The Role of α6-Containing Nicotinic Acetylcholine Receptors in Nicotine Reward and Withdrawal

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Nicotine Withdrawal

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Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling

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Neurobiological Mechanisms of Nicotine Reward and Aversion

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New mechanisms and perspectives in nicotine withdrawal

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The role of the habenula in the transition from reward to misery in substance use and mood disorders

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Negative affective states and cognitive impairments in nicotine dependence

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Inside-out neuropharmacology of nicotinic drugs

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Expression of Functional Human α6β2β3* Acetylcholine Receptors in Xenopus laevis Oocytes Achieved through Subunit Chimeras and Concatamers

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Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders

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Anxiety and Depression in Bidirectional Relations Between Pain and Smoking

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Habenula cholinergic neurons regulate anxiety during nicotine withdrawal via nicotinic acetylcholine receptors

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Parallel Anxiolytic-Like Effects and Upregulation of Neuronal Nicotinic Acetylcholine Receptors Following Chronic Nicotine and Varenicline

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Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors

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α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6β4 and α6β2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release

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AT-1001: A High Affinity and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist Blocks Nicotine Self-Administration in Rats

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Nicotinic acetylcholine receptors in dorsal root ganglion neurons include the α6β4 subtype

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Understanding the habenula: A major node in circuits regulating emotion and motivation

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The Molecular Neurobiology of Twelve Steps Program & Fellowship: Connecting the Dots for Recovery

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Extended access to nicotine leads to a CRF1receptor dependent increase in anxiety-like behavior and hyperalgesia in rats

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Nicotine deprivation increases pain intensity, neurogenic inflammation, and mechanical hyperalgesia among daily tobacco smokers.

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Differential Roles of α6β2* and α4β2* Neuronal Nicotinic Receptors in Nicotine- and Cocaine-Conditioned Reward in Mice

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Varenicline Is a Potent Partial Agonist at α6β2* Nicotinic Acetylcholine Receptors in Rat and Monkey Striatum

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The α3β4* nicotinic acetylcholine receptor subtype mediates nicotine reward and physical nicotine withdrawal signs independently of the α5 subunit in the mouse

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Animal Models of Nicotine Exposure: Relevance to Second-Hand Smoking, Electronic Cigarette Use, and Compulsive Smoking

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Mechanistic insights into nicotine withdrawal

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Characterization of a Novel α-Conotoxin from Conus textile That Selectively Targets α6/α3β2β3 Nicotinic Acetylcholine Receptors

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Addiction‐related neuroadaptations following chronic nicotine exposure

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Nicotinic Receptor Contributions to Smoking: Insights from Human Studies and Animal Models

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Nicotinic Receptor Antagonists as Treatments for Nicotine Abuse

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Positional Scanning Mutagenesis of α-Conotoxin PeIA Identifies Critical Residues That Confer Potency and Selectivity for α6/α3β2β3 and α3β2 Nicotinic Acetylcholine Receptors

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Assessing nicotine dependence using an oral nicotine free-choice paradigm in mice

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Insights into the Neurobiology of the Nicotinic Cholinergic System and Nicotine Addiction from Mice Expressing Nicotinic Receptors Harboring Gain-of-Function Mutations

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Drug withdrawal-induced depression: Serotonergic and plasticity changes in animal models

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Nicotinic acetylcholine receptors containing α6 subunits contribute to alcohol reward‐related behaviours

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α-Conotoxin PeIA[S9H,V10A,E14N] Potently and Selectively Blocks α6β2β3 versus α6β4 Nicotinic Acetylcholine Receptors

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Long-Term Nicotine Exposure Depresses Dopamine Release in Nonhuman Primate Nucleus Accumbens

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Acute Ethanol Inhibits Dopamine Release in the Nucleus Accumbens via α6 Nicotinic Acetylcholine Receptors

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Diverse strategies targeting α7 homomeric and α6β2* heteromeric nicotinic acetylcholine receptors for smoking cessation

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Genetically expressed HIV-1 viral proteins attenuate nicotine-induced behavioral sensitization and alter mesocorticolimbic ERK and CREB signaling in rats

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Low Dose Nicotine and Antagonism of β2 Subunit Containing Nicotinic Acetylcholine Receptors Have Similar Effects on Affective Behavior in Mice

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Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes

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Progress and challenges in the study of α6-containing nicotinic acetylcholine receptors

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The effects of lobeline on nicotine withdrawal-induced depression-like behavior in mice

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Characterizing functional α6β2 nicotinic acetylcholine receptors in vitro: Mutant β2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells

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The Necessity of α4* Nicotinic Receptors in Nicotine-Driven Behaviors: Dissociation Between Reinforcing and Motor Effects of Nicotine

