Imaging skin pathology with polarized light
Open accessAbstract
Linearly polarized light that illuminates skin is backscattered by superficial layers and rapidly depolarized by birefringent collagen fibers. It is possible to distinguish such superficially backscattered light from the total diffusely reflected light that is dominated by light penetrating deeply into the dermis. The method involves acquisition of two images through an analyzing linear polarizer in front of the camera, one image (I par) acquired with the analyzer oriented parallel to the polarization of illumination and one image (I per) acquired with the analyzer oriented perpendicular to the illumination. An image based on the polarization ratio, Pol5(I par-I per)/(I par+I per), is created. This paper compares normal light images, represented by I per , and Pol images of various skin pathologies in a pilot clinical study using incoherent visible-spectrum light. Images include pigmented skin sites (freckle, tattoo, pigmented nevi) and unpigmented skin sites [nonpigmented intradermal nevus, neurofibroma, actinic keratosis, malignant basal cell carcinoma, squamous cell carcinoma, vascular abnormality (venous lake), burn scar]. Images of a shadow cast from a razor blade onto a forearm skin site illustrate the behavior of Pol values near the shadow edge. Near the shadow edge, Pol approximately doubles in value because no I per photons are superficially scattered into the shadow-edge pixels by the shadow region while I par photons are directly backscattered from the superficial layer of these pixels. This result suggests that the point spread function in skin for cross-talk between Pol pixels has a half-width-half-max of about 390 µm.
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Some medical optical imaging techniques use polarized light including polarization-sensitive OCT, polarized light elastic scattering spectroscopy, and cross-polarized light imaging.
“some medical optical imaging techniques use polarized light including polarization-sensitive OCT, polarized light elastic scattering spectroscopy, and cross-polarized light imaging.149–151”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [150]
Changes in the polarisation state of light can be used to provide information about tissues, including the superficial layers of the skin, by characterising the depolarisation of light as it propagates.
“In addition, changes in the polarisation state of light can be used to provide information about tissues, including the superficial layers of the skin, by characterising the depolarisation of light as it propagates [88,89].”
From Relevance and utility of the in-vivo and ex-vivo optical properties of the skin reported in the literature: a review [Invited] (2023) · cites this paper as [88]
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Cites
In Vivo Confocal Scanning Laser Microscopy of Human Skin: Melanin Provides Strong Contrast
Rajadhyaksha, M. M., Grossman, M. C., Esterowitz, D., Webb, R. H., & Anderson, R. R. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12606215 · Cited by 1,090 · see citing works
de Boer, J. F., Milner, T. E., van Gemert, M. J. C., & Nelson, J. S. (1997) · Optics Letters · doi:10.1364/ol.22.000934 · Cited by 884 · see citing works
Perelman, L. T., Backman, V., Wallace, M. B., Zonios, G. I., Manoharan, R., Nusrat, A., Shields, S. J., Seiler, M., Lima, C., Hamano, T., et al. (1998) · Physical Review Letters · doi:10.1103/physrevlett.80.627 · Cited by 492 · see citing works
(1998) · Cited by 445 · see citing works
