Acute Rhodiola Rosea Intake Can Improve Endurance Exercise Performance
Abstract
Purpose: The purpose of this study was to investigate the effect of acute and 4-week Rhodiola rosea intake on physical capacity, muscle strength, speed of limb movement, reaction time, and attention. Methods: PHASE I: A double blind placebo-controlled randomized study (n = 24) was performed, consisting of 2 sessions (2 days per session). Day 1: One hour after acute Rhodiola rosea intake (R, 200-mg Rhodiola rosea extract containing 3% rosavin + 1% salidroside plus 500 mg starch) or placebo (P, 700 mg starch) speed of limb movement (plate tapping test), aural and visual reaction time, and the ability to sustain attention (Fepsy Vigilance test) were assessed. Day 2: Following the same intake procedure as on day 1, maximal isometric knee-extension torque and endurance exercise capacity were tested. Following a 5-day washout period, the experimental procedure was repeated, with the treatment regimens being switched between groups (session 2). PHASE II: A double blind placebo-controlled study (n = 12) was performed. Subjects underwent sessions 3 and 4, identical to Phase I, separated by a 4-week R/P intake, during which subjects ingested 200 mg R/P per day. Results: PHASE I: Compared with P, acute R intake in Phase I increased 0 < -05) time to exhaustion from 16.8 ± 0.7 min to 17.2 ± 0.8 min. Accordingly, VO 2peak (p < .05) and VCO 2peak(p< .05) increased during R compared to P from 50.9 ± 1.8 ml • min-1 • kg−1 to 52.9 ± 2.7 ml • min-1 • kg"’ (VO 2peak) and from 60.0 ± 2.3 ml • min-1 • kg-’ to 63.5 ± 2.7 ml • min-1 kg-1 (VCO 2peak). Pulmonary ventilation (p = .07) tended to increase more during R than during P(P: 115.9±7.7L/min; R: 124.8 ± 7.7 L/min). All other parameters remained unchanged. PHASE II: Four-week R intake did not alter any of the variables measured. Conclusion: Acute Rhodiola rosea intake can improve endurance exercise capacity in young healthy volunteers. This response was not altered by prior daily 4-week Rhodiola intake.
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De Bock et al. (2004) did not observe changes in muscle strength after 4 weeks of Rhodiola supplementation.
“However, our results are in accordance with those of De Bock et al. (2004) [21], since they did not observe changes in muscle strength after 4 weeks of Rhodiola supplementation, as we didn’t notice any synergestic effect in chronic study.”
Cites
Creatine and Creatinine Metabolism
Wyss, M., & Kaddurah-Daouk, R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1107 · Cited by 2,950 · see citing works
Loeb, M., Davies, D. R., & Parasuraman, R. (1984) · The American Journal of Psychology · doi:10.2307/1422535 · Cited by 716 · see citing works
A category-ratio perceived exertion scale
Noble, B. J., Borg, G. A. V., Jacobs, I. A., Ceci, R. L., & KAISER, P. (1983) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198315060-00015 · Cited by 627 · see citing works
Exploring the opioid system by gene knockout
Kieffer, B. L., & Gavériaux-Ruff, C. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00008-4 · Cited by 620 · see citing works
Exercise and Brain Neurotransmission
MEEUSEN, R. R., & Meirleir, K. D. (1995) · Sports Medicine · doi:10.2165/00007256-199520030-00004 · Cited by 548 · see citing works
Naturally occurring muscle pain during exercise: assessment and experimental evidence
Cook, D. B., O’Connor, P. J., EUBANKS, S. A., Smith, J. C., & Lee, M. J. (1997) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199708000-00004 · Cited by 314 · see citing works
Rhodiola rosea: a possible plant adaptogen.
Kelly, G. S. (2001) · PubMed · Cited by 300 · see citing works
Darbinyan, V., Kteyan, A., Panossian, A. G., Gabrielian, E. S., Wikman, G., & Wagner, H. (2000) · Phytomedicine · doi:10.1016/s0944-7113(00)80055-0 · Cited by 276 · see citing works
Спасов, А. А., Wikman, G., Мандриков, В. Б., Mironova, I. A., & Neumoin, V. V. (2000) · Phytomedicine · doi:10.1016/s0944-7113(00)80078-1 · Cited by 232 · see citing works
Ganzera, M., Akgül, Y., & Khan, I. A. (2001) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.49.465 · Cited by 103 · see citing works
Linh, P. T., Kim, Y. H., Hong, S. P., et al. (2000) · Archives of Pharmacal Research · doi:10.1007/bf02975446 · Cited by 92 · see citing works
Effect of naloxone on perceived exertion and exercise capacity during maximal cycle ergometry
Sgherza, A. L., Axen, K., Fain, R., Hoffman, R. S., Dunbar, C. C., & Haas, F. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00521.2002 · Cited by 81 · see citing works
Oades, R. D. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00105-0 · Cited by 71 · see citing works
[The cardioprotective and antiadrenergic activity of an extract of Rhodiola rosea in stress].
