Rapid Broad-Spectrum Analgesia through Activation of Peroxisome Proliferator-Activated Receptor-α

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The PPARs: From Orphan Receptors to Drug Discovery

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Role of the Immune system in chronic pain

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Control of pain initiation by endogenous cannabinoids

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The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide

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Carrageenan-Induced Paw Edema in the Rat and Mouse

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Design of a potent and selective inhibitor of the intermediate-conductance Ca 2+ -activated K + channel, IKCa1 : A potential immunosuppressant

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Inhibition of fatty acid amide hydrolase in the CNS prevents and reverses morphine tolerance in male and female mice

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Synergistic antinociceptive interaction between palmitoylethanolamide and tramadol in the mouse formalin test

Déciga‐Campos, M., Ramírez-Marín, P. M., & López‐Muñoz, F. J. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.08.025 · Cited by 19

Role of cannabinoid receptor 1 and the peroxisome proliferator-activated receptor α in mediating anti-nociceptive effects of synthetic cannabinoids and a cannabinoid-like compound

Alsalem, M., Haddad, M., Aldossary, S. A., Kalbouneh, H., Altarifi, A., Jaffal, S. M., Abbas, M. A., Aldaoud, N., & El‐Salem, K. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00584-7 · Cited by 20

Effects of Dual Peroxisome Proliferator-Activated Receptors α and γ Activation in Two Rat Models of Neuropathic Pain

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Broad Lipidomic and Transcriptional Changes of Prophylactic PEA Administration in Adult Mice

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New Insights into Antimetastatic and Antiangiogenic Effects of Cannabinoids

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Involvement of the L‐arginine/nitric oxide/cyclic guanosine monophosphate pathway in peripheral antinociception induced by N‐palmitoyl‐ethanolamine in rats

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Alteration of neuropathic and visceral pain in female C57BL/6J mice lacking the PPAR-α gene

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Effects of Ultramicronized Palmitoylethanolamide (um-PEA) in COVID-19 Early Stages: A Case–Control Study

Albanese, M., Marrone, G., Paolino, A., Lauro, M. D., Daniele, F. D., Chiaramonte, C., D’Agostini, C., Romani, A., Cavaliere, A., Guerriero, C., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15020253 · Cited by 18

Effects of Ultramicronized Palmitoylethanolamide on Mitochondrial Bioenergetics, Cerebral Metabolism, and Glutamatergic Transmission: An Integrated Approach in a Triple Transgenic Mouse Model of Alzheimer's Disease

Bellanti, F., Bukke, V. N., Moola, A., Villani, R., Scuderi, C., Steardo, L., Palombelli, G., Canese, R., Beggiato, S., Altamura, M., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.890855 · Cited by 18

NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice

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The Potential Benefits of Palmitoylethanolamide in Palliation: A Qualitative Systematic Review

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Activation of dsRNA-Dependent Protein Kinase R by miR-378 Sustains Metabolic Inflammation in Hepatic Insulin Resistance

Wang, H., Song, Y., Wu, Y., Kumar, V., Mahato, R. I., & Su, Q. (2021) · Diabetes · doi:10.2337/db20-0181 · Cited by 18

Differential tissue regulation of peroxisome proliferator-activated receptor α (PPARα) and cannabinoid receptor 1 (CB1) gene transcription pathways by diethylene glycol dibenzoate (DEGB): preliminary observations in a seabream (Sparus aurata) in vivo model

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N-Acylethanolamine Acid Amidase contributes to disease progression in a mouse model of multiple sclerosis

Pontis, S., Palese, F., Summa, M., Realini, N., Lanfranco, M., Mei, C. D., & Piomelli, D. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105064 · Cited by 16

Phytohormone abscisic acid elicits antinociceptive effects in rats through the activation of opioid and peroxisome proliferator-activated receptors β/δ

Mollashahi, M., Abbasnejad, M., & Esmaeili‐Mahani, S. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.05.013 · Cited by 17

PEA prevented early BBB disruption after cerebral ischaemic/reperfusion (I/R) injury through regulation of ROCK/MLC signaling

Kong, D., Xie, B., Li, Y., & Xu, Y. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.06.019 · Cited by 17

Sexually Dimorphic Expression of Fear-conditioned Analgesia in Rats and Associated Alterations in the Endocannabinoid System in the Periaqueductal Grey

Llorente‐Berzal, A., McGowan, F., Gaspar, J. C., Rea, K., Roche, M., & Finn, D. P. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.11.005 · Cited by 16

N-Acylethanolamine Acid Amidase (NAAA): Mechanism of Palmitoylethanolamide Hydrolysis Revealed by Mechanistic Simulations

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Are big potassium-type Ca2+-activated potassium channels a viable target for the treatment of epilepsy?

