The Role of α6-Containing Nicotinic Acetylcholine Receptors in Nicotine Reward and Withdrawal

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

Picciotto, M. R., Zoli, M., Rimondini, R., Léna, C., Marubio, L. M., Pich, E. M., Fuxe, K., & Changeux, J.-P. (1998) · Nature · doi:10.1038/34413 · Cited by 1,320 · see citing works

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs.

Pontieri, F. E., Tanda, G., Orzi, F., & Chiara, G. D. (1996) · Nature · doi:10.1038/382255a0 · Cited by 1,073 · see citing works

The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine

Corrigall, W. A., Franklin, K. B. J., Coen, K. M., & Clarke, P. B. S. (1992) · Psychopharmacology · doi:10.1007/bf02245149 · Cited by 829 · see citing works

Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area

Corrigall, W. A., Coen, K. M., & Adamson, K. L. (1994) · Brain Research · doi:10.1016/0006-8993(94)90401-4 · Cited by 740 · see citing works

Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization

Tapper, A. R., McKinney, S. L., Nashmi, R., Schwarz, J., Deshpande, P., Labarca, C., Whiteaker, P., Marks, M. J., Collins, A. C., & Lester, H. A. (2004) · Science · doi:10.1126/science.1099420 · Cited by 686 · see citing works

Molecular and Physiological Diversity of Nicotinic Acetylcholine Receptors in the Midbrain Dopaminergic Nuclei

Klink, R., d'Exaerde, A. D. K., Zoli, M., & Changeux, J.-P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01452.2001 · Cited by 674 · see citing works

Molecular and cellular aspects of nicotine abuse

Dani, J. A., & Heinemann, S. (1996) · Neuron · doi:10.1016/s0896-6273(00)80112-9 · Cited by 605 · see citing works

Reduced antinociception in mice lacking neuronal nicotinic receptor subunits

Marubio, L. M., Jiménez, M. D. M. A., Cordero‐Erausquin, M., Léna, C., Novère, N. G. L., d’Exaerde, A. D. K., Huchet, M., Damaj, M. I., & Changeux, J. (1999) · Nature · doi:10.1038/19756 · Cited by 533 · see citing works

Subunit Composition of Functional Nicotinic Receptors in Dopaminergic Neurons Investigated with Knock-Out Mice

Champtiaux, N., Gotti, C., Cordero‐Erausquin, M., David, D. J. P., Przybylski, C., Léna, C., Clementi, F., Moretti, M., Rossi, F., Novère, N. G. L., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07820.2003 · Cited by 505 · see citing works

The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity

Benwell, M. E. M., & Balfour, D. J. K. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09067.x · Cited by 426 · see citing works

Identification of the Nicotinic Receptor Subtypes Expressed on Dopaminergic Terminals in the Rat Striatum

Zoli, M., Moretti, M., Zanardi, A., McIntosh, J. M., Clementi, F., & Gotti, C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-08785.2002 · Cited by 407 · see citing works

Subunit Composition and Pharmacology of Two Classes of Striatal Presynaptic Nicotinic Acetylcholine Receptors Mediating Dopamine Release in Mice

Salminen, O., Murphy, K. L., McIntosh, J. M., Drago, J., Marks, M. J., Collins, A. C., & Grady, S. R. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.6.1526 · Cited by 401 · see citing works

Nicotinic effects on the firing pattern of midbrain dopamine neurons

GRENHOFF, J., ASTON‐JONES, G., & SVENSSON, T. H. (1986) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1986.tb07988.x · Cited by 399 · see citing works

Neuronal Nicotinic Receptor a6 Subunit mRNA is Selectively Concentrated in Catecholaminergic Nuclei of the Rat Brain

Le Novere, N., Zoli, M., & Changeux, J. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01206.x · Cited by 385 · see citing works

Distribution and Pharmacology of α6-Containing Nicotinic Acetylcholine Receptors Analyzed with Mutant Mice

Champtiaux, N., Han, Z., Bessis, A., Rossi, F., Zoli, M., Marubio, L. M., McIntosh, J. M., & Changeux, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-04-01208.2002 · Cited by 345 · see citing works

Crucial role of α4 and α6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration

Pons, S., Fattore, L., Cossu, G., Tolu, S., Porcu, E., McIntosh, J. M., Changeux, J. P., Maskos, U., & Fratta, W. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3918-08.2008 · Cited by 312 · see citing works

The distribution of mRNA encoded by a new member of the neuronal nicotinic acetylcholine receptor gene family (α5) in the rat central nervous system

Wada, E., McKinnon, D. H., Heinemann, S., Patrick, J., & Swanson, L. W. (1990) · Brain Research · doi:10.1016/0006-8993(90)90248-a · Cited by 254 · see citing works

