The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
SIRT‐1 and vascular endothelial dysfunction with ageing in mice and humans
Open accessAbstract
Non‐technical summary Advancing age is a major risk factor for the development of cardiovascular disease. A key characteristic of older arteries that may lead to cardiovascular disease is reduced endothelial function, characterized by blunted endothelium‐dependent dilatation. Sirtuins, specifically sirtuin‐1, are proteins linked to increases in lifespan and lower incidence of age‐related diseases. We hypothesized that diminished sirtuin‐1 with advancing age may alter regulation of a key endothelium dilatory enzyme, nitric oxide synthase. Our findings provide novel translational evidence that sirtuin‐1 expression and activity contribute to arterial endothelial dysfunction with ageing and that this may be due to altered nitric oxide synthase activation. Importantly, our results provide further compelling support for sirtuin‐1 as a potential therapeutic target for lifestyle and pharmacological interventions aimed at the prevention and treatment of arterial ageing and age‐associated cardiovascular diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., & Sinclair, D. A. (2004) · Science · doi:10.1126/science.1099196 · Cited by 1,924
Celermajer, D. S., Sorensen, K. E., Bull, C., Robinson, J., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90141-4 · Cited by 1,229
Yeboah, J., Crouse, J. R., Hsu, F.-C., Burke, G. L., & Herrington, D. M. (2007) · Circulation · doi:10.1161/circulationaha.106.678276 · Cited by 891
Mattagajasingh, I., Kim, C.-S., Naqvi, A., Yamamori, T., Hoffman, T. A., Jung, S.-B., DeRicco, J., Kasuno, K., & Irani, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704329104 · Cited by 881
Aging and vascular endothelial function in humans
Seals, D. R., Jablonski, K. L., & Donato, A. J. (2011) · Clinical Science · doi:10.1042/cs20100476 · Cited by 725
Self-citationEnhanced Peroxynitrite Formation Is Associated with Vascular Aging
van der Loo, B., Labugger, R., Skepper, J. N., Bachschmid, M., Kilo, J., Powell, J. M., Palacios-Callender, M., Erusalimsky, J. D., Quaschning, T., Malinski, T., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1731 · Cited by 675
Age-Related Reduction of NO Availability and Oxidative Stress in Humans
Taddei, S., Virdis, A., Ghiadoni, L., Salvetti, G., Bernini, G., Magagna, A., & Salvetti, A. (2001) · Hypertension · doi:10.1161/01.hyp.38.2.274 · Cited by 664
Reporting ethical matters in The Journal of Physiology: standards and advice
Drummond, G. B. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.167387 · Cited by 570
Metabolic adaptations through the PGC‐1α and SIRT1 pathways
Rodgers, J. T., Lerin, C., Gerhart-Hines, Z., & Puigserver, P. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.11.034 · Cited by 561
Donato, A. J., Eskurza, I., Silver, A. E., Levy, A. S., Pierce, G. L., Gates, P. E., & Seals, D. R. (2007) · Circulation Research · doi:10.1161/01.res.0000269183.13937.e8 · Cited by 558
Self-citationMenopause Is Associated With Endothelial Dysfunction in Women
Taddei, S., Virdis, A., Ghiadoni, L., Mattei, P., Sudano, I., Bernini, G., Pinto, S., & Salvetti, A. (1996) · Hypertension · doi:10.1161/01.hyp.28.4.576 · Cited by 474
Sirtuins as potential targets for metabolic syndrome
Guarente, L. (2006) · Nature · doi:10.1038/nature05486 · Cited by 468
Sirtuins: The ‘ magnificent seven ’, function, metabolism and longevity
Dali‐Youcef, N., Lagouge, M., Froelich, S., Koehl, C., Schoonjans, K., & Auwerx, J. (2007) · Annals of Medicine · doi:10.1080/07853890701408194 · Cited by 402
Zhang, Q.-J., Wang, Z., Chen, H.-Z., Zhou, S., Zheng, W., Liu, G., Wei, Y.-S., Cai, H., Liu, D.-P., & Liang, C.-C. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn224 · Cited by 349
Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase
Donato, A. J., Gano, L. B., Eskurza, I., Silver, A. E., Gates, P. E., Jablonski, K., & Seals, D. R. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00689.2008 · Cited by 316
Self-citationShear stress, SIRT1, and vascular homeostasis
Chen, Z., Peng, I.-C., Cui, X., Li, Y.-S., Chien, S., & Shyy, J. Y.-J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003833107 · Cited by 281
Mechanisms Underlying Caloric Restriction and Lifespan Regulation: Implications for Vascular Aging
Ungvari, Z. I., Parrado‐Fernández, C., Csiszár, A., & de Cabo, R. (2008) · Circulation Research · doi:10.1161/circresaha.107.168369 · Cited by 245
Durrant, J. R., Seals, D. R., Connell, M. L., Russell, M. J., Lawson, B. R., Folian, B. J., Donato, A. J., & Lesniewski, L. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.169771 · Cited by 244
Self-citationDonato, A. J., Black, A. D., Jablonski, K. L., Gano, L. B., & Seals, D. R. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00438.x · Cited by 237
Self-citationOta, H., Eto, M., Kano, M. R., Ogawa, S., Iijima, K., Akishita, M., & Ouchi, Y. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.164368 · Cited by 226
