxidase Activity in Long‐Term Culture
Méresse, S., Dehouck, M., Delorme, P., Bensaïd, M., Tauber, J.-P., Delbart, C., Fruchart, J., & Cecchelli, R. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb08526.x · Cited by 206 · see citing works
Heterozygous Cellular Glutathione Peroxidase Deficiency in the Mouse: Abnormalities in Vascular and Cardiac Function and Structure
Forgione, M. A., Cap, A., Liao, R., Moldovan, N. I., Eberhardt, R. T., Lim, C. C., Jones, J., Goldschmidt-Clermont, P. J., & Loscalzo, J. (2002) · Circulation · doi:10.1161/01.cir.0000026820.87824.6a · Cited by 200 · see citing works
Mitochondrial ROMK Channel Is a Molecular Component of MitoK ATP
Foster, D. B., Ho, A., Rucker, J. J., Garlid, A. O., Chen, L., Sidor, A., Garlid, K., & O'Rourke, B. P. (2012) · Circulation Research · doi:10.1161/circresaha.112.266445 · Cited by 194 · see citing works
Nutrient-dependent regulation of PGC-1α's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5
Dominy, J. E., Lee, Y., Gerhart‐Hines, Z., & Puigserver, P. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.11.023 · Cited by 192 · see citing works
Vitamin C Inhibits Endothelial Cell Apoptosis in Congestive Heart Failure
Rössig, L., Hoffmann, J., Hugel, B., Mallat, Z., Haase, A., Freyssinet, J.-M., Tedgui, A., Aicher, A., Zeiher, A. M., & Dimmeler, S. (2001) · Circulation · doi:10.1161/hc4301.098284 · Cited by 182 · see citing works
2-Deoxy-D-Glucose Treatment of Endothelial Cells Induces Autophagy by Reactive Oxygen Species-Mediated Activation of the AMP-Activated Protein Kinase
Wang, Q., Liang, B., Shirwany, N. A., & Zou, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017234 · Cited by 181 · see citing works
Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes
Widlansky, M. E., Wang, J., Shenouda, S. M., Hagen, T. M., SMITH, A. R. W., Kizhakekuttu, T. J., Kluge, M. A., Weihrauch, D., Gutterman, D. D., & Vita, J. A. (2010) · Translational research · doi:10.1016/j.trsl.2010.04.001 · Cited by 180 · see citing works
Physiological Roles of the Permeability Transition Pore
Brenner, C., & Moulin, M. (2012) · Circulation Research · doi:10.1161/circresaha.112.265942 · Cited by 179 · see citing works
From form to function: the role of Nox4 in the cardiovascular system
Chen, F., Haigh, S. B., Barman, S. A., & Fulton, D. J. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00412 · Cited by 172 · see citing works
Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival
Liu, X., Peyton, K. J., Shebib, A. R., Wang, H., Korthuis, R. J., & Durante, W. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00749.2010 · Cited by 171 · see citing works
Blockade of the Nuclear Factor-κB Pathway in the Endothelium Prevents Insulin Resistance and Prolongs Life Spans
Hasegawa, Y., Saito, T., Ogihara, T., Ishigaki, Y., Yamada, T., Imai, J., Uno, K., Gao, J., Kaneko, K., Shimosawa, T., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.054346 · Cited by 168 · see citing works
Cell Death Pathways in Acute Ischemia/Reperfusion Injury
Gottlieb, R. A. (2011) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248411409581 · Cited by 166 · see citing works
Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy
Higdon, A. N., Benavides, G. A., Chacko, B. K., Ouyang, X., Johnson, M. S., Landar, A. L., Zhang, J., & Darley-Usmar, V. M. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00584.2011 · Cited by 161 · see citing works
Markers of Autophagy Are Downregulated in Failing Human Heart After Mechanical Unloading
Kassiotis, C., Ballal, K., Wellnitz, K., Vela, D. C., Gong, M., Salazar, R., Frazier, O. H., & Taegtmeyer, H. (2009) · Circulation · doi:10.1161/circulationaha.108.842252 · Cited by 160 · see citing works
Short‐term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress
Rippe, C., Lesniewski, L. A., Connell, M. L., LaRocca, T. J., Donato, A. J., & Seals, D. R. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00557.x · Cited by 158 · see citing works
Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan
Mai, S., Muster, B., Bereiter‐Hahn, J., & Jendrach, M. (2012) · Autophagy · doi:10.4161/auto.8.1.18174 · Cited by 158 · see citing works
PGC-1β Deficiency Accelerates the Transition to Heart Failure in Pressure Overload Hypertrophy
Riehle, C., Wende, A. R., Zaha, V. G., Pires, K. M. P., Wayment, B. E., Olsen, C. D., Bugger, H., Buchanan, J., Wang, X., Moreira, A. B., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.243964 · Cited by 156 · see citing works
Mitochondrial Decay in the Aging Rat Heart
Hagen, T. M., Moreau, R. F., Suh, J. H., & Visioli, F. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02119.x · Cited by 155 · see citing works
ABC‐me: a novel mitochondrial transporter induced by GATA‐1 during erythroid differentiation
Shirihai, O. S., Gregory, T., Yu, C., Orkin, S. H., & Weiss, M. J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.11.2492 · Cited by 154 · see citing works
The Cardiac Mitochondrion: Nexus of Stress
Baines, C. P. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135929 · Cited by 154 · see citing works
Suppression of the JNK Pathway by Induction of a Metabolic Stress Response Prevents Vascular Injury and Dysfunction
Schulz, E., Dopheide, J. F., Schuhmacher, S., Thomas, S. R., Chen, K., Daiber, A., Wenzel, P., Münzel, T. F., & Keaney, J. F. (2008) · Circulation · doi:10.1161/circulationaha.108.784289 · Cited by 150 · see citing works
The Role of Mitochondria for Ca2+ Refilling of the Endoplasmic Reticulum
Malli, R., Frieden, M., Trenker, M., & Graier, W. F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409353200 · Cited by 147 · see citing works
Effects of Recombinant Adenovirus-Mediated Uncoupling Protein 2 Overexpression on Endothelial Function and Apoptosis
Lee, K.-U., Lee, I. K., Han, J., Song, D., Kim, Y., Song, H. S., Kim, H. S., Lee, W. J., Koh, E. H., Song, K., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000170075.73039.5b · Cited by 147 · see citing works
Hemoxygenase-1 in Cardiovascular Disease
Idriss, N. K., Blann, A. D., & Lip, G. Y. H. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.06.019 · Cited by 144 · see citing works
Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling
Bubolz, A. H., Mendoza, S. A., Zheng, X., Zinkevich, N. S., Li, R., Gutterman, D. D., & Zhang, D. X. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00717.2011 · Cited by 144 · see citing works
Mitochondrial outer membrane permeabilization during apoptosis: The role of mitochondrial fission
Landes, T., & Martinou, J. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.021 · Cited by 140 · see citing works
Uncoupling Protein-2 Protects Endothelial Function in Diet-Induced Obese Mice
