Ex Vivo Imaging of Fatty Acid Amide Hydrolase Activity and Its Inhibition in the Mouse Brain

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633 · see citing works

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011 · see citing works

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913 · see citing works

2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., & Waku, K. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2437 · Cited by 2,196 · see citing works

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

Cravatt, B. F., Demarest, K., Patricelli, M. P., Bracey, M. H., Giang, D. K., Martin, B. R., & Lichtman, A. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161191698 · Cited by 1,310 · see citing works

Modulation of anxiety through blockade of anandamide hydrolysis

Kathuria, S., Gaetani, S., Fegley, D., Valiño, F., Duranti, A., Tontini, A., Mor, M., Tarzia, G., Rana, G. L., Calignano, A., et al. (2003) · Nature Medicine · doi:10.1038/nm803 · Cited by 1,293 · see citing works

Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist

Deutsch, D. G., & Chin, S. A. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90486-g · Cited by 705 · see citing works

Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent

Fride, E., & Mechoulam, R. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90468-w · Cited by 453 · see citing works

Inverse agonism and neutral antagonism at cannabinoid CB1 receptors

Pertwee, R. G. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.10.025 · Cited by 444 · see citing works

Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2

Street, I. P., Lin, H. K., Laliberté, F., Ghomashchi, F., Wang, Z., Perrier, H., Tremblay, N. M., Huang, Z., WEECH, P. K., & Gelb, M. H. (1993) · Biochemistry · doi:10.1021/bi00074a003 · Cited by 419 · see citing works

Comparative analysis of fatty acid amide hydrolase and cb1 cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling

Egertová, M., Cravatt, B. F., & Elphick, M. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00145-3 · Cited by 347 · see citing works

Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence for an Unprecedented Combination of Potency and Selectivity

Lichtman, A. H., Leung, D., Shelton, C. C., Saghatelian, A., Hardouin, C., Boger, D. L., & Cravatt, B. F. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.069401 · Cited by 329 · see citing works

A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation

Dinh, T. P., Freund, T. F., & Piomelli, D. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00150-0 · Cited by 319 · see citing works

Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system

Cravatt, B. F., & Lichtman, A. H. (2003) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(03)00079-6 · Cited by 301 · see citing works

Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide

Boger, D. L., Sato, H., Lerner, A. E., Hedrick, M. P., Fecik, R. A., Miyauchi, H., Wilkie, G. D., Austin, B. J., Patricelli, M. P., & Cravatt, B. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5044 · Cited by 272 · see citing works

A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis

Robinson, P. J., Noronha, J. G. L., DeGeorge, J. J., Freed, L. M., Nariai, T., & Рапопорт, С. И. (1992) · Brain Research Reviews · doi:10.1016/0165-0173(92)90016-f · Cited by 250 · see citing works

Anandamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents

Crawley, J. N., Corwin, R. L., Robinson, J. K., Felder, C. C., Devane, W. A., & Axelrod, J. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90230-q · Cited by 231 · see citing works

Mechanisms of Endocannabinoid Inactivation: Biochemistry and Pharmacology

Giuffrida, A., Beltramo, M., & Piomelli, D. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29345-9 · Cited by 226 · see citing works

Pharmacological Activity of Fatty Acid Amides Is Regulated, but Not Mediated, by Fatty Acid Amide Hydrolase in Vivo

Lichtman, A. H., Hawkins, E. G., Griffin, G., & Cravatt, B. F. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.302.1.73 · Cited by 224 · see citing works

Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase

Deutsch, D. G., Omeir, R. L., Arreaza, G., Salehani, D., Prestwich, G. D., Huang, Z., & Howlett, A. C. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00830-1 · Cited by 217 · see citing works

The Cellular Uptake of Anandamide Is Coupled to Its Breakdown by Fatty-acid Amide Hydrolase

Deutsch, D. G., Glaser, S. T., Howell, J. M., Kunz, J. S., Puffenbarger, R. A., Hillard, C. J., & Abumrad, N. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m003161200 · Cited by 206 · see citing works

The endogenous cannabinoid system and its role in nociceptive behavior

Cravatt, B. F., & Lichtman, A. H. (2004) · Journal of Neurobiology · doi:10.1002/neu.20080 · Cited by 203 · see citing works

The Biodisposition and Metabolism of Anandamide in Mice

Willoughby, K. A., Moore, S. F., Martin, B. R., & Ellis, E. F. (1997) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36812-0 · Cited by 159 · see citing works

Endocannabinoids as cardiovascular modulators

Kunos, G., Járai, Z., Bátkai, S., Goparaju, S. K., Ishac, E. J. N., Liu, J., Wang, L., & Wagner, J. A. (2000) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(00)00194-8 · Cited by 158 · see citing works

Anandamide transport: A critical review

Glaser, S. T., Kaczocha, M., & Deutsch, D. G. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.05.007 · Cited by 144 · see citing works

Role of Fatty Acid Amide Hydrolase in the Transport of the Endogenous Cannabinoid Anandamide

Day, T. A., Rakhshan, F., Deutsch, D. G., & Barker, E. L. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.6.1369 · Cited by 136 · see citing works

Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry

Weber, A., Ni, J., Ling, K.-H. J., Acheampong, A., Tang‐Liu, D. D., Burk, R. M., Cravatt, B. F., & Woodward, D. F. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300475-jlr200 · Cited by 129 · see citing works

Novel Inhibitors of Brain, Neuronal, and Basophilic Anandamide Amidohydrolase

PETROCELLIS, L. D., Melck, D. J., Ueda, N., Maurelli, S., Kurahashi, Y., Yamamoto, S., Marino, G., & Marzo, V. D. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6000 · Cited by 117 · see citing works