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Chapter 4 Targeted Lipidomics as a Tool to Investigate Endocannabinoid Function

Astarita, G., Geaga, J. A., Ahmed, F., & Piomelli, D. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)85004-6 · Cited by 15

Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interventional study

Rao, A., Ebelt, P., Mallard, A. R., & Briskey, D. R. (2021) · Sleep Science and Practice · doi:10.1186/s41606-021-00065-3 · Cited by 16

Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of rats

Charrua, A., Matos, R., Oliveira, R., Marczylo, T. H., Nagy, I., & Cruz, F. (2019) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-019-01729-9 · Cited by 15

Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine

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N-acylethanolamine acid amidase (NAAA), a new path to unleash PPAR-mediated analgesia

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Pharmacological Blockade of PPARα Exacerbates Inflammatory Pain-Related Impairment of Spatial Memory in Rats

Gaspar, J. C., Healy, C. R., Ferdousi, M. I., Roche, M., & Finn, D. P. (2021) · Biomedicines · doi:10.3390/biomedicines9060610 · Cited by 14

Cannabinoid rescue of striatal progenitor cells in chronic Borna Disease viral encephalitis in rats

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Cannabinoid Analgesia in Postoperative Pain Management: From Molecular Mechanisms to Clinical Reality

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Synthesis, Biological Evaluation, and 3D QSAR Study of 2-Methyl-4-oxo-3-oxetanylcarbamic Acid Esters as N-Acylethanolamine Acid Amidase (NAAA) Inhibitors

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Effects of the glial modulator palmitoylethanolamide on chronic pain intensity and brain function

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Thiazolidine Derivatives Attenuate Carrageenan-Induced Inflammatory Pain in Mice

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Activation of dsRNA-Dependent Protein Kinase R by MicroRNA-378 Sustains Metabolic Inflammation in Hepatic Insulin Resistance

Wang, H., Song, Y., Wu, Y., Kumar, V., Mahato, R. I., & Su, Q. (2021) · Diabetes · doi:10.2337/20-0181 · Cited by 12

Antinociceptive Profile of ARN19702, (2-Ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone, a Novel Orally Active N-Acylethanolamine Acid Amidase Inhibitor, in Animal Models

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Cannabinoid activation of peroxisome proliferator‐activated receptors: an update and review of the physiological relevance

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N-(4-Methoxy-2-nitrophenyl)hexadecanamide, a palmitoylethanolamide analogue, reduces formalin-induced nociception

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Pharmacological Blockade of PPAR Isoforms Increases Conditioned Fear Responding in the Presence of Nociceptive Tone

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Palmitoylethanolamide and Related ALIAmides for Small Animal Health: State of the Art

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Palmitoylethanolamide causes dose-dependent changes in brain function and the lipidome

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Neuroprotective, anti-inflammatory, and analgesic activity of palmitoylethanolamide in sickle cell mice

Argueta, D. A., Avalos, B., Goel, Y., Tran, H., Fotio, Y., Piomelli, D., DiPatrizio, N. V., & Gupta, K. (2025) · Blood Advances · doi:10.1182/bloodadvances.2024015439 · Cited by 10

Structural improvement of new thiazolidinones compounds with antinociceptive activity in experimental chemotherapy‐induced painful neuropathy

Moreira, D. R. M., Santos, D. S., Santo, R. F. D. E., dos Santos, F. E., Filho, G. B. D. O., Leite, A. C. L., Soares, M. B. P., & Villarreal, C. F. (2017) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12951 · Cited by 10

Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice

Zambrana-Infantes, E. N., Rosell‐Valle, C., de Guevara‐Miranda, D. L., Galeano, P., Castilla‐Ortega, E., de Fonseca, F. R., Blanco, E., & Santín, L. J. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.01.002 · Cited by 10

Efficacy of Topical Palmitoylethanolamide (Levagen+) for the Management of Eczema Symptoms: A Double-Blind, Comparator-Controlled, Randomized Clinical Trial