Tian, X. Y., Wong, W. T., Xu, A., Lu, Y., Zhang, Y., Wang, L., Cheang, W. S., Wang, Y., Yao, X., & Huang, Y. (2012) · Circulation Research · doi:10.1161/circresaha.111.262170 · Cited by 139 · see citing works
Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells
Duval, C., Nègre‐Salvayre, A., Doglio, A., Salvayre, R., Pénicaud, L., & Casteilla, L. (2002) · Biochemistry and Cell Biology · doi:10.1139/o02-158 · Cited by 136 · see citing works
Attenuation of Angiotensin II–Induced Vascular Dysfunction and Hypertension by Overexpression of Thioredoxin 2
Widder, J. D., Fraccarollo, D., Galuppo, P., Hansen, J. M., Jones, D. P., Ertl, G., & Bauersachs, J. K. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.127928 · Cited by 136 · see citing works
N-acetylcysteine improves coronary and peripheral vascular function
Andrews, N. P., Prasad, A., & Quyyumi, A. A. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01093-7 · Cited by 135 · see citing works
Inhibition of Autophagy Rescues Palmitic Acid-induced Necroptosis of Endothelial Cells
Khan, M. J., Alam, M. R., Waldeck‐Weiermair, M., Karsten, F., Groschner, L. N., Riederer, M., Hallström, S., Rockenfeller, P., Kónya, V., Heinemann, Á., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.319129 · Cited by 134 · see citing works
Acute Exposure to Low Glucose Rapidly Induces Endothelial Dysfunction and Mitochondrial Oxidative Stress
Wang, J., Alexanian, A., Ying, R., Kizhakekuttu, T. J., Dharmashankar, K., Vasquez-Vivar, J., Gutterman, D. D., & Widlansky, M. E. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.227389 · Cited by 134 · see citing works
Endothelial mitochondria—less respiration, more integration
Groschner, L. N., Waldeck‐Weiermair, M., Malli, R., & Graier, W. F. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1085-z · Cited by 124 · see citing works
Exercise-induced brachial artery vasodilation: role of free radicals
Richardson, R. S., Donato, A. J., Uberoi, A., Wray, D. W., Lawrenson, L., Nishiyama, S. K., & Bailey, D. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01045.2006 · Cited by 121 · see citing works
PGC-1 coactivators in the cardiovascular system
Patten, I. S., & Arany, Z. P. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.09.007 · Cited by 119 · see citing works
The mechanism of flow-induced dilation in human adipose arterioles involves hydrogen peroxide during CAD
Phillips, S. A., Hatoum, O. A., & Gutterman, D. D. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00819.2006 · Cited by 117 · see citing works
The autophagy-lysosome pathway: A novel mechanism involved in the processing of oxidized LDL in human vascular endothelial cells
Zhang, Y., Cao, Y., Zhang, X., Liu, H., Tong, T., Xiao, G.-D., Yang, Y., & Liu, C. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.026 · Cited by 113 · see citing works
Nitration of the mitochondrial complex I subunit NDUFB8 elicits RIP1- and RIP3-mediated necrosis
Davis, C. W., Hawkins, B. J., Ramasamy, S., Irrinki, K. M., Cameron, B. A., Islam, K., Daswani, V. P., Doonan, P. J., Manevich, Y., & Madesh, M. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.11.001 · Cited by 111 · see citing works
Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species
Giedt, R. J., Yang, C., Zweier, J. L., Anastasios Matzavinos, A., & Alevriadou, B. R. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.491 · Cited by 111 · see citing works
Mitofusins are required for angiogenic function and modulate different signaling pathways in cultured endothelial cells
Lugus, J. J., Ngoh, G. A., Bachschmid, M. M., & Walsh, K. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.07.023 · Cited by 111 · see citing works
Ca2+-dependent regulation of mitochondrial dynamics by the Miro–Milton complex
Liu, X., & Hajnóczky, G. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.05.013 · Cited by 107 · see citing works
Adverse Alterations in Mitochondrial Function Contribute to Type 2 Diabetes Mellitus–Related Endothelial Dysfunction in Humans
Kizhakekuttu, T. J., Wang, J., Dharmashankar, K., Ying, R., Gutterman, D. D., Vita, J. A., & Widlansky, M. E. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.256024 · Cited by 105 · see citing works
Regulation of endothelial derived nitric oxide in health and disease
Sessa, W. C. (2005) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762005000900004 · Cited by 104 · see citing works
Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels
Rowlands, D. J., Islam, M. N., Das, S., Huertas, A., Quadri, S. K., Horiuchi, K., Inamdar, N. M., Emin, M. T., Lindert, J., Ten, V. S., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43839 · Cited by 102 · see citing works
Redox regulation of the mitochondrial KATP channel in cardioprotection
Queliconi, B. B., Wojtovich, A. P., Nadtochiy, S. M., Kowaltowski, A. J., & Brookes, P. S. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.11.005 · Cited by 99 · see citing works
CaM Kinase II-dependent pathophysiological signalling in endothelial cells
Cai, H. “., Liu, D., & Garcia, J. G. N. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm010 · Cited by 97 · see citing works
Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice
Moukdar, F., Robidoux, J., Lyght, O., Pi, J., Daniel, K. W., & Collins, S. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800273-jlr200 · Cited by 96 · see citing works
TZDs reduce mitochondrial ROS production and enhance mitochondrial biogenesis
Fujisawa, K., Nishikawa, T., Kukidome, D., Imoto, K., Yamashiro, T., Motoshima, H., Matsumura, T., & Araki, E. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.11.141 · Cited by 93 · see citing works
Dietary α-Lipoic Acid Supplementation Inhibits Atherosclerotic Lesion Development in Apolipoprotein E–Deficient and Apolipoprotein E/Low-Density Lipoprotein Receptor–Deficient Mice
Zhang, W.-J., Bird, K. E., McMillen, T. S., LeBoeuf, R. C., Hagen, T. M., & Frei, B. B. (2007) · Circulation · doi:10.1161/circulationaha.107.725275 · Cited by 91 · see citing works
Effect of Aging, MnSOD Deficiency, and Genetic Background on Endothelial Function
Brown, K. A., Didion, S. P., Andresen, J. J., & Faraci, F. M. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.146852 · Cited by 90 · see citing works
P66Shc signals to age
Trinei, M., Berniakovich, I., Beltrami, E., Migliaccio, E., Fassina, A., Pelicci, P. G., & Giorgio, M. (2009) · Aging · doi:10.18632/aging.100057 · Cited by 88 · see citing works
Human microvascular dysfunction and apoptotic injury induced by AL amyloidosis light chain proteins
Migrino, R. Q., Truran, S., Gutterman, D. D., Franco, D. A., Bright, M., Schlundt, B., Timmons, M. A., Motta, A. J., Phillips, S. A., & Hari, P. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00503.2011 · Cited by 87 · see citing works
Oxidized Low-Density Lipoprotein Stimulates p53-Dependent Activation of Proapoptotic Bax Leading to Apoptosis of Differentiated Endothelial Progenitor Cells