Demos, S. G., & Alfano, R. R. (1997) · Applied Optics · doi:10.1364/ao.36.000150 · Cited by 407 · see citing works
Backman, V., Gurjar, R. S., Badizadegan, K., Itzkan, I., Dasari, R. R., Perelman, L. T., & Feld, M. S. (1999) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/2944.796325 · Cited by 396 · see citing works
Imaging superficial tissues with polarized light
Jacques, S. L., Roman, J. R., & Lee, K. C. L. (2000) · Lasers in Surgery and Medicine · doi:10.1002/(sici)1096-9101(2000)26:2 · Cited by 370 · see citing works
Self-citationUse of polarized light to discriminate short-path photons in a multiply scattering medium
Schmitt, J. M., Gandjbakhche, A., & Bonner, R. F. (1992) · Applied Optics · doi:10.1364/ao.31.006535 · Cited by 293 · see citing works
Polarized Light Examination and Photography of the Skin
Anderson, R. R. (1991) · Archives of Dermatology · doi:10.1001/archderm.1991.01680060074007 · Cited by 292 · see citing works
Yao, G., & Wang, L. V. (1999) · Optics Letters · doi:10.1364/ol.24.000537 · Cited by 232 · see citing works
Hielscher, A. H., Mourant, J. R., & Bigio, I. J. (1997) · Applied Optics · doi:10.1364/ao.36.000125 · Cited by 229 · see citing works
Reflectance spectroscopy with polarized light: is it sensitive to cellular and nuclear morphology
Sokolov, K., Drezek, R. A., Gossage, K. W., & Richards-Kortum, R. R. (1999) · Optics Express · doi:10.1364/oe.5.000302 · Cited by 190 · see citing works
Jiao, S., Yao, G., & Wang, L. V. (2000) · Applied Optics · doi:10.1364/ao.39.006318 · Cited by 165 · see citing works
Comparison of polarized-light propagation in biological tissue and phantoms
Sankaran, V., Everett, M. J., Maitland, D. J., & Walsh, J. T. (1999) · Optics Letters · doi:10.1364/ol.24.001044 · Cited by 133 · see citing works
Interpreting Mueller matrix images of tissues
Smith, M. H. (2001) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.434690 · Cited by 87 · see citing works
Polarization discrimination of coherently propagating light in turbid media
Sankaran, V., Schönenberger, K., Walsh, J. T., & Maitland, D. J. (1999) · Applied Optics · doi:10.1364/ao.38.004252 · Cited by 79 · see citing works
Coherence and polarization of light propagating through scattering media and biological tissues
Jarry, G., Steimer, E., Damaschini, V., Epifanie, M., Jurczak, M., & Kaiser, R. (1998) · Applied Optics · doi:10.1364/ao.37.007357 · Cited by 71 · see citing works
Polarized light propagation through tissue phantoms containing densely packed scatterers
Sankaran, V., Walsh, J. T., & Maitland, D. J. (2000) · Optics Letters · doi:10.1364/ol.25.000239 · Cited by 61 · see citing works
Studinski, R., & Vitkin, I. A. (2000) · Journal of Biomedical Optics · doi:10.1117/1.430004 · Cited by 58 · see citing works
Jacques, S. L., Ostermeyer, M. R., Wang, L. V., & Stephens, D. V. (1996) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.240009 · Cited by 50 · see citing works
Self-citationCardaliaguet, P. (1997) · Applied Mathematics & Optimization · doi:10.1007/bf02683340 · Cited by 36 · see citing works
Nearfield polarization effects on light propagation in random media
Ostermeyer, M. R., Stephens, D. V., Wang, L., & Jacques, S. L. (2006) · Biomedical Optical Spectroscopy and Diagnostics · doi:10.1364/bosd.1996.sp2 · Cited by 22 · see citing works
Self-citationPolarized video imaging of skin
Jacques, S. L., & Lee, K. R. C. K. (1998) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.312307 · Cited by 19 · see citing works
Self-citationScattering properties of biological cells