Rao, A., Moussa, A. A., Erickson, J., & Briskey, D. R. (2023) · Skin Pharmacology and Physiology · doi:10.1159/000536670 · Cited by 10

Synergistic antinociceptive effects of concomitant NAAA and peripheral FAAH inhibition

Tagne, A. M., Fotio, Y., Uppal, P. S., & Piomelli, D. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114194 · Cited by 10

Enhancement of Antihyperalgesia by the Coadministration of N‐palmitoylethanolamide and Acetaminophen in Diabetic Rats

Déciga‐Campos, M., & Ortíz‐Andrade, R. (2015) · Drug Development Research · doi:10.1002/ddr.21259 · Cited by 10

Dietary fatty acid composition impacts plasma fatty acid ethanolamide levels and body composition in golden Syrian hamsters

Sihag, J., & Jones, P. J. H. (2018) · Food & Function · doi:10.1039/c8fo00621k · Cited by 10

Anti-nociceptive effect of Arbutus andrachne L. methanolic leaf extract mediated by CB1, TRPV1 and PPARs in mouse pain models

Jaffal, S. M., Oran, S. A., & Alsalem, M. (2020) · Inflammopharmacology · doi:10.1007/s10787-020-00746-y · Cited by 10

Intracisternal injection of palmitoylethanolamide inhibits the peripheral nociceptive evoked responses of dorsal horn wide dynamic range neurons

González‐Hernández, A., Martı́nez-Lorenzana, G., Rodríguez-Jiménez, J., Rojas‐Piloni, G., & Condés‐Lara, M. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1255-6 · Cited by 9

Synthesis, biological evaluation, and structure activity relationship (SAR) study of pyrrolidine amide derivatives as N -acylethanolamine acid amidase (NAAA) inhibitors

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High levels of endogenous lipid mediators ( N -acylethanolamines) in women with chronic widespread pain during acute tissue trauma

Stensson, N., Ghafouri, B., Ghafouri, N., & Gerdle, B. U. C. (2016) · Molecular Pain · doi:10.1177/1744806916662886 · Cited by 9

Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia

Okine, B. N., Gaspar, J. C., Madasu, M. K., Olango, W. M., Harhen, B., Roche, M., & Finn, D. P. (2016) · Brain Research · doi:10.1016/j.brainres.2016.11.022 · Cited by 9

Distribution of an analgesic palmitoylethanolamide and other N-acylethanolamines in human placental membranes

Svobodová, A., Vrkoslav, V., Šmeringaiová, I., & Jirsová, K. (2023) · PLoS ONE · doi:10.1371/journal.pone.0279863 · Cited by 8

Association of Serum Endocannabinoid Levels with Pancreatitis and Pancreatitis-Related Pain

Goodman, M. T., Lombardi, C. A., Torrens, A., Bresee, C. J., Saloman, J. L., Li, L., Yang, Y., Fisher, W. E., Fogel, E. L., Forsmark, C. E., et al. (2024) · Cannabis and Cannabinoid Research · doi:10.1089/can.2024.0079 · Cited by 8

Role of PPARα and PPARγ in Mediating the Analgesic Properties of Ibuprofen in vivo and the Effects of Dual PPARα/γ Activation in Inflammatory Pain Model in the Rat

Alsalem, M., Altarifi, A., Kalbouneh, H., Alzer, H., Azab, B., & Salem, K. E. (2016) · International Journal of Pharmacology · doi:10.3923/ijp.2016.812.820 · Cited by 8

N-acylethanolamine acid amidase (NAAA) inhibition decreases the motivation for alcohol in Marchigian Sardinian alcohol-preferring rats

Fotio, Y., Ciccocioppo, R., & Piomelli, D. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05678-7 · Cited by 8

Different roles for the acyl chain and the amine leaving group in the substrate selectivity of N-Acylethanolamine acid amidase

Ghidini, A., Scalvini, L., Palese, F., Lodola, A., Mor, M., & Piomelli, D. (2021) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2021.1912035 · Cited by 8

Probable involvement of Ca2+-activated Cl− channels (CaCCs) in the activation of CB1 cannabinoid receptors

Romero, T. R. L., Pacheco, D. D. F., & Duarte, I. D. G. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.10.006 · Cited by 8

PPAR-α acutely inhibits functional activity of ASICs in rat dorsal root ganglion neurons