Cheng, J., Cui, R., Chen, C., & Du, J. (2007) · Endocrinology · doi:10.1210/en.2006-1709 · Cited by 81 · see citing works
Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-α-lipoic acid
Smith, A. R. W., & Hagen, T. M. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311447 · Cited by 80 · see citing works
Endothelium-Selective Activation of AMP-Activated Protein Kinase Prevents Diabetes Mellitus–Induced Impairment in Vascular Function and Reendothelialization via Induction of Heme Oxygenase-1 in Mice
Li, F. Y. L., Lam, K. S. L., Tse, H., Chen, C., Wang, Y., Vanhoutte, P. M., & Xu, A. (2012) · Circulation · doi:10.1161/circulationaha.112.108159 · Cited by 80 · see citing works
Deletion of Mitochondrial Uncoupling Protein-2 Increases Ischemic Brain Damage after Transient Focal Ischemia by Altering Gene Expression Patterns and Enhancing Inflammatory Cytokines
Haines, B. A., Mehta, S. L., Pratt, S. M., Warden, C. H., & Li, P. A. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.52 · Cited by 78 · see citing works
Transcriptional Control of Cardiac Fuel Metabolism and Mitochondrial FunctionPreprint
Leone, T. C., & Kelly, D. P. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.011965 · Cited by 77 · see citing works
Mitochondrial Transporter ATP Binding Cassette Mitochondrial Erythroid Is a Novel Gene Required for Cardiac Recovery After Ischemia/Reperfusion
Liesa, M., Luptak, I., Qin, F., Hyde, B. B., Sahin, E., Siwik, D. A., Zhu, Z., Pimentel, D. R., Xu, X. J., Ruderman, N. B., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.003418 · Cited by 74 · see citing works
Ca2+ Influx through Reverse Mode Na+/Ca2+ Exchange Is Critical for Vascular Endothelial Growth Factor-mediated Extracellular Signal-regulated Kinase (ERK) 1/2 Activation and Angiogenic Functions of Human Endothelial Cells
Andrikopoulos, P., Baba, A., Matsuda, T., Djamgoz, M. B. A., Yaqoob, M., & Eccles, S. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.251777 · Cited by 73 · see citing works
Pathological Significance of Mitochondrial Glycation
Pun, P. B. L., & Murphy, M. P. (2012) · International Journal of Cell Biology · doi:10.1155/2012/843505 · Cited by 72 · see citing works
Endothelial cytoskeletal elements are critical for flow-mediated dilation in human coronary arterioles
Liu, Y., Li, H., Bubolz, A. H., Zhang, D. X., & Gutterman, D. D. (2008) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-008-0331-1 · Cited by 69 · see citing works
Downregulation of Mitochondrial Connexin 43 by High Glucose Triggers Mitochondrial Shape Change and Cytochrome c Release in Retinal Endothelial Cells
Trudeau, K. M., Muto, T., & Roy, S. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-9895 · Cited by 68 · see citing works
Alpha‐lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo‐controlled randomized trial
Heinisch, B. B., Francesconi, M., Mittermayer, F., Schaller, G., Gouya, G., Wolzt, M., & Pleiner, J. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2009.02236.x · Cited by 68 · see citing works
K ATP Channel Activation Induces Ischemic Preconditioning of the Endothelium in Humans In Vivo
Broadhead, M., Kharbanda, R. K., Peters, M. J., & MacAllister, R. J. (2004) · Circulation · doi:10.1161/01.cir.0000144304.91010.f0 · Cited by 68 · see citing works
The powerhouse takes control of the cell; the role of mitochondria in signal transduction
Darley-Usmar, V. M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.026 · Cited by 67 · see citing works
Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes
Mackenzie, R. M., Salt, I. P., Miller, W. H., Logan, A., Ibrahim, H., Degasperi, A., Dymott, J. A., Hamilton, C. A., Murphy, M. P., Delles, C., et al. (2012) · Clinical Science · doi:10.1042/cs20120239 · Cited by 67 · see citing works
An Exploratory Analysis of the Effects of a Weight Loss Plus Exercise Program on Cellular Quality Control Mechanisms in Older Overweight Women
Wohlgemuth, S. E., Lees, H. A., Marzetti, E., Manini, T. M., Aranda, J. M., Daniels, M. J., Pahor, M., Perri, M. G., Leeuwenburgh, C., & Anton, S. D. (2011) · Rejuvenation Research · doi:10.1089/rej.2010.1132 · Cited by 65 · see citing works
Hyperglycemic Conditions Affect Shape and Ca2+ Homeostasis of Mitochondria in Endothelial Cells
Paltauf‐Doburzynska, J., Malli, R., & Graier, W. F. (2004) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000139449.64337.1b · Cited by 63 · see citing works
Reactive oxygen metabolites increase mitochondrial calcium in endothelial cells: Implication of the Ca2+/Na+ exchanger
Jornot, L., Maechler, P., Wollheim, C. B., & Junod, A. F. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.7.1013 · Cited by 58 · see citing works
Cardiac Autophagy
Rifki, O. F., & Hill, J. A. (2012) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3182646cb1 · Cited by 56 · see citing works
A Chemical Screen Probing the Relationship between Mitochondrial Content and Cell Size
Kitami, T., Logan, D. J., Negri, J., Hasaka, T., Tolliday, N., Carpenter, A. E., Spiegelman, B., & Mootha, V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033755 · Cited by 56 · see citing works
Associations of the UCP2 Gene Locus With Asymptomatic Carotid Atherosclerosis in Middle-Aged Women
Oberkofler, H., Iglseder, B., Klein, K., Unger, J., Haltmayer, M., Krempler, F., Paulweber, B., & Patsch, W. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000153141.42033.22 · Cited by 53 · see citing works
Peroxisome Proliferator–Activated Receptor-γ Coactivator-1 Gene Locus
Oberkofler, H., Hölzl, B., Esterbauer, H., Xie, M., Iglseder, B., Krempler, F., Paulweber, B., & Patsch, W. (2003) · Hypertension · doi:10.1161/01.hyp.0000050962.48249.b7 · Cited by 50 · see citing works
The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance
Mitra, R., Nogee, D., Zechner, J. F., Yea, K., Gierasch, C. M., Kovács, A. D., Medeiros, D. M., Kelly, D. P., & Duncan, J. G. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.10.010 · Cited by 50 · see citing works
The Common −866G>A Variant in the Promoter of UCP2 Is Associated With Decreased Risk of Coronary Artery Disease in Type 2 Diabetic Men
Cheurfa, N., Dubois‐Laforgue, D., Ferrarezi, D. A. F., Reis, A. F., Brenner, G. M., Bouché, C., Feuvre, C. L., Fumeron, F., Timsit, J., Marre, M., et al. (2008) · Diabetes · doi:10.2337/db07-1292 · Cited by 47 · see citing works
ACE Inhibition Modulates Endothelial Apoptosis and Renewal via Endothelial Progenitor Cells in Patients with Acute Coronary Syndromes
Cangiano, E., Marchesini, J., Campo, G. C., Francolini, G., Fortini, C., Carrà, G., Miccoli, M., Ceconi, C., Tavazzi, L., & Ferrari, R. (2011) · American Journal of Cardiovascular Drugs · doi:10.2165/11589400-000000000-00000 · Cited by 44 · see citing works