Mourant, J. R., Hielscher, A. H., Freyer, J. P., Eick, A. A., Shen, D., & Johnson, T. M. (1998) · Biomedical Optical Spectroscopy and Diagnostics · doi:10.1364/bosd.1998.bma4 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Tissue polarimetry: concepts, challenges, applications, and outlook
Ghosh, N., & Vitkin, A. I. (2011) · Journal of Biomedical Optics · doi:10.1117/1.3652896 · Cited by 754 · see citing works
Polarisation optics for biomedical and clinical applications: a review
He, C., He, H., Chang, J., Chen, B., Ma, H., & Booth, M. J. (2021) · Light Science & Applications · doi:10.1038/s41377-021-00639-x · Cited by 627 · see citing works
Salomatina, E. V., Jiang, B., Novak, J., & Yaroslavsky, A. N. (2006) · Journal of Biomedical Optics · doi:10.1117/1.2398928 · Cited by 599 · see citing works
Active Polarization Descattering
Treibitz, T., & Schechner, Y. Y. (2009) · IEEE Transactions on Pattern Analysis and Machine Intelligence · doi:10.1109/tpami.2008.85 · Cited by 523 · see citing works
Polarized light interaction with tissues
Tuchin, V. V. (2016) · Journal of Biomedical Optics · doi:10.1117/1.jbo.21.7.071114 · Cited by 384 · see citing works
Gil, J. J. (2007) · The European Physical Journal Applied Physics · doi:10.1051/epjap:2007153 · Cited by 272 · see citing works
Alali, S., & Vitkin, I. A. (2015) · Journal of Biomedical Optics · doi:10.1117/1.jbo.20.6.061104 · Cited by 269 · see citing works
Mueller polarimetric imaging for surgical and diagnostic applications: a review
Qi, J., & Elson, D. S. (2017) · Journal of Biophotonics · doi:10.1002/jbio.201600152 · Cited by 268 · see citing works
Ghosh, N., Wood, M. F. G., & Vitkin, I. A. (2008) · Journal of Biomedical Optics · doi:10.1117/1.2960934 · Cited by 266 · see citing works
Polarimetric imaging of uterine cervix: a case study
Pierangelo, A., Nazac, A., Benali, A., Validire, P., Cohen, H., Novikova, T., Ibrahim, B. H., Manhas, S. S., Fallet, C., Antonelli, M.-R., et al. (2013) · Optics Express · doi:10.1364/oe.21.014120 · Cited by 256 · see citing works
Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues
Du, E., He, H., Zeng, N., Sun, M., Guo, Y., Wu, J., Liu, S., & Ma, H. (2014) · Journal of Biomedical Optics · doi:10.1117/1.jbo.19.7.076013 · Cited by 213 · see citing works
Sun, M., He, H., Zeng, N., Du, E., Guo, Y., Liu, S., Wu, J., He, Y., & Ma, H. (2014) · Biomedical Optics Express · doi:10.1364/boe.5.004223 · Cited by 212 · see citing works
He, H., Liao, R., Zeng, N., Li, P., Chen, Z., Liu, X., & Ma, H. (2018) · Journal of Lightwave Technology · doi:10.1109/jlt.2018.2868845 · Cited by 205 · see citing works
Tissue Optics and Photonics: Light-Tissue Interaction
Tuchin, V. V. (2015) · Journal of Biomedical Photonics & Engineering · doi:10.18287/jbpe-2015-1-2-98 · Cited by 203 · see citing works
Wang, Y., He, H., Chang, J., He, C., Liu, S., Li, M., Zeng, N., Wu, J., & Ma, H. (2016) · Journal of Biomedical Optics · doi:10.1117/1.jbo.21.7.071112 · Cited by 178 · see citing works
Multispectral optical imaging device for in vivo detection of oral neoplasia
Roblyer, D. M., Richards-Kortum, R. R., Sokolov, K., El‐Naggar, A. K., Williams, M. D., Kurachi, C., & Gillenwater, A. M. (2008) · Journal of Biomedical Optics · doi:10.1117/1.2904658 · Cited by 167 · see citing works
Mueller matrix decomposition for polarized light assessment of biological tissues
Ghosh, N., Wood, M. F. G., Li, S., Weisel, R. D., Wilson, B. C., Li, R., & Vitkin, I. A. (2008) · Journal of Biophotonics · doi:10.1002/jbio.200810040 · Cited by 163 · see citing works
Hyperspectral Imaging in Diabetic Foot Wound Care