Wu, J., Wang, J., Liu, T., Zhou, Y., Qiu, C., Shen, D., & Hu, W. (2017) · Oncotarget · doi:10.18632/oncotarget.21805 · Cited by 8

N‐acylethanolamine‐hydrolysing acid amidase: A new potential target to treat paclitaxel‐induced neuropathy

Toma, W. B., Caillaud, M., Patel, N. H., Tran, T. H., Donvito, G., Roberts, J. L., Bağdaş, D., Jackson, A. B., Lichtman, A. H., Gewirtz, D. A., et al. (2021) · European Journal of Pain · doi:10.1002/ejp.1758 · Cited by 8

N-palmitoylethanolamide synergizes the antinociception of morphine and gabapentin in the formalin test in mice

Déciga‐Campos, M., Jaramillo‐Morales, O. A., Espinosa‐Juárez, J. V., Aguilera-Martínez, M. E., Ventura‐Martínez, R., & López‐Muñoz, F. J. (2023) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgad004 · Cited by 7

Effects of Two Different Specific Neck Exercise Interventions on Palmitoylethanolamide and Stearoylethanolamide Concentrations in the Interstitium of the Trapezius Muscle in Women with Chronic Neck Shoulder Pain

Ghafouri, N., Ghafouri, B., Fowler, C. J., Larsson, B. K., Turkina, M. V., Karlsson, L., & Gerdle, B. U. C. (2014) · Pain Medicine · doi:10.1111/pme.12486 · Cited by 7

Insights Into the Prognostic Value and Immunological Role of NAAA in Pan-Cancer

Huang, D., Shen, J., Zhai, L., Chen, H., Jing, F., Zhu, X., & Zhou, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.812713 · Cited by 7

Cathepsin S in the spinal microglia facilitates morphine-induced antinociceptive tolerance in rats

Li, X., Han, X., Wang, X., Li, Q., Chen, Y., Cui, Y., & Chen, Y. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.10.043 · Cited by 7

Dietary fatty acid profile influences circulating and tissue fatty acid ethanolamide concentrations in a tissue-specific manner in male Syrian hamsters

Sihag, J., & Jones, P. J. H. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.07.002 · Cited by 6

Classical and Unexpected Effects of Ultra-Micronized PEA in Neuromuscular Function

Cifelli, P., Ruffolo, G., Ceccanti, M., Cambieri, C., Libonati, L., Palma, E., & Inghilleri, M. (2022) · Biomolecules · doi:10.3390/biom12060758 · Cited by 6

Systemic administration of WY-14643, a selective synthetic agonist of peroxisome proliferator activator receptor-alpha, alters spinal neuronal firing in a rodent model of neuropathic pain

Okine, B. N., Spicer, C. H., Millns, P. J., Bennett, A. J., & Chapman, V. (2015) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2015.06.004 · Cited by 6

Computational and Biological Evaluation of N-octadecyl-N′-propylsulfamide, a Selective PPARα Agonist Structurally Related to N-acylethanolamines

Moreno‐Santos, I., Pavón, F. J., Cuevas, M. R., Serrano, A., Cano, C., Suardíaz, M., Decara, J. M., Suárez, J., de Fonseca, F. R., & Macías‐González, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092195 · Cited by 6

A KCa3.1 Channel Opener, ASP0819, Modulates Nociceptive Signal Processing from Peripheral Nerves in Fibromyalgia-Like Pain in Rats

Takeshita, N., Oe, T., Kiso, T., & Kakimoto, S. (2021) · Journal of Pain Research · doi:10.2147/jpr.s274563 · Cited by 6

A thickening network of lipids

Piomelli, D. (2011) · Pain · doi:10.1016/j.pain.2011.09.026 · Cited by 6

Galactosyl prodrug of palmitoylethanolamide: Synthesis, stability, cell permeation and cytoprotective activity

Luongo, E., Russo, R., Avagliano, C., Santoro, A., Melisi, D., Orefice, N. S., Raso, G. M., Meli, R., Magliocca, S., Nieddu, M., et al. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.05.009 · Cited by 5

Amino Compound-Containing Lipids: a Novel Class of Signals Regulating Plant Development

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Improvement of Topical Palmitoylethanolamide Anti-Inflammatory Activity by Pegylated Prodrugs