Association of Genetic Variation in the Mitochondrial Genome With Blood Pressure and Metabolic Traits
Liu, C., Yang, Q., Hwang, S., Sun, F., Johnson, A. D., Shirihai, O. S., Vasan, R. S., Levy, D. A., & Schwartz, F. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.196519 · Cited by 42 · see citing works
Bcl-2 in endothelial cells is increased by vitamin E and α-lipoic acid supplementation but not exercise training
Marsh, S. A., Laursen, P. B., Pat, B., Gobe, G. C., & Coombes, J. S. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.11.026 · Cited by 42 · see citing works
Heme Oxygenase-Derived Carbon Monoxide Restores Vascular Function in Type 1 Diabetes
Rodella, L. F., Vanella, L., Peterson, S. J., Drummond, G., Rezzani, R., Falck, J. R., & Abraham, N. G. (2008) · Drug Metabolism Letters · doi:10.2174/187231208786734058 · Cited by 40 · see citing works
Loss of Bcl-2 During the Senescence Exacerbates the Impaired Angiogenic Functions in Endothelial Cells by Deteriorating the Mitochondrial Redox State
Uraoka, M., Ikeda, K., Nakano-Kurimoto, R., Nakagawa, Y., Koide, M., Akakabe, Y., Kitamura, Y., Ueyama, T., Matoba, S., Yamada, H., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.176701 · Cited by 38 · see citing works
Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status
Visioli, F., SMITH, A. R. W., Zhang, W., Keaney, J. F., Hagen, T. M., & Frei, B. B. (2002) · Redox Report · doi:10.1179/135100002125000604 · Cited by 36 · see citing works
Bariatric surgery to unload the stressed heart: a metabolic hypothesis
Algahim, M. F., Sen, S., & Taegtmeyer, H. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00626.2011 · Cited by 36 · see citing works
Effect of classic preconditioning and diazoxide on endothelial function and O2− and NO generation in the post-ischemic guinea-pig heart
BERSEWICZ, A., MCZEWSKI, M., & Duda, M. K. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.02.012 · Cited by 35 · see citing works
Sirtuins and Pyridine Nucleotides
Abdellatif, M. (2012) · Circulation Research · doi:10.1161/circresaha.111.246546 · Cited by 35 · see citing works
ApoE−/− PGC-1α−/− Mice Display Reduced IL-18 Levels and Do Not Develop Enhanced Atherosclerosis
Stein, S. M. A., Lohmann, C., Handschin, C., Stenfeldt, E., Borén, J., Lüscher, T. F., & Matter, C. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013539 · Cited by 33 · see citing works
Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a role for Bcl-2
de Brito, P. M., Simões, N. F., Almeida, L. M., & Dinis, T. C. P. (2008) · APOPTOSIS · doi:10.1007/s10495-008-0235-4 · Cited by 32 · see citing works
Age-Dependent Association of the Polymorphisms in the Mitochondria-Shaping Gene, OPA1, With Blood Pressure and Hypertension in Korean Population
Jin, H., Sõber, S., Hong, K., Org, E., Kim, B. Y., Laan, M., Oh, B., & Jeong, S. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.131 · Cited by 30 · see citing works

Flagged first, then by citations

Sorted by citations

Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases
Incalza, M. A., D’Oria, R., Natalicchio, A., Perrini, S., Laviola, L., & Giorgino, F. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.05.005 · Cited by 1,375 · see citing works
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand
McWilliams, T. G., Prescott, A. R., Montava-Garriga, L., Ball, G., Singh, F., Barini, E., Muqit, M. M. K., Brooks, S. P., & Ganley, I. G. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.12.008 · Cited by 591 · see citing works
Pathological effects of ionizing radiation: endothelial activation and dysfunction
Baselet, B., Sonveaux, P., Baatout, S., & Aerts, A. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2956-z · Cited by 555 · see citing works
NLRP3 inflammasome in endothelial dysfunction
Bai, B., Yang, Y., Wang, Q., Li, M., Tian, C., Liu, Y., Aung, L. H. H., Li, P., Yu, T., & Chu, X. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02985-x · Cited by 492 · see citing works
Hallmarks of Endothelial Cell Metabolism in Health and Disease
Li, X., Sun, X., & Carmeliet, P. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.011 · Cited by 460 · see citing works
Mesenchymal stem cells rescue injured endothelial cells in an in vitro ischemia–reperfusion model via tunneling nanotube like structure-mediated mitochondrial transfer
Liu, K., Ji, K., Guo, L., Wu, W., Lu, H., Shan, P., & Yan, C. (2014) · Microvascular Research · doi:10.1016/j.mvr.2014.01.008 · Cited by 391 · see citing works
The Link Between Angiogenesis and Endothelial Metabolism
Potente, M., & Carmeliet, P. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105134 · Cited by 353 · see citing works
Mitochondria, endothelial cell function, and vascular diseases
Tang, X., Luo, Y., Chen, H., & Liu, D. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00175 · Cited by 345 · see citing works
Mitochondrial dysfunction in aging
Guo, Y., Guan, T., Shafiq, K., Yu, Q., Jiao, X., Na, D., Li, M., Zhang, G., & Kong, J. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101955 · Cited by 350 · see citing works
New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury
Wang, J., Toan, S., & Zhou, H. (2020) · Angiogenesis · doi:10.1007/s10456-020-09720-2 · Cited by 311 · see citing works
Laminar Shear Stress Inhibits Endothelial Cell Metabolism via KLF2-Mediated Repression of PFKFB3
Doddaballapur, A., Michalik, K., Manavski, Y., Lucas, T., Houtkooper, R. H., You, X. A., Chen, W., Zeiher, A. M., Potente, M., Dimmeler, S., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304277 · Cited by 298 · see citing works
Inhibitory Effect of Astaxanthin on Oxidative Stress-Induced Mitochondrial Dysfunction-A Mini-Review
Kim, S. H., & Kim, H. (2018) · Nutrients · doi:10.3390/nu10091137 · Cited by 291 · see citing works
A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan
Mohammed, I., Hollenberg, M. D., Ding, H., & Triggle, C. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.718942 · Cited by 278 · see citing works
Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice
Gioscia‐Ryan, R. A., LaRocca, T. J., Sindler, A. L., Zigler, M. C., Murphy, M. P., & Seals, D. R. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.268680 · Cited by 263 · see citing works
Role of mitochondrial quality surveillance in myocardial infarction: From bench to bedside
Zhou, H., Ren, J. T., Toan, S., & Mui, D. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101250 · Cited by 251 · see citing works
Hydrogen peroxide signaling in vascular endothelial cells
Bretón-Romero, R., & Lamas, S. (2014) · Redox Biology · doi:10.1016/j.redox.2014.02.005 · Cited by 209 · see citing works
Mechanisms of Endothelial Dysfunction in Pre-eclampsia and Gestational Diabetes Mellitus: Windows Into Future Cardiometabolic Health?
