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The Role of α6-Containing Nicotinic Acetylcholine Receptors in Nicotine Reward and Withdrawal
Open accessAbstract
The alpha6 nicotinic acetylcholine receptor (nAChR) subunit is involved in nicotine-stimulated dopamine release in the striatum. It is expressed in brain regions and coexpressed with nAChR subtypes implicated in nicotine dependence behaviors; hence, this subunit may play a role in nicotine dependence. Using the alpha6-selective antagonist alpha-conotoxin H9A;L15A (MII[H9A;L15A]), we determined the role of alpha6* nAChRs in the pharmacological and behavioral effects of nicotine. We measured effects of pretreatment with MII[H9A;L15A] on analgesia, locomotion, and body temperature after a single injection of nicotine. Effects of MII[H9A;L15A] on nicotine reward were measured using the conditioned place preference (CPP) paradigm. We further measured physical (somatic signs and hyperalgesia) and affective [anxiety-related behavior and conditioned place aversion (CPA)] nicotine withdrawal behaviors after extended nicotine exposure. Results showed that MII[H9A;L15A] did not block acute nicotine effects on the behaviors measured. Conversely, MII[H9A:l15A] blocked the expression of nicotine CPP, as well as withdrawal-associated CPA and anxiety-related behavior in the elevated plus maze, but not withdrawal-induced somatic signs or hyperalgesia. These results suggest a role for the alpha6 nAChR subunit in nicotine reward and affective nicotine withdrawal but not acute nicotine-induced or physical withdrawal behaviors.
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“There was no influence on the somatic symptoms of withdrawal, suggesting a selective role for α6 nAChR subunits in the affective manifestations of withdrawal (Jackson et al. 2009).”
From Nicotine Withdrawal (2015) · cites this paper as Jackson et al. 2009
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In the citing paper
“and there is a documented role for α6* nAChRs in withdrawal-induced CPA (Jackson et al. 2009).”
From Nicotine Withdrawal (2015) · cites this paper as Jackson et al. 2009
In the citing paper
“Pharmacological studies in nAChR null mice indicate that β2-containing and α6-containing nAChRs are necessary for CPA, but neither the α5, nor the α7 subunits affect CPA behavior [170, 172, 189].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [172]
In the citing paper
“Interestingly, somatic signs of withdrawal are preserved in mice lacking the β2 or the α6 nAChR subunits [11, 172]”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [172]
In the citing paper
“So far, it has been established that the β2 and α6 nAChR subunits are necessary for increased anxiety during withdrawal [170, 172], whereas, α5 and α7 may not be required [170].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [172]
In the citing paper
“In addition, infusion and systemic administration of drugs that selectively inhibit ␣42* and/or ␣62* nAChRs blocked behaviors linked to nicotine reward and reinforcement”
From Varenicline Is a Potent Partial Agonist at α6β2* Nicotinic Acetylcholine Receptors in Rat and Monkey Striatum (2012) · cites this paper as Jackson et al., 2009
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Picciotto, M. R., Zoli, M., Rimondini, R., Léna, C., Marubio, L. M., Pich, E. M., Fuxe, K., & Changeux, J.-P. (1998) · Nature · doi:10.1038/34413 · Cited by 1,320
Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs.