Tronino, D., Russo, R., Ostacolo, C., Mazzolari, A., Caro, C. D., Avagliano, C., Laneri, S., Rana, G. L., Sacchi, A., Valle, F. D., et al. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00397 · Cited by 5

Common Receptors for Endocannabinoid-Like Mediators and Plant Cannabinoids

Alexander, S. P. H. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-420126-2.00010-9 · Cited by 4

Lipid signaling and fat storage in the dark-eyed junco

Ho, J. M., Burns, C. M. B., Rendon, N. M., Rosvall, K. A., Bradshaw, H. B., Ketterson, E. D., & Demas, G. E. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.01.029 · Cited by 4

Treatment of Established Chemotherapy-Induced Neuropathy with N-Palmitoylethanolamide: A Randomized, Double-Blind Phase II Pilot Study

Davis, M. P., Ulrich, A., Segal, R. A., Gudena, V. K., Ruddy, K. J., D’Andre, S. D., Giridhar, K. V., Vasireddy, V. K., Agarwal, R., Azzouqa, A., et al. (2024) · Cancers · doi:10.3390/cancers16244244 · Cited by 3

Palmitoylethanolamide Does Not Affect Recovery from Exercise-Induced Muscle Damage in Healthy Males

Schouten, M., Dalle, S., Costamagna, D., Ramaekers, M., Bogaerts, S., Thienen, R. V., Peers, K. H. E., Thomis, M. A., & Koppo, K. (2024) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003517 · Cited by 7

Il sistema endocannabinoide: attuali conoscenze e potenziali applicazioni in odontostomatologia

Pavanini, S., Lauriola, S., Mottola, A., & Cocchi, R. (2011) · Italian Oral Surgery · doi:10.1016/j.ios.2010.11.004 · Cited by 3

Complex role of peroxisome proliferator activator receptors (PPARs) in nociception

Giniatullin, R. A., Bart, G., & Tavi, P. (2015) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2015.08.006 · Cited by 3

Peroxisome Proliferator-Activated Receptor-Review

Adedapo, A. D. A., Asunloye, O. O., & Adeoye, B. O. (2018) · International Journal of Biochemistry Research & Review · doi:10.9734/ijbcrr/2018/40221 · Cited by 3

Insights in the Mechanism of Action and Inhibition of N-Acylethanolamine Acid Amidase by Means of Computational Methods

Lodola, A., Rivara, S., & Mor, M. (2014) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2014.06.007 · Cited by 3

N-acylethanolamine acid amide hydrolase is a novel target for drugs against SARS-CoV-2 and Zika virusPreprint

Lai, M., Rocca, V. L., Amato, R., Iacono, E., Filipponi, C., Catelli, E., Bogani, L., Fonnesu, R., Lottini, G., Carli, A. D., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.08.479661 · Cited by 3

Role of peroxisome proliferator-activated receptor alpha in neurodegenerative diseases and other neurological disorders: Clinical application prospects

Wu, Z., Zhao, Y., Hao, S., An, M., Song, C., & Li, J. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01371 · Cited by 4

An injectable carrier-free and self-assembling nanofiber hydrogel with anti-inflammatory and spatiotemporally-controllable anti-VEGF releasing capability for treatment of choroidal neovascularization

Xiu, Y., Yuan, H., Fan, Y., Su, Y., Zhang, Y., Yuan, X., Zhao, S., Gao, Z., Hu, T., Qiu, Y., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.165601 · Cited by 2

Age differences in endocannabinoid tone are ameliorated after recent cannabis use

Morris, A. W. J., Mueller, R. L., Sempio, C., Klawitter, J., Bryan, A. D., Bidwell, L. C., & Hutchison, K. E. (2026) · Scientific Reports · doi:10.1038/s41598-025-27618-1 · Cited by 2

Identification of the Involvement of Potassium Channels in Fibromyalgia

Lawson, K. (2022) · Frontiers in Bioscience-Scholar · doi:10.31083/j.fbs1404029 · Cited by 2

Prospective observational study on the efficacy and tolerability of a complex of phytochemicals vs. dutasteride in the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia

Saitta, G., Mantovani, F., Calabrese, B., Aliboni, C., Paola, G. D., Meazza, A. L., & Seveso, M. (2024) · Archivio Italiano di Urologia e Andrologia · doi:10.4081/aiua.2024.12869 · Cited by 2