McElwain, C. J., Tuboly, E., McCarthy, F. P., & McCarthy, C. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00655 · Cited by 223 · see citing works
Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells
Zhou, X., Chen, M., Zeng, X., Yang, J., Deng, H., Yi, L., & Mt, M. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.530 · Cited by 208 · see citing works
The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis
Yetkin-Arik, B., Vogels, I. M. C., Nowak-Sliwinska, P. M., Weiss, A., Houtkooper, R. H., Noorden, C. J. F. V., Klaassen, I., & Schlingemann, R. O. (2019) · Scientific Reports · doi:10.1038/s41598-019-48676-2 · Cited by 186 · see citing works
Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes
García, N. A., Moncayo, J., Sepúlveda, P., & Díez‐Juan, A. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv260 · Cited by 185 · see citing works
Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: New insights into the mechanisms and therapeutic potentials
Wang, J., Toan, S., & Zhou, H. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104771 · Cited by 185 · see citing works
PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury
Wu, W., Xu, H. Y., Wang, Z., Mao, Y. J., Yuan, L., Luo, W., Cui, Z., Cui, T., Wang, X. L., & Shen, Y. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132499 · Cited by 181 · see citing works
l -Carnitine and heart disease
Wang, Z., Liu, Y., Liu, G., Lu, H., & Mao, C.-Y. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.12.015 · Cited by 182 · see citing works
Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events
Carvalho, C., & Moreira, P. I. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00806 · Cited by 175 · see citing works
Regulation of Mitochondrial Structure and Dynamics by the Cytoskeleton and Mechanical Factors
Bartolák‐Suki, E., Imsirovic, J., Nishibori, Y., Krishnan, R., & Suki, B. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081812 · Cited by 170 · see citing works
Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence
Kim, Y.-M., Youn, S., Varadarajan, S., Das, A., Chandhri, R., Cuervo, H., Kweon, J., Leanhart, S., He, L., Tóth, P. T., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.054 · Cited by 169 · see citing works
Palmitic acid dysregulates the Hippo–YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS–STING–IRF3 signaling mechanism
Yuan, L., Mao, Y. J., Luo, W., Wu, W., Xu, H. Y., Wang, X. L., & Shen, Y. H. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.804005 · Cited by 161 · see citing works
Metabolic memory: mechanisms and diseases
Dong, H., Sun, Y., Nie, L., Cui, A., Zhao, P., Leung, W. K., & Wang, Q. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01755-x · Cited by 181 · see citing works
Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke
Liu, K., Guo, L., Zhou, Z., Pan, M., & Yan, C. (2019) · Microvascular Research · doi:10.1016/j.mvr.2019.01.001 · Cited by 156 · see citing works
Mitochondria in endothelial cells: Sensors and integrators of environmental cues
Caja, S., & Enrı́quez, J. A. (2017) · Redox Biology · doi:10.1016/j.redox.2017.04.021 · Cited by 150 · see citing works
Mitochondrial Dysfunction in Atherosclerosis
Peng, W., Cai, G., Xia, Y., Chen, J., Wu, P., Wang, Z., Li, G., & Wei, D. (2019) · DNA and Cell Biology · doi:10.1089/dna.2018.4552 · Cited by 153 · see citing works
Oxidative Stress in Ischemic Heart Disease
Kibel, A., Lukinac, A. M., Đambić, V., Jurić, I., & Selthofer-Relatić, K. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6627144 · Cited by 149 · see citing works
Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases
Kirkman, D. L., Robinson, A. T., Rossman, M. J., Seals, D. R., & Edwards, D. G. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00917.2020 · Cited by 146 · see citing works
Leaky brain in neurological and psychiatric disorders: Drivers and consequences
Morris, G., Fernandes, B. S., Puri, B. K., Walker, A. J., Carvalho, A. F., & Berk, M. (2018) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867418796955 · Cited by 144 · see citing works
From DNA damage to functional changes of the trabecular meshwork in aging and glaucoma
Saccà, S. C., Gandolfi, S., Bagnis, A., Manni, G., Damonte, G., Traverso, C. E., & Izzotti, A. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.05.012 · Cited by 140 · see citing works
You're Only as Old as Your Arteries: Translational Strategies for Preserving Vascular Endothelial Function with Aging
Seals, D. R., Kaplon, R. E., Gioscia‐Ryan, R. A., & LaRocca, T. J. (2014) · Physiology · doi:10.1152/physiol.00059.2013 · Cited by 138 · see citing works
The metabolic engine of endothelial cells
Falkenberg, K. D., Rohlenová, K., Luo, Y., & Carmeliet, P. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0117-9 · Cited by 136 · see citing works
Large Stokes shift benzothiazolium cyanine dyes with improved intramolecular charge transfer (ICT) for cell imaging applications
Abeywickrama, C. S. (2022) · Chemical Communications · doi:10.1039/d2cc03880c · Cited by 136 · see citing works
SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress
Chang, R. P., Mamun, A., Dominic, A., & Le, N. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.605908 · Cited by 131 · see citing works
Pathological Roles of Mitochondrial Oxidative Stress and Mitochondrial Dynamics in Cardiac Microvascular Ischemia/Reperfusion Injury
Zhou, H., & Toan, S. (2020) · Biomolecules · doi:10.3390/biom10010085 · Cited by 133 · see citing works
Current insights on lipid nanocarrier-assisted drug delivery in the treatment of neurodegenerative diseases
Teixeira, M. I., Lopes, C. M., Amaral, M. H., & Costa, P. C. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2020.01.005 · Cited by 132 · see citing works
Empagliflozin attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial homeostasis
Zou, R., Shi, W., Qiu, J., Zhou, N., Du, N., Zhou, H., Chen, X., & Ma, L. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01532-6 · Cited by 128 · see citing works