Yudovsky, D., Nouvong, A., & Pilon, L. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400508 · Cited by 158 · see citing works
He, H., Zeng, N., Du, E., Guo, Y., Li, D., Liao, R., & Ma, H. (2013) · Photonics and Lasers in Medicine · doi:10.1515/plm-2012-0052 · Cited by 156 · see citing works
The Appearance of Human Skin: A Survey
Igarashi, T., Nishino, K., & Nayar, S. K. (2007) · Foundations and Trends® in Computer Graphics and Vision · doi:10.1561/0600000013 · Cited by 154 · see citing works
Kim, Y. L., Liu, Y., Wali, R. K., Roy, H. K., Goldberg, M. J., Kromin, A. K., Chen, K., & Backman, V. (2003) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/jstqe.2003.814183 · Cited by 147 · see citing works
A review of polarization-based imaging technologies for clinical and preclinical applications
Ramella‐Roman, J. C., Saytashev, I., & Piccini, M. (2020) · Journal of Optics · doi:10.1088/2040-8986/abbf8a · Cited by 146 · see citing works
Self-citationВладимирович, Д. В., Marcinkevičs, Z., Zherebtsov, E., Popov, A., Grabovskis, A., Kronberga, H., Geldnere, K., Doronin, A. A., Meglinski, I. V., & Bykov, A. V. (2021) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2021.3049591 · Cited by 144 · see citing works
Infrared imaging of subcutaneous veins
Zharov, V. P., Ferguson, S., Eidt, J. F., Howard, P. C., Fink, L. M., & Waner, M. (2004) · Lasers in Surgery and Medicine · doi:10.1002/lsm.10248 · Cited by 141 · see citing works
Sub‐epidermal imaging using polarized light spectroscopy for assessment of skin microcirculation
O’Doherty, J., Henricson, J., Anderson, C. D., Leahy, M. J., Nilsson, G., & Sjöberg, F. (2007) · Skin Research and Technology · doi:10.1111/j.1600-0846.2007.00253.x · Cited by 132 · see citing works
He, C., He, H., Chang, J., Dong, Y., Liu, S., Zeng, N., He, Y., & Ma, H. (2015) · Biomedical Optics Express · doi:10.1364/boe.6.002934 · Cited by 126 · see citing works
The Appearance of Human Skin: A Survey
Igarashi, T., Nishino, K., & Nayar, S. K. (2007) · now publishers, Inc. eBooks · doi:10.1561/9781601980878 · Cited by 124 · see citing works
Wang, Y., He, H., Chang, J., Zeng, N., Liu, S., Li, M., & Ma, H. (2015) · Micron · doi:10.1016/j.micron.2015.07.014 · Cited by 117 · see citing works
‘ Go with the flow ’: A review of methods and advancements in blood flow imaging
Daly, S. M., & Leahy, M. J. (2012) · Journal of Biophotonics · doi:10.1002/jbio.201200071 · Cited by 117 · see citing works
A high definition Mueller polarimetric endoscope for tissue characterisation
Qi, J., & Elson, D. S. (2016) · Scientific Reports · doi:10.1038/srep25953 · Cited by 116 · see citing works
In vivo imaging of uterine cervix with a Mueller polarimetric colposcope
Vizet, J., Rehbinder, J., Deby, S., Roussel, S., Nazac, A., Soufan, R., Genestie, C., Haie-Méder, C., Fernandez, H., Moreau, F., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02645-9 · Cited by 111 · see citing works
Wood, M. F. G., Guo, X., & Vitkin, I. A. (2007) · Journal of Biomedical Optics · doi:10.1117/1.2434980 · Cited by 101 · see citing works
Hyperspectral Imaging for Resection Margin Assessment during Cancer Surgery
Kho, E., de Boer, L. L., de Vijver, K. K. V., van Duijnhoven, F. H., Peeters, M.-J. T. F. D. V., Sterenborg, H. J. C. M., & Ruers, T. J. M. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2089 · Cited by 98 · see citing works
Chang, J., He, H., Wang, Y., Huang, Y., Li, X., He, C., Liao, R., Zeng, N., Liu, S., & Ma, H. (2016) · Journal of Biomedical Optics · doi:10.1117/1.jbo.21.5.056002 · Cited by 96 · see citing works