Characterization of spontaneous and precipitated nicotine withdrawal in the mouse

Damaj, M. I., Kao, W., & Martin, B. R. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.054908 · Cited by 222 · see citing works

Differential Role of Nicotinic Acetylcholine Receptor Subunits in Physical and Affective Nicotine Withdrawal Signs

Jackson, K. J., Martin, B. R., Changeux, J. P., & Damaj, M. I. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.132977 · Cited by 208 · see citing works

The β2 but not α7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice

Walters, C. L., Brown, S., Changeux, J.-P., Martin, B., & Damaj, M. I. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0295-x · Cited by 206 · see citing works

Nicotine dependence and reward differ between adolescent and adult male mice

Kota, D., Martin, B. R., Robinson, S. E., & Damaj, M. I. (2007) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.121616 · Cited by 202 · see citing works

Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome

Hildebrand, B. E., Nomikos, G. G., Hertel, P., Schilström, B., & Svensson, T. H. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01135-9 · Cited by 200 · see citing works

In vivo activation of midbrain dopamine neurons via sensitized, high-affinity α6 nicotinic acetylcholine receptors

Drenan, R. M., Grady, S. R., Whiteaker, P., McClure-Begley, T., McKinney, S., Miwa, J. M., Bupp, S., Heintz, N., McIntosh, J. M., Bencherif, M., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.009 · Cited by 197 · see citing works

Analogs of α-Conotoxin MII Are Selective for α6-Containing Nicotinic Acetylcholine Receptors

McIntosh, J. M., Azam, L., Staheli, S. T., Dowell, C. D., Lindstrom, J. M., Kuryatov, A., Garrett, J. E., Marks, M. J., & Whiteaker, P. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.4.944 · Cited by 194 · see citing works

Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons

Léna, C., d’Exaerde, A. D. K., Cordero‐Erausquin, M., Novère, N. G. L., Jiménez, M. D. M. A., & Changeux, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12126 · Cited by 181 · see citing works

Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area

Laviolette, S. R., & van der Kooy, D. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001197 · Cited by 180 · see citing works

Effects of nicotine and mecamylamine-induced withdrawal on extracellular dopamine and acetylcholine in the rat nucleus accumbens

Rada, P., Jensen, K., & Hoebel, B. (2001) · Psychopharmacology · doi:10.1007/s002130100781 · Cited by 141 · see citing works

Long-Term Nicotine Treatment Decreases Striatal α6* Nicotinic Acetylcholine Receptor Sites and Function in Mice

Lai, A., Parameswaran, N., Khwaja, M., Whiteaker, P., Lindstrom, J. M., Fan, H., McIntosh, J. M., Grady, S. R., & Quik, M. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.006429 · Cited by 112 · see citing works

Involvement of α6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion

Novère, N. G. L., Zoli, M., Léna, C., Ferrari, R., Picciotto, M. R., Merlo‐Pich, E., & Changeux, J. (1999) · Neuroreport · doi:10.1097/00001756-199908200-00012 · Cited by 86 · see citing works

Genetic dissociation of two behaviors associated with nicotine addiction: Beta-2 containing nicotinic receptors are involved in nicotine reinforcement but not in withdrawal syndrome

Besson, M., David, V., Suarez, S., Cormier, A., Cazala, P., Changeux, J.-P., & Granon, S. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0418-z · Cited by 73 · see citing works

Adaptations in cholinergic transmission in the ventral tegmental area associated with the affective signs of nicotine withdrawal in rats

Bruijnzeel, A. W., & Markou, A. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.05.005 · Cited by 60 · see citing works

Null mutant analysis of responses to nicotine: Deletion of β2 nicotinic acetylcholine receptor subunit but not α7 subunit reduces sensitivity to nicotine-induced locomotor depression and hypothermia

Tritto, T., McCallum, S. E., Waddle, S., Hutton, S. R., Paylor, R. E., Collins, A. C., & Marks, M. J. (2004) · Nicotine & Tobacco Research · doi:10.1080/14622200310001656966 · Cited by 57 · see citing works

Decrease of ventral tegmental area dopamine neuronal activity in nicotine withdrawal rats

Liu, Z.-H., & Jin, W.-Q. (2004) · Neuroreport · doi:10.1097/01.wnr.0000126218.25235.b6 · Cited by 41 · see citing works

Nicotinic Agonists Administered into the Fourth Ventricle Stimulate Norepinephrine Secretion in the Hypothalamic Paraventricular Nucleus: An in vivo Microdialysis Study

Matta, S. G., McCoy, J. G., Foster, C. A., & Sharp, B. M. (2008) · Neuroendocrinology · doi:10.1159/000126860 · Cited by 35 · see citing works

Comparison of the effects of nicotine and epibatidine on the striatal extracellular dopamine

