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Cited by 167

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Radiation dose enhancement in tumors with iodine

Mello, Renato Santos, Callisen, Hannes, Winter, James, Kagan, A. Robert, Norman, Amos·1983·Medical Physics
DOI 10.1118/1.595378
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Abstract

The loading of tissue with iodine can result in the enhancement of the radiation dose absorbed from low‐energy x‐ray or gamma ray sources. We have explored the potential of this phenomenon for radiation therapy. We have demonstrated the effect of iodine concentration and radiation quality on this dose enhancement in lymphocytes, we have calculated the effect of such enhancement on depth dose distributions in the brain, we have estimated the iodine content in two human brain tumors during computerized tomography (CT) scans, we have studied the dispersion of the iodine contrast media after direct injection into rabbit tumors, and we have demonstrated that the combination of x‐ray and contrast media injection is far more effective than either agent alone in causing the regression of mouse tumors. These results suggest that there may be a therapeutic advantage from loading tumors with iodine and treating them with low‐energy photons.

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Metadata

Authors
Mello, R. S., Callisen, H., Winter, J., Kagan, A. R., & Norman, A.
Venue
Medical Physics
Publisher
Wiley
Published
1983-01
Volume
10
Issue
1
Pages
75-78
ISSN
  • 0094-2405 (ISSN-L)
  • 2473-4209
DOI
10.1118/1.595378
OpenAlex
W2052745473
Cited by
167
References
0
FWCI
0.59
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Radiation dose enhancement in tumors with iodine. https://app.cochat.ai/papers/10.1118/1.595378
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Mello, R. S., Callisen, H., Winter, J., Kagan, A. R., & Norman, A. (1983). Radiation dose enhancement in tumors with iodine. Medical Physics. https://doi.org/10.1118/1.595378

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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