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Unraveling the neurobiology of nicotine dependence using genetically engineered mice

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Nicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms

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Assessment of nicotine withdrawal-induced changes in sucrose preference in mice

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Neuronal nicotinic receptor ligands modulate chronic nicotine-induced ethanol consumption in C57BL/6J mice

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Preclinical Evidence That Activation of Mesolimbic Alpha 6 Subunit Containing Nicotinic Acetylcholine Receptors Supports Nicotine Addiction Phenotype

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Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal

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Varenicline enhances dopamine release facilitation more than nicotine after long‐term nicotine treatment and withdrawal

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Cholinergic Receptors and Addiction

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Alpha6-containing nicotinic acetylcholine receptor is a highly sensitive target of alcohol

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Native α6β4∗ nicotinic receptors control exocytosis in human chromaffin cells of the adrenal gland

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Attenuation by baclofen of nicotine rewarding properties and nicotine withdrawal manifestations

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α6 nAChR subunit residues that confer α‐conotoxin BuIA selectivity

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Insights Into Nicotinic Receptor Signaling in Nicotine Addiction: Implications for Prevention and Treatment

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Nicotinic acetylcholine receptor subtype expression, function, and pharmacology: Therapeutic potential of α-conotoxins

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A Single Administration of Low-Dose Varenicline Saturates α4β2* Nicotinic Acetylcholine Receptors in the Human Brain

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Long‐term nicotine treatment down‐regulates α6β2* nicotinic receptor expression and function in nucleus accumbens

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Crucial roles of the CHRNB3–CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research

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Endogenous opioid system: a promising target for future smoking cessation medications

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α-Conotoxin TxIB: A Uniquely Selective Ligand for α6/α3β2β3 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Conditioned Place Preference in Mice

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Effects of nicotine deprivation on current pain intensity among daily cigarette smokers.

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The β3 subunit of the nicotinic acetylcholine receptor: Modulation of gene expression and nicotine consumption

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Expression of cloned α6* nicotinic acetylcholine receptors

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Mouse models for studying genetic influences on factors determining smoking cessation success in humans

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α6 subunit‐containing nicotinic receptors mediate low‐dose ethanol effects on ventral tegmental area neurons and ethanol reward

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Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal

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Influence of calcium channel antagonists on nonsomatic signs of nicotine and d-amphetamine withdrawal in mice

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Intra-ventral tegmental area HIV-1 Tat1–86 attenuates nicotine-mediated locomotor sensitization and alters mesocorticolimbic ERK and CREB signaling in rats

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Nicotinic Acetylcholine Receptor Accessory Subunits Determine the Activity Profile of Epibatidine Derivatives

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Comparison of effects produced by nicotine and the α4β2-selective agonist 5-I-A-85380 on intracranial self-stimulation in rats.

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ACSL6 Is Associated with the Number of Cigarettes Smoked and Its Expression Is Altered by Chronic Nicotine Exposure

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Beta2-containing nicotinic acetylcholine receptors mediate calcium/calmodulin-dependent protein kinase-II and synapsin I protein levels in the nucleus accumbens after nicotine withdrawal in mice

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Molecular, Neuronal, and Behavioral Effects of Ethanol and Nicotine Interactions

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Genetic matters: Thirty years of progress using mouse models in nicotinic research

Marks, M. J. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.05.021 · Cited by 13

A role for α4(non-α6)* nicotinic acetylcholine receptors in motor behavior

Soll, L. G., Grady, S. R., Salminen, O., Marks, M. J., & Tapper, A. R. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.001 · Cited by 15

Modulation of ethanol reward sensitivity by nicotinic acetylcholine receptors containing the α6 subunit

Guildford, M. J., Sacino, A. V., & Tapper, A. R. (2016) · Alcohol · doi:10.1016/j.alcohol.2016.08.006 · Cited by 14

Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population

Li, W., Han, H., Liu, Q., Su, K., Yang, Z., Cui, W., Yuan, W., Ma, Y., Fan, R., Chen, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09492-8 · Cited by 15

The role of pituitary adenylyl cyclase activating polypeptide in affective signs of nicotine withdrawal

Nega, S., Marquez, P. V., Hamid, A., Ahmad, S. M., & Lutfy, K. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24649 · Cited by 14

Brain Nicotinic Receptors as Emerging Targets for Drug Addiction

Rahman, S. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385506-0.00008-9 · Cited by 14

Neuroscience of nicotine for addiction medicine

D’Souza, M. S. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.07.008 · Cited by 13

Deletion of lynx1 reduces the function of α6* nicotinic receptors

Parker, R. L., O’Neill, H. C., Henley, B. M., Wageman, C. R., Drenan, R. M., Marks, M. J., Miwa, J. M., Grady, S. R., & Lester, H. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188715 · Cited by 14