Functional and morphological characteristics of the retinal and choroidal vasculature
Yu, D., Yu, P. K., Cringle, S. J., Kang, M. H., & Su, E. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.02.001 · Cited by 126 · see citing works
Mitochondrial Morphofunction in Mammalian Cells
Bulthuis, E. P., Adjobo-Hermans, M. J. W., Willems, P. H. G. M., & Koopman, W. J. H. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7534 · Cited by 128 · see citing works
The Role of Mitochondrial Reactive Oxygen Species in Cardiovascular Injury and Protective Strategies
Muntean, D. M., Sturza, A., Dănilă, M. D., Borza, C., Duicu, O., & Mornoş, C. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8254942 · Cited by 122 · see citing works
Treating the host response to emerging virus diseases: lessons learned from sepsis, pneumonia, influenza and Ebola
Fedson, D. S. (2016) · Annals of Translational Medicine · doi:10.21037/atm.2016.11.03 · Cited by 124 · see citing works
Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response
Zeng, H., Pan, T. S., Zhan, M., Hailiwu, R., Liu, B., Yang, H. Q., & Li, P. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01097-6 · Cited by 122 · see citing works
Aging: Molecular Pathways and Implications on the Cardiovascular System
de Almeida, A. J. P. O., Ribeiro, T. P., & de Medeiros, I. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7941563 · Cited by 117 · see citing works
Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders
Morris, G., Puri, B. K., Walker, A. J., Maes, M. H. J., Carvalho, A. F., Bortolasci, C. C., Walder, K. R., & Berk, M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.025 · Cited by 112 · see citing works
Involvement of mitochondrial dynamics and mitophagy in diabetic endothelial dysfunction and cardiac microvascular injury
Zhang, X., Zhou, H., & Chang, X. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03599-w · Cited by 114 · see citing works
Mitochondrial toxicity of tobacco smoke and air pollution
Fetterman, J. L., Sammy, M. J., & Ballinger, S. W. (2017) · Toxicology · doi:10.1016/j.tox.2017.08.002 · Cited by 113 · see citing works
Relation of mitochondrial oxygen consumption in peripheral blood mononuclear cells to vascular function in type 2 diabetes mellitus
Hartman, M.-L., Shirihai, O. S., HOLBROOK, M. M., Xu, G., Kocherla, M., Shah, A. K., Fetterman, J. L., Kluge, M. A., Frame, A. A., Hamburg, N. M., et al. (2014) · Vascular Medicine · doi:10.1177/1358863x14521315 · Cited by 109 · see citing works
Mitochondrial protection restores renal function in swine atherosclerotic renovascular disease
Eirin, A., Ebrahimi, B., Zhang, X., Zhu, X.-Y., Woollard, J. R., He, Q., Textor, S. C., Lerman, A., & Lerman, L. O. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu157 · Cited by 110 · see citing works
New Insights in Mechanisms and Therapeutics for Short- and Long-Term Impacts of Hepatic Ischemia Reperfusion Injury Post Liver Transplantation
Liu, H., & Man, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158210 · Cited by 108 · see citing works
Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular disease
Fetterman, J. L., Holbrook, M., Westbrook, D. G., Brown, J. A., Feeley, K. P., Bretón‐Romero, R., Linder, E. A., Berk, B. D., Weisbrod, R. M., Widlansky, M. E., et al. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0372-y · Cited by 106 · see citing works
High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission
Abuarab, N., Munsey, T. S., Jiang, L.-H., Li, J., & Sivaprasadarao, A. (2017) · Science Signaling · doi:10.1126/scisignal.aal4161 · Cited by 102 · see citing works
Mitochondrial mechanisms of endothelial dysfunction
Szewczyk, A. M., Jarmuszkiewicz, W., Kozieł, A., Broniarek, I., Nobik, W., Łukasiak, A., Skup, A., Bednarczyk, P., Drabarek, B., Dymkowska, D., et al. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.04.009 · Cited by 106 · see citing works
DNA Damage and Pulmonary Hypertension
Ranchoux, B., Meloche, J., Paulin, R., Boucherat, O., Provencher, S., & Bonnet, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060990 · Cited by 105 · see citing works
Role of PGC-1α in Vascular Regulation
Kadlec, A. O., Chabowski, D. S., Ait‐Aissa, K., & Gutterman, D. D. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307123 · Cited by 102 · see citing works
Mitochondrial injury and dysfunction in hypertension-induced cardiac damage
Eirin, A., Lerman, A., & Lerman, L. O. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu436 · Cited by 100 · see citing works
Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes
Paneni, F., Costantino, S., Castello, L., Battista, R., Capretti, G., Chiandotto, S., D’Amario, D., Scavone, G., Villano, A., Rustighi, A., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu179 · Cited by 101 · see citing works
The Role of Endothelial Ca2+ Signaling in Neurovascular Coupling: A View from the Lumen
Guerra, G., Lucariello, A., Perna, A., Botta, L., Luca, A. D., & Moccia, F. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19040938 · Cited by 100 · see citing works
Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects
Salvatore, T., Pafundi, P. C., Galiero, R., Rinaldi, L., Caturano, A., Vetrano, E., Aprea, C., Albanese, G., Di Martino, A., Ricozzi, C., et al. (2020) · Biomedicines · doi:10.3390/biomedicines9010003 · Cited by 97 · see citing works
MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury
Mannam, P., Shinn, A. S., Srivastava, A., Neamu, R., Walker, W. E., Bohanon, M. J., Merkel, J., Kang, M., Cruz, C. S. D., Ahasic, A. M., et al. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00272.2013 · Cited by 95 · see citing works
Silver nanoparticles induce endothelial cytotoxicity through ROS-mediated mitochondria-lysosome damage and autophagy perturbation: The protective role of N-acetylcysteine
He, J., Ma, Y., Niu, X., Pei, J., Yan, R., Xu, F., Ma, J., Xiao-juan, M., Jia, S., & Ma, W. (2024) · Toxicology · doi:10.1016/j.tox.2024.153734 · Cited by 90 · see citing works