Maslova, L. V., Kondrat'ev, B. I., Маслов, Л. Н., et al. (1995) · PubMed · Cited by 55 · see citing works
Boon-Niermeijer, E. K., van den Berg, A. J. J., Wikman, G., & Wiegant, F. A. C. (2000) · Phytomedicine · doi:10.1016/s0944-7113(00)80060-4 · Cited by 51 · see citing works
Biochemical Mechanism of Caffeine Tolerance
Ammon, H. P. T. (1991) · Archiv der Pharmazie · doi:10.1002/ardp.19913240502 · Cited by 42 · see citing works
Удинцев, С. Н., & Vp, S. (1991) · PubMed · Cited by 40 · see citing works
Mb, L., Petkov, V. D., Vl, M., et al. (1986) · PubMed · Cited by 38 · see citing works
The molecular biology of addictive drugs
Mackler, S. A., & Eberwine, J. H. (1991) · Molecular Neurobiology · doi:10.1007/bf02935612 · Cited by 35 · see citing works
Foods, Nutrition, and Sports Performance
Williams, C., & Devlin, J. T. (1993) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199308000-00021 · Cited by 33 · see citing works
[Plasma beta-endorphin and stress hormones in stress and adaptation].
Lishmanov, I. B., Trifonova, Z. V., Tsibin, A. N., Maslova, L. V., & Dement'eva, L. A. (1987) · PubMed · Cited by 29 · see citing works
Lishmanov, I. B., Naumova, A. V., Afanas'ev, S. A., et al. (1997) · PubMed · Cited by 22 · see citing works
[The effect of elton, leveton, fitoton and adapton on the work capacity of experimental animals].
Azizov, A. P., & Сейфулла, Р. Д. (1998) · PubMed · Cited by 21 · see citing works
Flamini, G., Cioni, P. L., Puleio, R., Morelli, I., & Panizzi, L. (1999) · Phytotherapy Research · doi:10.1002/(sici)1099-1573(199906)13:4 · Cited by 10 · see citing works
Sustained Attention and Unintentional Injury Among Preschool-Aged Children
Murphy, L. B., Murphy, E., & Rose, C. L. (2001) · Child Neuropsychology · doi:10.1076/chin.7.2.72.3128 · Cited by 8 · see citing works
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Wankhede, S., Langade, D., Joshi, K., Sinha, S. R., & Bhattacharyya, S. (2015) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-015-0104-9 · Cited by 168 · see citing works
Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining
Liu, Y., Zhou, R., Guo, Y., Hu, B., Xie, L., An, Y., Wen, J., Liu, Z., Zhou, M., Kuang, W., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2024.12.005 · Cited by 78 · see citing works
Huang, S.-C. (2009) · The Chinese Journal of Physiology · doi:10.4077/cjp.2009.amh029 · Cited by 73 · see citing works
Jówko, E., Sadowski, J., Długołęcka, B., Gierczuk, D., Opaszowski, B., & Cieśliński, I. (2018) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2016.05.005 · Cited by 68 · see citing works
Ballmann, C. G., Maze, S. B., Wells, A. C., Marshall, M. R., & Rogers, R. R. (2019) · Journal of Sports Sciences · doi:10.1080/02640414.2018.1538028 · Cited by 45 · see citing works
Noah, L., Morel, V., Bertin, C., Pouteau, E., Macian, N., Dualé, C., Pereira, B., & Pickering, G. (2022) · Nutrients · doi:10.3390/nu14091863 · Cited by 27 · see citing works
Roumanille, R., Vernus, B., Brioche, T., Descossy, V., Van Ba, C. T., Campredon, S., Philippe, A. G., Delobel, P., Bertrand-Gaday, C., Chopard, A., et al. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00390-5 · Cited by 26 · see citing works
Ryan, E. D., Gerstner, G. R., Mota, J. A., Trexler, E. T., Giuliani, H. K., Blue, M. N. M., Hirsch, K. R., & Smith-Ryan, A. E. (2021) · Journal of Dietary Supplements · doi:10.1080/19390211.2020.1790709 · Cited by 7 · see citing works
- Authors
- De Bock, K., Eijnde, B. O., Ramaekers, M., & Hespel, P.
- Venue
- International Journal of Sport Nutrition and Exercise Metabolism
- Publisher
- Human Kinetics
- Published
- 2004-06
- Volume
- 14
- Issue
- 3
- Pages
- 298-307
- ISSN
- 1526-484X (ISSN-L)
- 1543-2742
- OpenAlex
- W2159144305
- Cited by
- 149
- References
- 25
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 8 · 2019: 3 · 2018: 8 · 2017: 10 · 2016: 10 · 2015: 8 · 2014: 10 · 2013: 10 · 2012: 4
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Sport Nutrition and Exercise Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- Rhodiola rosea, acute supplementation, endurance exercise performance, time to exhaustion, peak oxygen uptake, pulmonary ventilation, salidroside, rosavin, reaction time, attention, muscle strength, isometric knee extension, vigilance test, physical capacity, cognitive performance, oxidative stress, antioxidant enzymes, lipid peroxidation
- MeSH terms
- Adult, Double-Blind Method, Female, Humans, Male, Oxygen Consumption, Physical Endurance, Plant Extracts, Task Performance and Analysis, Cross-Over Studies, Rhodiola
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