Anandamide and Other Acylethanolamides

Petrosino, S., & Marzo, V. D. (2009) · Springer eBooks · doi:10.1007/978-0-387-30378-9_5 · Cited by 2

Endocannabinoid System in a Planarian Model

Mustonen, K. L. (2010) · doi:10.12794/metadc33188 · Cited by 2

Cannabinoids And Cannabinoid-Like Compounds: Biochemical Characterization And Pharmacological Perspectives

Kytikovа, O. Y., Denisenko, Y., Novgorodtseva, T. P., & Kovalenko, I. S. (2023) · Russian Open Medical Journal · doi:10.15275/rusomj.2023.0107 · Cited by 1

The effects of formulated palmitoylethanolamide supplementation on indicators of stress and heart rate variability in female university students: a randomised cross-over trial

Deb, S. K., Kim, N., Parolin, B., Renshaw, D. W., & Zariwala, M. G. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1586409 · Cited by 1

Xanthohumol alleviates central sensitization in migraine via PPARα-mediated activation of the AMPK pathway and suppression of neuroinflammation

Yan, W. J., Huang, Y., Zhou, Y., Xie, Q., Huang, W., Lei, Y., & Xiao, Z. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.157816 · Cited by 1

Pain Management

Hesselink, J. K. (2014) · Springer eBooks · doi:10.1007/978-3-642-13706-8_16 · Cited by 1

Endocannabinoids and Related Lipids in Chronic Pain : Analytical and Clinical Aspects

Stensson, N. (2018) · Linköping University medical dissertations · doi:10.3384/diss.diva-147653 · Cited by 1

Peroxisome Proliferator-Activated Receptors - Alpha in Chronic Inflammation - Mini-Review

Popa, E., Zugun‐Eloae, F., Zlei, M., Traian, M. G., Bacușcă, A. I., Popa, A. E., & Coman, A. E. (2019) · International Journal of Pharmacology Phytochemistry and Ethnomedicine · doi:10.18052/www.scipress.com/ijppe.12.1 · Cited by 1

The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study

Weideman, R. (2013) · Open University of Cape Town (University of Cape Town) · Cited by 1

Cannabinoid-Dopamine Interactions: Modulation of Midbrain DA Neurons by Endocannabinoids

Georges, F. E., & Melis, M. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2294-9_17

The cellular processing of the endocannabinoid anandamide and its pharmacological manipulation

Thors, L. (2009) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Endocannabinoids and N-acylethanolamines in translational pain research : from monoacylglycerol lipase to muscle pain

Ghafouri, N. (2013) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Role of the Endocannabinoid System in Systems Toxicity

Pistos, C. M., & Theocharis, S. E. (2009) · General, Applied and Systems Toxicology · doi:10.1002/9780470744307.gat206

The Treatment of Neuropathic Pain with Cannabinoid Based Nanotechnology

Linsell, O. (2013) · Otago University Research Archive (University of Otago)

TARGETING METHYLGLYOXAL AND PPAR GAMMA TO ALLEVIATE NEUROPATHIC PAIN ASSOCIATED WITH TYPE 2 DIABETES

Griggs, R. B. (2015) · UKnowledge (University of Kentucky)

Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha.

Piomelli, D., LoVerme, J., Russo, R., La Rana, G., Fu, J., Farthing, J., Mattace-Raso, G., Meli, R., Hohmann, A. G., & Calignano, A. (2006) · eScholarship (California Digital Library)

Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-. J Pharmacol Exp Ther 319:1051–1061

LoVerme, J., Russo, R., Rana, G. L., Fu, J., Farthing, J. N., Meli, R., Hohmann, A. G., Calignano, A., & Piomelli, D. (2006)

A role for PPAR-alpha in the Central Nervous System in pain and inflammation control

D’Agostino, G. (2010)

Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-κB nuclear signalling in dorsal root ganglia

D’Agostino, G., Rana, G. L., Russo, R., Sasso, O., Iacono, A., Esposito, E., Raso, G. M., Cuzzocrea, S., LoVerme, J., Piomelli, D., et al. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.04.022 · Cited by 136

A role for PPARα in the medial prefrontal cortex in formalin‐evoked nociceptive responding in rats

Okine, B., Rea, K., Olango, W., Price, J., Herdman, S., Madasu, M., Roche, M., & Finn, D. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12540 · Cited by 29