Angiogenesis revisited – role and therapeutic potential of targeting endothelial metabolism
Stapor, P. C., Wang, X., Goveia, J., Moens, S., & Carmeliet, P. (2014) · Journal of Cell Science · doi:10.1242/jcs.153908 · Cited by 90 · see citing works
Mitochondrial Dysfunction and DNA Damage in the Context of Pathogenesis of Atherosclerosis
Shemiakova, T. S., Ivanova, E. A., Grechko, A. V., Владимировна, Г. Е., Sobenin, I. A., & Orekhov, A. N. (2020) · Biomedicines · doi:10.3390/biomedicines8060166 · Cited by 89 · see citing works
Circulating mitochondria in organ donors promote allograft rejection
Lin, L., Xu, H., Bishawi, M. M., Feng, F., Samy, K. P., Truskey, G. A., Barbas, A. S., Kirk, A. D., & Brennan, T. V. (2019) · American Journal of Transplantation · doi:10.1111/ajt.15309 · Cited by 89 · see citing works
Endothelium
Boulanger, C. M. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.306940 · Cited by 88 · see citing works
Mitochondria in endothelial cells angiogenesis and function: current understanding and future perspectives
Luo, Z., Yao, J., Wang, Z., & Xu, J. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04286-1 · Cited by 87 · see citing works
Mitochondria Targeted Viral Replication and Survival Strategies—Prospective on SARS-CoV-2
Gatti, P., Ilamathi, H. S., Todkar, K. J., & Germain, M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.578599 · Cited by 86 · see citing works
Targeting SIRT1 Rescues Age- and Obesity-Induced Microvascular Dysfunction in Ex Vivo Human Vessels
Mengozzi, A., Costantino, S., Paneni, F., Duranti, E., Nannipieri, M., Mancini, R., Lai, M., Rocca, V. L., Puxeddu, I., Antonioli, L., et al. (2022) · Circulation Research · doi:10.1161/circresaha.122.320888 · Cited by 87 · see citing works
Endothelial dysfunction in neuroprogressive disorders—causes and suggested treatments
Morris, G., Puri, B. K., OLIVE, L. S., Carvalho, A. F., Berk, M., Walder, K. R., Gustad, L. T., & Maes, M. H. J. (2020) · BMC Medicine · doi:10.1186/s12916-020-01749-w · Cited by 83 · see citing works
Endothelial cell–cardiomyocyte crosstalk in diabetic cardiomyopathy
Wan, A., & Rodrigues, B. B. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw159 · Cited by 84 · see citing works
Novel strategies and underlying protective mechanisms of modulation of vagal activity in cardiovascular diseases
He, X., Zhao, M. F., Bi, X., Sun, L., Yu, X., Zhao, M., & Zang, W. (2014) · British Journal of Pharmacology · doi:10.1111/bph.13010 · Cited by 81 · see citing works
Pathophysiological Mechanisms of Diabetes-Induced Macrovascular and Microvascular Complications: The Role of Oxidative Stress
Roy, B. (2025) · Medical Sciences · doi:10.3390/medsci13030087 · Cited by 89 · see citing works
Ameliorating Endothelial Mitochondrial Dysfunction Restores Coronary Function via Transient Receptor Potential Vanilloid 1–Mediated Protein Kinase A/Uncoupling Protein 2 Pathway
Xiong, S., Wang, P., Ma, L., Gao, P., Gong, L., Li, L., Li, Q., Sun, F., Zhou, X., He, H., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.06223 · Cited by 81 · see citing works
Mitochondrial quality-control dysregulation in conditional HO-1–/– mice
Suliman, H. B., Keenan, J. E., & Piantadosi, C. A. (2017) · JCI Insight · doi:10.1172/jci.insight.89676 · Cited by 78 · see citing works
From Mitochondria to Atherosclerosis: The Inflammation Path
Suarez-Rivero, J. M., Pastor‐Maldonado, C. J., Povea-Cabello, S., Álvarez-Córdoba, M., Villalón-García, I., Talaverón-Rey, M., Suárez-Carrillo, A., Munuera-Cabeza, M., & Sánchez-Alcázar, J. A. (2021) · Biomedicines · doi:10.3390/biomedicines9030258 · Cited by 77 · see citing works
Mitochondrial ATP Production is Required for Endothelial Cell Control of Vascular Tone
Wilson, C., Lee, M. D., Buckley, C., Zhang, X., & McCarron, J. G. (2022) · Function · doi:10.1093/function/zqac063 · Cited by 77 · see citing works
Exercise-Mediated Wall Shear Stress Increases Mitochondrial Biogenesis in Vascular Endothelium
Kim, B., Lee, H., Kawata, K., & Park, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111409 · Cited by 77 · see citing works
Myeloperoxidase: A versatile mediator of endothelial dysfunction and therapeutic target during cardiovascular disease
Maiocchi, S. L., Ku, J., Thai, T., Chan, E., Rees, M. D., & Thomas, S. R. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107711 · Cited by 75 · see citing works
Intracellular endothelial cell metabolism in vascular function and dysfunction
Citrin, K. M., Chaube, B., Fernandez-Hernando, C. F., & Suárez, Y. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.11.004 · Cited by 76 · see citing works
Glycolysis-mediated control of blood-brain barrier development and function
Salmina, A. B., Kuvacheva, N. V., Morgun, A. V., Komleva, Y. K., Пожиленкова, Е. А., Lopatina, O. L., Gorina, Y. V., Таранушенко, Т. Е., & Petrova, L. L. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.04.005 · Cited by 75 · see citing works
Epigenetic Control of Mitochondrial Function in the Vasculature
Mohammed, S. A., Ambrosini, S., Lüscher, T. F., Paneni, F., & Costantino, S. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00028 · Cited by 76 · see citing works
Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity
Costantino, S., Paneni, F., Virdis, A., Hussain, S., Mohammed, S. A., Capretti, G., Akhmedov, A. T., Dalgaard, K., Chiandotto, S., Pospisilik, J. A., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx615 · Cited by 74 · see citing works
Shear stress-induced mitochondrial biogenesis decreases the release of microparticles from endothelial cells
Kim, J., Kim, B., Lee, H., Thakkar, S. R., Babbitt, D. M., Eguchi, S., Brown, M. D., & Park, J. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00438.2014 · Cited by 73 · see citing works
Ferroptosis and its role in cardiomyopathy
Li, D., Pi, W., Sun, Z., Liu, X., & Jiang, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113279 · Cited by 72 · see citing works
