Rapid Broad-Spectrum Analgesia through Activation of Peroxisome Proliferator-Activated Receptor-α

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The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide

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Carrageenan-Induced Paw Edema in the Rat and Mouse

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Role of anorectic N-acylethanolamines in intestinal physiology and satiety control with respect to dietary fat

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Oral Palmitoylethanolamide Treatment Is Associated with Reduced Cutaneous Adverse Effects of Interferon-β1a and Circulating Proinflammatory Cytokines in Relapsing–Remitting Multiple Sclerosis

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Innovative Nanoparticles Enhance N-Palmitoylethanolamide Intraocular Delivery

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Lipids as targets for novel anti-inflammatory therapies

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The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1

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Lack of effect of chronic pre‐treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system

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Endocannabinoids, Adipose Tissue and Lipid Metabolism

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New Targets in Pain, Non-Neuronal Cells, and the Role of Palmitoylethanolamide

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Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-α receptor agonist GW7647

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Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome-Proliferator Activated Receptor-α

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Synthesis and Structure−Activity Relationships of N-(2-Oxo-3-oxetanyl)amides as N-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors

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A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase

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Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway

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Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependent

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Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity

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Bacterial meningitis: an update of new treatment options

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Palmitoylethanolamide protects mice against 6-OHDA-induced neurotoxicity and endoplasmic reticulum stress: In vivo and in vitro evidence

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Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models

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Palmitoylethanolamide Reverses Paclitaxel-Induced Allodynia in Mice

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The effects of oleoylethanolamide, an endogenous PPAR‐α agonist, on risk factors for NAFLD: A systematic review

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Micronized Palmitoylethanolamide Reduces the Symptoms of Neuropathic Pain in Diabetic Patients

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N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis and Structure–Activity and Structure–Property Relationships

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FAAH inhibition as a preventive treatment for migraine: A pre-clinical study

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Targeting Peroxisome Proliferator-Activated Receptor-α (PPAR- α) to reduce paclitaxel-induced peripheral neuropathy

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Synthesis and Structure–Activity Relationship (SAR) of 2-Methyl-4-oxo-3-oxetanylcarbamic Acid Esters, a Class of Potent N-Acylethanolamine Acid Amidase (NAAA) Inhibitors

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Palmitoylethanolamide Prevents Metabolic Alterations and Restores Leptin Sensitivity in Ovariectomized Rats

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Vagal afferents are not necessary for the satiety effect of the gut lipid messenger oleoylethanolamide

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Potential analgesic effects of a novel N-acylethanolamine acid amidase inhibitor F96 through PPAR-α

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Peroxisome proliferator-activated receptor agonists modulate neuropathic pain: a link to chemokines?

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Delay of Morphine Tolerance by Palmitoylethanolamide

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Inhibition of fatty acid amide hydrolase suppresses referred hyperalgesia induced by bladder inflammation

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Endocannabinoids and Acute Pain Following Total Knee Arthroplasty

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Functional and biochemical interaction between PPARα receptors and TRPV1 channels: Potential role in PPARα agonists-mediated analgesia

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Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies

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Central mechanisms mediating the hypophagic effects of oleoylethanolamide and N-acylphosphatidylethanolamines: different lipid signals?

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Inhibition of the Soluble Epoxide Hydrolase as an Analgesic Strategy: A Review of Preclinical Evidence

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Chapter 13 PPAR and Pain

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Antiepileptogenic Effect of Subchronic Palmitoylethanolamide Treatment in a Mouse Model of Acute Epilepsy

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N-Palmitoylethanolamide protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress

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Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections

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Cellular Distribution of Canonical and Putative Cannabinoid Receptors in Canine Cervical Dorsal Root Ganglia

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Painful interactions: Microbial compounds and visceral pain

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NAAA-regulated lipid signaling governs the transition from acute to chronic pain

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A multimodal disease modifying approach to treat neuropathic pain – inhibition of soluble epoxide hydrolase (sEH)

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Palmitoylethanolamide: A Potential Alternative to Cannabidiol

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Palmitoylethanolamide modulates pentobarbital-evoked hypnotic effect in mice

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Palmitoylethanolamide, a neutraceutical, in nerve compression syndromes: efficacy and safety in sciatic pain and carpal tunnel syndrome

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Interaction of ligands for the peroxisome proliferator‐activated receptor γ with the endocannabinoid system

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High Levels of N-Palmitoylethanolamide and N-Stearoylethanolamide in Microdialysate Samples from Myalgic Trapezius Muscle in Women

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Palmitoylethanolamide and Related ALIAmides: Prohomeostatic Lipid Compounds for Animal Health and Wellbeing

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The Role of the Endogenous Cannabinoid System in Peripheral Analgesia

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In vivo pharmacology of endocannabinoids and their metabolic inhibitors: Therapeutic implications in Parkinson's disease and abuse liability

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RAR/RXR and PPAR/RXR Signaling in Spinal Cord Injury

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Peripheral mechanisms of burn injury-associated pain

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N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism

Okine, B. N., Madasu, M. K., McGowan, F., Prendergast, C., Gaspar, J. C., Harhen, B., Roche, M., & Finn, D. P. (2016) · Pain · doi:10.1097/j.pain.0000000000000687 · Cited by 33

N-Acylethanolamine acid amidase (NAAA) inhibitor F215 as a novel therapeutic agent for osteoarthritis.

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A Fenofibrate Diet Prevents Paclitaxel-Induced Peripheral Neuropathy in Mice

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Oral 2‐hydroxyoleic acid inhibits reflex hypersensitivity and open–field‐induced anxiety after spared nerve injury

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Endocannabinoid Receptors in the CNS: Potential Drug Targets for the Prevention and Treatment of Neurologic and Psychiatric Disorders

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Brain permeant and impermeant inhibitors of fatty-acid amide hydrolase suppress the development and maintenance of paclitaxel-induced neuropathic pain without producing tolerance or physical dependence in vivo and synergize with paclitaxel to reduce tumor cell line viability in vitro

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N-Palmitoyl-ethanolamine (PEA) Induces Peripheral Antinociceptive Effect by ATP-Sensitive K+-Channel Activation

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Therapeutic Effects of PPARαon Neuronal Death and Microvascular Impairment

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Synthesis, Structure–Activity, and Structure–Stability Relationships of 2‐Substituted‐N‐(4‐oxo‐3‐oxetanyl) N‐Acylethanolamine Acid Amidase (NAAA) Inhibitors

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Chronic Pain in Dogs and Cats: Is There Place for Dietary Intervention with Micro-Palmitoylethanolamide?

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The endocannabinoid system and related lipids as potential targets for the treatment of migraine‐related pain

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Peroxisome proliferator‐activated receptor alpha and the ketogenic diet

Cullingford, T. E. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01840.x · Cited by 29

Effects of Palmitoylethanolamide on Aqueous Humor Outflow

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Endogenous Molecules Stimulating N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA)

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3‐Aminoazetidin‐2‐one Derivatives as N‐Acylethanolamine Acid Amidase (NAAA) Inhibitors Suitable for Systemic Administration

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Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure–activity relationship (SAR) studies

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PEA and luteolin synergistically reduce mast cell-mediated toxicity and elicit neuroprotection in cell-based models of brain ischemia

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PPARγ Agonists Attenuate Trigeminal Neuropathic Pain

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Activity-Based Probe for N-Acylethanolamine Acid Amidase

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Nanoparticles prolong N-palmitoylethanolamide anti-inflammatory and analgesic effects in vivo

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