In vivo approaches to quantifying and imaging brain arachidonic and docosahexaenoic acid metabolism

Rapoport, S. I. (2003) · The Journal of Pediatrics · doi:10.1067/s0022-3476(03)00399-8 · Cited by 109 · see citing works

Fatty Acid Amide Hydrolase Inhibition by Neurotoxic Organophosphorus Pesticides

Quistad, G. B., Sparks, S. E., & Casida, J. E. (2001) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9175 · Cited by 107 · see citing works

Intravenous injection of [1‐14C]arachidonate to examine regional brain lipid metabolism in unanesthetized rats

DeGeorge, J. J., Noronha, J. G. L., Bell, J., Robinson, P., & Рапопорт, С. И. (1989) · Journal of Neuroscience Research · doi:10.1002/jnr.490240311 · Cited by 105 · see citing works

Physiological and behavioural effects of the endogenous cannabinoid, arachidonylethanolamide (anandamide), in the rat

Stein, E. A., Fuller, S. A., Edgemond, W. S., & Campbell, W. B. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15683.x · Cited by 79 · see citing works

In Vivo Fatty Acid Incorporation into Brain Phospholipids in Relation to Signal Transduction and Membrane Remodeling

Rapoport, S. I. (1999) · Neurochemical Research · doi:10.1023/a:1022584707352 · Cited by 77 · see citing works

Brain Incorporation of [ 11 C]Arachidonic Acid in Young Healthy Humans Measured with Positron Emission Tomography

Giovacchini, G., Chang, M., Channing, M. A., et al. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000033209.60867.7a · Cited by 70 · see citing works

Endocannabinoids in the intact retina:3H-anandamide uptake, fatty acid amide hydrolase immunoreactivity and hydrolysis of anandamide

Glaser, S. T., Deutsch, D. G., Studholme, K. M., ZIMOV, S., & Yazulla, S. (2005) · Visual Neuroscience · doi:10.1017/s0952523805226020 · Cited by 33 · see citing works

Brain Incorporation of [11C]Arachidonic Acid in Young Healthy Humans Measured With Positron Emission Tomography

Giovacchini, G., Chang, M., Channing, M. A., et al. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200212000-00006 · Cited by 31 · see citing works

Depressant effects of hypoxia and hypoglycaemia on neuro‐effector transmission of guinea‐pig intestine studied in vitro with a pharmacological model

Corbett, A. D., & Lees, G. M. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0700870 · Cited by 27 · see citing works

Selective Effects of the Endogenous Cannabinoid Arachidonylethanolamide (Anandamide) on Regional Cerebral Blood Flow in the Rat

Stein, E. A. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00043-8 · Cited by 25 · see citing works

Metabolism of arachidonate and stearate injected simultaneously into the mouse brain

Sun, G. Y. (1977) · Lipids · doi:10.1007/bf02533761 · Cited by 25 · see citing works

Intravenously injected radiolabelled fatty acids image brain tumour phospholipids in vivo: differential uptakes of palmitate, arachidonate and docosahexaenoate

Nariai, T., Greig, N. H., DeGeorge, J. J., et al. (1993) · Clinical & Experimental Metastasis · doi:10.1007/bf00114972 · Cited by 21 · see citing works

Serum Endocannabinoid Content is Altered in Females with Depressive Disorders: A Preliminary Report

Hill, M., Miller, G., Ho, W.-S., Gorzalka, B., & Hillard, C. (2008) · Pharmacopsychiatry · doi:10.1055/s-2007-993211 · Cited by 292 · see citing works

Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans

Dlugos, A., Childs, E., Stuhr, K. L., Hillard, C. J., & de Wit, H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.100 · Cited by 248 · see citing works

Plasma concentrations of endocannabinoids and related primary fatty acid amides in patients with post-traumatic stress disorder

Hauer, D., Schelling, G., Gola, H., Campolongo, P., Morath, J., Roozendaal, B., Hamuni, G., Karabatsiakis, A., Atsak, P., Vogeser, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062741 · Cited by 200 · see citing works

Exercise-induced endocannabinoid signaling is modulated by intensity

Raichlen, D. A., Foster, A. D., Seillier, A., Giuffrida, A., & Gerdeman, G. L. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2495-5 · Cited by 181 · see citing works

Paracetamol is a centrally acting analgesic using mechanisms located in the periaqueductal grey

Barrière, D. A., Boumezbeur, F., Dalmann, R., Cadeddu, R., Richard, D., Pinguet, J., Daulhac, L., Sarret, P., Whittingstall, K., Keller, M., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.14934 · Cited by 34 · see citing works

Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors

Wise, L. E., Shelton, C. C., Cravatt, B. F., Martin, B. R., & Lichtman, A. H. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.11.002 · Cited by 40 · see citing works

Short communication Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB 1 receptors

Wise, L. E., Shelton, C. C., Cravatt, B. F., Martin, B. R., & Lichtman, A. H. (2007)

Endocannabinoid structure–activity relationships for interaction at the cannabinoid receptors

Reggio, P. H. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0343 · Cited by 40 · see citing works

Cannabimimetic Fatty Acid Derivatives: The Anandamide Family and Other 'Endocannabinoids'

Melck, D. J., Marzo, V. D., Bisogno, T., PETROCELLIS, L. D., & Martin, B. R. (1999) · Current Medicinal Chemistry · doi:10.2174/0929867306666220401141630 · Cited by 119 · see citing works

Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents

Wiley, J. L., Walentiny, D. M., Wright, M. J., Beardsley, P. M., Burston, J. J., Poklis, J. L., Lichtman, A. H., & Vann, R. E. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.05.013 · Cited by 31 · see citing works