Polarization-Sensitive Hyperspectral Imaging in vivo: A Multimode Dermoscope for Skin Analysis
Vasefi, F., MacKinnon, N. B., Saager, R. B., Durkin, A. J., Chave, R. G., Lindsley, E. H., & Farkas, D. L. (2014) · Scientific Reports · doi:10.1038/srep04924 · Cited by 93 · see citing works
Narrow band 3 × 3 Mueller polarimetric endoscopy
Qi, J., Ye, M., Singh, M., Clancy, N. T., & Elson, D. S. (2013) · Biomedical Optics Express · doi:10.1364/boe.4.002433 · Cited by 93 · see citing works
Ex vivo Mueller polarimetric imaging of the uterine cervix: a first statistical evaluation
Rehbinder, J., Haddad, H., Deby, S., Teig, B., Nazac, A., Novikova, T., Pierangelo, A., & Moreau, F. (2016) · Journal of Biomedical Optics · doi:10.1117/1.jbo.21.7.071113 · Cited by 94 · see citing works
Separating azimuthal orientation dependence in polarization measurements of anisotropic media
Li, P., Lv, D., He, H., & Ma, H. (2018) · Optics Express · doi:10.1364/oe.26.003791 · Cited by 89 · see citing works
Ayed, I. B., Mitiche, A., & Belhadj, Z. (2006) · IEEE Transactions on Pattern Analysis and Machine Intelligence · doi:10.1109/tpami.2006.191 · Cited by 90 · see citing works
Polarization-Sensitive Multimodal Imaging for Detecting Breast Cancer
Patel, R. P., Khan, A. A., Quinlan, R., & Yaroslavsky, A. N. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2411 · Cited by 88 · see citing works
Ex vivo characterization of normal and adenocarcinoma colon samples by Mueller matrix polarimetry
Ahmad, I., Ahmad, M., Khan, K., Ashraf, S., Ahmad, S., & Ikram, M. (2015) · Journal of Biomedical Optics · doi:10.1117/1.jbo.20.5.056012 · Cited by 88 · see citing works
He, H., Sun, M., Zeng, N., Du, E., Liu, S., Guo, Y., Wu, J., He, Y., & Ma, H. (2014) · Journal of Biomedical Optics · doi:10.1117/1.jbo.19.10.106007 · Cited by 87 · see citing works
Image analysis methods for diffuse optical tomography
Pogue, B. W., Davis, S. C., Song, X., Brooksby, B. A., Dehghani, H., & Paulsen, K. D. (2006) · Journal of Biomedical Optics · doi:10.1117/1.2209908 · Cited by 87 · see citing works
Barton, J. K., Gossage, K. W., Xu, W., Ranger-Moore, J. R., Saboda, K., Brooks, C. A., Duckett, L. D., Salasche, S. J., Warneke, J. A., & Alberts, D. S. (2003) · Technology in Cancer Research & Treatment · doi:10.1177/153303460300200605 · Cited by 85 · see citing works
Coherent backscattering spectroscopy
Kim, Y. L., Liu, Y., Turzhitsky, V. M., Roy, H. K., Wali, R. K., & Backman, V. (2004) · Optics Letters · doi:10.1364/ol.29.001906 · Cited by 79 · see citing works
Biophotonic methods in microcirculation imaging
Leahy, M. J., Enfield, J. G., Clancy, N. T., O’Doherty, J., McNamara, P., & Nilsson, G. (2007) · Medical Laser Application · doi:10.1016/j.mla.2007.06.003 · Cited by 77 · see citing works
Polarimetric Imaging via Deep Learning: A Review
Li, X., Yan, L., Qi, P., Zhang, L., Goudail, F., Liu, T., Zhai, J., & Hu, H. (2023) · Remote Sensing · doi:10.3390/rs15061540 · Cited by 76 · see citing works
Linear polarization difference imaging and its potential applications
Nan, Z., Jiang, X., Gao, Q., He, Y., & Ma, H. (2009) · Applied Optics · doi:10.1364/ao.48.006734 · Cited by 76 · see citing works
Lim, S., Ha, M., Lee, Y., & Ko, H. (2018) · Advanced Optical Materials · doi:10.1002/adom.201800615 · Cited by 74 · see citing works
Surgical polarimetric endoscopy for the detection of laryngeal cancer
Qi, J., Tatla, T. S., Nissanka-Jayasuriya, E. H., Yuan, A. Y., Stoyanov, D. V., & Elson, D. S. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01018-0 · Cited by 73 · see citing works
