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Metabolic adaptations through the PGC‐1α and SIRT1 pathways
Abstract
Energy homeostasis in mammals is achieved through tight regulation of tissue‐specific metabolic pathways that become dysregulated in metabolic diseases including diabetes and obesity. At the molecular level, main nutrient and hormonal signaling pathways impinge on expression of genes encoding for metabolic enzymes. Among the major components of this transcriptional circuitry are the PGC‐1α transcriptional complexes. An important regulatory mechanism of this complex is through acetylation and SIRT1‐mediated lysine de‐acetylation under low nutrient conditions. Activation of SIRT1 can mimic several metabolic aspects of calorie restriction that target selective nutrient utilization and mitochondrial oxidative function to regulate energy balance. Thus, understanding the PGC‐1α and SIRT1 pathways might have important implications for comprehending metabolic and age‐associated diseases.
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In liver cells, AMPK suppresses autophagy at the level of cargo sequestration.
“In liver cells, AMPK suppresses autophagy at the level of cargo sequestration, as indicated by the rapid sequestration-inhibitory effects of a variety of AMPK activators”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [665]
AMPK appears to stimulate autophagy in many other cell types, including fibroblasts, colon carcinoma cells and skeletal muscle.
“whereas it appears to stimulate autophagy in many other cell types, including fibroblasts, colon carcinoma cells and skeletal muscle [656-665]”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [665]
Under glucose starvation, AMPK apparently promotes autophagy by directly activating ULK1 through phosphorylation, although the exact AMPK-mediated ULK1 phosphorylation site(s) remains controversial.
“Under glucose starvation, AMPK apparently promotes autophagy by directly activating ULK1 through phosphorylation, although the exact AMPK-mediated ULK1 phosphorylation site(s) remains controversial (Table 2) [665, 669-671].”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [665]
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Metadata
- Authors
- Rodgers, J. T., Lerin, C., Gerhart-Hines, Z., & Puigserver, P.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2007-11-26
- Volume
- 582
- Issue
- 1
- Pages
- 46-53
- ISSN
- 0014-5793
- 1873-3468
- Cited by
- 561
- References
- 20
- Language
- en
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