Janhunen, S. K., & Ahtee, L. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.05.015 · Cited by 32 · see citing works

Effects of nicotine and epibatidine on locomotor activity and conditioned place preference in rats

Janhunen, S. K., Linnervuo, A., Svensk, M., & Ahtee, L. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.12.012 · Cited by 24 · see citing works

Attenuation of morphine withdrawal signs by a D1 receptor agonist in the locus coeruleus of rats

Mirzaii‐Dizgah, I., Karimian, S. M., Zarrindast, M., & Sohanaki, H. (2005) · Neuroreport · doi:10.1097/01.wnr.0000180142.91644.65 · Cited by 23 · see citing works

Nicotine addiction and nicotinic receptors: lessons from genetically modified mice

Changeux, J.-P. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2849 · Cited by 453 · see citing works

Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction

Wittenberg, R. E., Wolfman, S. L., Biasi, M. D., & Dani, J. A. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108256 · Cited by 200 · see citing works

Nicotine Withdrawal

McLaughlin, I., Dani, J. A., & De Biasi, M. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/978-3-319-13482-6_4 · Cited by 173 · see citing works

The habenulo-interpeduncular pathway in nicotine aversion and withdrawal

Antolin-Fontes, B., Ables, J. L., Görlich, A., & Ibañez-Tallon, I. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.019 · Cited by 154 · see citing works

Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system

Berrendero, F., Robledo, P., Trigo, J. M., Martín-García, E., & Maldonado, R. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.02.006 · Cited by 140 · see citing works

Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling

Papke, R. L., & Lindstrom, J. M. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108021 · Cited by 123 · see citing works

Pain, nicotine, and tobacco smoking: current state of the science

LaRowe, L. R., & Ditre, J. W. (2020) · Pain · doi:10.1097/j.pain.0000000000001874 · Cited by 122 · see citing works

Neurobiological Mechanisms of Nicotine Reward and Aversion

Wills, L. P., Ables, J. L., Braunscheidel, K. M., Caligiuri, S. P. B., Elayouby, K. S., Fillinger, C., Ishikawa, M., Moen, J. K., & Kenny, P. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000299 · Cited by 126 · see citing works

New mechanisms and perspectives in nicotine withdrawal

Jackson, K. J., Muldoon, P. P., Biasi, M. D., & Damaj, M. I. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.009 · Cited by 103 · see citing works

The role of the habenula in the transition from reward to misery in substance use and mood disorders

Batalla, A., Homberg, J. R., Lipina, T. V., Sescousse, G., Luijten, M., Ivanova, S. А., Schellekens, A., & LOONEN, A. J. M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.019 · Cited by 100 · see citing works

Negative affective states and cognitive impairments in nicotine dependence

Hall, F. S., Der‐Avakian, A., Gould, T. J., Markou, A., Shoaib, M. C., & Young, J. W. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.004 · Cited by 104 · see citing works

Inside-out neuropharmacology of nicotinic drugs

Henderson, B. J., & Lester, H. A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.022 · Cited by 102 · see citing works

Expression of Functional Human α6β2β3* Acetylcholine Receptors in Xenopus laevis Oocytes Achieved through Subunit Chimeras and Concatamers

Kuryatov, A., & Lindstrom, J. M. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.066159 · Cited by 97 · see citing works

Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders

Quik, M., Perez, X. A., & Grady, S. R. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.001 · Cited by 94 · see citing works

Anxiety and Depression in Bidirectional Relations Between Pain and Smoking

Zale, E. L., Maisto, S. A., & Ditre, J. W. (2015) · Behavior Modification · doi:10.1177/0145445515610744 · Cited by 92 · see citing works

Habenula cholinergic neurons regulate anxiety during nicotine withdrawal via nicotinic acetylcholine receptors

Pang, X.-Y., Liu, L., Ngolab, J., Zhao-Shea, R., McIntosh, J. M., Gardner, P. D., & Tapper, A. R. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.03.039 · Cited by 84 · see citing works

Parallel Anxiolytic-Like Effects and Upregulation of Neuronal Nicotinic Acetylcholine Receptors Following Chronic Nicotine and Varenicline

Turner, J. R., Castellano, L. M., & Blendy, J. A. (2011) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntq206 · Cited by 78 · see citing works

Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors

Henderson, B. J., Srinivasan, R., Nichols, W. A., Dilworth, C. N., Gutierrez, D. F., Mackey, E. D. W., McKinney, S., Drenan, R. M., Richards, C. I., & Lester, H. A. (2014) · Journal of General Physiology · doi:10.1085/jgp.201311102 · Cited by 78 · see citing works

α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6β4 and α6β2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release