Pontieri, F. E., Tanda, G., Orzi, F., & Chiara, G. D. (1996) · Nature · doi:10.1038/382255a0 · Cited by 1,073
The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine
Corrigall, W. A., Franklin, K. B. J., Coen, K. M., & Clarke, P. B. S. (1992) · Psychopharmacology · doi:10.1007/bf02245149 · Cited by 829
Corrigall, W. A., Coen, K. M., & Adamson, K. L. (1994) · Brain Research · doi:10.1016/0006-8993(94)90401-4 · Cited by 740
Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization
Tapper, A. R., McKinney, S. L., Nashmi, R., Schwarz, J., Deshpande, P., Labarca, C., Whiteaker, P., Marks, M. J., Collins, A. C., & Lester, H. A. (2004) · Science · doi:10.1126/science.1099420 · Cited by 686
Klink, R., d'Exaerde, A. D. K., Zoli, M., & Changeux, J.-P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01452.2001 · Cited by 674
Molecular and cellular aspects of nicotine abuse
Dani, J. A., & Heinemann, S. (1996) · Neuron · doi:10.1016/s0896-6273(00)80112-9 · Cited by 605
Reduced antinociception in mice lacking neuronal nicotinic receptor subunits
Marubio, L. M., Jiménez, M. D. M. A., Cordero‐Erausquin, M., Léna, C., Novère, N. G. L., d’Exaerde, A. D. K., Huchet, M., Damaj, M. I., & Changeux, J. (1999) · Nature · doi:10.1038/19756 · Cited by 538
Self-citationChamptiaux, N., Gotti, C., Cordero‐Erausquin, M., David, D. J. P., Przybylski, C., Léna, C., Clementi, F., Moretti, M., Rossi, F., Novère, N. G. L., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07820.2003 · Cited by 512
Self-citationBenwell, M. E. M., & Balfour, D. J. K. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09067.x · Cited by 426
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Items 101–135 of 135
Miszkiel, J., Kruk, M., McCreary, A. C., Przegaliński, E., Biała, G., & Filip, M. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70720-4 · Cited by 7
Mao, K., Li, X., Chen, Z., Dong, X., Zhangsun, D., Zhu, X., & Luo, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.802917 · Cited by 7
Unraveling the Role of CHRNA6, the Neuronal α6 Nicotinic Acetylcholine Receptor Subunit
Heydary, Y. H., Castro, E. M., Lotfipour, S., & Leslie, F. M. (2025) · Receptors · doi:10.3390/receptors4010001 · Cited by 8
Specificity of a rodent alpha(α)6 nicotinic acetylcholine receptor subunit antibody
Cardenas, A. M., Elabd, M., & Lotfipour, S. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05413-x · Cited by 6
Li, X., Xiong, J., Zhang, B., Zhangsun, D., & Luo, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.772990 · Cited by 6
Dynamic Effects of Ventral Hippocampal NRG3/ERBB4 Signaling on Nicotine Withdrawal-Induced Responses
Fisher, M. L., Prantzalos, E. R., O’Donovan, B., Anderson, T. L., Sahoo, P. K., Twiss, J. L., Ortinski, P. I., & Turner, J. R. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109846 · Cited by 6
Jackson, A. B., Toma, W. B., Contreras, K. M., Alkhlaif, Y., & Damaj, M. I. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.05.003 · Cited by 6
Self-citationKruk, M., Miszkiel, J., McCreary, A. C., Przegaliński, E., Filip, M., & Biała, G. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70929-5 · Cited by 6
Shankar, K., Bonnet-Zahedi, S., & George, O. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06852-5 · Cited by 6
Carreño, D., Facundo, A., Nguyen, M. T. T., & Lotfipour, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073676 · Cited by 5
Carreño, D., Facundo, A., Cardenas, A. M., & Lotfipour, S. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1445303 · Cited by 6
Reynaga, D. D., Cano, M., Belluzzi, J. D., & Leslie, F. M. (2023) · Advances in Drug and Alcohol Research · doi:10.3389/adar.2023.11324 · Cited by 5
Cannabinoid-Nicotine Interactions
Auber, A., Justinová, Z., Scherma, M., Goldberg, S. R., & Panlilio, L. V. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2294-9_13 · Cited by 4
L-theanine attenuates nicotine reward and withdrawal signs in mice
Alkhlaif, Y., El-Halawany, M. S., Toma, W. B., Park, A. J., Hamouda, A. K., & Damaj, M. I. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137279 · Cited by 4
Self-citationXie, T., Qin, Y., Zhao, J., Dong, J., Qi, P., Zhang, P., Zhangsun, D., Zhu, X., Yu, J., & Luo, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108618 · Cited by 3
Trigo, J. M., & Foll, B. L. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9554-7_11 · Cited by 3