Target enhanced 3D reconstruction based on polarization-coded structured light
Huang, X. M., Bai, J. Y., Wang, K., Liu, Q., Luo, Y., Yang, K., & Zhang, X. (2017) · Optics Express · doi:10.1364/oe.25.001173 · Cited by 73 · see citing works
Vitkin, I. A., Ghosh, N., & Martino, A. D. (2015) · Photonics · doi:10.1002/9781119011804.ch7 · Cited by 74 · see citing works
Setchfield, K., Gorman, A., Simpson, A. H. R. W., Somekh, M. G., & Wright, A. J. (2024) · Journal of Biomedical Optics · doi:10.1117/1.jbo.29.1.010901 · Cited by 72 · see citing works
Li, P., Dong, Y., Wan, J., He, H., Aziz, T., & Ma, H. (2021) · Journal of Physics D Applied Physics · doi:10.1088/1361-6463/ac292f · Cited by 71 · see citing works
Igarashi, T., Nishino, K., & Nayar, S. K. (2005) · doi:10.7916/d8qr589c · Cited by 71 · see citing works
Polarimetric imaging for the diagnosis of cervical cancer
Anastasiadou, M., Martino, A. D., Clement, D., Liège, F., Laude-Boulesteix, B., Quang, N., Dreyfuss, J., Huynh, B., Nazac, A., Schwartz, L. H., et al. (2008) · Physica status solidi. C, Conferences and critical reviews/Physica status solidi. C, Current topics in solid state physics · doi:10.1002/pssc.200777805 · Cited by 71 · see citing works
Liu, T., Sun, T. S., He, H., Liu, S., Dong, Y., Wu, J., & Ma, H. (2018) · Biomedical Optics Express · doi:10.1364/boe.9.004413 · Cited by 70 · see citing works
Nieman, L. T., Myakov, A. V., Aaron, J., & Sokolov, K. (2004) · Applied Optics · doi:10.1364/ao.43.001308 · Cited by 69 · see citing works
The response of tissue to laser light
Douplik, A., Saiko, G., Schelkanova, I., & Tuchin, V. V. (2013) · Elsevier eBooks · doi:10.1533/9780857097545.1.47 · Cited by 65 · see citing works
Demonstration of full 4×4 Mueller polarimetry through an optical fiber for endoscopic applications
Manhas, S. S., Vizet, J., Deby, S., Vanel, J., Boito, P., Verdier, M., Martino, A. D., & Pagnoux, D. (2015) · Optics Express · doi:10.1364/oe.23.003047 · Cited by 66 · see citing works
Investigation of depth selectivity of polarization gating for tissue characterization
Liu, Y., Kim, Y. L., Li, X., & Backman, V. (2005) · Optics Express · doi:10.1364/opex.13.000601 · Cited by 65 · see citing works
Low-coherent backscattering spectroscopy for tissue characterization
Kim, Y. L., Liu, Y., Wali, R. K., Roy, H. K., & Backman, V. (2005) · Applied Optics · doi:10.1364/ao.44.000366 · Cited by 64 · see citing works
Design, testing, and clinical studies of a handheld polarized light camera
Ramella‐Roman, J. C., Lee, K. C. L., Prahl, S. A., & Jacques, S. L. (2004) · Journal of Biomedical Optics · doi:10.1117/1.1781667 · Cited by 62 · see citing works
Self-citationSpectral morphological analysis of skin lesions with a polarization multispectral dermoscope
Kapsokalyvas, D., Bruscino, N., Alfieri, D., GIORGI, V. D., Cannarozzo, G., Cicchi, R., Massi, D., Pimpinelli, N., & Pavone, F. S. (2013) · Optics Express · doi:10.1364/oe.21.004826 · Cited by 61 · see citing works
He, C., He, H., Li, X., Chang, J., Wang, Y., Liu, S., Zeng, N., He, Y., & Ma, H. (2015) · Journal of Biomedical Optics · doi:10.1117/1.jbo.20.10.105009 · Cited by 60 · see citing works
Optics of Biological Particles
Hoekstra, A. G., Maltsev, V. P., & Videen, G. W. (2007) · Springer eBooks · doi:10.1007/978-1-4020-5502-7 · Cited by 60 · see citing works
Optical techniques for cervical neoplasia detection
Novikova, T. (2017) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.8.186 · Cited by 59 · see citing works
Optical phantoms for biomedical polarimetry: a review