Azam, L., Maskos, U., Changeux, J., Dowell, C. D., Christensen, S. B., Biasi, M. D., & McIntosh, J. M. (2010) · The FASEB Journal · doi:10.1096/fj.10-166272 · Cited by 77 · see citing works

AT-1001: A High Affinity and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist Blocks Nicotine Self-Administration in Rats

Toll, L., Zaveri, N. T., Polgar, W. E., Jiang, F., Khroyan, T. V., Zhou, W., Xie, X., Stauber, G. B., Costello, M. R., & Leslie, F. M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.322 · Cited by 78 · see citing works

Nicotinic acetylcholine receptors in dorsal root ganglion neurons include the α6β4 subtype

Hone, A. J., Meyer, E. L., McIntyre, M., & McIntosh, J. M. (2011) · The FASEB Journal · doi:10.1096/fj.11-195883 · Cited by 76 · see citing works

Understanding the habenula: A major node in circuits regulating emotion and motivation

Ables, J. L., Park, K., & Ibáñez-Tallon, I. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106734 · Cited by 76 · see citing works

The Molecular Neurobiology of Twelve Steps Program & Fellowship: Connecting the Dots for Recovery

Blum, K., Thompson, B., Demotrovics, Z., Femino, J., Giordano, J., Oscar-Berman, M., Teitelbaum, S., Smith, D. E., Roy, A. K., Agan, G., et al. (2015) · Journal of Reward Deficiency Syndrome · doi:10.17756/jrds.2015-008 · Cited by 73 · see citing works

Extended access to nicotine leads to a CRF1receptor dependent increase in anxiety-like behavior and hyperalgesia in rats

Cohen, A., Treweek, J. B., Edwards, S., Leão, R. M., Schulteis, G., Koob, G. F., & George, O. (2013) · Addiction Biology · doi:10.1111/adb.12077 · Cited by 73 · see citing works

Nicotine deprivation increases pain intensity, neurogenic inflammation, and mechanical hyperalgesia among daily tobacco smokers.

Ditre, J. W., Zale, E. L., LaRowe, L. R., Kosiba, J. D., & Vita, M. J. D. (2018) · Journal of Abnormal Psychology · doi:10.1037/abn0000353 · Cited by 73 · see citing works

Differential Roles of α6β2* and α4β2* Neuronal Nicotinic Receptors in Nicotine- and Cocaine-Conditioned Reward in Mice

Sanjakdar, S. S., Maldoon, P. P., Marks, M. J., Brunzell, D. H., Maskos, U., McIntosh, J. M., Bowers, M. S., & Damaj, M. I. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.177 · Cited by 71 · see citing works

Varenicline Is a Potent Partial Agonist at α6β2* Nicotinic Acetylcholine Receptors in Rat and Monkey Striatum

Bordia, T., Hrachova, M., Chin, M., McIntosh, J. M., & Quik, M. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.194852 · Cited by 70 · see citing works

The α3β4* nicotinic acetylcholine receptor subtype mediates nicotine reward and physical nicotine withdrawal signs independently of the α5 subunit in the mouse

Jackson, K. J., Sanjakdar, S. S., Muldoon, P. P., McIntosh, J. M., & Damaj, M. I. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.01.017 · Cited by 69 · see citing works

Animal Models of Nicotine Exposure: Relevance to Second-Hand Smoking, Electronic Cigarette Use, and Compulsive Smoking

Cohen, A., & George, O. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00041 · Cited by 67 · see citing works

Mechanistic insights into nicotine withdrawal

Paolini, M., & De Biasi, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.075 · Cited by 66 · see citing works

Characterization of a Novel α-Conotoxin from Conus textile That Selectively Targets α6/α3β2β3 Nicotinic Acetylcholine Receptors

Luo, S., Zhangsun, D., Wu, Y., Zhu, X., Hu, Y., McIntyre, M., Christensen, S. B., Akcan, M., Craik, D. J., & McIntosh, J. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.427898 · Cited by 62 · see citing works

Addiction‐related neuroadaptations following chronic nicotine exposure

Wills, L., & Kenny, P. J. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15356 · Cited by 61 · see citing works

Nicotinic Receptor Contributions to Smoking: Insights from Human Studies and Animal Models

Brunzell, D. H., Stafford, A. M., & Dixon, C. I. (2015) · Current Addiction Reports · doi:10.1007/s40429-015-0042-2 · Cited by 58 · see citing works

Nicotinic Receptor Antagonists as Treatments for Nicotine Abuse

Crooks, P. A., Bardo, M. T., & Dwoskin, L. P. (2014) · Advances in pharmacology · doi:10.1016/b978-0-12-420118-7.00013-5 · Cited by 54 · see citing works

Positional Scanning Mutagenesis of α-Conotoxin PeIA Identifies Critical Residues That Confer Potency and Selectivity for α6/α3β2β3 and α3β2 Nicotinic Acetylcholine Receptors

