The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Association Between Energy Balance and Metabolic Hormone Suppression During Ultraendurance Exercise
Abstract
Ultraendurance athletes often accumulate an energy deficit when engaging in ultraendurance exercise, and on completion of the exercise, they exhibit endocrine changes that are reminiscent of starvation. However, it remains unclear whether these endocrine changes are a result of the exercise per se or secondary to the energy deficit and, more important, whether these changes can be attenuated by increased dietary intake. The goal of the study was to assess the relationship between changes in key metabolic hormones after ultraendurance exercise and measures of energy balance. Metabolic hormones, as well as energy intake and expenditure, were assessed in 14 well-trained male cyclists who completed a 1230-km ultraendurance cycling event. After completion of the event, serum testosterone (–67% ± 18%), insulin-like growth factor-1 (IGF-1) (–45% ± 8%), and leptin (–79% ± 9%) were significantly suppressed (P < .001) and remained suppressed after a 12-h recovery period (P < .001). Changes in IGF-1 were positively correlated with energy balance over the course of the event (r = .65, P = .037), which ranged from an 11,859-kcal deficit to a 3593-kcal surplus. The marked suppression of testosterone, IGF-1, and leptin after ultraendurance exercise is comparable to changes occurring during acute starvation. The suppression of IGF-1, but not that of other metabolic hormones, was strongly associated with the magnitude of the energy deficit, indicating that athletes who attained a greater energy deficit exhibited a more pronounced drop in IGF-1. Future studies are needed to determine whether increased dietary intake can attenuate the endocrine response to ultraendurance exercise.
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“In a study of 14 well-trained male cyclists who completed a 1230-km ultra-endurance cycling event, serum testosterone fell by -67% ± 18%; in this small study there was no correlation between the testosterone decline and the estimated energy balance, which ranged from a 11 000-kcal deficit to a 3500-kcal surplus (27).”
From Dysregulation of the Hypothalamic-Pituitary-Testicular Axis due to Energy Deficit (2021) · cites this paper as [27]
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Cites
Ghrelin and the short- and long-term regulation of appetite and body weight
Cummings, D. E. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.022 · Cited by 620
Nutrition for endurance sports: Marathon, triathlon, and road cycling
Jeukendrup, A. E. (2011) · Journal of Sports Sciences · doi:10.1080/02640414.2011.610348 · Cited by 388
Endocrine markers of semistarvation in healthy lean men in a multistressor environment
Friedl, K. E., Moore, R. J., Hoyt, R. W., Marchitelli, L. J., Martinez-Lopez, L. E., & Askew, E. W. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.5.1820 · Cited by 316 · cited 1×
“protected from reductions in IGF-1 and testosterone following short-term, moderate energy deficiency,(29) larger energy deficits of 1,000 to 4,000 kcal/d have been associated with changes in IGF-1 and testosterone comparable to our study.(21,24,30,31) Further research is needed to determine”
Nutritional Intake and Gastrointestinal Problems during Competitive Endurance Events
PFEIFFER, B., STELLINGWERFF, T., HODGSON, A. B., RANDELL, R., PÖTTGEN, K., RES, P., & JEUKENDRUP, A. E. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31822dc809 · Cited by 287
Leptin in humans: lessons from translational research
Blüher, S., & Mantzoros, C. S. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26788e · Cited by 203
Koehler, K., Hoerner, N. R., Gibbs, J. C., Zinner, C., Braun, H., De Souza, M. J., & Schaenzer, W. (2016) · Journal of Sports Sciences · doi:10.1080/02640414.2016.1142109 · Cited by 164
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IOC consensus statement on relative energy deficiency in sport (RED-S): 2018 update
Mountjoy, M., Sundgot-Borgen, J. K., Burke, L. M., Ackerman, K. E., Blauwet, C., Constantini, N., Lebrun, C., Lundy, B., Melin, A. K., Meyer, N. L., et al. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-099193 · Cited by 883
Mountjoy, M., Sundgot-Borgen, J., Burke, L., Ackerman, K. E., Blauwet, C., Constantini, N., Lebrun, C., Lundy, B., Melin, A., Meyer, N., et al. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0136 · Cited by 447
Endocrine Effects of Relative Energy Deficiency in Sport
Elliott-Sale, K. J., Tenforde, A. S., Parziale, A. L., Holtzman, B., & Ackerman, K. E. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0127 · Cited by 229
Stellingwerff, T., Heikura, I. A., Meeusen, R., Bermon, S., Seiler, S., Mountjoy, M. L., & Burke, L. M. (2021) · Sports Medicine · doi:10.1007/s40279-021-01491-0 · Cited by 171
Nutrition in Ultra-Endurance: State of the Art
Nikolaidis, P. T., Veniamakis, E., Rosemann, T., & Knechtle, B. (2018) · Nutrients · doi:10.3390/nu10121995 · Cited by 70
Muscle Glycogen Content during Endurance Training under Low Energy Availability
KOJIMA, C., ISHIBASHI, A., TANABE, Y., IWAYAMA, K., KAMEI, A., TAKAHASHI, H., & GOTO, K. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002098 · Cited by 55
Dysregulation of the Hypothalamic-Pituitary-Testicular Axis due to Energy Deficit
Grossmann, M., & Wittert, G. A. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab517 · Cited by 24
Metadata
- Authors
- Geesmann, B., Gibbs, J. C., Mester, J., & Koehler, K.
- Venue
- International Journal of Sports Physiology and Performance
- Publisher
- Human Kinetics
- Published
- 2017-08
- Volume
- 12
- Issue
- 7
- Pages
- 984-989
- ISSN
- 1555-0265
- 1555-0273
- Cited by
- 37
- References
- 6
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