Chue-Sang, J. J., Gonzalez, M., Pierre, A., Laughrey, M., Saytashev, I., Novikova, T., & Ramella‐Roman, J. C. (2019) · Journal of Biomedical Optics · doi:10.1117/1.jbo.24.3.030901 · Cited by 57 · see citing works
Self-citationMueller matrix polarimetry for characterization of skin tissue samples: A review
Ahmad, I., Khaliq, A., Iqbal, M., & Khan, S. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.101708 · Cited by 57 · see citing works
Low-cost, multimodal, portable screening system for early detection of oral cancer
Rahman, M. S., Chaturvedi, P., Gillenwater, A. M., & Richards-Kortum, R. R. (2008) · Journal of Biomedical Optics · doi:10.1117/1.2907455 · Cited by 57 · see citing works
Assessing facial wrinkles: automatic detection and quantification
Cula, G. O., Bargo, P. R., Nkengne, A., & Kollias, N. (2012) · Skin Research and Technology · doi:10.1111/j.1600-0846.2012.00635.x · Cited by 56 · see citing works
Spectropolarimetric imaging for pathological analysis of skin
Zhao, Y., Lei Zhang, A., & Pan, Q. (2009) · Applied Optics · doi:10.1364/ao.48.00d236 · Cited by 54 · see citing works
Alali, S., Kim, A., Vurgun, N., Wood, M. F., & Ahmad, M. (2012) · Journal of Biomedical Optics · doi:10.1117/1.jbo.17.4.045004 · Cited by 53 · see citing works
Shen, Y., Huang, R., He, H., Liu, S., Dong, Y., Wu, J., & Ma, H. (2020) · Biomedical Optics Express · doi:10.1364/boe.410989 · Cited by 54 · see citing works
Wu, P. J., & Walsh, J. T. (2006) · Journal of Biomedical Optics · doi:10.1117/1.2162851 · Cited by 54 · see citing works
Polarised stereo endoscope and narrowband detection for minimal access surgery
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da Silva, D. D. F. T., Vidal, B. D. C., Zezéll, D. M., Zorn, T. M. T., Núñez, S. C., & Ribeiro, M. S. (2006) · Journal of Biomedical Optics · doi:10.1117/1.2187418 · Cited by 53 · see citing works
Sun, M., He, H., Zeng, N., Du, E., Guo, Y., Peng, C., He, Y., & Ma, H. (2014) · Applied Optics · doi:10.1364/ao.53.002949 · Cited by 52 · see citing works
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Sridhar, S., & Silva, A. D. (2016) · Journal of Biomedical Optics · doi:10.1117/1.jbo.21.7.071107 · Cited by 52 · see citing works
Yudovsky, D., & Pilon, L. (2009) · Applied Optics · doi:10.1364/ao.48.006670 · Cited by 51 · see citing works
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Ghosh, N., Patel, H., & Gupta, P. K. (2003) · Optics Express · doi:10.1364/oe.11.002198 · Cited by 50 · see citing works
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Yang, B., Lesicko, J., Sharma, M., Hill, M. R. S., Sacks, M. S., & Tunnell, J. W. (2015) · Biomedical Optics Express · doi:10.1364/boe.6.001520 · Cited by 49 · see citing works
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Tchvialeva, L., Dhadwal, G., Lui, H., Kalia, S., Zeng, H., McLean, D. I., & Lee, T. K. (2012) · Journal of Biomedical Optics · doi:10.1117/1.jbo.18.6.061211 · Cited by 49 · see citing works
Detection and Discrimination of Bacterial Colonies with Mueller Matrix Imaging
Badieyan, S., Dilmaghani‐Marand, A., Hajipour, M. J., Ameri, A., Razzaghi, M. R., Rafii‐Tabar, H., Mahmoudi, M., & Sasanpour, P. (2018) · Scientific Reports · doi:10.1038/s41598-018-29059-5 · Cited by 49 · see citing works
Adie, S. G., Hillman, T. R., & Sampson, D. D. (2007) · Optics Express · doi:10.1364/oe.15.018033 · Cited by 48 · see citing works
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Jiang, S., Li, J., Li, J., Lai, J., & Yi, F. (2022) · Optics Express · doi:10.1364/oe.452981 · Cited by 47 · see citing works