Hone, A. J., Ruiz, M., Scadden, M., Christensen, S. B., Gajewiak, J., Azam, L., & McIntosh, J. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.482059 · Cited by 53 · see citing works

Assessing nicotine dependence using an oral nicotine free-choice paradigm in mice

Bağdaş, D., Diester, C. M., Riley, J., Carper, M., Alkhlaif, Y., Alomari, D., Alayoubi, H., Poklis, J. L., & Damaj, M. I. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107669 · Cited by 51 · see citing works

Insights into the Neurobiology of the Nicotinic Cholinergic System and Nicotine Addiction from Mice Expressing Nicotinic Receptors Harboring Gain-of-Function Mutations

Drenan, R. M., & Lester, H. A. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.004671 · Cited by 51 · see citing works

Drug withdrawal-induced depression: Serotonergic and plasticity changes in animal models

Renoir, T., Pang, T. Y., & Lanfumey, L. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.10.003 · Cited by 52 · see citing works

Nicotinic acetylcholine receptors containing α6 subunits contribute to alcohol reward‐related behaviours

Powers, M. S., Broderick, H. J., Drenan, R. M., & Chester, J. A. (2013) · Genes Brain & Behavior · doi:10.1111/gbb.12042 · Cited by 49 · see citing works

α-Conotoxin PeIA[S9H,V10A,E14N] Potently and Selectively Blocks α6β2β3 versus α6β4 Nicotinic Acetylcholine Receptors

Hone, A. J., Scadden, M., Gajewiak, J., Christensen, S. B., Lindstrom, J. M., & McIntosh, J. M. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.080853 · Cited by 46 · see citing works

Long-Term Nicotine Exposure Depresses Dopamine Release in Nonhuman Primate Nucleus Accumbens

Perez, X. A., Ly, J., McIntosh, J. M., & Quik, M. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.194084 · Cited by 43 · see citing works

Acute Ethanol Inhibits Dopamine Release in the Nucleus Accumbens via α6 Nicotinic Acetylcholine Receptors

Schilaty, N. D., Hedges, D. M., Jang, E. Y., Folsom, R. J., Yorgason, J. T., McIntosh, J. M., & Steffensen, S. C. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.211490 · Cited by 42 · see citing works

Diverse strategies targeting α7 homomeric and α6β2* heteromeric nicotinic acetylcholine receptors for smoking cessation

Brunzell, D. H., McIntosh, J. M., & Papke, R. L. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12421 · Cited by 40 · see citing works

Genetically expressed HIV-1 viral proteins attenuate nicotine-induced behavioral sensitization and alter mesocorticolimbic ERK and CREB signaling in rats

Midde, N. M., Gomez, A. M., Harrod, S. B., & Zhu, J. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.03.013 · Cited by 39 · see citing works

Low Dose Nicotine and Antagonism of β2 Subunit Containing Nicotinic Acetylcholine Receptors Have Similar Effects on Affective Behavior in Mice

Anderson, S. M., & Brunzell, D. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048665 · Cited by 40 · see citing works

Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes

Gold, A. B., & Lerman, C. E. (2012) · Human Genetics · doi:10.1007/s00439-012-1143-9 · Cited by 40 · see citing works

Progress and challenges in the study of α6-containing nicotinic acetylcholine receptors

Letchworth, S. R., & Whiteaker, P. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.022 · Cited by 39 · see citing works

The effects of lobeline on nicotine withdrawal-induced depression-like behavior in mice

Roni, M. A., & Rahman, S. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3472-y · Cited by 37 · see citing works

Characterizing functional α6β2 nicotinic acetylcholine receptors in vitro: Mutant β2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells

Xiao, C., Srinivasan, R., Drenan, R. M., Mackey, E. D. W., McIntosh, J. M., & Lester, H. A. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.05.005 · Cited by 37 · see citing works

The Necessity of α4* Nicotinic Receptors in Nicotine-Driven Behaviors: Dissociation Between Reinforcing and Motor Effects of Nicotine

Cahir, E., Pillidge, K., Drago, J., & Lawrence, A. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.35 · Cited by 36 · see citing works

Unraveling the neurobiology of nicotine dependence using genetically engineered mice

Stoker, A. K., & Markou, A. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.02.013 · Cited by 35 · see citing works

Nicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms

Zuo, W., Xiao, C., Gao, M., Hopf, F. W., Krnjević, K., McIntosh, J. M., Fu, R., Wu, J., Bekker, A., & Ye, J.-H. (2016) · Scientific Reports · doi:10.1038/srep32937 · Cited by 32 · see citing works

Assessment of nicotine withdrawal-induced changes in sucrose preference in mice

Alkhlaif, Y., Bağdaş, D., Jackson, A. B., Park, A. J., & Damaj, M. I. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.08.013 · Cited by 33 · see citing works

Neuronal nicotinic receptor ligands modulate chronic nicotine-induced ethanol consumption in C57BL/6J mice

Sajja, R. K., & Rahman, S. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.03.017 · Cited by 32 · see citing works

Preclinical Evidence That Activation of Mesolimbic Alpha 6 Subunit Containing Nicotinic Acetylcholine Receptors Supports Nicotine Addiction Phenotype

Brunzell, D. H. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/nts089 · Cited by 32 · see citing works

Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal

Turner, J. R., Wilkinson, D. S., Poole, R. L., Gould, T. J., Carlson, G. C., & Blendy, J. A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.105 · Cited by 29 · see citing works

Varenicline enhances dopamine release facilitation more than nicotine after long‐term nicotine treatment and withdrawal

Perez, X. A., Khroyan, T. V., McIntosh, J. M., & Quik, M. (2014) · Pharmacology Research & Perspectives · doi:10.1002/prp2.105 · Cited by 29 · see citing works

Cholinergic Receptors and Addiction

Papke, R. L., Brunzell, D. H., & Biasi, M. D. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_139 · Cited by 30 · see citing works

Alpha6-containing nicotinic acetylcholine receptor is a highly sensitive target of alcohol

Gao, F., Chen, D., Ma, X., Sudweeks, S. N., Yorgason, J. T., Gao, M., Turner, D., Eaton, J. B., McIntosh, J. M., Lukas, R. J., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.01.021 · Cited by 29 · see citing works

Native α6β4∗ nicotinic receptors control exocytosis in human chromaffin cells of the adrenal gland

Pérez‐Alvarez, A., Hernández‐Vivanco, A., McIntosh, J. M., & Albillos, A. (2011) · The FASEB Journal · doi:10.1096/fj.11-190223 · Cited by 29 · see citing works

Attenuation by baclofen of nicotine rewarding properties and nicotine withdrawal manifestations

Varani, A. P., Aso, E., Moutinho, L. M., Maldonado, R. J., & Balerio, G. N. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3469-6 · Cited by 28 · see citing works

α6 nAChR subunit residues that confer α‐conotoxin BuIA selectivity

Kim, H., & McIntosh, J. M. (2012) · The FASEB Journal · doi:10.1096/fj.12-204487 · Cited by 27 · see citing works

Insights Into Nicotinic Receptor Signaling in Nicotine Addiction: Implications for Prevention and Treatment

Liu, W., & Li, M. D. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170801103009 · Cited by 27 · see citing works

Nicotinic acetylcholine receptor subtype expression, function, and pharmacology: Therapeutic potential of α-conotoxins

Tae, H., & Adams, D. J. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106747 · Cited by 26 · see citing works

A Single Administration of Low-Dose Varenicline Saturates α4β2* Nicotinic Acetylcholine Receptors in the Human Brain

Lotfipour, S., Mandelkern, M. A., Alvarez-Estrada, M., & Brody, A. L. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.20 · Cited by 26 · see citing works

Long‐term nicotine treatment down‐regulates α6β2* nicotinic receptor expression and function in nucleus accumbens

Perez, X. A., McIntosh, J. M., & Quik, M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12442 · Cited by 27 · see citing works

Crucial roles of the CHRNB3–CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research

Wen, L., Yang, Z., Cui, W., & Li, M. D. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.103 · Cited by 26 · see citing works

Endogenous opioid system: a promising target for future smoking cessation medications

Norman, H., & D’Souza, M. S. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4582-0 · Cited by 23 · see citing works

α-Conotoxin TxIB: A Uniquely Selective Ligand for α6/α3β2β3 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Conditioned Place Preference in Mice

You, S., Li, X., Xiong, J., Zhu, X., Zhangsun, D., Zhu, X., & Luo, S. (2019) · Marine Drugs · doi:10.3390/md17090490 · Cited by 22 · see citing works

Effects of nicotine deprivation on current pain intensity among daily cigarette smokers.

LaRowe, L. R., Kosiba, J. D., Zale, E. L., & Ditre, J. W. (2018) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000218 · Cited by 21 · see citing works

The β3 subunit of the nicotinic acetylcholine receptor: Modulation of gene expression and nicotine consumption

Kamens, H. M., Miyamoto, J. H., Powers, M. S., Ro, K., Soto, M., Cox, R. J., Stitzel, J. A., & Ehringer, M. A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.035 · Cited by 20 · see citing works

Expression of cloned α6* nicotinic acetylcholine receptors

Wang, J., Kuryatov, A., & Lindstrom, J. M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.009 · Cited by 20 · see citing works

Mouse models for studying genetic influences on factors determining smoking cessation success in humans

Hall, F. S., Markou, A., Levin, E. D., & Uhl, G. R. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06415.x · Cited by 18 · see citing works

α6 subunit‐containing nicotinic receptors mediate low‐dose ethanol effects on ventral tegmental area neurons and ethanol reward

Steffensen, S. C., Shin, S. I., Nelson, A. C., Pistorius, S. S., Williams, S. B., Woodward, T. J., Park, H.-J., Friend, L. N., Gao, M., Gao, F., et al. (2017) · Addiction Biology · doi:10.1111/adb.12559 · Cited by 18 · see citing works

Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal

Varani, A. P., Pedrón, V. T., Moutinho, L. M., Antonelli, M. C., Bettler, B., & Balerio, G. N. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.013 · Cited by 17 · see citing works

Influence of calcium channel antagonists on nonsomatic signs of nicotine and d-amphetamine withdrawal in mice

Biała, G., Polak, P., Michalak, A., Kruk-Słomka, M., & Budzyńska, B. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2014.02.003 · Cited by 17 · see citing works

Intra-ventral tegmental area HIV-1 Tat1–86 attenuates nicotine-mediated locomotor sensitization and alters mesocorticolimbic ERK and CREB signaling in rats

Zhu, J., Midde, N. M., Gomez, A. M., Sun, W., & Harrod, S. B. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00540 · Cited by 16 · see citing works

Nicotinic Acetylcholine Receptor Accessory Subunits Determine the Activity Profile of Epibatidine Derivatives

Corrie, L. W.-C., Stokes, C. A., Wilkerson, J. L., Carroll, F. I., McMahon, L. R., & Papke, R. L. (2020) · Molecular Pharmacology · doi:10.1124/molpharm.120.000037 · Cited by 18 · see citing works

Comparison of effects produced by nicotine and the α4β2-selective agonist 5-I-A-85380 on intracranial self-stimulation in rats.

Freitas, K., Carroll, F. I., & Negus, S. S. (2015) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000055 · Cited by 16 · see citing works

ACSL6 Is Associated with the Number of Cigarettes Smoked and Its Expression Is Altered by Chronic Nicotine Exposure

Chen, J., Brunzell, D. H., Jackson, K. J., van der Vaart, A. D., Ma, J. Z., Payne, T. J., Sherva, R., Farrer, L. A., Gejman, P. V., Levinson, D. F., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028790 · Cited by 15 · see citing works

Beta2-containing nicotinic acetylcholine receptors mediate calcium/calmodulin-dependent protein kinase-II and synapsin I protein levels in the nucleus accumbens after nicotine withdrawal in mice

Jackson, K. J., & Damaj, M. I. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.12.005 · Cited by 15 · see citing works

Molecular, Neuronal, and Behavioral Effects of Ethanol and Nicotine Interactions

Klenowski, P. M., & Tapper, A. R. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2017_89 · Cited by 15 · see citing works

Genetic matters: Thirty years of progress using mouse models in nicotinic research

Marks, M. J. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.05.021 · Cited by 13 · see citing works

A role for α4(non-α6)* nicotinic acetylcholine receptors in motor behavior

Soll, L. G., Grady, S. R., Salminen, O., Marks, M. J., & Tapper, A. R. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.001 · Cited by 14 · see citing works

Modulation of ethanol reward sensitivity by nicotinic acetylcholine receptors containing the α6 subunit

Guildford, M. J., Sacino, A. V., & Tapper, A. R. (2016) · Alcohol · doi:10.1016/j.alcohol.2016.08.006 · Cited by 14 · see citing works

Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population

Li, W., Han, H., Liu, Q., Su, K., Yang, Z., Cui, W., Yuan, W., Ma, Y., Fan, R., Chen, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09492-8 · Cited by 14 · see citing works

The role of pituitary adenylyl cyclase activating polypeptide in affective signs of nicotine withdrawal

Nega, S., Marquez, P. V., Hamid, A., Ahmad, S. M., & Lutfy, K. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24649 · Cited by 14 · see citing works

Brain Nicotinic Receptors as Emerging Targets for Drug Addiction

Rahman, S. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385506-0.00008-9 · Cited by 13 · see citing works

Neuroscience of nicotine for addiction medicine

D’Souza, M. S. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.07.008 · Cited by 13 · see citing works

Deletion of lynx1 reduces the function of α6* nicotinic receptors

Parker, R. L., O’Neill, H. C., Henley, B. M., Wageman, C. R., Drenan, R. M., Marks, M. J., Miwa, J. M., Grady, S. R., & Lester, H. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188715 · Cited by 14 · see citing works

Effects of the BDNF Val66Met Polymorphism on Anxiety-Like Behavior Following Nicotine Withdrawal in Mice