Molecular Neurobiology of Recovery with the Twelve Steps
Blum, K., Femino, J., Teitelbaum, S. A., Giordano, J., Oscar‐Berman, M., & Gold, M. S. (2013) · SpringerBriefs in neuroscience · doi:10.1007/978-1-4614-7230-8_2 · Cited by 2
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Carcoba, L. M., Torres, O. V., Pipkin, J. A., Ontiveros, T., & O’Dell, L. E. (2016) · Current Addiction Reports · doi:10.1007/s40429-016-0091-1 · Cited by 1
The Habenulo-Interpeduncular Pathway and Nicotine Withdrawal
Fowler, C. D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802574-1.00011-9 · Cited by 1
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Gogineni, H. P., Sachs, D. P. L., & Brunzell, D. H. (2023) · Respiratory medicine · doi:10.1007/978-3-031-24914-3_3 · Cited by 2
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Li, M. D. (2018) · Springer eBooks · doi:10.1007/978-981-10-7530-8_6 · Cited by 1
Nicotinic Acetylcholine Receptor Expression in Rat Dorsal Root Ganglion Neurons
Hone, J. C. (2014) · J. Willard Marriott Library · doi:10.26053/0h-ag63-v600
Steiner, R. C., & Picciotto, M. R. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.025
Fox-Loe, A. M. (2016) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2016.461
Garcia, K. L. P. (2016) · TSpace (University of Toronto)
Palmisano, A. N. (2019) · OpenCommons at University of Connecticut (University of Connecticut)
Substance dependence and abuse
Pietropaolo, S., Sluyter, F., & Crusio, W. E. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.024
Azarn, L., Maskos, U., Changeux, J., Dowell, C. D., Christensen, S. B., Biasi, M. D., & McIntosh, J. M. (2010) · The FASEB Journal · doi:10.1096/fj.10.166272
Self-citationCholinergic modulation of circuits
Addy, N., Fowler, C. D., & Wickham, R. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823453-2.00004-7 · Cited by 1
Nicotinic Acetylcholine Receptors, Cannabinoid Receptors, and Their Interplay in Drug Addiction
Vallés, A. S., & Barrantes, F. J. (2024) · Springer eBooks · doi:10.1007/978-3-031-72219-6_24
Nurkkala, J., Lampela, H., Sammalkorpi, H. E., Liisanantti, J. H., Kontinen, V., & Schramko, A. A. (2025) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.70163
Raval, N. R., Calakos, K. C., Zheng, M.-Q., Huttner, A. J., Esterlis, I., Huang, Y. H., Calhoun, V. D., Picciotto, M. R., Cosgrove, K., & Hillmer, A. T. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-025-02311-z
The role of β4-containing nicotinic acetylcholine receptors in nicotine addiction
Harrington, L. (2015) · theses.fr (ABES) · doi:10.70675/835afebdzb53ez461ez920cz1f4b0acd17a6
Conditioned place preference and conditioned place aversion in goldfish
Watanabe, S. (2026) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000887
Role of α6 nAChRs in Ethanol Modulation of VTA Neurons
Shin, S. I. (2014) · ScholarsArchive (Brigham Young University)
Metadata
- Authors
- Jackson, K. J., McIntosh, J. M., Brunzell, D. H., Sanjakdar, S. S., & Damaj, M. I.
- Affiliations
- Virginia Commonwealth University (US)
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 331
- Issue
- 2
- Pages
- 547-554
- ISSN
- 0022-3565 (ISSN-L)
- PMC
- PMC2775251
- OpenAlex
- W2133971381
- Cited by
- 135
- References
- 38
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 8 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 15 · 2014: 17 · 2013: 13 · 2012: 14
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (MH53631, GM 48677)
- National Institute of Mental Health (MH53631, R01MH053631, R29MH053631)
- National Institute on Drug Abuse (R01DA012610, DA 05274, DA-12610, R03DA023114, DA023114, P50DA005274)
- National Institute of General Medical Sciences (P01GM048677, GM48677)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotine reward, nicotine withdrawal, conditioned place preference, conditioned place aversion, anxiety-like behavior, nicotine dependence, dopamine release, striatum, hyperalgesia, locomotion, analgesia, body temperature
- MeSH terms
- Animals, Anxiety, Avoidance Learning, Body Temperature, Calcium Channel Blockers, Conditioning, Operant, Dose-Response Relationship, Drug, Injections, Intraventricular, Male, Mice, Inbred C57BL, Motor Activity, Nicotine, Pain Measurement, Reaction Time, Receptors, Nicotinic, Reward, Substance Withdrawal Syndrome, Nicotinic Agonists, Nicotinic Antagonists, Conotoxins, Mice
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