Low shear stress induced vascular endothelial cell pyroptosis by TET2/SDHB/ROS pathway
Chen, J., Zhang, J., Wu, J., Zhang, S., Liang, Y., Zhou, B., Wu, P., & Wei, D. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.11.017 · Cited by 71 · see citing works
Epigenetic Signatures and Vascular Risk in Type 2 Diabetes: A Clinical Perspective
Paneni, F., Costantino, S., Volpe, M., Lüscher, T. F., & Cosentino, F. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.07.003 · Cited by 70 · see citing works
Salidroside Stimulates Mitochondrial Biogenesis and Protects against H2O2-Induced Endothelial Dysfunction
Xing, S., Yang, X., Li, W., Bian, F., Wu, D., Chi, J., Xu, G., Zhang, Y., & Jin, S. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/904834 · Cited by 70 · see citing works
Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis
Dominic, A., Banerjee, P., Hamilton, D. J., Le, N., & Abe, J. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101614 · Cited by 71 · see citing works
Hyperoxia Causes Mitochondrial Fragmentation in Pulmonary Endothelial Cells by Increasing Expression of Pro-Fission Proteins
Ma, C., Beyer, A., Durand, M. J., Clough, A. V., Zhu, D., Toro, L. N., Terashvili, M., Ebben, J. D., Hill, R. B., Audi, S. H., et al. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.310605 · Cited by 70 · see citing works
Vitamin D Deficiency in Older Patients—Problems of Sarcopenia, Drug Interactions, Management in Deficiency
Kupisz-Urbańska, M., Płudowski, P., & Marcinowska-Suchowierska, E. (2021) · Nutrients · doi:10.3390/nu13041247 · Cited by 69 · see citing works
Inorganic nitrite supplementation for healthy arterial aging
Sindler, A. L., DeVan, A. E., Fleenor, B. S., & Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01100.2013 · Cited by 68 · see citing works
Ovarian mitochondrial dynamics and cell fate regulation in an androgen-induced rat model of polycystic ovarian syndrome
Salehi, R., Mazier, H. L., Nivet, A., Reunov, A., Lima, P., Wang, Q., Fiocco, A., Isidoro, C., & Tsang, B. K. (2020) · Scientific Reports · doi:10.1038/s41598-020-57672-w · Cited by 68 · see citing works
Lifelong voluntary aerobic exercise prevents age‐ and Western diet‐ induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice
Gioscia‐Ryan, R. A., Clayton, Z. S., Zigler, M. C., Richey, J. J., Cuevas, L. M., Rossman, M. J., Battson, M. L., Ziemba, B. P., Hutton, D. A., VanDongen, N. S., et al. (2020) · The Journal of Physiology · doi:10.1113/jp280607 · Cited by 68 · see citing works
Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension
Eirin, A., Ebrahimi, B., Kwon, S. H., Fiala, J. A., WILLIAMS, B. J., Woollard, J. R., He, Q., Gupta, R. C., Sabbah, H. N., Prakash, Y. S., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.003118 · Cited by 67 · see citing works
12(S)-HETE mediates diabetes-induced endothelial dysfunction by activating intracellular endothelial cell TRPV1
Otto, M., Bucher, C., Liu, W., Müller, M., Schmidt, T., Kardell, M., Driessen, M. N., Rossaint, J., Gross, E. R., & Wagner, N. (2020) · Journal of Clinical Investigation · doi:10.1172/jci136621 · Cited by 66 · see citing works
A detrimental role of endothelial S1PR2 in cardiac ischemia-reperfusion injury via modulating mitochondrial dysfunction, NLRP3 inflammasome activation, and pyroptosis
Duan, Y., Li, Q., Wu, J., Zhou, C., Liu, X., Yue, J., Chen, X., Liu, J., Zhang, Q., Zhang, Y., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103244 · Cited by 66 · see citing works

Mitochondria, endothelial cell function, and vascular diseases
Tang, X., Luo, Y., Chen, H., & Liu, D. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00175 · Cited by 345 · see citing works
Endothelial mitochondria—less respiration, more integration
Groschner, L. N., Waldeck‐Weiermair, M., Malli, R., & Graier, W. F. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1085-z · Cited by 124 · see citing works
MOLECULAR AND CELLULAR MECHANISMS OF DISEASE Endothelial mitochondria—less respiration, more integration
Groschner, L. N., Waldeck‐Weiermair, M., & Graier, W. F. (2012)
Mitochondrial signaling in the vascular endothelium: beyond reactive oxygen species
Kadlec, A. O., Beyer, A., Ait‐Aissa, K., & Gutterman, D. D. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0546-5 · Cited by 59 · see citing works
Mitochondrial reactive oxygen species-mediated signaling in endothelial cells
Zhang, D. X., & Gutterman, D. D. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01283.2006 · Cited by 432 · see citing works

Authors: Kluge, M. A., Fetterman, J. L., & Vita, J. A.
Affiliations: Boston University (US)
ORCID: Fetterman, Jessica L.
Vita, Joseph A.
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2013-04-12
Volume: 112
Issue: 8
Pages: 1171-1188
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.111.300233
PMC: PMC3700369
OpenAlex: W2171435588
Cited by: 508
References: 213
Citations by year: 2026: 25 · 2025: 44 · 2024: 49 · 2023: 34 · 2022: 60 · 2021: 52 · 2020: 49 · 2019: 33 · 2018: 37 · 2017: 37 · 2016: 25 · 2015: 25 · 2014: 34 · 2013: 4
FWCI: 2.76
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (P01HL060886, R01HL102299, HL081587, P50HL083801, K12HL083781, P01HL081587, R01HL075795, T32HL007224, HL083781, R01HL083269, HL083801, HL102299, R01HL115391)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords: mitochondria, endothelial cells, endothelial function, mitochondrial biogenesis, mitochondrial dynamics, mitophagy, reactive oxygen species, calcium homeostasis, regulated cell death, heme biosynthesis, vascular tone, angiogenesis, inflammation, mitochondrial-targeted therapy, cardiovascular disease
MeSH terms: Animals, Autophagy, Endothelium, Vascular, Homeostasis, Humans, Mitochondria, Signal Transduction, Reactive Oxygen Species, Endothelial Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mitochondria and Endothelial Function

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks