Shape memory polymer therapeutic devices for stroke
Open accessAbstract
Shape memory polymers (SMPs) are attracting a great deal of interest in the scientific community for their use in applications ranging from light weight structures in space to micro-actuators in MEMS devices. These relatively new materials can be formed into a primary shape, reformed into a stable secondary shape, and then controllably actuated to recover their primary shape. The first part of this presentation will be a brief review of the types of polymeric structures which give rise to shape memory behavior in the context of new shape memory polymers with highly regular network structures recently developed at LLNL for biomedical devices. These new urethane SMPs have improved optical and physical properties relative to commercial SMPs, including improved clarity, high actuation force, and sharper actuation transition. In the second part of the presentation we discuss the development of SMP based devices for mechanically removing neurovascular occlusions which result in ischemic stroke. These devices are delivered to the site of the occlusion in compressed form, are pushed through the occlusion, actuated (usually optically) to take on an expanded conformation, and then used to dislodge and grip the thrombus while it is withdrawn through the catheter.
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It might be useful to customize polymers to a lower switching temperature in a narrow range of 45-50°C, rather than using materials of relatively high Tg, to enable activation at lower laser power.
“Thus, it might be useful to customize polymers to a lower switching temperature in a narrow range of 45-50°C, rather than using materials of relatively high T g in order to enable activation at lower laser power [116].”
From Shape-memory polymers as a technology platform for biomedical applications (2010) · cites this paper as [116]
The Conclusions (page unavailable) report polymers with glass transitions ranging from 34 to 87°C and very narrow transitions, supporting the possibility of tailoring a lower switching temperature. The Coil Stroke Devices section (page unavailable) describes laser actuation, but the paper does not specify a 45–50°C target or say that choosing it would enable activation at lower laser power. (LLM, conf=0.85)
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- Authors
- Wilson, T. S., Small IV, W., Benett, W. J., Bearinger, J. P., & Maitland, D. J.
- Affiliations
- Lawrence Livermore National Laboratory (US)
- Venue
- SPIE Proceedings
- Publisher
- SPIE
- Published
- 2005-11-09
- Volume
- 6007
- Pages
- 60070R
- ISSN
- 0277-786X (ISSN-L)
- OpenAlex
- W1995727135
- Cited by
- 27
- References
- 0
- Citations by year
- 2019: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 2
- FWCI
- 10.67
- Type
- conference paper
- Language
- en
- Open access
- green
- www.osti.gov
- Locations
- Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- University of North Texas Digital Library (University of North Texas) (submittedVersion)
- Topics
- Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
- Physical Sciences › Materials Science › Polymers and Plastics › Polymer composites and self-healing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- shape memory polymers, stroke, ischemic stroke, thrombus removal, polymer network structure, optical actuation, biomedical devices, actuation force
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