Endothelial Function in Resistance and Conduit Arteries and 5-Year Risk of Cardiovascular Disease
Lind, L., Berglund, L., Larsson, A., & Sundström, J. (2011) · Circulation · doi:10.1161/circulationaha.110.984047 · Cited by 218
Ota, H., Eto, M., Kano, M. R., Kahyo, T., Setou, M., Ogawa, S., Iijima, K., Akishita, M., & Ouchi, Y. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.110.210500 · Cited by 218
Spier, S. A., Delp, M. D., Meininger, C. J., Donato, A. J., Ramsey, M. W., & Muller‐Delp, J. M. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.060301 · Cited by 209
Self-citationFleming, I., & Busse, R. (1999) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1998.0839 · Cited by 198
Silver, A. E., Beske, S. D., Christou, D. D., Donato, A. J., Moreau, K. L., Eskurza, I., Gates, P. E., & Seals, D. R. (2007) · Circulation · doi:10.1161/circulationaha.106.657486 · Cited by 190
Self-citationPierce, G. L., Beske, S. D., Lawson, B. R., Southall, K. L., Benay, F. J., Donato, A. J., & Seals, D. R. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.111427 · Cited by 168
Self-citationRippe, C., Lesniewski, L., Connell, M., LaRocca, T., Donato, A., & Seals, D. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00557.x · Cited by 159
Self-citationWoodman, C. R., Price, E. M., & Laughlin, M. H. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00461.2002 · Cited by 119
Gates, P. E., Boucher, M. L., Silver, A., Monahan, K. D., & Seals, D. R. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00660.2006 · Cited by 107
Self-citationEskurza, I., Kahn, Z. D., & Seals, D. R. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.102566 · Cited by 99
Self-citationAscorbic Acid Selectively Improves Large Elastic Artery Compliance in Postmenopausal Women
Moreau, K. L., Gavin, K. M., Plum, A. E., & Seals, D. R. (2005) · Hypertension · doi:10.1161/01.hyp.0000165678.63373.8c · Cited by 96
Self-citationDonato, A. J., Lesniewski, L. A., & Delp, M. D. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.10.023 · Cited by 94
Self-citationLesniewski, L. A., Connell, M., Durrant, J., Folian, B. J., Anderson, M. C., Donato, A. J., & Seals, D. R. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln049 · Cited by 90
Self-citationAgeing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arterioles
Donato, A. J., Lesniewski, L. A., & Delp, M. D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.120055 · Cited by 89
Self-citationColombo, P. C., Ashton, A. W., Celaj, S., Talreja, A., Banchs, J. E., Dubois, N. B., Marinaccio, M., Malla, S., Lachmann, J. S., Ware, J. A., et al. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00680.2001 · Cited by 79
Aging‐Induced Adaptations of Microvascular Reactivity
Muller‐Delp, J. M. (2006) · Microcirculation · doi:10.1080/10739680600619023 · Cited by 76
Lesniewski, L. A., Durrant, J., Connell, M., Folian, B. J., Donato, A. J., & Seals, D. R. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq233 · Cited by 72
Self-citationHuman Endothelium: Endovascular Biopsy and Molecular Analysis
Feng, L., Stern, D. M., & Pile‐Spellman, J. (1999) · Radiology · doi:10.1148/radiology.212.3.r99au28655 · Cited by 60
Sirtuins, nuclear hormone receptor acetylation and transcriptional regulation
Whittle, J. R., Powell, M. J., Popov, V. M., Shirley, L. A., Wang, C., & Pestell, R. G. (2007) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2007.07.007 · Cited by 51
Donato, A. J., Eskurza, I., Jablonski, K., Gano, L. B., Pierce, G. L., & Seals, D. R. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90629.2008 · Cited by 27
Self-citation
Cited by
Ungvari, Z., Tarantini, S., Donato, A. J., Galvan, V., & Csiszar, A. (2018) · Circulation Research · doi:10.1161/circresaha.118.311378 · Cited by 919
Self-citationMartens, C. R., Denman, B. A., Mazzo, M. R., Armstrong, M. L., Reisdorph, N., McQueen, M. B., Chonchol, M., & Seals, D. R. (2018) · Nature Communications · doi:10.1038/s41467-018-03421-7 · Cited by 588
Self-citationCellular and molecular biology of aging endothelial cells
Donato, A. J., Morgan, R. G., Walker, A. E., & Lesniewski, L. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.01.021 · Cited by 538
Self-citationMitochondria and Endothelial Function
Kluge, M. A., Fetterman, J. L., & Vita, J. A. (2013) · Circulation Research · doi:10.1161/circresaha.111.300233 · Cited by 508
Picciotto, N. E., Gano, L. B., Johnson, L. C., Martens, C. R., Sindler, A. L., Mills, K. F., Imai, S., & Seals, D. R. (2016) · Aging Cell · doi:10.1111/acel.12461 · Cited by 396
Self-citation
Metadata
- Authors
- Donato, A. J., Magerko, K. A., Lawson, B. R., Durrant, J. R., Lesniewski, L. A., & Seals, D. R.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2011-09
- Volume
- 589
- Issue
- 18
- Pages
- 4545-4554
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1578616085
- Cited by
- 271
- References
- 40
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