Effects of the BDNF Val66Met Polymorphism on Anxiety-Like Behavior Following Nicotine Withdrawal in Mice

Lee, B. G., Anastasía, A., Hempstead, B. L., Lee, F. S., & Blendy, J. A. (2015) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntv047 · Cited by 13

α-Conotoxin TxID and [S9K]TxID, α3β4 nAChR Antagonists, Attenuate Expression and Reinstatement of Nicotine-Induced Conditioned Place Preference in Mice

Li, X., You, S., Xiong, J., Qiao, Y., Yu, J., Zhangsun, D., & Luo, S. (2020) · Marine Drugs · doi:10.3390/md18120646 · Cited by 12

Monkey Adrenal Chromaffin Cells Express α6β4* Nicotinic Acetylcholine Receptors

Hernández‐Vivanco, A., Hone, A. J., Scadden, M., Carmona‐Hidalgo, B., McIntosh, J. M., & Albillos, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094142 · Cited by 12

Sex- and Genotype-Dependent Nicotine-Induced Behaviors in Adolescent Rats with a Human Polymorphism (rs2304297) in the 3′-UTR of the CHRNA6 Gene

Cardenas, A. M., Bai, Y., Heydary, Y. H., Li, J., Leslie, F. M., & Lotfipour, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063145 · Cited by 12

Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons

Collo, G., Cavalleri, L., Zoli, M., Maskos, U., Ratti, E., & Pich, E. M. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00572 · Cited by 10

More than Smoke and Patches: The Quest for Pharmacotherapies to Treat Tobacco Use Disorder

Moerke, M. J., McMahon, L. R., & Wilkerson, J. L. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018028 · Cited by 11

In Vitro and in Vivo Neuronal Nicotinic Receptor Properties of (+)- and (−)-Pyrido[3,4]homotropane [(+)- and (−)-PHT]: (+)-PHT Is a Potent and Selective Full Agonist at α6β2 Containing Neuronal Nicotinic Acetylcholine Receptors

Carroll, F. I., Navarro, H. A., Mascarella, S. W., Castro, A. H., Luetje, C. W., Wageman, C. R., Marks, M. J., Jackson, A. B., & Damaj, M. I. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00077 · Cited by 10

Conditioned Place Preference as a Preclinical Model for Screening Pharmacotherapies for Drug Abuse

Bardo, M. T., Horton, D. B., & Yates, J. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420172-9.00007-2 · Cited by 9

Blockade of nicotinic acetylcholine receptor enhances the responsiveness to bupropion in the mouse forced swim test

Bağdaş, D., AlSharari, S. D., Roni, M. A., Campbell, V. C., Muldoon, P. P., Carroll, F. I., & Damaj, M. I. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.027 · Cited by 9

TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors

Wall, T. R., Henderson, B. J., Voren, G., Wageman, C. R., Deshpande, P., Cohen, B. N., Grady, S. R., Marks, M. J., Yohannes, D., Kenny, P. J., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00641 · Cited by 8

Differential Roles of α6β2* and α4β2* Neuronal Nicotinic Receptors in Nicotine- and Cocaine-Conditioned Reward in Mice

Sanjakdar, S. S., Maldoon, P. P., Marks, M. J., Brunzell, D. H., Maskos, U., McIntosh, J. M., Bowers, M. S., & Damaj, M. I. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.177 · Cited by 74

The α3β4* nicotinic acetylcholine receptor subtype mediates nicotine reward and physical nicotine withdrawal signs independently of the α5 subunit in the mouse

Jackson, K. J., Sanjakdar, S. S., Muldoon, P. P., McIntosh, J. M., & Damaj, M. I. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.01.017 · Cited by 69

Role of α5 Nicotinic Acetylcholine Receptors in Pharmacological and Behavioral Effects of Nicotine in Mice

Jackson, K. J., Marks, M. J., Vann, R. E., Chen, X., Gamage, T. F., Warner, J. A., & Damaj, M. I. (2010) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.165738 · Cited by 156

Distribution and Pharmacology of α6-Containing Nicotinic Acetylcholine Receptors Analyzed with Mutant Mice

Champtiaux, N., Han, Z., Bessis, A., Rossi, F., Zoli, M., Marubio, L. M., McIntosh, J. M., & Changeux, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-04-01208.2002 · Cited by 344

Chronic Nicotine Differentially Regulates α6- and β3-Containing Nicotinic Cholinergic Receptors in Rat Brain

Perry, D. C., Mao, D., Gold, A. B., McIntosh, J. M., Pezzullo, J. C., & Kellar, K. J. (2007) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.121228 · Cited by 106