The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Evaluating the physiological significance of respiratory sinus arrhythmia: looking beyond ventilation–perfusion efficiency
Open accessAbstract
Key points Respiratory sinus arrhythmia (RSA) is the variation of heart rate with breathing: heart rate increases during inspiration and decreases during expiration. RSA is seen in many species including humans where it is strongest in the young and fit. The loss of RSA has been linked with cardiac mortality; however, the function of RSA is presently unknown. One hypothesis proposed previously is that RSA allows for more efficient gas exchange between the lungs and the blood. Our theoretical study does not support this hypothesis. Instead, a new hypothesis is proposed and tested using computational tools – that RSA helps the heart do less work while maintaining healthy levels of blood gases. Of course, this new hypothesis needs to be further tested both experimentally and by using more sophisticated mathematical models, but if correct, it could explain why inducing RSA artificially in patients with cardiovascular disease improves their health.
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Citations
Cites
Respiratory sinus arrhythmia in humans: how breathing pattern modulates heart rate
Hirsch, J. A., & Bishop, B. (1981) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1981.241.4.h620 · Cited by 1,105
Yasuma, F., & Hayano, J.-I. (2004) · Chest · doi:10.1378/chest.125.2.683 · Cited by 907
Chronic vagus nerve stimulation: A new and promising therapeutic approach for chronic heart failure
De Ferrari, G. M., Crijns, H. J. G. M., Borggrefe, M., Milasinovic, G., Smid, J., Zabel, M., Gavazzi, A., Sanzo, A., Dennert, R., Kuschyk, J., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehq391 · Cited by 523
Hayano, J., Yasuma, F., Okada, A., Mukai, S., & Fujinami, T. (1996) · Circulation · doi:10.1161/01.cir.94.4.842 · Cited by 332
The yin and yang of cardiac autonomic control: Vago-sympathetic interactions revisited
Paton, J. F. R., Boscan, P., Pickering, A. E., & Nalivaiko, E. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.02.005 · Cited by 308
Self-citationRespiratory sinus arrhythmia in conscious humans during spontaneous respiration.
Larsen, P. D., Tzeng, Y. C., Sin, P. Y. W., & Galletly, D. C. (2010) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2010.04.021 · Cited by 161 · cited 2×
“2005, 2006), yet the physiological significance of RSA remains controversial (Larsen et al. 2010).”
BackgroundGiardino, N. D., Glenny, R. W., Borson, S., & Chan, L. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00893.2002 · Cited by 144
Cited by
The physiological effects of slow breathing in the healthy human
Russo, M. A., Santarelli, D. M., & O’Rourke, D. (2017) · Breathe · doi:10.1183/20734735.009817 · Cited by 665
“Cardiorespiratory Augments LF HRV and baroreflex sensitivity [41, 60, 65, 66, 77] Increases RSA (maximises around 6 breaths per min (resonant frequency)) [41, 61, 62, 72–75] Improves pulmonary gas exchange efficiency [45, 47, 48, 78–80], minimises cardiac work [74, 80, 81], buffers blood pressure fluctuations [29, 35]…”
BackgroundEverything Hertz: methodological issues in short-term frequency-domain HRV.
Heathers, J. A. J. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00177 · Cited by 322
The nucleus of the solitary tract and the coordination of respiratory and sympathetic activities
Zoccal, D. B., Furuya, W. I., Bassi, M., Colombari, D. S. A., & Colombari, E. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00238 · Cited by 254
Dick, T. E., Hsieh, Y.-H., Dhingra, R. R., Baekey, D. M., Galán, R. F., Wehrwein, E., & Morris, K. F. (2014) · Progress in Brain Research · doi:10.1016/b978-0-444-63274-6.00010-2 · Cited by 178
Increased cardio-respiratory coupling evoked by slow deep breathing can persist in normal humans
Dick, T. E., Mims, J. R., Hsieh, Y.-H., Morris, K. F., & Wehrwein, E. A. (2014) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2014.09.013 · Cited by 65
Metadata
- Authors
- Ben‐Tal, A., Shamailov, S. S., & Paton, J. F. R.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2012-04-13
- Volume
- 590
- Issue
- 8
- Pages
- 1989-2008
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1580490094
- Cited by
- 161
- References
- 7
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- green
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