Cited by 131Cardiac electrophysiology and arrhythmiasCardiac pacing and defibrillation studiesCardiovascular Function and Risk Factors

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Biomechanics of Cardiac Electromechanical Coupling and Mechanoelectric Feedback

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Pfeiffer, Emily R., Tangney, Jared R., Omens, Jeffrey H., McCulloch, Andrew D.·2014·Journal of Biomechanical Engineering

DOI 10.1115/1.4026221PMC PMC4023651

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Abstract

Cardiac mechanical contraction is triggered by electrical activation via an intracellular calcium-dependent process known as excitation–contraction coupling. Dysregulation of cardiac myocyte intracellular calcium handling is a common feature of heart failure. At the organ scale, electrical dyssynchrony leads to mechanical alterations and exacerbates pump dysfunction in heart failure. A reverse coupling between cardiac mechanics and electrophysiology is also well established. It is commonly referred as cardiac mechanoelectric feedback and thought to be an important contributor to the increased risk of arrhythmia during pathological conditions that alter regional cardiac wall mechanics, including heart failure. At the cellular scale, most investigations of myocyte mechanoelectric feedback have focused on the roles of stretch-activated ion channels, though mechanisms that are independent of ionic currents have also been described. Here we review excitation–contraction coupling and mechanoelectric feedback at the cellular and organ scales, and we identify the need for new multicellular tissue-scale model systems and experiments that can help us to obtain a better understanding of how interactions between electrophysiological and mechanical processes at the cell scale affect ventricular electromechanical interactions at the organ scale in the normal and diseased heart.

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Authors: Pfeiffer, E. R., Tangney, J. R., Omens, J. H., & McCulloch, A. D.
Affiliations: University of California San Diego (US)
Corresponding author: McCulloch, Andrew D.
ORCID: Pfeiffer, Emily R.
Omens, Jeffrey H.
McCulloch, Andrew D.
Venue: Journal of Biomechanical Engineering
Publisher: ASME International
Published: 2014-02-01
Volume: 136
Issue: 2
Pages: 021007-021007
ISSN: 0148-0731 (ISSN-L)
1528-8951
DOI: 10.1115/1.4026221
PMC: PMC4023651
OpenAlex: W2028446666
Cited by: 131
References: 152
Citations by year: 2026: 7 · 2025: 11 · 2024: 10 · 2023: 15 · 2022: 11 · 2021: 13 · 2020: 13 · 2019: 12 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 11 · 2014: 4
FWCI: 1.31
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Biomechanical Engineering (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL105242)
National Institute of General Medical Sciences
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords: mechano-electric feedback, excitation-contraction coupling, intracellular calcium homeostasis, heart failure, electrical dyssynchrony, ventricular arrhythmias, stretch-activated channels, cardiomyocytes, ventricular mechanics
MeSH terms: Animals, Heart Conduction System, Humans, Models, Cardiovascular, Myocardial Contraction, Ventricular Function, Feedback, Physiological, Myocytes, Cardiac, Excitation Contraction Coupling

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Biomechanics of Cardiac Electromechanical Coupling and Mechanoelectric Feedback

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