The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The role of fructose transporters in diseases linked to excessive fructose intake
Open accessAbstract
Fructose intake has increased dramatically since humans were hunter‐gatherers, probably outpacing the capacity of human evolution to make physiologically healthy adaptations. Epidemiological data indicate that this increasing trend continued until recently. Excessive intakes that chronically increase portal and peripheral blood fructose concentrations to >1 and 0.1 m m, respectively, are now associated with numerous diseases and syndromes. The role of the fructose transporters GLUT5 and GLUT2 in causing, contributing to or exacerbating these diseases is not well known. GLUT5 expression seems extremely low in neonatal intestines, and limited absorptive capacities for fructose may explain the high incidence of malabsorption in infants and cause problems in adults unable to upregulate GLUT5 levels to match fructose concentrations in the diet. GLUT5‐ and GLUT2‐mediated fructose effects on intestinal electrolyte transporters, hepatic uric acid metabolism, as well as renal and cardiomyocyte function, may play a role in fructose‐induced hypertension. Likewise, GLUT2 may contribute to the development of non‐alcoholic fatty liver disease by facilitating the uptake of fructose. Finally, GLUT5 may play a role in the atypical growth of certain cancers and fat tissues. We also highlight research areas that should yield information needed to better understand the role of these GLUTs in fructose‐induced diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696
Stanhope, K. L., Schwarz, J. M., Keim, N. L., Griffen, S. C., Bremer, A. A., Graham, J. L., Hatcher, B., Cox, C. L., Dyachenko, A., Zhang, W., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37385 · Cited by 1,765
Glucose transporters in the 21st Century
Thorens, B., & Mueckler, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00712.2009 · Cited by 1,013
Gorboulev, V., Schürmann, A., Vallon, V., Kipp, H., Jaschke, A., Klessen, D., Friedrich, A., Scherneck, S., Rieg, T., Cunard, R., et al. (2012) · Diabetes · doi:10.2337/db11-1029 · Cited by 687
Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study
Choi, H. K., & Curhan, G. (2008) · BMJ · doi:10.1136/bmj.39449.819271.be · Cited by 577
National Estimates of Dietary Fructose Intake Increased from 1977 to 2004 in the United States
Marriott, B. P., Cole, N., & Lee, E. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.098277 · Cited by 473
Dietary and developmental regulation of intestinal sugar transport
FERRARIS, R. P. (2001) · Biochemical Journal · doi:10.1042/bj3600265 · Cited by 328 · cited 4×
“Consumption of 65% fructose pellets by young rats results in 26 mM fructose concentrations in the intestinal lumen, although luminal sugar concentrations in the gut are known to increase dramatically at night (up to an average of ∼100 mM) when rats eat (Ferraris et al. 1990; Jiang & Ferraris, 2001).”
BackgroundInfluentialSelf-citationIncomplete absorption of pure fructose in healthy subjects and the facilitating effect of glucose.
Truswell, A., Seach, J., & Thorburn, A. (1988) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/48.6.1424 · Cited by 189
Cited by
Review article: the diagnosis and management of food allergy and food intolerances
Turnbull, J. L., Adams, H. N., & Gorard, D. A. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12984 · Cited by 306
Glucose transporters in the small intestine in health and disease
Koepsell, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02439-5 · Cited by 290
Intestinal Absorption of Fructose
Ferraris, R. P., Choe, J.-Y., & Patel, C. R. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051707 · Cited by 180
Self-citationMastrocola, R., Ferrocino, I., Liberto, E., Chiazza, F., Cento, A. S., Collotta, D., Querio, G., Nigro, D., Bitonto, V., Cutrin, J. C., et al. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.02.003 · Cited by 68
Fructose metabolism and noncommunicable diseases: recent findings and new research perspectives
Tappy, L. (2018) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000460 · Cited by 37
Metadata
- Authors
- Douard, V., & Ferraris, R. P.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2012-12-17
- Volume
- 591
- Issue
- 2
- Pages
- 401-414
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1557716110
- Cited by
- 185
- References
- 8
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The role of fructose transporters in diseases linked to excessive fructose intake. https://app.cochat.ai/papers/10.1113/jphysiol.2011.215731
- The paper
- Douard, V., & Ferraris, R. P. (2013). The role of fructose transporters in diseases linked to excessive fructose intake. The Journal of Physiology. https://doi.org/10.1113/jphysiol.2011.215731
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