Lee, B. G., Anastasía, A., Hempstead, B. L., Lee, F. S., & Blendy, J. A. (2015) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntv047 · Cited by 13 · see citing works

α-Conotoxin TxID and [S9K]TxID, α3β4 nAChR Antagonists, Attenuate Expression and Reinstatement of Nicotine-Induced Conditioned Place Preference in Mice

Li, X., You, S., Xiong, J., Qiao, Y., Yu, J., Zhangsun, D., & Luo, S. (2020) · Marine Drugs · doi:10.3390/md18120646 · Cited by 12 · see citing works

Monkey Adrenal Chromaffin Cells Express α6β4* Nicotinic Acetylcholine Receptors

Hernández‐Vivanco, A., Hone, A. J., Scadden, M., Carmona‐Hidalgo, B., McIntosh, J. M., & Albillos, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094142 · Cited by 12 · see citing works

Sex- and Genotype-Dependent Nicotine-Induced Behaviors in Adolescent Rats with a Human Polymorphism (rs2304297) in the 3′-UTR of the CHRNA6 Gene

Cardenas, A. M., Bai, Y., Heydary, Y. H., Li, J., Leslie, F. M., & Lotfipour, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063145 · Cited by 10 · see citing works

Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons

Collo, G., Cavalleri, L., Zoli, M., Maskos, U., Ratti, E., & Pich, E. M. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00572 · Cited by 10 · see citing works

More than Smoke and Patches: The Quest for Pharmacotherapies to Treat Tobacco Use Disorder

Moerke, M. J., McMahon, L. R., & Wilkerson, J. L. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018028 · Cited by 11 · see citing works

In Vitro and in Vivo Neuronal Nicotinic Receptor Properties of (+)- and (−)-Pyrido[3,4]homotropane [(+)- and (−)-PHT]: (+)-PHT Is a Potent and Selective Full Agonist at α6β2 Containing Neuronal Nicotinic Acetylcholine Receptors

Carroll, F. I., Navarro, H. A., Mascarella, S. W., Castro, A. H., Luetje, C. W., Wageman, C. R., Marks, M. J., Jackson, A. B., & Damaj, M. I. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00077 · Cited by 10 · see citing works

Conditioned Place Preference as a Preclinical Model for Screening Pharmacotherapies for Drug Abuse

Bardo, M. T., Horton, D. B., & Yates, J. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420172-9.00007-2 · Cited by 9 · see citing works

Blockade of nicotinic acetylcholine receptor enhances the responsiveness to bupropion in the mouse forced swim test

Bağdaş, D., AlSharari, S. D., Roni, M. A., Campbell, V. C., Muldoon, P. P., Carroll, F. I., & Damaj, M. I. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.027 · Cited by 9 · see citing works

TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors

Wall, T. R., Henderson, B. J., Voren, G., Wageman, C. R., Deshpande, P., Cohen, B. N., Grady, S. R., Marks, M. J., Yohannes, D., Kenny, P. J., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00641 · Cited by 8 · see citing works

Differential Roles of α6β2* and α4β2* Neuronal Nicotinic Receptors in Nicotine- and Cocaine-Conditioned Reward in Mice

Sanjakdar, S. S., Maldoon, P. P., Marks, M. J., Brunzell, D. H., Maskos, U., McIntosh, J. M., Bowers, M. S., & Damaj, M. I. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.177 · Cited by 71 · see citing works

The α3β4* nicotinic acetylcholine receptor subtype mediates nicotine reward and physical nicotine withdrawal signs independently of the α5 subunit in the mouse

Jackson, K. J., Sanjakdar, S. S., Muldoon, P. P., McIntosh, J. M., & Damaj, M. I. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.01.017 · Cited by 69 · see citing works

Role of α5 Nicotinic Acetylcholine Receptors in Pharmacological and Behavioral Effects of Nicotine in Mice

Jackson, K. J., Marks, M. J., Vann, R. E., Chen, X., Gamage, T. F., Warner, J. A., & Damaj, M. I. (2010) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.165738 · Cited by 156 · see citing works

Distribution and Pharmacology of α6-Containing Nicotinic Acetylcholine Receptors Analyzed with Mutant Mice

Champtiaux, N., Han, Z., Bessis, A., Rossi, F., Zoli, M., Marubio, L. M., McIntosh, J. M., & Changeux, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-04-01208.2002 · Cited by 345 · see citing works

Chronic Nicotine Differentially Regulates α6- and β3-Containing Nicotinic Cholinergic Receptors in Rat Brain

Perry, D. C., Mao, D., Gold, A. B., McIntosh, J. M., Pezzullo, J. C., & Kellar, K. J. (2007) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.121228 · Cited by 106 · see citing works