Gareau, D. S., Hennessey, R. J., Wan, E. A., Pellacani, G., & Jacques, S. L. (2010) · Journal of Biomedical Optics · doi:10.1117/1.3524301 · Cited by 47 · see citing works
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Layden, D., Ghosh, N., & Vitkin, I. A. (2013) · Series in optics and optoelectronics · doi:10.1201/b15256-3 · Cited by 47 · see citing works
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Robinson, D., Hoong, K., Kleijn, W. B., Doronin, A. A., Rehbinder, J., Vizet, J., Pierangelo, A., & Novikova, T. (2023) · Journal of Biomedical Optics · doi:10.1117/1.jbo.28.10.102904 · Cited by 46 · see citing works
Goudail, F. (2016) · Optics Letters · doi:10.1364/ol.41.005772 · Cited by 45 · see citing works
Liquid Crystals: A Novel Approach for Cancer Detection and Treatment
Vallamkondu, J., Corgiat, E. B., Gollapelli, B., Kandimalla, R. J. L., & Reddy, P. H. (2018) · Cancers · doi:10.3390/cancers10110462 · Cited by 45 · see citing works
Zaffar, M., & Pradhan, A. (2019) · Applied Optics · doi:10.1364/ao.377105 · Cited by 45 · see citing works
Ghosh, N., Pradhan, A., Gupta, P. K., Gupta, S., Jaiswal, V. K., & Singh, R. P. (2004) · Physical Review E · doi:10.1103/physreve.70.066607 · Cited by 45 · see citing works
Kuznetsov, V., Lee, H., Maurer-Stroh, S., Molnár, M., Pongor, S., Eisenhaber, B., & Eisenhaber, F. (2013) · Health Information Science and Systems · doi:10.1186/2047-2501-1-2 · Cited by 37 · see citing works
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Sviridov, A. P., Chernomordik, V., Hassan, M., Russo, A., Eidsath, A. B., Smith, P. D., & Gandjbakhche, A. (2005) · Journal of Biomedical Optics · doi:10.1117/1.1854677 · Cited by 44 · see citing works
Nishidate, I., Maeda, T., Aizu, Y., & Niizeki, K. (2007) · Journal of Biomedical Optics · doi:10.1117/1.2798703 · Cited by 43 · see citing works
Kapsokalyvas, D., Cicchi, R., Bruscino, N., Alfieri, D., Prignano, F., Massi, D., Lotti, T., & Pavone, F. S. (2014) · Biomedical Optics Express · doi:10.1364/boe.5.002405 · Cited by 42 · see citing works
- Authors
- Jacques, S. L., Ramella-Roman, J. C., & Lee, K.
- Affiliations
- Providence St. Vincent Medical Center (US)
- Oregon Health and Science Univ.
- Oregon Medical Laser Ctr.
- Venue
- Journal of Biomedical Optics
- Publisher
- SPIE-Intl Soc Optical Eng
- Published
- 2002-07-01
- Volume
- 7
- Issue
- 03
- Pages
- 329-340
- ISSN
- 1083-3668 (ISSN-L)
- 1560-2281
- OpenAlex
- W2044515481
- Cited by
- 582
- References
- 24
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 16 · 2023: 25 · 2022: 24 · 2021: 22 · 2020: 25 · 2019: 25 · 2018: 30 · 2017: 28 · 2016: 45 · 2015: 34 · 2014: 31 · 2013: 27 · 2012: 28
- FWCI
- 15.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Biomedical Optics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca080985-03)
- National Cancer Institute (R01-CA84587, R01-CA80985)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Optical Polarization and Ellipsometry
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Keywords
- polarization imaging, dermatopathology, collagen birefringence, polarization ratio, skin pigmentation, freckles, tattoos, pigmented nevi, neurofibroma, actinic keratosis, basal cell carcinoma, squamous cell carcinoma, venous lakes, burn scars, point spread function
- MeSH terms
- Adult, Biophysics, Burns, Basal Cell Carcinoma, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Cicatrix, Humans, Keratosis, Neurofibroma, Nevus, Pigmented, Pilot Projects, Scattering, Radiation, Skin, Skin Abnormalities, Skin Neoplasms, Optics and Photonics, Biophysical Phenomena
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